Beneficial Effects of a Perindopril/Indapamide Single-Pill Combination in Hypertensive Patients with Diabetes and/or Obesity or Metabolic Syndrome: A Post Hoc Pooled Analysis of Four Observational Studies
ConclusionsSwitching to Per/Ind SPC led to rapid and effective BP decreases in patients with T2DM, obesity, or MetS. BP control was achieved in 6 –7 out of 10 previously treated but uncontrolled patients. Treatment was well tolerated. The results confirm the beneficial effects of a Per/Ind SPC for difficult-to-control patient populations. (Source: Advances in Therapy)
Source: Advances in Therapy - February 25, 2021 Category: Drugs & Pharmacology Source Type: research
Risk of skin cancer in new users of thiazides and thiazide-like diuretics: a cohort study using an active comparator group
CONCLUSIONS: Our results corroborate the previously reported increased risk of SCC (but not of BCC or CMM) for long-term use of HCTZ. BFT may be a safer alternative for patients at increased risk of skin cancer.PMID:33609289 | DOI:10.1111/bjd.19880 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 20, 2021 Category: Dermatology Authors: R Schneider D Reinau S Stoffel S S Jick C R Meier J Spoendlin Source Type: research
Risk of skin cancer in new users of thiazides and thiazide-like diuretics: a cohort study using an active comparator group.
CONCLUSIONS: Our results corroborate the previously reported increased risk of SCC (but not of BCC or CMM) for long-term use of HCTZ. BFT may be a safer alternative for patients at increased risk of skin cancer.
PMID: 33609289 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 20, 2021 Category: Dermatology Authors: Schneider R, Reinau D, Stoffel S, Jick SS, Meier CR, Spoendlin J Tags: Br J Dermatol Source Type: research
Development and Validation of a Novel UV Spectrophotometric Method for Simultaneous Analysis of Amlodipine Indapamide and Perindopril
ERICA ALVES, CELINA NAZARETH* AND SANELLY PEREIRA (Source: Indian Journal of Pharmaceutical Sciences)
Source: Indian Journal of Pharmaceutical Sciences - January 19, 2021 Category: Drugs & Pharmacology Source Type: research
Combination of Hydroxychloroquine and Indapamide Attenuates Neurodegeneration in Models Relevant to Multiple Sclerosis
AbstractAs the underlying pathophysiology of progressive forms of multiple sclerosis (MS) remains unclear, current treatment strategies are inadequate. Progressive MS is associated with increased oxidative stress and neuronal damage in lesions along with an extensive representation of activated microglia/macrophages. To target these disease mechanisms, we tested the novel combination of generic medications, hydroxychloroquine (HCQ), and indapamide, in tissue culture and in mice. HCQ is an anti-malarial medication found to inhibit microglial activation and to ameliorate disease activity in experimental autoimmune encephalom...
Source: Neurotherapeutics - January 6, 2021 Category: Neurology Source Type: research
Determination of amlodipine, indapamide and perindopril in human plasma by a novel LC-MS/MS method; Application to a bioequivalence study.
Abstract
A robust and rapid UPLC-MS/MS method has been developed, optimized, and validated for determination of amlodipine (AML), indapamide (IND) and perindopril (PRN) in human plasma. A positive electrospray ionization mode was used in Xevo TQD LC-MS/MS instrument. A single sample preparation step using extraction technique was applied to extract the three analytes from plasma samples. There was no need to extract indapamide from blood samples in a further step. Extraction of the three drugs and internal standards was done using a solvent mixture composed of methyl tertiary butyl ether, dichloromethane, ...
Source: Biomedical Chromatography : BMC - December 11, 2020 Category: Biomedical Science Authors: Rezk MR, Badr KA Tags: Biomed Chromatogr Source Type: research
Effectiveness of Perindopril/Indapamide Single-Pill Combination in Uncontrolled Patients with Hypertension: A Pooled Analysis of the FORTISSIMO, FORSAGE, ACES and PICASSO Observational Studies
ConclusionIn this hypertensive population including difficult-to-control patient subgroups, switching to Per/Ind 10/2.5 mg SPC led to rapid and important reductions in BP. BP control was achieved in 70% of patients overall in an everyday practice context. (Source: Advances in Therapy)
Source: Advances in Therapy - November 5, 2020 Category: Drugs & Pharmacology Source Type: research
Safety implications of combining ACE inhibitors with thiazides for the treatment of hypertensive patients.
Authors: Borghi C, Soldati M, Bragagni A, Cicero AFG
Abstract
INTRODUCTION: ACE-inhibitors (ACEI) and diuretics are the typical first-line antihypertensive drugs with complementary mechanisms of action. The present paper is summarizing the evidence supporting the efficacy of their combination in a broad range of hypertensive patients.
AREAS COVERED: This source of data are different trials investigating the use of ACEI and diuretics in different populations of patients. The available evidence supports some advantage for thiazide-type compounds (chlortalidone-CHT and indapamide-IND) in the preventio...
Source: Expert Opinion on Drug Safety - October 15, 2020 Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
Effect of Perindopril/Indapamide on Cerebral Blood Flow in Middle-Aged, Treatment-Na ïve Patients with Hypertension
ConclusionIn middle-aged, treatment-na ïve patients with hypertension, Pa/I SPC was associated with increased CBF in the cortical plate of the frontal lobes, which achieved levels of normotensive controls. The increase in CBF had no clear association with observed BP changes.Registration numberISRCTN67799751. (Source: Advances in Therapy)
Source: Advances in Therapy - October 6, 2020 Category: Drugs & Pharmacology Source Type: research
Analytical tools for greenness assessment of chromatographic approaches: Application to pharmaceutical combinations of Indapamide, Perindopril and Amlodipine
Publication date: December 2020Source: Microchemical Journal, Volume 159Author(s): Sarah S. Saleh, Hayam M. Lotfy, Gizem Tiris, Nevin Erk, Yasmin Rostom (Source: Microchemical Journal)
Source: Microchemical Journal - October 1, 2020 Category: Chemistry Source Type: research
Blood-pressure Lowering Efficacy and Safety of Perindopril / Indapamide / Amlodipine Single-pill Combination in Hypertensive Patients: Phase III Trial in India.
Conclusion: This study showed the clinical efficacy, safety and acceptability of the perindopril/indapamide/amlodipine SPC in patients with grade 2/3 hypertension inadequately controlled with two-drug therapy. The clinical effectiveness was observed in more than 96 % patients. The benefit of single-pill combination (SPC) therapy in hypertension control was reconfirmed in this study.
PMID: 32978924 [PubMed - in process] (Source: Journal of the Association of Physicians of India)
Source: Journal of the Association of Physicians of India - September 29, 2020 Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Introduction of cellulose-cysteine Schiff base as a new ligand for the fabrication of blue fluorescent gold nanoclusters for the detection of indapamide drug
Publication date: 1 December 2020Source: Journal of Molecular Liquids, Volume 319Author(s): Suresh Kumar Kailasa, Mehul R. Kateshiya, Naved I. Malek (Source: Journal of Molecular Liquids)
Source: Journal of Molecular Liquids - September 25, 2020 Category: Molecular Biology Source Type: research
Acute bilateral myopia induced by Triplixam: a case report
Side effects of the systemic drugs used to treat eyes are not common. Triplixam is used to treat systemic hypertension and contains amlodipine, indapamide and perindopril arginine as active ingredients which m... (Source: BMC Ophthalmology)
Source: BMC Ophthalmology - September 22, 2020 Category: Opthalmology Authors: Ruta Jaruseviciene and Ginte Sirvydyte Tags: Case report Source Type: research
