Estimating Cost-Effectiveness Using Alternative Preference-Based Scores and Within-Trial Methods: Exploring the Dynamics of the Quality-Adjusted Life-Year Using the EQ-5D 5-Level Version and Recovering Quality of Life Utility Index
This study aimed to explore quality-adjusted life-year (QALY) and subsequent cost-effectiveness estimates based on the more physical health –focused EQ-5D 5-level version (EQ-5D-5L) value set for England or cross-walked EQ-5D 3-level version UK value set scores or more mental health recovery-focused Recovering Quality of Life Utility Index (ReQoL-UI), when using alternative within-trial statistical methods. We describe possible reason s for the different QALY estimates based on the interaction between item scores, health state profiles, preference-based scores, and mathematical and statistical methods chosen. (Source: Value in Health)
Source: Value in Health - January 13, 2022 Category: International Medicine & Public Health Authors: Matthew Franklin, Rachael Maree Hunter, Angel Enrique, Jorge Palacios, Derek Richards Tags: Preference-Based Assessments Source Type: research

Developing a New Generic Health and Wellbeing Measure: Psychometric Survey Results for the EQ Health and Wellbeing
This study explored the psychometric performance of candidate items, testing their validity in patients, social carer users, and carers. (Source: Value in Health)
Source: Value in Health - January 13, 2022 Category: International Medicine & Public Health Authors: Tessa Peasgood, Clara Mukuria, John Brazier, Ole Marten, Simone Kreimeier, Nan Luo, Brendan Mulhern, Wolfgang Greiner, A. Simon Pickard, Federico Augustovski, Lidia Engel, Luz Gibbons, Zhihao Yang, Andrea L. Monteiro, Maja Kuharic, Maria Belizan, Jakob Bj Tags: Themed Section Source Type: research

Fulfilling the Promise of Artificial Intelligence in the Health Sector: Let ’s Get Real
This study aimed to showcase the potential and key concerns and risks of artificial intelligence (AI) in the health sector, illustrating its application with current examples, and to provide policy guidance for the development, assessment, and adoption of AI technologies to advance policy objectives. (Source: Value in Health)
Source: Value in Health - January 13, 2022 Category: International Medicine & Public Health Authors: Tiago Cravo Oliveira Hashiguchi, Jillian Oderkirk, Luke Slawomirski Tags: Themed Section Source Type: research

Qualitative Review on Domains of Quality of Life Important for Patients, Social Care Users, and Informal Carers to Inform the Development of the EQ Health and Wellbeing
To identify the themes to inform the content of a new generic measure, the EQ Health and Wellbeing (EQ-HWB), that can be used in economic evaluation across health, social care, and public health, based on the views of users and beneficiaries of these services including informal carers. (Source: Value in Health)
Source: Value in Health - January 13, 2022 Category: International Medicine & Public Health Authors: Clara Mukuria, Janice Connell, Jill Carlton, Tessa Peasgood, Alison Scope, Mark Clowes, Stacey Rand, Karen Jones, John Brazier Tags: Themed Section Source Type: research

Cost-Effectiveness of Extracorporeal Photopheresis for the Treatment of Patients With Erythrodermic (Stage T4, M0) Cutaneous T-Cell Lymphoma in the Australian Setting
Cutaneous T-cell lymphoma (CTCL) is a rare and incurable disease, and patients currently experience a lack of treatment options in Australia. This analysis evaluated the cost-effectiveness of extracorporeal photopheresis (ECP) compared with standard of care therapy for the treatment of patients with erythrodermic (stage T4, M0) CTCL, who are refractory to previous systemic treatment. (Source: Value in Health)
Source: Value in Health - January 11, 2022 Category: International Medicine & Public Health Authors: Adrian Peacock, Francis Dehle, Oscar Alejandro Mesa Zapata, H. Miles Prince, Francesca Gennari, Colman Taylor Tags: Economic Evaluation Source Type: research

Economic Evaluations of Remote Patient Monitoring for Chronic Disease: A Systematic Review
This study aimed to systematically review and summarize economic evaluations of noninvasive remote patient monitoring (RPM) for chronic diseases compared with usual care. (Source: Value in Health)
Source: Value in Health - January 11, 2022 Category: International Medicine & Public Health Authors: Keshia R. De Guzman, Centaine L. Snoswell, Monica L. Taylor, Leonard C. Gray, Liam J. Caffery Tags: Themed Section Source Type: research

Stepwise Design and Evaluation of a Values-Oriented Ambient Intelligence Healthcare Monitoring Platform
The majority of all developed digital health technologies do not reach successful implementation. A discrepancy among technology design, the context of use, and user needs and values is identified as the main reason for this failure. Value-sensitive design (VSD) is a design method enabling to align design with user values by embedding values in technology, yet the method is lacking clear heuristics for practical application. To improve the successful design and implementation of digital health, we propose and evaluate a stepwise approach to VSD. (Source: Value in Health)
Source: Value in Health - January 11, 2022 Category: International Medicine & Public Health Authors: Merlijn Smits, Metin Nacar, Geke D.S. Ludden, Harry van Goor Tags: Themed Section Source Type: research

Economic Evaluation of Vaccination Programs: A Guide for Selecting Modeling Approaches
Illustrate 3 economic evaluation methods whose value measures may be useful to decision makers considering vaccination programs. (Source: Value in Health)
Source: Value in Health - January 10, 2022 Category: International Medicine & Public Health Authors: Josephine Mauskopf, Leslie Blake, Amanda Eiden, Craig Roberts, Tianyan Hu, Mawuli Nyaku Tags: Methodology Source Type: research

Cost and Cost-Effectiveness of a Digital Adherence Technology for Tuberculosis Treatment Support in Uganda
Digital adherence technologies like 99DOTS are increasingly considered as an alternative to directly observed therapy for tuberculosis (TB) treatment supervision. We evaluated the cost and cost-effectiveness of 99DOTS in a high-TB-burden setting. (Source: Value in Health)
Source: Value in Health - January 6, 2022 Category: International Medicine & Public Health Authors: Ryan R. Thompson, Alex Kityamuwesi, Alice Kuan, Denis Oyuku, Austin Tucker, Olivia Ferguson, Lynn Kunihira Tinka, Rebecca Crowder, Stavia Turyahabwe, Adithya Cattamanchi, David W. Dowdy, Achilles Katamba, Hojoon Sohn Tags: Themed Section Source Type: research

Development of an EQ-5D Value Set for India Using an Extended Design (DEVINE) Study: The Indian 5-Level Version EQ-5D Value Set
This study aimed to develop the Indian 5-level version EQ-5D (EQ-5D-5L) value set, which is a key input in health technology assessment for resource allocation in healthcare. (Source: Value in Health)
Source: Value in Health - January 5, 2022 Category: International Medicine & Public Health Authors: Gaurav Jyani, Atul Sharma, Shankar Prinja, Sitanshu Sekhar Kar, Mayur Trivedi, Binod Kumar Patro, Aarti Goyal, Fredrick Dermawan Purba, Aureliano Paolo Finch, Kavitha Rajsekar, Swati Raman, Elly Stolk, Manmeet Kaur Tags: Preference-Based Assessment Source Type: research

An Exploratory Analysis of the “Was It Worth It?” Questionnaire as a Novel Metric to Capture Patient Perceptions of Cancer Treatment
Asking “Was it worth it?” (WIWI) potentially captures the patient perception of a treatment’s benefit weighed against its harms. This exploratory analysis evaluates the WIWI questionnaire as a metric of patients’ perspectives on the worthwhileness of cancer treatment. (Source: Value in Health)
Source: Value in Health - January 3, 2022 Category: International Medicine & Public Health Authors: Gita Thanarajasingam, Ethan Basch, Carolyn Mead-Harvey, Antonia V. Bennett, Gina L. Mazza, Gisela Schwab, Jessica Roydhouse, Lauren J. Rogak, Amylou C. Dueck Tags: Brief Report Source Type: research

Consolidated Health Economic Evaluation Reporting Standards (CHEERS) 2022 Explanation and Elaboration: A Report of the ISPOR CHEERS II Good Practices Task Force
Health economic evaluations are comparative analyses of alternative courses of action in terms of their costs and consequences. The Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement, published in 2013, was created to ensure health economic evaluations are identifiable, interpretable, and useful for decision making. It was intended as guidance to help authors report accurately which health interventions were being compared and in what context, how the evaluation was undertaken, what the findings were, and other details that may aid readers and reviewers in interpretation and use of the study. (S...
Source: Value in Health - January 1, 2022 Category: International Medicine & Public Health Authors: Don Husereau, Michael Drummond, Federico Augustovski, Esther de Bekker-Grob, Andrew H. Briggs, Chris Carswell, Lisa Caulley, Nathorn Chaiyakunapruk, Dan Greenberg, Elizabeth Loder, Josephine Mauskopf, C. Daniel Mullins, Stavros Petrou, Raoh-Fang Pwu, Soph Tags: ISPOR Report Source Type: research

CHEERS to Updated Guidelines for Reporting Health Economic Evaluations!
In this issue, the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) 2022 makes its global debut.1 Whether this report remains known as CHEERS 2022 (a good vintage year, we are hoping) or simply becomes “CHEERS II,” it is a sequel worthy of its predecessor. The original CHEERS report was published in Value in Health in 2013,2 along with shorter summaries in 9 other journals, including the European Journal of Health Economics, Clinical Therapeutics, Cost Effective Resource Allocation, BMC Medici ne, BMJ, Pharmacoeconomics, Journal of Medical Economics, the International Journal of Technology A...
Source: Value in Health - January 1, 2022 Category: International Medicine & Public Health Authors: Richard J. Willke, Laura T. Pizzi Tags: ISPOR Report: Editorial Source Type: research

Consolidated Health Economic Evaluation Reporting Standards 2022 (CHEERS 2022) Statement: Updated Reporting Guidance for Health Economic Evaluations
Health economic evaluations are comparative analyses of alternative courses of action in terms of their costs and consequences. The Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement, published in 2013, was created to ensure health economic evaluations are identifiable, interpretable, and useful for decision making. It was intended as guidance to help authors report accurately which health interventions were being compared and in what context, how the evaluation was undertaken, what the findings were, and other details that may aid readers and reviewers in interpretation and use of the study. (S...
Source: Value in Health - January 1, 2022 Category: International Medicine & Public Health Authors: Don Husereau, Michael Drummond, Federico Augustovski, Esther de Bekker-Grob, Andrew H. Briggs, Chris Carswell, Lisa Caulley, Nathorn Chaiyakunapruk, Dan Greenberg, Elizabeth Loder, Josephine Mauskopf, C. Daniel Mullins, Stavros Petrou, Raoh-Fang Pwu, Soph Tags: ISPOR Report Source Type: research

Editorial Board
(Source: Value in Health)
Source: Value in Health - January 1, 2022 Category: International Medicine & Public Health Source Type: research

Table of Contents
(Source: Value in Health)
Source: Value in Health - January 1, 2022 Category: International Medicine & Public Health Source Type: research

Copyright/Subscription
(Source: Value in Health)
Source: Value in Health - January 1, 2022 Category: International Medicine & Public Health Source Type: research

A Review of Patient-Reported Outcome Labeling of FDA-Approved New Drugs (2016-2020): Counts, Categories, and Comprehensibility
A review of new drug approvals (NDAs) by the US Food and Drug Administration (FDA) for 2006 to 2015 showed that approximately 20% of new drugs had labeling based on patient-reported outcomes (PROs). The purpose of this study was to review labeling text based on PRO endpoints for NDAs from 2016 to 2020, with a special focus on the comprehensibility of such statements when included. (Source: Value in Health)
Source: Value in Health - December 24, 2021 Category: International Medicine & Public Health Authors: Ari Gnanasakthy, Lindsey Norcross, Carla (DeMuro) Romano, Robyn T. Carson Tags: Patient-Reported Outcomes Source Type: research

Reported Challenges in Health Technology Assessment of Complex Health Technologies
This study aimed to identify challenges in HTA of complex health technologies. (Source: Value in Health)
Source: Value in Health - December 22, 2021 Category: International Medicine & Public Health Authors: Milou A. Hogervorst, Rick A. Vreman, Aukje K. Mantel-Teeuwisse, Wim G. Goettsch Tags: Health Policy Analysis Source Type: research

The Value of Federated Data Networks in Oncology: What Research Questions Do They Answer? Outcomes From a Systematic Literature Review
Real-world evidence (RWE) plays an important role in addressing key research questions of interest to healthcare decision makers. Federated data networks (FDNs) apply novel technology to enable the conduct of RWE studies with multiple partners, without the need to share the individual partner ’s data set. A systematic review of the published literature was performed to determine which types of research questions can best be addressed through FDNs, specifically in the field of oncology. (Source: Value in Health)
Source: Value in Health - December 22, 2021 Category: International Medicine & Public Health Authors: Matthias Hunger, Kristina Bardenheuer, Alun Passey, Ren é Schade, Ruchika Sharma, Clare Hague Tags: Systematic Literature Review Source Type: research

A Framework for Using Real-World Data and Health Outcomes Modeling to Evaluate Machine Learning –Based Risk Prediction Models
We propose a framework of health outcomes modeling with dynamic decision making and real-world data (RWD) to evaluate the potential utility of novel risk prediction models in clinical practice. Lung transplant (LTx) referral decisions in cystic fibrosis offer a complex case study. (Source: Value in Health)
Source: Value in Health - December 22, 2021 Category: International Medicine & Public Health Authors: Patricia J. Rodriguez, David L. Veenstra, Patrick J. Heagerty, Christopher H. Goss, Kathleen J. Ramos, Aasthaa Bansal Tags: Themed Section Source Type: research

Value of Magnetic Resonance Imaging Compared With Urine-Based Markers in the Detection of Prostate Cancer
Urine and serum biomarkers have become increasingly adopted to aid in the risk stratification and diagnosis of prostate cancer, given that prostate-specific antigen (PSA) has a relatively low specificity for prostate cancer. A microsimulation model of prostate cancer progression and survival was recently used to compare the value of using different urine-based biomarkers and multiparametric magnetic resonance imaging (mpMRI) as reflex tests in men with elevated PSA.1 The authors characterize mpMRI as a reflex test within this study, which underestimates and devalues its utility. (Source: Value in Health)
Source: Value in Health - December 20, 2021 Category: International Medicine & Public Health Authors: Joshua S. Jue, Javier Gonz ález, Mahmoud Alameddine Tags: Letter to the Editor Source Type: research

The Cost-Effectiveness of Selective Internal Radiation Therapies Compared with Sorafenib for Treating Advanced Unresectable Hepatocellular Carcinoma in the United Kingdom
To assess the cost-effectiveness of selective internal radiation therapy (SIRT) compared with sorafenib for the treatment of patients with advanced hepatocellular carcinoma in the United Kingdom, including a selected subgroup of patients who have been identified as benefiting from treatment with SIRT. (Source: Value in Health)
Source: Value in Health - December 16, 2021 Category: International Medicine & Public Health Authors: Lindsay Claxton, Matthew Walton, Sahar Sharif-Hurst, Ros Wade, Alison Eastwood, Robert Hodgson Tags: Economic Evaluation Source Type: research

Appraising the Costs of Genomic Testing for Histology-Independent Technologies: An Illustrative Example for NTRK Fusions
Histology-independent (HI) technologies are authorized for patients with advanced or metastatic cancer if they express a particular biomarker regardless of its position in the body. Although this represents an important advancement in cancer treatment, genomic testing to identify eligible individuals for HI technologies will require substantial investment and impact their cost-effectiveness. Estimating these costs is complicated by several issues, which affect not only the overall cost of testing but also the distribution of testing costs across tumor types. (Source: Value in Health)
Source: Value in Health - December 16, 2021 Category: International Medicine & Public Health Authors: Lucy Beresford, Peter Murphy, Sofia Dias, Lindsay Claxton, Matthew Walton, Robert Metcalf, Helene Schlecht, Christian Ottensmeier, Marta Pereira, Robert Hodgson Tags: Health Policy Analysis Source Type: research

Systematic Review of Health Economic Evaluations Focused on Artificial Intelligence in Healthcare: The Tortoise and the Cheetah
This study aimed to systematically review recent health economic evaluations (HEEs) of artificial intelligence (AI) applications in healthcare. The aim was to discuss pertinent methods, reporting quality and challenges for future implementation of AI in healthcare, and additionally advise future HEEs. (Source: Value in Health)
Source: Value in Health - December 16, 2021 Category: International Medicine & Public Health Authors: Madelon M. Voets, Jeroen Veltman, Cornelis H. Slump, Sabine Siesling, Hendrik Koffijberg Tags: Themed Section Source Type: research

Economic Evaluation of In-Hospital Clinical Practices in Acute Injury Care: A Systematic Review
Underuse of high-value clinical practices and overuse of low-value practices are major sources of inefficiencies in modern healthcare systems. To achieve value-based care, guidelines and recommendations should target both underuse and overuse and be supported by evidence from economic evaluations. We aimed to conduct a systematic review of the economic value of in-hospital clinical practices in acute injury care to advance knowledge on value-based care in this patient population. (Source: Value in Health)
Source: Value in Health - December 15, 2021 Category: International Medicine & Public Health Authors: Blanchard Conombo, Jason R. Guertin, Pier-Alexandre Tardif, Marc-Aur èle Gagnon, Cécile Duval, Patrick Archambault, Simon Berthelot, François Lauzier, Alexis F. Turgeon, Henry T. Stelfox, Michaël Chassé, Jeffrey S. Hoch, Belinda Gabbe, Howard Champio Tags: Systematic Literature Review Source Type: research

Comparison of the PROMIS Preference Score (PROPr) and EQ-5D-5L Index Value in General Population Samples in the United Kingdom, France, and Germany
The Patient-Reported Outcome Measurement Information System (PROMIS) Preference score (PROPr) can be used to assess health state utility (HSU) and estimate quality-adjusted life-years in cost-effectiveness analyses. It is based on item response theory and promises to overcome limitations of existing HSU scores such as ceiling effects. The PROPr contains 7 PROMIS domains: cognitive abilities, depression, fatigue, pain, physical function, sleep disturbance, and ability to participate in social roles and activities. (Source: Value in Health)
Source: Value in Health - December 15, 2021 Category: International Medicine & Public Health Authors: Christoph Paul Klapproth, Christopher J. Sidey-Gibbons, Jos é Martinez Valderas, Matthias Rose, Felix Fischer Tags: Patient-Reported Outcomes Source Type: research

The Roadmap for Implementing Value-Based Healthcare in European University Hospitals —Consensus Report and Recommendations
Value-based healthcare (VBHC) aims at improving patient outcomes while optimizing the use of hospitals ’ resources among medical personnel, administrations, and support services through an evidence-based, collaborative approach. In this article, we present a blueprint for the implementation of VBHC in hospitals, based on our experience as members of the European University Hospital Alliance. (Source: Value in Health)
Source: Value in Health - December 15, 2021 Category: International Medicine & Public Health Authors: Yolima Cossio-Gil, Maisa Omara, Carolina Watson, Joseph Casey, Alexandre Chakhunashvili, Mar ía Gutiérrez-San Miguel, Pascal Kahlem, Samuel Keuchkerian, Valerie Kirchberger, Virginie Luce-Garnier, Dominik Michiels, Matteo Moro, Barbara Philipp-Jaschek, Tags: Methodology Source Type: research

Effectiveness and Cost-Effectiveness of 360 Disease-Modifying Treatment Escalation Sequences in Multiple Sclerosis
The rapid expansion in treatment options for relapsing-remitting multiple sclerosis (RRMS) of the past decade requires clinical decision making on the sequential prescription of these treatments. Here, we compare 360 treatment escalation sequences for patients with RRMS in terms of health outcomes and societal costs in The Netherlands. (Source: Value in Health)
Source: Value in Health - December 15, 2021 Category: International Medicine & Public Health Authors: Matthijs M. Versteegh, Simone A. Huygens, Beatrijs W.H. Wokke, Joost Smolders Tags: Economic Evaluation Source Type: research

Long-Term Cost-Effectiveness Comparison of Catheter Ablation and Antiarrhythmic Drugs in Atrial Fibrillation Treatment Using Discrete Event Simulation
To evaluate the lifetime cost-effectiveness of 3 widely used atrial fibrillation (AF) treatments from the perspectives of Chinese healthcare system: antiarrhythmic drugs (AADs), ThermoCool SmartTouch guided by ablation index (STAI), and second-generation cryoballoon (CB2). (Source: Value in Health)
Source: Value in Health - December 13, 2021 Category: International Medicine & Public Health Authors: Min Hu, Yi Han, Wangyang Zhao, Wen Chen Tags: Economic Evaluation Source Type: research

The Effects of Severe Acute Respiratory Syndrome Coronavirus 2 on the Reported Mental Health Symptoms of Nonprofessional Carers: An Analysis Across Europe
This study tries to analyze how the crisis generated by severe acute respiratory syndrome coronavirus 2 has affected the reported mental health symptoms of informal caregivers in different European countries. (Source: Value in Health)
Source: Value in Health - December 11, 2021 Category: International Medicine & Public Health Authors: Luz Mar ía Peña-Longobardo, Juan Oliva-Moreno, Beatriz Rodríguez-Sánchez Tags: Themed Section Source Type: research

Variation in Model-Based Economic Evaluations of Low-Dose Computed Tomography Screening for Lung Cancer: A Methodological Review
There is significant heterogeneity in the results of published model-based economic evaluations of low-dose computed tomography (LDCT) screening for lung cancer. We sought to understand and demonstrate how these models differ. (Source: Value in Health)
Source: Value in Health - December 11, 2021 Category: International Medicine & Public Health Authors: Jaime L. Peters, Tristan M. Snowsill, Edward Griffin, Sophie Robinson, Chris J. Hyde Tags: Systematic Literature Review Source Type: research

Comparison of Alternative Methods to Assess the Cost-Effectiveness of Tumor-Agnostic Therapies: A Triangulation Approach Using Larotrectinib as a Case Study
The study objective was to investigate the economic value of tumor-agnostic therapies when only single-arm effectiveness data are available at launch by applying multiple methodologies to establish comparative effectiveness. (Source: Value in Health)
Source: Value in Health - December 11, 2021 Category: International Medicine & Public Health Authors: Andrew Briggs, Beth Wehler, Jennifer G. Gaultney, Alex Upton, Antoine Italiano, Carsten Bokemeyer, Noman Paracha, Sean D. Sullivan Tags: Methodology Source Type: research

Key Considerations in the Health Technology Assessment of Advanced Therapy Medicinal Products in Scotland, The Netherlands, and England
Advanced therapy medicinal products (ATMPs) are highly innovative therapies. Their costs and uncertain value  claims have raised concerns among health technology assessment (HTA) bodies and payers. Little is known about how underlying considerations in HTA of ATMPs shape assessment and reimbursement recommendations. We aim to identify and assess key considerations that played a role in HTA of ATMPs unde rlying reimbursement recommendations. (Source: Value in Health)
Source: Value in Health - December 10, 2021 Category: International Medicine & Public Health Authors: Renske M.T. ten Ham, Geert W.J. Frederix, Oliva Wu, Wim Goettsch, Hubert G.M. Leufkens, Olaf H. Klungel, Jarno Hoekman Tags: Comparative-Effectiveness Research Source Type: research

Accounting for Intergenerational Cascade Testing in Economic Evaluations of Clinical Genomics —A Scoping Review
Clinical genomics is emerging as a diagnostic tool in the identification of blood relatives at risk of developing heritable diseases. Our objective was to identify how genetic cascade screening has been incorporated into health economic evaluations. (Source: Value in Health)
Source: Value in Health - December 10, 2021 Category: International Medicine & Public Health Authors: Jason Zischke, Nicole White, Louisa Gordon Tags: Comparative-Effectiveness Research Source Type: research

Optimizing the Design of a Repeated Fecal Immunochemical Test Bowel Cancer Screening Programme With a Limited Endoscopy Capacity From a Health Economic Perspective
This study informed decision making by determining the most cost-effective FIT screening strategy (age range, frequency, and FIT threshold) under a constrained endoscopy capacity. (Source: Value in Health)
Source: Value in Health - December 9, 2021 Category: International Medicine & Public Health Authors: Sophie Whyte, Chloe Thomas, Jim Chilcott, Ben Kearns Tags: Economic Evaluation Source Type: research

Quantifying the Effect of Public Activity Intervention Policies on COVID-19 Pandemic Containment Using Epidemiologic Data From 145 Countries
Most countries have adopted public activity intervention policies to control the coronavirus disease 2019 (COVID-19) pandemic. Nevertheless, empirical evidence of the effectiveness of different interventions on the containment of the epidemic was inconsistent. (Source: Value in Health)
Source: Value in Health - December 7, 2021 Category: International Medicine & Public Health Authors: Jichao Sun, Yefeng Zheng, Wenhua Liang, Zifeng Yang, Zhiqi Zeng, Tiegang Li, Junjie Luo, Man Tat Alexander Ng, Jianxing He, Nanshan Zhong Tags: Themed Section Source Type: research

Accounting for Unobservable Preference Heterogeneity and Evaluating Alternative Anchoring Approaches to Estimate Country-Specific EQ-5D-Y Value Sets: A Case Study Using Spanish Preference Data
The EuroQol Group published the EQ-5D-Y valuation protocol that recommends 2 valuation techniques to elicit preferences: composite time trade-off (C-TTO) and discrete choice experiments (DCEs). The protocol left the decision of what modeling approach to use open for researchers. Our aims were to explore modeling strategies allowing generation of EQ-5D-Y value sets and to produce an EQ-5D-Y Spanish value set. (Source: Value in Health)
Source: Value in Health - December 4, 2021 Category: International Medicine & Public Health Authors: Juan M. Ramos-Go ñi, Mark Oppe, Anabel Estévez-Carrillo, Oliver Rivero-Arias, IMPACT HTA HRQoL Group Tags: Preference-Based Assessments Source Type: research

Genetic-Guided Pharmacotherapy for Atrial Fibrillation: A Systematic and Critical Review of Economic Evaluations
This study aimed to examine the extent and quality of evidence from economic evaluations (EEs) of genetic-guided pharmacotherapy (PGx) for atrial fibrillation (AF) and to identify variables influential in changing base-case conclusions. (Source: Value in Health)
Source: Value in Health - December 2, 2021 Category: International Medicine & Public Health Authors: Ahmad Amir Kamil, Ka Keat Lim, Rositsa Koleva-Kolarova, Philip Chowienczyk, Charles D.A. Wolfe, Julia Fox-Rushby Tags: Systematic Literature Review Source Type: research

Varying Willingness to Pay Based on Severity of Illness: Impact on Health Technology Assessment Outcomes of Inpatient and Outpatient Drug Therapies in The Netherlands
Since 2015, Zorginstituut Nederland (ZIN) has linked disease severity ranges of 0.10 to 0.40, 0.41 to 0.70, and 0.71 to 1.00 with willingness-to-pay (WTP) reference values of €20 000, €50 000, and €80 000 per quality-adjusted life year gained, respectively. We sought to review whether these changes have affected ZIN health technology assessment (HTA) outcomes for specialist and outpatient drugs. (Source: Value in Health)
Source: Value in Health - December 1, 2021 Category: International Medicine & Public Health Authors: Marieke Schurer, Suzette M. Matthijsse, Carla Y. Vossen, Marjolijn van Keep, James Horscroft, Ann-Marie Chapman, Ron L. Akehurst Tags: Health Policy Analysis Source Type: research

Implementing Risk-Sharing Arrangements for Innovative Medicines: The Experience in Catalonia (Spain)
Publications assessing health and economic outcomes of risk-sharing arrangements (RSAs) are limited. Better knowledge of these outcomes would shed light on the pertinence of such arrangements, informing design improvements for the future. The aim of the study is to describe the different types of RSAs implemented in Catalonia and their health and economic outcomes. (Source: Value in Health)
Source: Value in Health - December 1, 2021 Category: International Medicine & Public Health Authors: Laura Guarga, Montse Gasol, Anna Reyes, Marta Roig, Enric Alonso, Ana Clop és, Joaquim Delgadillo Tags: Health-Policy Analysis Source Type: research

Cost-Effectiveness of Systemic Treatments for Metastatic Castration-Sensitive Prostate Cancer: An Economic Evaluation Based on Network Meta-Analysis
To assess the cost-effectiveness of systemic treatments for metastatic castration-sensitive prostate cancer from the US healthcare sector perspective with a lifetime horizon. (Source: Value in Health)
Source: Value in Health - December 1, 2021 Category: International Medicine & Public Health Authors: Lin Wang, Hwanhee Hong, G. Caleb Alexander, Otis W. Brawley, Channing J. Paller, Jeromie Ballreich Tags: Economic Evaluation Source Type: research

Table of Contents
(Source: Value in Health)
Source: Value in Health - November 25, 2021 Category: International Medicine & Public Health Source Type: research

Copyright/Subscription
(Source: Value in Health)
Source: Value in Health - November 25, 2021 Category: International Medicine & Public Health Source Type: research

Editorial Board
(Source: Value in Health)
Source: Value in Health - November 25, 2021 Category: International Medicine & Public Health Source Type: research

Barriers and Expectations for Patients in Post-Osteoporotic Fracture Care in France: The EFFEL Study
This study aimed to quantify the relative importance of barriers to better secondary prevention of osteoporotic fractures and of care expectations expressed by patients with osteoporotic fractures in France. (Source: Value in Health)
Source: Value in Health - November 25, 2021 Category: International Medicine & Public Health Authors: Robert Launois, Elise Cabout, Daniel Benamouzig, Livia Velpry, Karine Briot, Fran çoise Alliot, Laure Perrin, Laurent Grange, Rahma Sellami, Chantal Touboul, Jean-Michel Joubert, Christian Roux Tags: Comparative-Effectiveness Research Source Type: research

Investigating 5-Level EQ-5D (EQ-5D-5L) Values Based on Preferences of Patients With Heart Disease
Several studies have shown that patients with heart disease value hypothetical health states differently from the general population. We aimed to investigate the health preferences of patients with heart disease and develop a value set for the 5-level EQ-5D (EQ-5D-5L) based on these patient preferences. (Source: Value in Health)
Source: Value in Health - November 24, 2021 Category: International Medicine & Public Health Authors: Mihir Gandhi, Ru San Tan, Shir Lynn Lim, Kim Rand, Carolyn S.P. Lam, Nan Luo, Yin Bun Cheung Tags: Preference-Based Assessments Source Type: research

Parametric Survival Extrapolation of Early Survival Data in Economic Analyses: A Comparison of Projected Versus Observed Updated Survival
This study aimed to examine the projected survival based on parametric extrapolations compared with observed survival based on updated data. (Source: Value in Health)
Source: Value in Health - November 24, 2021 Category: International Medicine & Public Health Authors: Louis Everest, Scott Blommaert, Ryan W. Chu, Kelvin K.W. Chan, Ambica Parmar Tags: Economic Evaluation Source Type: research

Cost-Effectiveness Analysis of SAPIEN 3 Transcatheter Aortic Valve Implantation Procedure Compared With Surgery in Patients With Severe Aortic Stenosis at Low Risk of Surgical Mortality in France
This study uses PARTNER 3 outcomes in combination with a French national hospital claim database to inform a cost-utility model and examine the cost implications of TAVI ove r SAVR in a low-risk population. (Source: Value in Health)
Source: Value in Health - November 17, 2021 Category: International Medicine & Public Health Authors: Martine Gilard, H élène Eltchaninoff, Bernard Iung, Thierry Lefèvre, Christian Spaulding, Nicolas Dumonteil, Pierre Mutuon, Christophe Roussel, Pascal Candolfi, Gérard de Pouvourville, Michelle Green, Judith Shore Tags: Economic Evaluation Source Type: research

Do Cost-Effectiveness Analyses Account for Drug Genericization? A Literature Review and Assessment of Implications
We investigated how health technology assessment (HTA) organizations around the world have handled drug genericization (an allowance for future generic drug entry and subsequent drug price declines) in their guidelines for cost-effectiveness analyses (CEAs). We also analyzed a large sample of published CEAs to examine prevailing practices in the field. (Source: Value in Health)
Source: Value in Health - November 12, 2021 Category: International Medicine & Public Health Authors: Peter J. Neumann, Meghan I. Podolsky, Anirban Basu, Daniel A. Ollendorf, Joshua T. Cohen Tags: Economic Evaluation Source Type: research