Cost-Utility Analysis Of Hypertensive Treatment With Indapamide And Amlodipine Single-Pill Combination In The Polish Setting
To assess cost-effectiveness of indapamide 1.5 mg +amlodipine 5/10 mg single-pill combination (SPC) compared with free combination (FC), in the Polish setting. (Source: Value in Health)
Source: Value in Health - November 1, 2014 Category: Global & Universal Authors: E. Stawowczyk, P. Holko, P. Kawalec, L. Borowiec, K.J. Filipiak Source Type: research
Budget Impact Analysis Of Hypertensive Treatment With Indapamide And Amlodipine Single-Pill Combination In The Polish Setting
The aim of this study was to calculate and compare public payer and patients’ costs of hypertensive treatment with indapamide 1.5 mg and amlodipine 5 mg or 10 mg single-pill combination (SPC) and free combination (FC), in the Polish setting. (Source: Value in Health)
Source: Value in Health - November 1, 2014 Category: Global & Universal Authors: P. Kawalec, E. Stawowczyk, P. Holko, L. Borowiec, K.J. Filipiak Source Type: research
Degree of blood pressure reduction and recurrent stroke: the PROGRESS trial
Conclusions
The present analysis provided no evidence of an increase in recurrent stroke associated with larger reductions in SBP produced by treatment among patients with cerebrovascular disease. (Source: Journal of Neurology, Neurosurgery and Psychiatry)
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 17, 2014 Category: Neurosurgery Authors: Arima, H., Anderson, C., Omae, T., Woodward, M., MacMahon, S., Mancia, G., Bousser, M.-G., Tzourio, C., Harrap, S., Liu, L., Neal, B., Chalmers, J., for the PROGRESS Collaborative Group Tags: Stroke, Hypertension Cerebrovascular disease Source Type: research
Natriuresis and blood pressure reduction in hypertensive patients with diabetes mellitus: the NESTOR study
The antihypertensive effect of indapamide has never been clearly understood, particularly in hypertensive patients with diabetes mellitus. (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - October 13, 2014 Category: Cardiology Authors: Yi Zhang, Davide Agnoletti, Ji-Guang Wang, Yawei Xu, Michel E. Safar Source Type: research
Triple Combination Therapy in Hypertension: The Antihypertensive Efficacy of Treatment with Perindopril, Amlodipine, and Indapamide SR
Conclusion
A triple combination of perindopril, amlodipine, and indapamide SR controlled BP effectively in hypertensive patients uncontrolled by previous antihypertensive monotherapy or bitherapy, including RAAS inhibitor/amlodipine or RAAS inhibitor/hydrochlorothiazide combinations. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - September 25, 2014 Category: Drugs & Pharmacology Source Type: research
Acyclovir and Hyponatremia: A Case Report
A 61-year-old man attended the emergency department with decreased level of consciousness, repetitive language, and memory loss. Clinical history included type II diabetes and hypertension. Domiciliary treatment included oral metformin 850 mg every 24 hours and oral indapamide 2.5 mg every 24 hours. Laboratory tests disclosed high glycemia (198 mg/dL), increased C-reactive protein (7.4 mg/dL), and normal renal function. Intravenous acyclovir of 800 mg every 8 hours was started on admission due to suspicion of viral encephalitis. Blood analysis on 10th day displayed hyponatremia (123 mmol/L) that was at first explained by t...
Source: American Journal of Therapeutics - September 1, 2014 Category: Drugs & Pharmacology Tags: Case Report Source Type: research
Thiazide-Like/Calcium Channel Blocker Agents: A Major Combination for Hypertension Management
Abstract
In recent years, treatment strategies for hypertension have often focused on combination therapies that include diuretics and renin angiotensin aldosterone system blockers such as angiotensin-converting enzyme inhibitors or angiotensin receptor blockers. However, in clinical practice, a significant number of patients do not respond completely to these combination treatments, and long-term reduction of cardiovascular risk remains insufficient. The particularly high residual cardiovascular risk of hypertensive patients, even when adequately treated with strategies based on renin angiotensin aldoste...
Source: American Journal of Cardiovascular Drugs - August 28, 2014 Category: Cardiology Source Type: research
A systematic review and meta‐analysis of thiazide‐induced hyponatraemia: time to reconsider electrolyte monitoring regimens after thiazide initiation?
ConclusionsPatients with thiazide‐induced hyponatraemia were characterised by advanced age, female gender, inappropriate saliuresis and mild hypokalaemia. Low BMI was not found to be a significant risk factor, despite previous suggestions. The time from thiazide initiation to presentation with hyponatraemia suggests that the recommended practice of performing a single investigation of serum biochemistry 7–14 days after thiazide initiation may be insufficient or suboptimal. Further larger and more systematic studies of thiazide‐induced hyponatraemia are required. (Source: British Journal of Clinical Pharmacology)
Source: British Journal of Clinical Pharmacology - August 1, 2014 Category: Drugs & Pharmacology Authors: Jennifer Barber, Tricia M. McKeever, Sarah E. McDowell, Jennifer A. Clayton, Robin E. Ferner, Richard D. Gordon, Michael Stowasser, Kevin M. O'Shaughnessy, Ian P. Hall, Mark Glover Tags: Systematic Review Source Type: research
Which thiazide to choose as add-on therapy for hypertension?
Vivencio Barrios,1 Carlos Escobar2 1Department of Cardiology, Hospital Ramon y Cajal, 2Department of Cardiology, Hospital La Paz, Madrid, Spain Abstract: Combined therapy is required in the majority of patients with hypertension to achieve blood pressure (BP) targets. Although different antihypertensive drugs can be combined, not all combinations are equally effective and safe. In this context, the combination of a renin angiotensin system inhibitor with a diuretic, usually a thiazide, particularly hydrochlorothiazide (HCTZ) or thiazide-like diuretics, such as chlorthalidone or indapamide, is recommended. However, not all...
Source: Integrated Blood Pressure Control - July 29, 2014 Category: Cardiology Tags: Integrated Blood Pressure Control Source Type: research
The effect of indapamide versus hydrochlorothiazide on ventricular and arterial function in patients with hypertension and diabetes: Results of a randomized trial
Conclusion: Indapamide was found to improve measures of endothelial and arterial functions and to increase longitudinal left ventricular function compared with hydrochlorothiazide in patients with hypertension and diabetes, after 6 months of treatment. This study suggests that indapamide, a thiazide-like diuretic, has important vascular effects that can improve ventriculoarterial coupling. (Source: American Heart Journal)
Source: American Heart Journal - June 16, 2014 Category: Cardiology Authors: Dragos Vinereanu, Raluca Dulgheru, Stefania Magda, Ruxandra Dragoi Galrinho, Maria Florescu, Mircea Cinteza, Christopher Granger, Andrea O. Ciobanu Tags: Trial Designs Source Type: research
The effect of Indapamide versus Hydrochlorothiazide on ventricular and arterial function in patients with hypertension and diabetes: results of a randomized trial
(Source: American Heart Journal)
Source: American Heart Journal - June 13, 2014 Category: Cardiology Authors: Dragos Vinereanu, Raluca Dulgheru, Stefania Magda, Ruxandra Dragoi Galrinho, Maria Florescu, Mircea Cinteza, Christopher Granger, Andrea O. Ciobanu Source Type: research
The influence of selected antihypertensive drugs on zinc, copper, and iron status in spontaneously hypertensive rats.
Abstract
Mineral homeostasis in hypertensive patients may be affected by hypotensive drugs. The aim of this study was to assess the influence of selected antihypertensive drugs on mineral homeostasis in a rat model of hypertension. Eight-week-old male spontaneously hypertensive rats (SHRs) were treated with perindopril, metoprolol, indapamide, amlodipine, or no drug for 45 days. In another experiment, the SHRs were treated with indapamide or amlodipine in the presence of zinc and copper gluconate supplement. Lipids, glucose, and insulin levels-along with superoxide dismutase and catalase activities-were as...
Source: European Journal of Pharmacology - June 10, 2014 Category: Drugs & Pharmacology Authors: Suliburska J, Bogdanski P, Jakubowski H Tags: Eur J Pharmacol Source Type: research
Subgroup and per-protocol analyses from the Hypertension in the Very Elderly Trial
Background:The results of the Hypertension in the Very Elderly Trial showed positive benefits from blood pressure-lowering treatment in those aged 80 and over.
Method:An analysis by the pre-specified subgroups [age, sex, history of cardiovascular disease (CVD) and initial SBP] was performed. The Hypertension in the Very Elderly Trial was a randomized, double-blind, placebo-controlled trial of 3845 participants aged 80 and over with SBPs of 160–199 mmHg and diastolic pressures below 110 mmHg recruited from Europe, China, Australasia and Tunisia. Active treatment was indapamide sustained-release 1.5 mg with the addition ...
Source: Journal of Hypertension - June 6, 2014 Category: Cardiology Tags: ORIGINAL PAPERS: Elderly Source Type: research
Blood pressure-lowering efficacy of monotherapy with thiazide diuretics for primary hypertension.
CONCLUSIONS: This systematic review shows that hydrochlorothiazide has a dose-related blood pressure-lowering effect. The mean blood pressure-lowering effect over the dose range 6.25 mg, 12.5 mg, 25 mg and 50 mg/day is 4/2 mmHg, 6/3 mmHg, 8/3 mmHg and 11/5 mmHg, respectively. For other thiazide drugs, the lowest doses studied lowered blood pressure maximally and higher doses did not lower it more. Due to the greater effect on systolic than on diastolic blood pressure, thiazides lower pulse pressure by 4 mmHg to 6 mmHg. This exceeds the mean 3 mmHg pulse pressure reduction achieved by ACE inhibitors, ARBs and renin inhibito...
Source: Cochrane Database of Systematic Reviews - June 3, 2014 Category: Journals (General) Authors: Musini VM, Nazer M, Bassett K, Wright JM Tags: Cochrane Database Syst Rev Source Type: research
Effects of Combination Therapy With Olmesartan and Azelnidipine on Serum Osteoprotegerin in Patients With Hypertension
Conclusion:
Azelnidipine, but not indapamide, combined with olmesartan, improved arterial stiffness and were associated with significant decrease in OPG, MMP-2, and hs-CRP concentrations. These results suggest that the beneficial effects of the combination treatments of olmesartan/azelnidipine on arterial stiffness are mediated by alteration in bone-remodeling and inflammatory markers. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 16, 2014 Category: Cardiology Authors: Uzui, H., Morishita, T., Nakano, A., Amaya, N., Fukuoka, Y., Ishida, K., Arakawa, K., Lee, J.-D., Tada, H. Tags: Clinical Studies Source Type: research
