Matching-Adjusted Indirect Comparisons of Lorlatinib Versus Chemotherapy for Patients With Second-Line or Later Anaplastic Lymphoma Kinase –Positive Non–Small Cell Lung Cancer
This study aimed to compare the relative efficacy of lorlatinib, an anaplastic lymphoma kinase –tyrosine kinase inhibitor, with chemotherapy, for patients with second-line or later advanced anaplastic lymphoma kinase–positive non–small cell lung cancer. The endpoints of interest were overall survival (OS) and progression-free survival (PFS). (Source: Value in Health)
Source: Value in Health - August 16, 2022 Category: International Medicine & Public Health Authors: Sarah Smith, Fernando Albuquerque de Almeida, Monica In ês, Laura Iadeluca, Miranda Cooper Tags: Comparative-Effectiveness Research/HTA Source Type: research

Why We Need a New Outcomes-Based Value Attribution Framework for Combination Regimens in Oncology
Novel oncology treatment strategies increasingly use medicines with distinct but complementary mechanisms of action in combination or in close sequence. Payers, when confronted with higher total cost of providing combination regimens involving multiple therapies and usually longer treatment durations, are reluctant to reimburse them, particularly when they perceive the expected incremental benefits from adding a new medicine (the add-on) to a currently reimbursed medicine (the backbone) not to represent value for money to the health system. (Source: Value in Health)
Source: Value in Health - August 14, 2022 Category: International Medicine & Public Health Authors: Adrian Towse, Mickael Lothgren, Lotte Steuten, Andrew Bruce Tags: Comparative-Effectiveness Research/HTA Source Type: research

Analyzing the Pain/Discomfort and Anxiety/Depression Composite Domains and the Meaning of Discomfort in the EQ-5D: A Mixed-Methods Study
This study aims to explore how respondents use the composites to self-report health and what the meaning of discomfort is in the EQ-5D for the general public. (Source: Value in Health)
Source: Value in Health - August 13, 2022 Category: International Medicine & Public Health Authors: Fanni Rencz, Mathieu F. Janssen Tags: Patient-Reported Outcomes Source Type: research

Caregiving-Related Work Productivity Loss Among Employed Family and Other Unpaid Caregivers of Older Adults
Although nearly half of all family and unpaid caregivers to older adults work, little is known about short-term work impacts of caregiving using measures encompassing both missed work time and reduced productivity while physically at work. We quantify the prevalence, costs, and correlates of caregiving-related work productivity loss. (Source: Value in Health)
Source: Value in Health - August 13, 2022 Category: International Medicine & Public Health Authors: Maningb è B. Keita Fakeye, Laura J. Samuel, Emmanuel F. Drabo, Karen Bandeen-Roche, Jennifer L. Wolff Tags: Patient-Reported Outcomes Source Type: research

The Value of Vaccines in Maintaining Health System Capacity in England
We present a pragmatic approach for conceptualizing vaccines ’ health system capacity value when considering opportunity costs. (Source: Value in Health)
Source: Value in Health - August 13, 2022 Category: International Medicine & Public Health Authors: Simon Brassel, Margherita Neri, Hannah Schirrmacher, Lotte Steuten Tags: Policy Perspectives Source Type: research

Cost-Effectiveness and Budget Impact of Future Developments With Whole-Genome Sequencing for Patients With Lung Cancer
This study aimed to investigate the cost-effectiveness, budget impact (BI), and impact of uncertainty of future developments concerning whole-genome sequencing (WGS) as a clinical diagnostic test compared with standard of care (SoC) in patients with locally advanced and metastatic non –small cell lung cancer. (Source: Value in Health)
Source: Value in Health - August 13, 2022 Category: International Medicine & Public Health Authors: Martijn J.H.G. Simons, Carin A. Uyl-de Groot, Valesca P. Ret èl, Joanne M. Mankor, Bram L.T. Ramaekers, Manuela A. Joore, Wim H. van Harten Tags: Economic Evaluation Source Type: research

Test-Retest Reliability of EQ-5D-Y-3L Best-Worst Scaling Choices of Adolescents and Adults
There is an increasing interest to obtain adolescents ’ own health state valuation preferences and to understand how these differ from adult preferences for the same health state. An important question in health state valuation is whether adolescents can report preferences reliably, yet research remains limited. (Source: Value in Health)
Source: Value in Health - August 13, 2022 Category: International Medicine & Public Health Authors: Xiuqin Xiong, Kim Dalziel, Li Huang, Oliver Rivero-Arias Tags: Brief Report Source Type: research

A Guide to Selecting Flexible Survival Models to Inform Economic Evaluations of Cancer Immunotherapies
Parametric models are routinely used to estimate the benefit of cancer drugs beyond trial follow-up. The advent of immune checkpoint inhibitors has challenged this paradigm, and emerging evidence suggests that more flexible survival models, which can better capture the shapes of complex hazard functions, might be needed for these interventions. Nevertheless, there is a need for an algorithm to help analysts decide whether flexible models are required and, if so, which should be chosen for testing. (Source: Value in Health)
Source: Value in Health - August 13, 2022 Category: International Medicine & Public Health Authors: Stephen Palmer, Isabelle Borget, Tim Friede, Don Husereau, Jonathan Karnon, Ben Kearns, Emma Medin, Elisabeth F.P. Peterse, Sven L. Klijn, Elisabeth J.M. Verburg-Baltussen, Elisabeth Fenwick, John Borrill Tags: Comparative-Effectiveness Research/HTA Source Type: research

Can Observational Analyses of Routinely Collected Data Emulate Randomized Trials? Design and Feasibility of the Observational Patient Evidence for Regulatory Approval Science and Understanding Disease Project
The Observational Patient Evidence for Regulatory Approval Science and Understanding Disease (OPERAND) project examines whether real-world data (RWD) can be used to inform regulatory decision making. (Source: Value in Health)
Source: Value in Health - August 12, 2022 Category: International Medicine & Public Health Authors: William Crown, Issa J. Dahabreh, Xiaojuan Li, Sengwee Toh, Barbara Bierer Tags: Comparative-Effectiveness Research/HTA Source Type: research

Quality-Adjusted Life Expectancy Norms for the English Population
The National Institute for Health and Care Excellence in England has implemented severity-of-disease modifiers that give greater weight to health benefits accruing to patients who experience a larger shortfall in quality-adjusted life-years (QALYs) under current standard of care than healthy individuals. This requires an estimate of quality-adjusted life expectancy (QALE) of the general population based on age and sex. Previous QALE population norms are based on nearly 30-year-old assessments of health-related quality of life in the general population. (Source: Value in Health)
Source: Value in Health - August 12, 2022 Category: International Medicine & Public Health Authors: Simon McNamara, Paul P. Schneider, James Love-Koh, Tim Doran, Nils Gutacker Tags: Brief Report Source Type: research

An Epidemiology Model for Estimating the Numbers of US Patients With Multiple Myeloma by Line of Therapy and Treatment Exposure
The objective of this study was to estimate the number of patients with MM by LOT and the number of patients who have received at least 4 previous LOTs including proteasome inhibitors, immunomodulatory agents, and anti-CD38 monoclonal antibodies (mAbs). (Source: Value in Health)
Source: Value in Health - August 11, 2022 Category: International Medicine & Public Health Authors: Andreas Nikolaou, Cosmina Hogea, Yevgeniy Samyshkin, Eric M. Maiese, Leah Sansbury, Mustafa Oguz, Javier Cid-Ruzafa, Ritika Kapoor, Feng Wang Tags: Methodology Source Type: research

Association Between Receipt of Definitive Treatment for Localized Prostate Cancer and Adverse Health Outcomes: A Claims-Based Approach
This study aimed to examine adverse health outcomes associated with receipt of definitive treatments (prostatectomy, intensity-modulated radiation therapy [IMRT] and brachytherapy). (Source: Value in Health)
Source: Value in Health - August 11, 2022 Category: International Medicine & Public Health Authors: Jean M. Mitchell, Carole Roan Gresenz Tags: Health Policy Analysis Source Type: research

Cost-Effectiveness of Newborn Screening for Spinal Muscular Atrophy in The Netherlands
Spinal muscular atrophy (SMA) is a rare genetic disorder that causes progressive muscle weakness and paralysis. In its most common and severe form, the majority of untreated infants die before 2 years of age. Early detection and treatment, ideally before symptom onset, maximize survival and achievement of age-appropriate motor milestones, with potentially substantial impact on health-related quality of life. Therefore, SMA is an ideal candidate for inclusion in newborn screening (NBS) programs. We evaluated the cost-effectiveness of including SMA in the NBS program in The Netherlands. (Source: Value in Health)
Source: Value in Health - August 11, 2022 Category: International Medicine & Public Health Authors: Rimma Velikanova, Simon van der Schans, Matthias Bischof, Rudolf Walther van Olden, Maarten Postma, Cornelis Boersma Tags: Economic Evaluation Source Type: research

Modeling the Recovery of Elective Waiting Lists Following COVID-19: Scenario Projections for England
The objective of this study was to estimate the trajectory of future waiting list size and waiting times up to December 2025. (Source: Value in Health)
Source: Value in Health - August 10, 2022 Category: International Medicine & Public Health Authors: Nicholas C. Howlett, Richard M. Wood Tags: Themed Section Source Type: research

Measuring, Analyzing, and Presenting Work Productivity Loss in Randomized Controlled Trials: A Scoping Review
This study aimed to conduct a scoping review of randomized controlled trials (RCTs) and investigate which work productivity loss outcomes were measured in these RCTs, how each outcome was measured and analyzed, and how the results for each outcome were presented. (Source: Value in Health)
Source: Value in Health - August 9, 2022 Category: International Medicine & Public Health Authors: Wei Zhang, Paige Tocher, Jacynthe L ’Heureux, Julie Sou, Huiying Sun Tags: Systematic Literature Review Source Type: research