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Time Trade-Off Value Set for EQ-5D-3L Based on a Nationally Representative Chinese Population Survey
To obtain a nationally representative Chinese three-level EuroQol five-dimensional questionnaire value set based on the time trade-off (TTO) method. (Source: Value in Health)
Source: Value in Health - May 18, 2018 Category: International Medicine & Public Health Authors: Lang Zhuo, Ling Xu, Jingtao Ye, Sun Sun, Yaoguang Zhang, Kristina Burstrom, Jiaying Chen Source Type: research

Predictors of Drug Shortages and Association with Generic Drug Prices: A Retrospective Cohort Study
Prescription drug shortages can disrupt essential patient care and drive up drug prices. (Source: Value in Health)
Source: Value in Health - May 18, 2018 Category: International Medicine & Public Health Authors: Chintan V. Dave, Ajinkya Pawar, Erin R. Fox, Gregory Brill, Aaron S. Kesselheim Source Type: research

Physicians ’ decision making on adoption of new technologies and role of coverage with evidence development: A qualitative study
To foster value-based pricing and coverage with evidence development in Germany, certain new diagnostic and treatment methods have been subject to a benefit assessment since 2016 to determine their reimbursement. Although this is a paradigm shift, the German approach is limited to some few specific technologies for which reimbursement is requested. As physicians encounter this regulatory instrument, the aim of the study was to understand physicians ’ decision making regarding the adoption of new medical technologies and to identify their perspectives on the evidence base and financing with additional reimbursement sy...
Source: Value in Health - May 15, 2018 Category: International Medicine & Public Health Authors: Susanne Felgner, Patricia Ex, Cornelia Henschke Source Type: research

Heterogeneity and Uncertainties Specific to Genome-Based Health Technological Assessments
Genomic information has the potential to have an impact on many aspects of health care, but the marked variation present in the human genome, corresponding to a variant found in every eight nucleotides sequenced [1], highlights the complexity and importance of context surrounding economic evaluation of genome-based technologies. (Source: Value in Health)
Source: Value in Health - May 11, 2018 Category: International Medicine & Public Health Authors: Lara Petelin, Danny Liew, Gillian Mitchell, Paul A. James, Alison H. Trainer Tags: Correspondence Source Type: research

General Population Norms for the Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue Scale
The Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue Scale is an internationally used validated measure. General population –based age- and sex-specific percentile norms are, however, not published to date, although these are needed as reference for the interpretation of clinical research data. (Source: Value in Health)
Source: Value in Health - May 11, 2018 Category: International Medicine & Public Health Authors: Inka Montan, Bernd L öwe, David Cella, Anja Mehnert, Andreas Hinz Source Type: research

Important Group Differences on the Functional Assessment of Cancer Therapy –Kidney Symptom Index Disease-Related Symptoms (FKSI-DRS) in Patients with Metastatic Renal Cell Carcinoma
The Functional Assessment of Cancer Therapy –Kidney Symptom Index Disease-Related Symptoms (FKSI-DRS) is important to gauge clinical benefit in metastatic renal cell carcinoma (mRCC). (Source: Value in Health)
Source: Value in Health - May 10, 2018 Category: International Medicine & Public Health Authors: David Cella, Robert J. Motzer, Brian I. Rini, Joseph C. Cappelleri, Krishnan Ramaswamy, Subramanian Hariharan, Bhakti Arondekar, Andrew G. Bushmakin Source Type: research

Development and Validation of an Algorithm for Identifying Patients with Hemophilia A in an Administrative Claims Database
The accuracy with which hemophilia A can be identified in claims databases is unknown. (Source: Value in Health)
Source: Value in Health - May 7, 2018 Category: International Medicine & Public Health Authors: Jennifer Lyons, Vibha Desai, Yaping Xu, Greg Ridgeway, William Finkle, Paul Solari, Sean Sullivan, Stephan Lanes Tags: Methodological Article Source Type: research

Health-Related Quality of Life in People Living with Psychotic Illness, and Factors Associated with Its Variation
To establish whether the four-dimensional Assessment of Quality of Life (AQoL-4D) produces robust utility values in adults with psychotic illness, and identify health inequalities compared with the general population. (Source: Value in Health)
Source: Value in Health - May 4, 2018 Category: International Medicine & Public Health Authors: Amanda L. Neil, Vaughan J. Carr, Andrew Mackinnon, Debra L. Foley, Vera A. Morgan Source Type: research

Systematic Review and Network Meta-Analysis of Treatments for Chemotherapy-Naive Patients with Asymptomatic/Mildly Symptomatic Metastatic Castration-Resistant Prostate Cancer
To estimate the relative effectiveness of enzalutamide in chemotherapy-naive metastatic castration-resistant prostate cancer by conducting a systematic literature review and a network meta-analysis (NMA). (Source: Value in Health)
Source: Value in Health - May 3, 2018 Category: International Medicine & Public Health Authors: Rachael McCool, Kelly Fleetwood, Julie Glanville, Mick Arber, Howard Goodall, Shevani Naidoo Source Type: research

Evaluating and Valuing Drugs for Rare Conditions: No Easy Answers
We find ourselves in an era of unprecedented growth in the development and use of so-called “orphan” drugs to treat rare diseases, which are poised to represent more than one-fifth of pharmaceutical expenditures by 2022. This widespread use has been facilitated by legislative and regulatory incentives in both the United States and abroad, yet US payers and health systems have not yet m ade a concerted effort to understand whether and how rare diseases require special considerations on their part and how to adapt traditional methods of health technology assessment and economic evaluation to accommodate these sit...
Source: Value in Health - May 1, 2018 Category: International Medicine & Public Health Authors: Daniel A. Ollendorf, Richard H. Chapman, Steven D. Pearson Source Type: research

Societal Preferences for Funding Orphan Drugs in the United Kingdom: An Application of Person Trade-Off and Discrete Choice Experiment Methods
It is unclear whether UK National Health Service (NHS) policies for orphan drugs, which permit funding of non –cost-effective treatments, reflect societal preferences. (Source: Value in Health)
Source: Value in Health - May 1, 2018 Category: International Medicine & Public Health Authors: Siobhan M. Bourke, Catrin O. Plumpton, Dyfrig A. Hughes Source Type: research

Editorial Board
(Source: Value in Health)
Source: Value in Health - May 1, 2018 Category: International Medicine & Public Health Source Type: research

Table of Contents
(Source: Value in Health)
Source: Value in Health - May 1, 2018 Category: International Medicine & Public Health Source Type: research

Copyright/Subscription
(Source: Value in Health)
Source: Value in Health - May 1, 2018 Category: International Medicine & Public Health Source Type: research

Does Selecting Covariates Using Factor Analysis in Mapping Algorithms Improve Predictive Accuracy? A Case of Predicting EQ-5D-5L and SF-6D Utilities from the Women ’s Health Questionnaire
In addition to theoretical justifications, many statistical methods have been used for selecting covariates to include in algorithms mapping nonutility measures onto utilities. However, it is not clear whether using exploratory factor analysis (EFA) as one such method improves the predictive ability of these algorithms. (Source: Value in Health)
Source: Value in Health - April 28, 2018 Category: International Medicine & Public Health Authors: Billingsley Kaambwa, Caroline Smith, Sheryl de Lacey, Julie Ratcliffe Source Type: research

Accuracy of Linking VR-12 and PROMIS Global Health Scores in Clinical Practice
To examine the accuracy of general health cross-walk tables in a clinical sample of patients with spine disorders. Published tables (Schalet BD, Rothrock NE, Hays RD, et al. Linking physical and mental health summary scores from the Veterans RAND 12-Item Health Survey (VR-12) to the PROMIS( ®) Global Health Scale. J Gen Intern Med 2015;30:1524–30) link scores from the Veterans RAND 12-Item Health Survey (VR-12) to the 10-Item Patient-Reported Outcome Measurement Information System (PROMIS), a global health scale metric for both mental (GMH) and physical (GPH) summary scores. (Source: Value in Health)
Source: Value in Health - April 26, 2018 Category: International Medicine & Public Health Authors: Brittany R. Lapin, Tyler G. Kinzy, Nicolas R. Thompson, Ajit Krishnaney, Irene L. Katzan Source Type: research

Experiences of Structured Elicitation for Model-Based Cost-Effectiveness Analyses
Empirical evidence supporting the cost-effectiveness estimates of particular health care technologies may be limited, or it may even be missing entirely. In these situations, additional information, often in the form of expert judgments, is needed to reach a decision. There are formal methods to quantify experts ’ beliefs, termed as structured expert elicitation (SEE), but only limited research is available in support of methodological choices. Perhaps as a consequence, the use of SEE in the context of cost-effectiveness modelling is limited. (Source: Value in Health)
Source: Value in Health - April 24, 2018 Category: International Medicine & Public Health Authors: Marta O. Soares, Linda Sharples, Alec Morton, Karl Claxton, Laura Bojke Source Type: research

A Generic Model for Follicular Lymphoma: Predicting Cost, Life Expectancy, and Quality-Adjusted-Life-Year Using UK Population –Based Observational Data
To use real-world data to develop a flexible generic decision model to predict cost, life expectancy, and quality-adjusted life-years (QALYs) for follicular lymphoma (FL) in the general patient population. (Source: Value in Health)
Source: Value in Health - April 23, 2018 Category: International Medicine & Public Health Authors: Han-I Wang, Eve Roman, Simon Crouch, Eline Aas, Cathy Burton, Russell Patmore, Alexandra Smith Source Type: research

Association between Higher Generic Drug Use and Medicare Part D Star Ratings: An Observational Analysis
Increasing generic drug use, due to potential for cost savings and drug access, is a viable consideration for Medicare prescription drug plans to achieve high star ratings and improve quality of plan offerings for Medicare beneficiaries. (Source: Value in Health)
Source: Value in Health - April 18, 2018 Category: International Medicine & Public Health Authors: Natalie Hohmann, Richard Hansen, Kimberly B. Garza, Ilene Harris, Zippora Kiptanui, Jingjing Qian Source Type: research

Economic Modeling Considerations for Rare Diseases
To identify challenges that affect the feasibility and rigor of economic models in rare diseases and strategies that manufacturers have employed in health technology assessment submissions to demonstrate the value of new orphan products that have limited study data. (Source: Value in Health)
Source: Value in Health - April 17, 2018 Category: International Medicine & Public Health Authors: Isobel Pearson, Ben Rothwell, Andrew Olaye, Christopher Knight Source Type: research

Evaluation of the Measurement Properties of Four Performance Outcome Measures in Patients with Elective Hip Replacements, Elective Knee Replacements, or Hip Fractures
To evaluate the measurement properties of four performance outcome (PerfO) measures (timed up and go, four-step stair climb, long stair climb, and repeated chair stand) in three patient populations(elective total hip replacement [eTHR], elective total knee replacement [eTKR], and hip fracture [HF]). (Source: Value in Health)
Source: Value in Health - April 12, 2018 Category: International Medicine & Public Health Authors: Helen Doll, Brittany Gentile, Elizabeth Nicole Bush, Rachel Ballinger Tags: Original Research Source Type: research

On the Value of the Umbilical Cord Blood Supply
Several public cord blood banks are struggling financially, and the question remains as to whether additional allocations of funds to them are justified. (Source: Value in Health)
Source: Value in Health - April 12, 2018 Category: International Medicine & Public Health Authors: Aaron Strong, Tadeja Gra čner, Peggy Chen, Kandice Kapinos Source Type: research

Evaluation of the Measurement Properties of Four Performance Outcome Measures in Patients with Elective Hip Replacements, Elective Knee Replacements, or Hip Fractures
To evaluate the measurement properties of four performance outcome (PerfO) measures (timed up and go, four-step stair climb, long stair climb, and repeated chair stand) in three patient populations(elective total hip replacement [eTHR], elective total knee replacement [eTKR], and hip fracture [HF]). (Source: Value in Health)
Source: Value in Health - April 12, 2018 Category: International Medicine & Public Health Authors: Helen Doll, Brittany Gentile, Elizabeth Nicole Bush, Rachel Ballinger Tags: Original Research Source Type: research

On the Value of the Umbilical Cord Blood Supply
Several public cord blood banks are struggling financially, and the question remains as to whether additional allocations of funds to them are justified. (Source: Value in Health)
Source: Value in Health - April 12, 2018 Category: International Medicine & Public Health Authors: Aaron Strong, Tadeja Gra čner, Peggy Chen, Kandice Kapinos Source Type: research

A Modeling Study of the Cost Effectiveness of a Risk-Stratified Surveillance Program for Melanoma in the United Kingdom
Population-wide screening for melanoma is unlikely to be cost-effective. Nevertheless, targeted surveillance of high-risk individuals may be. (Source: Value in Health)
Source: Value in Health - April 11, 2018 Category: International Medicine & Public Health Authors: Edward C.F. Wilson, Juliet A. Usher-Smith, Jon Emery, Pippa Corrie, Fiona M. Walter Source Type: research

Initial Development and Content Validation of a Health-Related Symptom Index for Persons either Treated or Monitored for Anal High-Grade Squamous Intraepithelial Lesions (HSILs): AMC-A02
Anal cancer, caused by oncogenic types of human papillomavirus, is a growing problem in the United States. A key focus of anal cancer prevention has been screening for and treating precancerous high-grade squamous intraepithelial anal lesions (HSILs). (Source: Value in Health)
Source: Value in Health - April 11, 2018 Category: International Medicine & Public Health Authors: Jack E. Burkhalter, Thomas M. Atkinson, J. Berry-Lawhorn, Stephen Goldstone, Mark H. Einstein, Timothy J. Wilkin, Jeannette Lee, David Cella, Joel M. Palefsky, ANCHOR HRQOL Implementation Group Source Type: research

Evaluating the Content Validity of Four Performance Outcome Measures in Patients with Elective Hip Replacements and Hip Fractures
To assess the content validity of performance outcome (PerfO) measures for use with patients undergoing hip fracture (HF) surgery and elective total hip replacement (eTHR). (Source: Value in Health)
Source: Value in Health - April 11, 2018 Category: International Medicine & Public Health Authors: Rachel Ballinger, Cicely Kerr, Fiona Mowbray, Elizabeth Nicole Bush Tags: Original Research Source Type: research

The Development of a Patient-Reported Outcome Measure for Geriatric Care: The Older Persons and Informal Caregivers Survey Short Form (TOPICS-SF)
The Older Persons and Informal Caregivers Minimum Data Set (TOPICS-MDS) is a standardized data set that was developed to evaluate the quality of multidimensional geriatric care. There is an inherent need to reduce the number of TOPICS-MDS survey items to core outcomes to allow it to be more easily applied as a patient-reported outcome measure in clinical settings. (Source: Value in Health)
Source: Value in Health - April 11, 2018 Category: International Medicine & Public Health Authors: Angelina M.M. Santoso, Jennifer E. Lutomski, Cynthia S. Hofman, Silke F. Metzelthin, Jeanet W. Blom, Philip J. van der Wees, Marcel G.M. Olde Rikkert, Ren é J.F. Melis, on behalf of TOPICS-MDS Consortium Source Type: research

Challenges in Research and Health Technology Assessment of Rare Disease Technologies: Report of the ISPOR Rare Disease Special Interest Group
Successful development of new treatments for rare diseases (RDs) and their sustainable patient access require overcoming a series of challenges related to research and health technology assessment (HTA). These impediments, which may be unique to RDs or also apply to common diseases but are particularly pertinent in RDs, are diverse and interrelated. (Source: Value in Health)
Source: Value in Health - April 11, 2018 Category: International Medicine & Public Health Authors: Sandra Nestler-Parr, Daria Korchagina, Mondher Toumi, Chris L. Pashos, Christopher Blanchette, Elizabeth Molsen, Thomas Morel, Steven Simoens, Zolt án Kaló, Ruediger Gatermann, William Redekop Source Type: research

A Modeling Study of the Cost Effectiveness of a Risk-Stratified Surveillance Program for Melanoma in the United Kingdom
Population-wide screening for melanoma is unlikely to be cost-effective. Nevertheless, targeted surveillance of high-risk individuals may be. (Source: Value in Health)
Source: Value in Health - April 11, 2018 Category: International Medicine & Public Health Authors: Edward C.F. Wilson, Juliet A. Usher-Smith, Jon Emery, Pippa Corrie, Fiona M. Walter Source Type: research

Initial Development and Content Validation of a Health-Related Symptom Index for Persons either Treated or Monitored for Anal High-Grade Squamous Intraepithelial Lesions (HSILs): AMC-A02
Anal cancer, caused by oncogenic types of human papillomavirus, is a growing problem in the United States. A key focus of anal cancer prevention has been screening for and treating precancerous high-grade squamous intraepithelial anal lesions (HSILs). (Source: Value in Health)
Source: Value in Health - April 11, 2018 Category: International Medicine & Public Health Authors: Jack E. Burkhalter, Thomas M. Atkinson, J. Berry-Lawhorn, Stephen Goldstone, Mark H. Einstein, Timothy J. Wilkin, Jeannette Lee, David Cella, Joel M. Palefsky, ANCHOR HRQOL Implementation Group Source Type: research

Evaluating the Content Validity of Four Performance Outcome Measures in Patients with Elective Hip Replacements and Hip Fractures
To assess the content validity of performance outcome (PerfO) measures for use with patients undergoing hip fracture (HF) surgery and elective total hip replacement (eTHR). (Source: Value in Health)
Source: Value in Health - April 11, 2018 Category: International Medicine & Public Health Authors: Rachel Ballinger, Cicely Kerr, Fiona Mowbray, Elizabeth Nicole Bush Tags: Original Research Source Type: research

The Development of a Patient-Reported Outcome Measure for Geriatric Care: The Older Persons and Informal Caregivers Survey Short Form (TOPICS-SF)
The Older Persons and Informal Caregivers Minimum Data Set (TOPICS-MDS) is a standardized data set that was developed to evaluate the quality of multidimensional geriatric care. There is an inherent need to reduce the number of TOPICS-MDS survey items to core outcomes to allow it to be more easily applied as a patient-reported outcome measure in clinical settings. (Source: Value in Health)
Source: Value in Health - April 11, 2018 Category: International Medicine & Public Health Authors: Angelina M.M. Santoso, Jennifer E. Lutomski, Cynthia S. Hofman, Silke F. Metzelthin, Jeanet W. Blom, Philip J. van der Wees, Marcel G.M. Olde Rikkert, Ren é J.F. Melis, on behalf of TOPICS-MDS Consortium Source Type: research

Challenges in Research and Health Technology Assessment of Rare Disease Technologies: Report of the ISPOR Rare Disease Special Interest Group
Successful development of new treatments for rare diseases (RDs) and their sustainable patient access require overcoming a series of challenges related to research and health technology assessment (HTA). These impediments, which may be unique to RDs or also apply to common diseases but are particularly pertinent in RDs, are diverse and interrelated. (Source: Value in Health)
Source: Value in Health - April 11, 2018 Category: International Medicine & Public Health Authors: Sandra Nestler-Parr, Daria Korchagina, Mondher Toumi, Chris L. Pashos, Christopher Blanchette, Elizabeth Molsen, Thomas Morel, Steven Simoens, Zolt án Kaló, Ruediger Gatermann, William Redekop Source Type: research

Rare Diseases: Addressing the Challenges in Diagnosis, Drug Approval, and Patient Access
Rare diseases represent a wide range of disorders and constellations of clinical signs and symptoms. Many rare diseases cause chronic or progressive physical deterioration, disability, or premature death and start in childhood, creating a huge burden on parents and caregivers. Most rare diseases are thought to be genetic and there may be as many as 7000 rare diseases [1]. Although there is no universally accepted terminology or definition as to what constitutes a rare disease, it is typically characterized by its low frequency of occurrence. (Source: Value in Health)
Source: Value in Health - April 10, 2018 Category: International Medicine & Public Health Authors: Kati Copley-Merriman Tags: Editorial Source Type: research

Computer Modeling of Diabetes and Its Transparency: A Report on the Eighth Mount Hood Challenge
The Eighth Mount Hood Challenge (held in St. Gallen, Switzerland, in September 2016) evaluated the transparency of model input documentation from two published health economics studies and developed guidelines for improving transparency in the reporting of input data underlying model-based economic analyses in diabetes. (Source: Value in Health)
Source: Value in Health - April 9, 2018 Category: International Medicine & Public Health Authors: Andrew J. Palmer, Lei Si, Michelle Tew, Xinyang Hua, Michael S. Willis, Christian Asseburg, Phil McEwan, Jos é Leal, Alastair Gray, Volker Foos, Mark Lamotte, Talitha Feenstra, Patrick J. O’Connor, Michael Brandle, Harry J. Smolen, James C. Gahn, Willi Source Type: research

The Problem of Rarity: Estimation of Prevalence in Rare Disease
From a disease ’s first description to its wider recognition, factors such as changes over time in diagnostic criteria, available therapies, and subsequent mortality rates may influence diagnosed prevalence of rare diseases. (Source: Value in Health)
Source: Value in Health - April 5, 2018 Category: International Medicine & Public Health Authors: St éphane Auvin, John Irwin, Paul Abi-Aad, Alysia Battersby Source Type: research

Can Severity Outweigh Smaller Numbers? A Deliberative Perspective from Canada
To use structured deliberation to elicit and describe the values of the public in Alberta, Canada, on the question of whether the severity of a rare condition can justify it being given priority in funding over common conditions affecting larger numbers of patients, and what aspects of a condition drive this judgment. (Source: Value in Health)
Source: Value in Health - April 5, 2018 Category: International Medicine & Public Health Authors: Monica Magalhaes Source Type: research

The Problem of Rarity: Estimation of Prevalence in Rare Disease
From a disease ’s first description to its wider recognition, factors such as changes over time in diagnostic criteria, available therapies, and subsequent mortality rates may influence diagnosed prevalence of rare diseases. (Source: Value in Health)
Source: Value in Health - April 5, 2018 Category: International Medicine & Public Health Authors: St éphane Auvin, John Irwin, Paul Abi-Aad, Alysia Battersby Source Type: research

Can Severity Outweigh Smaller Numbers? A Deliberative Perspective from Canada
To use structured deliberation to elicit and describe the values of the public in Alberta, Canada, on the question of whether the severity of a rare condition can justify it being given priority in funding over common conditions affecting larger numbers of patients, and what aspects of a condition drive this judgment. (Source: Value in Health)
Source: Value in Health - April 5, 2018 Category: International Medicine & Public Health Authors: Monica Magalhaes Source Type: research

A multigene test could cost-effectively help extend life expectancy for women at risk of hereditary breast cancer —Reply to letter to the editor by Petelin et al.
In our article [1], we compared the cost effectiveness of two strategies of pathogenic gene variant testing for women at high risk of breast cancer: testing only the BRCA1/2 genes and testing a multigene panel that included BRCA1/2 and five additional breast cancer –associated genes. The authors of the letter [2] express three areas of concern about how input parameter assumptions can affect the results of the analysis. (Source: Value in Health)
Source: Value in Health - April 4, 2018 Category: International Medicine & Public Health Authors: Yonghong Li, James J. Devlin Source Type: research

Minimally Important Difference of the EQ-5D-5L Index Score in Adults with Type 2 Diabetes
The EuroQol five-dimensional questionnaire (EQ-5D) is a generic preference-based measure of health-related quality of life, and several studies have made attempts to estimate the minimally important difference (MID) for the EQ-5D index score. (Source: Value in Health)
Source: Value in Health - April 3, 2018 Category: International Medicine & Public Health Authors: Nathan S. McClure, Fatima Al Sayah, Arto Ohinmaa, Jeffrey A. Johnson Tags: Methodological Article Source Type: research