A Systematic Review of Patient-Reported Satisfaction with Oral Medication Therapy in Patients with Type 2 Diabetes
The systematic review provides a detailed description and evaluation of all available in English with medication instruments used for type 2 diabetes oral medications. (Source: Value in Health)
Source: Value in Health - July 16, 2018 Category: International Medicine & Public Health Authors: Yu Wang, Matthew Perri Source Type: research

Calculating the Expected Value of Sample Information Using Efficient Nested Monte Carlo: A Tutorial
The expected value of sample information (EVSI) quantifies the economic benefit of reducing uncertainty in a health economic model by collecting additional information. This has the potential to improve the allocation of research budgets. Despite this, practical EVSI evaluations are limited partly due to the computational cost of estimating this value using the gold-standard nested simulation methods. Recently, however, Heath et al. developed an estimation procedure that reduces the number of simulations required for this gold-standard calculation. (Source: Value in Health)
Source: Value in Health - July 16, 2018 Category: International Medicine & Public Health Authors: Anna Heath, Gianluca Baio Source Type: research

COMMENTARY Realizing the “Great Potential” of MCDA in HTA
We read with interest the insightful article by Marsh et al. [1], “The Use of MCDA in HTA: Great Potential, but More Effort Needed.” In the article, the authors describe three challenges to the use of multicriterion decision analysis (MCDA): the use of additive models, a lack of connection between criteria scales and weights, and the use of MCDA in economic ev aluation. The authors offer several suggestions for improving current methods including more careful consideration of criteria to avoid overlap and maintain independence, greater precision in the development of “ranges of consequences” and &ld...
Source: Value in Health - July 16, 2018 Category: International Medicine & Public Health Authors: William Hall, Craig Mitton, Adrian Levy Source Type: research

Time Is Money: Investigating the Value of Leisure Time and Unpaid Work
This study investigated the monetary value of unpaid work and leisure time to enable the inclusion of patient time in economic evaluations. (Source: Value in Health)
Source: Value in Health - July 15, 2018 Category: International Medicine & Public Health Authors: Kaya Verbooy, Renske Hoefman, Job van Exel, Werner Brouwer Source Type: research

Does Inclusion of Interactions Result in Higher Precision of Estimated Health State Values?
Most preference-based instruments producing overall values for health states are devised on the simplifying assumption that the overall effect of distinct health-related quality of life domains (attributes) of the instrument equals the sum of the attributes. Nevertheless, health attributes are often inter-related and depend on each other. (Source: Value in Health)
Source: Value in Health - July 15, 2018 Category: International Medicine & Public Health Authors: Anna Nicolet, Catharina G.M. Groothuis-Oudshoorn, Paul F.M. Krabbe Source Type: research

A Rights-Based Approach for Service Providers to Measure the Quality of Life of Children with a Disability
This paper identifies the best instruments for service providers to measure the quality of life (QoL) of children with a disability, with a focus on their alignment with the Convention on the Rights of Persons with a Disability (CRPD). (Source: Value in Health)
Source: Value in Health - July 10, 2018 Category: International Medicine & Public Health Authors: Elise Davis, Dana Young, Kim-Michelle Gilson, Elena Swift, Jeffrey Chan, Lisa Gibbs, Utsana Tonmukayakul, Dinah Reddihough, Katrina Williams Source Type: research

Cost-Utility Analysis Using EQ-5D-5L Data: Does How the Utilities Are Derived Matter?
To explore how the use of EQ-5D-5L value set and crosswalk from EQ-5D-5L to EQ-5D-3L (and use of 3L value set) would affect cost-effectiveness analysis results for England and six other countries (Canada, the Netherlands, China, Japan, South Korea, and Singapore). (Source: Value in Health)
Source: Value in Health - July 4, 2018 Category: International Medicine & Public Health Authors: Fan Yang, Nancy Devlin, Nan Luo Source Type: research

Psychometric Evaluation of the Patient ’s Knee Implant Performance Questionnaire
To evaluate the psychometric properties of Patient ’s Knee Implant Performance Questionnaire (PKIP), a new patient-reported measure of knee implant functional performance assessing patient experiences before and after primary total knee arthroplasty (TKA). (Source: Value in Health)
Source: Value in Health - July 2, 2018 Category: International Medicine & Public Health Authors: Theresa Coles, Valerie Williams, Kim Dwyer, Margaret Mordin Source Type: research

Prediction of Drug-Related Risks Using Clinical Context Information in Longitudinal Claims Data
To develop and internally validate prediction models for medication-related risks arising from overuse, misuse, and underuse that utilize clinical context information and are suitable for routine risk assessment in claims data (i.e., medication-based models predicting the risk for hospital admission apparent in routine claims data or MEDI-RADAR). (Source: Value in Health)
Source: Value in Health - July 2, 2018 Category: International Medicine & Public Health Authors: Andreas D. Meid, Andreas Groll, Dirk Heider, Sarah M ächler, Jürgen-Bernhard Adler, Christian Günster, Hans-Helmut König, Walter E. Haefeli Source Type: research

Editorial Board
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Focused Ultrasound Thalamotomy and Other Interventions for Medication-Refractory Essential Tremor: An Indirect Comparison of Short-Term Impact on Health-Related Quality of Life
This study aimed to identify and analyze evidence supporting the use of the emerging magnetic resonance –guided focused ultrasound (MRgFUS) compared to alternative stimulatory and ablative interventions for the treatment of medication-refractory essential tremor: radiofrequency thalamotomy, unilateral deep brain stimulation (DBS), and stereotactic radiosurgery. (Source: Value in Health)
Source: Value in Health - June 27, 2018 Category: International Medicine & Public Health Authors: Bryony E. Langford, Christian J.A. Ridley, Rebecca C. Beale, Sophie C.L. Caseby, William J. Marsh, Lance Richard Source Type: research

Researchers, Patients, and Stakeholders Evaluating Comparative Effectiveness Research: A Mixed-Methods Study of the PCORI Reviewer Experience
The Patient-Centered Outcomes Research Institute (PCORI) includes patients and stakeholders alongside scientists in reviewing research applications using unique review criteria including patient-centeredness and patient and/or stakeholder engagement. To support extension of this unique collaborative model to other funders, information from the reviewers on the review process is needed to understand how scientists and nonscientists evaluate research proposals together. Thus, this study aimed to describe reviewers ’ perspectives of the interactions during the in-person review panel; to examine the value and challenges ...
Source: Value in Health - June 11, 2018 Category: International Medicine & Public Health Authors: Laura P. Forsythe, Lori B. Frank, Rachel Hemphill, Tsahai A. Tafari, Victoria Szydlowski, Michael Lauer, Christine Goertz, Steven Clauser Source Type: research

A Method for Approximating Future Entry of Generic Drugs
To develop and test a method for approximating generic entry of top-selling drugs. (Source: Value in Health)
Source: Value in Health - June 11, 2018 Category: International Medicine & Public Health Authors: Reed F. Beall, Jonathan J. Darrow, Aaron S. Kesselheim Tags: Methodological Article Source Type: research

Surveying the Cost Effectiveness of the 20 Procedures with the Largest Public Health Services Waiting Lists in Ireland: Implications for Ireland ’s Cost-Effectiveness Threshold
To survey the cost effectiveness of procedures with the largest waiting lists in the Irish public health system to inform a reconsideration of Ireland ’s current cost-effectiveness threshold of €45,000/quality-adjusted life-year (QALY). (Source: Value in Health)
Source: Value in Health - June 11, 2018 Category: International Medicine & Public Health Authors: Tse Chiang Chen, Dane Wanniarachige, S íofra Murphy, Katie Lockhart, James O’Mahony Source Type: research

Budget Impact of Next-Generation Sequencing for Molecular Assessment of Advanced Non –Small Cell Lung Cancer
Genetic testing for nonsquamous advanced non –small cell lung cancer (aNSCLC) is recommended to guide first-line therapy. Activating mutations can be identified via single-gene testing or next-generation sequencing (NGS). (Source: Value in Health)
Source: Value in Health - June 8, 2018 Category: International Medicine & Public Health Authors: Tiffany M. Yu, Carl Morrison, Edward J. Gold, Alison Tradonsky, Ren ée J.G. Arnold Source Type: research

Unique Review Criteria and Patient and Stakeholder Reviewers: Analysis of PCORI ’s Approach to Research Funding
This study assessed the extent to which different reviewer types influence review scores and funding outcomes, the emphasis placed on technical merit compared to other criteria by a multistakeholder panel, and the impact of the in-person discussion on agreement among different reviewer types. (Source: Value in Health)
Source: Value in Health - June 8, 2018 Category: International Medicine & Public Health Authors: Laura P. Forsythe, Lori B. Frank, Tsahai A. Tafari, Sarah S. Cohen, Michael Lauer, Steven Clauser, Christine Goertz, Suzanne Schrandt Source Type: research

Health State Values Derived from People with Multiple Sclerosis for a Condition-Specific Preference-Based Measure: Multiple Sclerosis Impact Scale –Eight Dimensions–Patient Version (MSIS-8D-P)
In economic evaluation, health outcomes are commonly quantified using quality-adjusted life-years (QALYs) derived from the preferences of a sample of the general population. It can be argued that this approach ignores the preferences of people with experience of the condition, and that patient preferences have a place in the valuation of health outcomes. Here we report the estimation of a preference-based index for an existing condition-specific preference-based measure for multiple sclerosis (MS), the MSIS-8D, based on the preferences of people with MS. (Source: Value in Health)
Source: Value in Health - June 8, 2018 Category: International Medicine & Public Health Authors: Elizabeth Goodwin, Colin Green, Annie Hawton Source Type: research

Assessing Rationality in Discrete-Choice Experiments in Health: An Investigation into the Use of Dominance Tests
Dominance tests are often applied to test for the rationality in the choice behavior of participants in discrete-choice experiments (DCEs). (Source: Value in Health)
Source: Value in Health - June 6, 2018 Category: International Medicine & Public Health Authors: Tommi Tervonen, Tabea Schmidt-Ott, Kevin Marsh, John F.P. Bridges, Matthew Quaife, Ellen Janssen Source Type: research

Qualitative Research to Explore the Patient Experience of X-Linked Hypophosphatemia and Evaluate the Suitability of the BPI-SF and WOMAC ® as Clinical Trial End Points
X-linked hypophosphatemia (XLH) is a rare genetic disorder characterized by renal phosphate wasting and defective bone mineralization. Symptoms include bone pain, joint pain, stiffness, and fatigue. Published evidence regarding the patient experience of XLH is sparse and no XLH-specific outcome measures have been validated. (Source: Value in Health)
Source: Value in Health - June 5, 2018 Category: International Medicine & Public Health Authors: Christina Theodore-Oklota, Nicola Bonner, Holly Spencer, Rob Arbuckle, Chao-Yin Chen, Alison Skrinar Source Type: research

Editorial Board
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Source: Value in Health - June 1, 2018 Category: International Medicine & Public Health Source Type: research

C2: Editorial board PU 21/5
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Source: Value in Health - June 1, 2018 Category: International Medicine & Public Health Source Type: research

Model Comparisons of the Effectiveness and Cost-effectiveness of Vaccination: A Systematic Review of the Literature
To describe all published articles that have conducted comparisons of model-based effectiveness and cost-effectiveness results in the field of vaccination. Specific objectives were to 1) describe the methodologies used and 2) identify the strengths and limitations of the studies. (Source: Value in Health)
Source: Value in Health - May 24, 2018 Category: International Medicine & Public Health Authors: M élanie Drolet, Élodie Bénard, Mark Jit, Raymond Hutubessy, Marc Brisson Source Type: research

Can Social Care Needs and Well-Being Be Explained by the EQ-5D? Analysis of the Health Survey for England
The recent shift to an integrated approach to health and social care aims to provide cohesive support to those who are in need of care, but raises a challenge for resource allocation decision making, in particular for comparison of diverse benefits from different types of care across the two sectors. (Source: Value in Health)
Source: Value in Health - May 23, 2018 Category: International Medicine & Public Health Authors: Jeshika Singh, Subhash Pokhrel, Louise Longworth Tags: Original Research Source Type: research

Estimating a Dutch Value Set for the Paediatric Preference-Based CHU9D Using a Discrete Choice Experiment with Duration
This article presents the development of the Dutch value set for the Child Health Utility 9D, a pediatric preference-based measure of quality of life that can be used to generate quality-adjusted life-years. (Source: Value in Health)
Source: Value in Health - May 21, 2018 Category: International Medicine & Public Health Authors: Donna Rowen, Brendan Mulhern, Katherine Stevens, Jan Hendrik Vermaire Source Type: research

Time Trade-Off Value Set for EQ-5D-3L Based on a Nationally Representative Chinese Population Survey
To obtain a nationally representative Chinese three-level EuroQol five-dimensional questionnaire value set based on the time trade-off (TTO) method. (Source: Value in Health)
Source: Value in Health - May 18, 2018 Category: International Medicine & Public Health Authors: Lang Zhuo, Ling Xu, Jingtao Ye, Sun Sun, Yaoguang Zhang, Kristina Burstrom, Jiaying Chen Source Type: research

Predictors of Drug Shortages and Association with Generic Drug Prices: A Retrospective Cohort Study
Prescription drug shortages can disrupt essential patient care and drive up drug prices. (Source: Value in Health)
Source: Value in Health - May 18, 2018 Category: International Medicine & Public Health Authors: Chintan V. Dave, Ajinkya Pawar, Erin R. Fox, Gregory Brill, Aaron S. Kesselheim Source Type: research

Physicians ’ decision making on adoption of new technologies and role of coverage with evidence development: A qualitative study
To foster value-based pricing and coverage with evidence development in Germany, certain new diagnostic and treatment methods have been subject to a benefit assessment since 2016 to determine their reimbursement. Although this is a paradigm shift, the German approach is limited to some few specific technologies for which reimbursement is requested. As physicians encounter this regulatory instrument, the aim of the study was to understand physicians ’ decision making regarding the adoption of new medical technologies and to identify their perspectives on the evidence base and financing with additional reimbursement sy...
Source: Value in Health - May 15, 2018 Category: International Medicine & Public Health Authors: Susanne Felgner, Patricia Ex, Cornelia Henschke Source Type: research

Heterogeneity and Uncertainties Specific to Genome-Based Health Technological Assessments
Genomic information has the potential to have an impact on many aspects of health care, but the marked variation present in the human genome, corresponding to a variant found in every eight nucleotides sequenced [1], highlights the complexity and importance of context surrounding economic evaluation of genome-based technologies. (Source: Value in Health)
Source: Value in Health - May 11, 2018 Category: International Medicine & Public Health Authors: Lara Petelin, Danny Liew, Gillian Mitchell, Paul A. James, Alison H. Trainer Tags: Correspondence Source Type: research

General Population Norms for the Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue Scale
The Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue Scale is an internationally used validated measure. General population –based age- and sex-specific percentile norms are, however, not published to date, although these are needed as reference for the interpretation of clinical research data. (Source: Value in Health)
Source: Value in Health - May 11, 2018 Category: International Medicine & Public Health Authors: Inka Montan, Bernd L öwe, David Cella, Anja Mehnert, Andreas Hinz Source Type: research

Important Group Differences on the Functional Assessment of Cancer Therapy –Kidney Symptom Index Disease-Related Symptoms (FKSI-DRS) in Patients with Metastatic Renal Cell Carcinoma
The Functional Assessment of Cancer Therapy –Kidney Symptom Index Disease-Related Symptoms (FKSI-DRS) is important to gauge clinical benefit in metastatic renal cell carcinoma (mRCC). (Source: Value in Health)
Source: Value in Health - May 10, 2018 Category: International Medicine & Public Health Authors: David Cella, Robert J. Motzer, Brian I. Rini, Joseph C. Cappelleri, Krishnan Ramaswamy, Subramanian Hariharan, Bhakti Arondekar, Andrew G. Bushmakin Source Type: research

Development and Validation of an Algorithm for Identifying Patients with Hemophilia A in an Administrative Claims Database
The accuracy with which hemophilia A can be identified in claims databases is unknown. (Source: Value in Health)
Source: Value in Health - May 7, 2018 Category: International Medicine & Public Health Authors: Jennifer Lyons, Vibha Desai, Yaping Xu, Greg Ridgeway, William Finkle, Paul Solari, Sean Sullivan, Stephan Lanes Tags: Methodological Article Source Type: research

Health-Related Quality of Life in People Living with Psychotic Illness, and Factors Associated with Its Variation
To establish whether the four-dimensional Assessment of Quality of Life (AQoL-4D) produces robust utility values in adults with psychotic illness, and identify health inequalities compared with the general population. (Source: Value in Health)
Source: Value in Health - May 4, 2018 Category: International Medicine & Public Health Authors: Amanda L. Neil, Vaughan J. Carr, Andrew Mackinnon, Debra L. Foley, Vera A. Morgan Source Type: research

Systematic Review and Network Meta-Analysis of Treatments for Chemotherapy-Naive Patients with Asymptomatic/Mildly Symptomatic Metastatic Castration-Resistant Prostate Cancer
To estimate the relative effectiveness of enzalutamide in chemotherapy-naive metastatic castration-resistant prostate cancer by conducting a systematic literature review and a network meta-analysis (NMA). (Source: Value in Health)
Source: Value in Health - May 3, 2018 Category: International Medicine & Public Health Authors: Rachael McCool, Kelly Fleetwood, Julie Glanville, Mick Arber, Howard Goodall, Shevani Naidoo Source Type: research

Evaluating and Valuing Drugs for Rare Conditions: No Easy Answers
We find ourselves in an era of unprecedented growth in the development and use of so-called “orphan” drugs to treat rare diseases, which are poised to represent more than one-fifth of pharmaceutical expenditures by 2022. This widespread use has been facilitated by legislative and regulatory incentives in both the United States and abroad, yet US payers and health systems have not yet m ade a concerted effort to understand whether and how rare diseases require special considerations on their part and how to adapt traditional methods of health technology assessment and economic evaluation to accommodate these sit...
Source: Value in Health - May 1, 2018 Category: International Medicine & Public Health Authors: Daniel A. Ollendorf, Richard H. Chapman, Steven D. Pearson Source Type: research

Societal Preferences for Funding Orphan Drugs in the United Kingdom: An Application of Person Trade-Off and Discrete Choice Experiment Methods
It is unclear whether UK National Health Service (NHS) policies for orphan drugs, which permit funding of non –cost-effective treatments, reflect societal preferences. (Source: Value in Health)
Source: Value in Health - May 1, 2018 Category: International Medicine & Public Health Authors: Siobhan M. Bourke, Catrin O. Plumpton, Dyfrig A. Hughes Source Type: research

Editorial Board
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Table of Contents
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Does Selecting Covariates Using Factor Analysis in Mapping Algorithms Improve Predictive Accuracy? A Case of Predicting EQ-5D-5L and SF-6D Utilities from the Women ’s Health Questionnaire
In addition to theoretical justifications, many statistical methods have been used for selecting covariates to include in algorithms mapping nonutility measures onto utilities. However, it is not clear whether using exploratory factor analysis (EFA) as one such method improves the predictive ability of these algorithms. (Source: Value in Health)
Source: Value in Health - April 28, 2018 Category: International Medicine & Public Health Authors: Billingsley Kaambwa, Caroline Smith, Sheryl de Lacey, Julie Ratcliffe Source Type: research

Accuracy of Linking VR-12 and PROMIS Global Health Scores in Clinical Practice
To examine the accuracy of general health cross-walk tables in a clinical sample of patients with spine disorders. Published tables (Schalet BD, Rothrock NE, Hays RD, et al. Linking physical and mental health summary scores from the Veterans RAND 12-Item Health Survey (VR-12) to the PROMIS( ®) Global Health Scale. J Gen Intern Med 2015;30:1524–30) link scores from the Veterans RAND 12-Item Health Survey (VR-12) to the 10-Item Patient-Reported Outcome Measurement Information System (PROMIS), a global health scale metric for both mental (GMH) and physical (GPH) summary scores. (Source: Value in Health)
Source: Value in Health - April 26, 2018 Category: International Medicine & Public Health Authors: Brittany R. Lapin, Tyler G. Kinzy, Nicolas R. Thompson, Ajit Krishnaney, Irene L. Katzan Source Type: research

Experiences of Structured Elicitation for Model-Based Cost-Effectiveness Analyses
Empirical evidence supporting the cost-effectiveness estimates of particular health care technologies may be limited, or it may even be missing entirely. In these situations, additional information, often in the form of expert judgments, is needed to reach a decision. There are formal methods to quantify experts ’ beliefs, termed as structured expert elicitation (SEE), but only limited research is available in support of methodological choices. Perhaps as a consequence, the use of SEE in the context of cost-effectiveness modelling is limited. (Source: Value in Health)
Source: Value in Health - April 24, 2018 Category: International Medicine & Public Health Authors: Marta O. Soares, Linda Sharples, Alec Morton, Karl Claxton, Laura Bojke Source Type: research

A Generic Model for Follicular Lymphoma: Predicting Cost, Life Expectancy, and Quality-Adjusted-Life-Year Using UK Population –Based Observational Data
To use real-world data to develop a flexible generic decision model to predict cost, life expectancy, and quality-adjusted life-years (QALYs) for follicular lymphoma (FL) in the general patient population. (Source: Value in Health)
Source: Value in Health - April 23, 2018 Category: International Medicine & Public Health Authors: Han-I Wang, Eve Roman, Simon Crouch, Eline Aas, Cathy Burton, Russell Patmore, Alexandra Smith Source Type: research

Association between Higher Generic Drug Use and Medicare Part D Star Ratings: An Observational Analysis
Increasing generic drug use, due to potential for cost savings and drug access, is a viable consideration for Medicare prescription drug plans to achieve high star ratings and improve quality of plan offerings for Medicare beneficiaries. (Source: Value in Health)
Source: Value in Health - April 18, 2018 Category: International Medicine & Public Health Authors: Natalie Hohmann, Richard Hansen, Kimberly B. Garza, Ilene Harris, Zippora Kiptanui, Jingjing Qian Source Type: research