Blood Pressure Differences Between Home Monitoring and Daytime Ambulatory Values and their Reproducibility in Treated Hypertensive Stroke and TIA Patients
Publication date: Available online 19 October 2018Source: American Heart JournalAuthor(s): William J Davison, Phyo Kyaw Myint, Allan B Clark, John F PotterAbstractBackgroundGuidelines recommend ambulatory or home blood pressure monitoring to improve hypertension diagnosis and monitoring. Both these methods are ascribed the same threshold values, but whether they produce similar results has not been established in certain patient groups.MethodsAdults with mild/moderate stroke or transient ischaemic attack (N=80) completed two sets of ambulatory and home blood pressure monitoring. Systolic and diastolic blood pressure values...
Source: American Heart Journal - October 20, 2018 Category: Cardiology Source Type: research

A randomized clinical trial of early invasive intervention for atrial fibrillation (EARLY-AF) - methods and rationale
DiscussionThe EARLY-AF study is a randomized trial designed to evaluate the optimal first management approach for patients with AF. We hypothesize that catheter ablation will be superior to drug therapy in prevention of AF recurrence. (Source: American Heart Journal)
Source: American Heart Journal - October 19, 2018 Category: Cardiology Source Type: research

Trends in catheter-directed thrombolysis and systemic thrombolysis for the treatment of pulmonary embolism
Publication date: Available online 2 October 2018Source: American Heart JournalAuthor(s): Srinath Adusumalli, Bram J. Geller, Lin Yang, Jay Giri, Peter W. Groeneveld (Source: American Heart Journal)
Source: American Heart Journal - October 18, 2018 Category: Cardiology Source Type: research

Rationale and design for a cluster randomized quality-improvement trial to increase the uptake of evidence-based therapies for patients at high cardiovascular risk: The BRIDGE-CARDIOVASCULAR PREVENTION trial
Publication date: Available online 17 October 2018Source: American Heart JournalAuthor(s): Maria Julia Machline-Carrion, Rafael Marques Soares, Lucas Petri Damiani, Viviane Bezerra Campos, Bruna Sampaio, Juliana Yamashita, Francisco H. Fonseca, Maria Cristina Izar, Celso Amodeo, Octavio Marques Pontes-Neto, Pedro Gabriel de Melo Barros, Renato D. Lopes, Nilton Brandão da Silva, Hélio Penna Guimarães, Leopoldo Piegas, Airton T. Stein, Otavio BerwangerAbstractBackgroundTranslating evidence into clinical practice in the management of high cardiovascular risk patients is challenging. Few quality improvemen...
Source: American Heart Journal - October 17, 2018 Category: Cardiology Source Type: research

The International Polycap Study-3 (TIPS-3): Design, baseline characteristics and challenges in conduct
ConclusionResults of the TIP-3 study will be key to determining the appropriateness of FDC therapy as a strategy in the global prevention of CVD. (Source: American Heart Journal)
Source: American Heart Journal - October 17, 2018 Category: Cardiology Source Type: research

Real world comparison of in-hospital reveal LINQ Insertable cardiac monitor insertion inside and outside of the cardiac catheterization or electrophysiology laboratory
ConclusionsThis real-world analysis demonstrates the feasibility of performing Reveal LINQ™ ICM insertion procedures outside of the traditional hospital settings without increasing the risk of infection or other adverse events. (Source: American Heart Journal)
Source: American Heart Journal - October 14, 2018 Category: Cardiology Source Type: research

Rationale and design of the randomized prospective ATLAS study: Avoid Transvenous leads in appropriate subjects
This study will determine if using an S-ICD compared to a TV-ICD reduces a primary composite outcome of perioperative complications including pulmonary or pericardial perforation, lead dislodgement or dysfunction, tricuspid regurgitation and ipsilateral venous thrombosis. Five hundred patients will be enrolled from 14 Canadian hospitals, and data collected to both early- (at 6 months) and mid-term complications (at 24 months) as well as mortality and ICD shock efficacy.SummaryThe ATLAS randomized trial is comparing early- and mid-term vascular and lead-related complications among S-ICD versus TV-ICD recipients wh...
Source: American Heart Journal - October 10, 2018 Category: Cardiology Source Type: research

Proarrhythmia and death with antiarrhythmic drugs for atrial fibrillation, and the unfulfilled promise of comparative effectiveness research
Publication date: Available online 12 September 2018Source: American Heart JournalAuthor(s): Fabian R. Reimold, Matthew R. Reynolds (Source: American Heart Journal)
Source: American Heart Journal - October 4, 2018 Category: Cardiology Source Type: research

Patterns of use of targeted temperature Management for Acute Myocardial Infarction Patients Following out-of-Hospital Cardiac Arrest: Insights from the National Cardiovascular Data Registry
Publication date: Available online 24 September 2018Source: American Heart JournalAuthor(s): Christopher B. Fordyce, Anita Y. Chen, Tracy Y. Wang, Joseph Lucas, Abhinav Goyal, Graham C. Wong, Sean van Diepen, Michael C. Kontos, Timothy D. Henry, Christopher B. Granger, Matthew T. RoeAbstractContemporary utilization patterns for targeted temperature management (TTM) among patients with acute myocardial infarction (MI) and out-of-hospital cardiac arrest (OHCA) have not been well characterized in the United States (U.S.). In this nationwide evaluation of MI patients with OHCA (01/2015–03/2016; 691 hospitals), 34.1% (179...
Source: American Heart Journal - October 4, 2018 Category: Cardiology Source Type: research

Home monitoring with IT-supported specialist management versus home monitoring alone in patients with heart failure: Design and baseline results of the SUPPORT-HF 2 randomized trial
ConclusionsPreliminary experience suggests that central provision of tailored specialist management using commercially available low-cost monitoring and computing devices, enhanced by customized applications, is feasible. (Source: American Heart Journal)
Source: American Heart Journal - October 4, 2018 Category: Cardiology Source Type: research

Central arteriovenous anastomosis for the treatment of patients with uncontrolled hypertension and paroxysmal AF
This study assessed the change in AF burden following coupler implantation in patients with paroxysmal AF (PAF) and hypertension. Good blood pressure control using the coupler results in a significant reduction in AF burden. (Source: American Heart Journal)
Source: American Heart Journal - October 4, 2018 Category: Cardiology Source Type: research

Risk stratification and clinical outcomes after surgical pulmonary valve replacement
Publication date: Available online 29 September 2018Source: American Heart JournalAuthor(s): Alexander C. Egbe, William R. Miranda, Sameh M. Said, Heidi M. ConnollyAbstractBackgroundTo determine if RV volume was predictive of survival and cardiovascular adverse event (CAE) after pulmonary valve replacement (PVR).MethodsWe reviewed the MACHD (Mayo Adult Congenital Heart Disease) database for patients with tetralogy of Fallot (TOF) undergoing PVR, 2000–2015. The patients were divided into quartiles based on RV end-diastolic volume index (RVEDVI); those in the lowest quartile (Group A, n = 46) and the top quar...
Source: American Heart Journal - October 4, 2018 Category: Cardiology Source Type: research

Rationale and Design of the Pemafibrate to reduce cardiovascular outcomes by reducing triglycerides in patients with diabetes (PROMINENT) study
Publication date: Available online 29 September 2018Source: American Heart JournalAuthor(s): Aruna D. Pradhan, Nina P. Paynter, Brendan M. Everett, Robert J. Glynn, Pierre Amarenco, Marshall Elam, Henry Ginsberg, William R. Hiatt, Shun Ishibashi, Wolfgang Koenig, Børge G. Nordestgaard, Jean-Charles Fruchart, Peter Libby, Paul M RidkerAbstractObservational, genetic, and experimental data indicate that triglyceride rich lipoproteins (TRLs) likely participate causally in atherothrombosis. Yet, robust clinical trial evidence that triglyceride (TG) lowering therapy reduces cardiovascular events remains elusive. The selec...
Source: American Heart Journal - October 4, 2018 Category: Cardiology Source Type: research

Admission diagnoses among patients with heart failure: Variation by ACO performance on a measure of risk- standardized acute admission rates
We examined admission diagnoses among 220 Medicare Shared Savings Program ACOs in 2013. ACOs were stratified into quartiles by their performance on a measure of unplanned risk-standardized acute admission rates (RSAARs) among patients with HF. Using a previously validated algorithm, we categorized admissions by principal discharge diagnosis into: HF, Cardiovascular/Non-HF, and Non-Cardiovascular. We compared the mean admission rates by admission type as well as the proportion of admission types across RSAAR quartiles (Q1-Q4).ResultsAmong 220 ACOs caring for 227,356 patients with HF, the median (IQR) RSAARs per 100 person-y...
Source: American Heart Journal - October 4, 2018 Category: Cardiology Source Type: research

An international cluster randomized quality-improvement trial to increase the adherence to evidence-based therapies for acute ischemic stroke and transient ischemic attack patients: Rationale and design of the BRIDGE STROKE trial
Publication date: Available online 30 September 2018Source: American Heart JournalAuthor(s): Maria Julia Machline-Carrion, Eliana Vieira Santucci, Lucas Petri Damiani, Cecilia Bahit, Germán Málaga, Octávio Marques Ponte-Neto, Sheila Cristina Ouriques Martins, Viviane Flumignan Zétola, Karina Normilio-Silva, Gabriel Rodrigues de Freitas, Alessandra Gorgulho, Antônio De Salles, Beatriz Gonzales Pacheco da Silva, Juliana Yamashita Santos, Isabella de Andrade Jesuíno, Priscila Regina Torres Bueno, Alexandre Biasi Cavalcanti, Hélio Penna Guimarães, Ying Xian, Janet Prvu Bet...
Source: American Heart Journal - October 4, 2018 Category: Cardiology Source Type: research

Trends in catheter directed thrombolysis and systemic thrombolysis for the treatment of pulmonary embolism
Publication date: Available online 2 October 2018Source: American Heart JournalAuthor(s): Srinath Adusumalli, Bram J. Geller, Lin Yang, Jay Giri, Peter W. Groeneveld (Source: American Heart Journal)
Source: American Heart Journal - October 4, 2018 Category: Cardiology Source Type: research

Sex differences in long-term outcomes of patients across the spectrum of coronary artery disease
Publication date: Available online 2 October 2018Source: American Heart JournalAuthor(s): Neha J. Pagidipati, Daniel W. Mudrick, Karen Chiswell, Amanda Brucker, Eric D. Peterson, Pamela S. DouglasAbstractBackgroundPatients with non-obstructive coronary artery disease (CAD) have worse outcomes compared with those without CAD; however, few studies have compared the intermediate- and long-term impact of CAD severity as a function of patient sex.MethodsWe evaluated 5-year and long-term all-cause mortality of women and men undergoing elective coronary angiography at a single center by degree of CAD: no CAD (1–24% stenosis...
Source: American Heart Journal - October 4, 2018 Category: Cardiology Source Type: research

Recovery of failing hearts by mechanical unloading: Pathophysiologic insights and clinical relevance
This article aims to provide an overview of the existing knowledge about VAD-promoted cardiac improvement focusing on the importance of bench-to-bedside research which is mandatory for attaining the future goal to use long-term VADs also as therapy-devices for reversal of chronic HF. (Source: American Heart Journal)
Source: American Heart Journal - September 18, 2018 Category: Cardiology Source Type: research

TEMPORARY REMOVAL: Article Coming Soon
ConclusionsThe results of this trial will provide initial evidence for the ability of a smartwatch algorithm to identify pulse irregularity and variability which may reflect previously unknown AF. The Apple Heart Study will help provide a foundation for how wearable technology can inform the clinical approach to AF identification and screening. (Source: American Heart Journal)
Source: American Heart Journal - September 15, 2018 Category: Cardiology Source Type: research

Countering clinical inertia in lipid management: Expert workshop summary
Publication date: Available online 14 September 2018Source: American Heart JournalAuthor(s): Leah L. Zullig, Lisa Egbuonu-Davis, Anjali Trasy, Christiana Oshotse, Karen M. Goldstein, Hayden B. Bosworth (Source: American Heart Journal)
Source: American Heart Journal - September 14, 2018 Category: Cardiology Source Type: research

TEMPORARY REMOVAL: Rationale and design of a large-scale app-based study to identify cardiac arrhythmias using a smartwatch: The Apple Heart Study
ConclusionsThe results of this trial will provide initial evidence for the ability of a smartwatch algorithm to identify pulse irregularity and variability which may reflect previously unknown AF. The Apple Heart Study will help provide a foundation for how wearable technology can inform the clinical approach to AF identification and screening. (Source: American Heart Journal)
Source: American Heart Journal - September 13, 2018 Category: Cardiology Source Type: research

Pro-arrhythmia and death with antiarrhythmic drugs for atrial fibrillation, and the unfulfilled promise of comparative effectiveness research
Publication date: Available online 12 September 2018Source: American Heart JournalAuthor(s): Fabian R. Reimold, Matthew R. Reynolds (Source: American Heart Journal)
Source: American Heart Journal - September 12, 2018 Category: Cardiology Source Type: research

Temporal trends, determinants and impact of high-intensity statin prescriptions after percutaneous coronary intervention: Results from a large single-center prospective registry
Publication date: Available online 12 September 2018Source: American Heart JournalAuthor(s): Paul Guedeney, Usman Baber, Bimmer Claessen, Melissa Aquino, Anton Camaj, Sabato Sorrentino, Birgit Vogel, Serdar Farhan, Michela Faggioni, Jaya Chandrasekhar, Deborah N. Kalkman, Jason C. Kovacic, Joseph Sweeny, Nitin Barman, Pedro Moreno, Pooja Vijay, Srushthi Shah, George Dangas, Annapoorna Kini, Samin SharmaAbstractBackgroundHigh-intensity statins (HIS) are recommended for secondary prevention following percutaneous coronary intervention (PCI). We aimed to describe temporal trends and determinants of HIS prescriptions after PCI...
Source: American Heart Journal - September 12, 2018 Category: Cardiology Source Type: research

Rationale and design of a large-scale app-based study to identify cardiac arrhythmias using a smartwatch: The apple heart study
ConclusionsThe results of this trial will provide initial evidence for the ability of a smartwatch algorithm to identify pulse irregularity and variability which may reflect previously unknown AF. The Apple Heart Study will help provide a foundation for how wearable technology can inform the clinical approach to AF identification and screening. (Source: American Heart Journal)
Source: American Heart Journal - September 8, 2018 Category: Cardiology Source Type: research

The east–west late lumen loss study: Comparison of angiographic late lumen loss between eastern and Western drug eluting stent study cohorts
ConclusionsIn the world's largest compilation of DES protocol 8–13 month angiographic follow-up data, clinically meaningful comparability of in-segment LLL by independent core laboratory QCA in East and West cohorts was demonstrated in both unadjusted and adjusted comparisons. These findings suggest that DES LLL, once characterized, could be generalized across regulatory jurisdictions over the course of global registration efforts. (Source: American Heart Journal)
Source: American Heart Journal - September 7, 2018 Category: Cardiology Source Type: research

Design and baseline characteristics of the eValuation of ERTugliflozin effIcacy and safety CardioVascular outcomes trial (VERTIS-CV)
ConclusionThe results from the VERTIS-CV trial will define the CV and renal safety and efficacy of ertugliflozin in patients with T2DM and ASCVD.ClinicalTrials.gov identifier: NCT01986881 (Source: American Heart Journal)
Source: American Heart Journal - September 6, 2018 Category: Cardiology Source Type: research

Thirty-day outcomes in patients with acute pulmonary embolism who discontinued anticoagulant therapy before 90 days
Publication date: Available online 5 September 2018Source: American Heart JournalAuthor(s): José A. Nieto, Julio A. Vicente, Luis M. Prieto, David Jiménez, Behnood Bikdeli, Agustina Rivas, José Antonio Porras, Mª del Valle Morales, Marijan Bosevski, Manuel Monreal, RIETE InvestigatorsBackgroundThe contemporary natural history of patients with acute pulmonary embolism (PE) not receiving (or early discontinuing) anticoagulant therapy has not been consistently evaluated.ObjectiveTo assess the rate of the composite outcome of PE-related death, sudden death, or recurrent thromboembolism (VTE) within 30...
Source: American Heart Journal - September 5, 2018 Category: Cardiology Source Type: research

System-integrated technology-enabled model of care to improve the health of stroke patients in rural China: protocol for SINEMA--a cluster-randomized controlled trial
This study aims to develop a system-integrated technology-enabled intervention model of care (SINEMA) for the secondary prevention of stroke in rural China and to evaluate the effectiveness of the model compared with usual care.MethodsThe SINEMA model is being implemented and evaluated through a one-year cluster-randomized controlled trial in Nanhe County, Hebei Province in China. Fifty villages from five townships are randomized in a 1:1 ratio to either the intervention or the control arm (usual care) with a target to enroll 25 stroke survivors per village. Village doctors in the intervention arm 1) receive systematic cas...
Source: American Heart Journal - September 5, 2018 Category: Cardiology Source Type: research

Long-term mortality and estimated functional capacity among women with symptoms of ischemic heart disease: From the NHLBI-sponsored Women's ischemia syndrome evaluation
Publication date: Available online 30 August 2018Source: American Heart JournalAuthor(s): Islam Y. Elgendy, Hend Mansoor, Qian Li, Yi Guo, Eileen M. Handberg, C. Noel Bairey Merz, Carl J. PepineAbstractThe aim of this study was to determine the long-term prognostic value of the Duke Activity Status Index (DASI)-estimated metabolic equivalents (METs) values among women with suspected ischemic heart disease (IHD). At a median of 9.6 years, the incidence of death was 23.4% in those with METs 9.9, P 
Source: American Heart Journal - August 31, 2018 Category: Cardiology Source Type: research

The first Brazilian registry of hypertension
The objective of the First National Registry of Patients with Hypertension in Brazil (RBH) is to evaluate the clinical profile, treatment patterns, and outcomes of diagnosed hypertensive patients in the country. (Source: American Heart Journal)
Source: American Heart Journal - August 30, 2018 Category: Cardiology Source Type: research

International Study of Comparative Health Effectiveness with Medical and Invasive Approaches–Chronic Kidney Disease (ISCHEMIA-CKD): Rationale and design
Publication date: November 2018Source: American Heart Journal, Volume 205Author(s): Sripal Bangalore, David J. Maron, Jerome L. Fleg, Sean M. O’Brien, Charles A. Herzog, Gregg W. Stone, Daniel B. Mark, John A. Spertus, Karen P. Alexander, Mandeep S. Sidhu, Glenn M. Chertow, William E. Boden, Judith S. Hochman, on behalf of the ISCHEMIA-CKD Research GroupBackgroundPatients with chronic kidney disease (CKD) and stable ischemic heart disease are at markedly increased risk of cardiovascular events. Prior trials comparing a strategy of optimal medical therapy (OMT) with or without revascularization have largely excluded p...
Source: American Heart Journal - August 30, 2018 Category: Cardiology Source Type: research

EdoxabaN Versus standard of care and theIr effectS on clinical outcomes in pAtients havinG undergonE Transcatheter Aortic Valve Implantation in Atrial Fibrillation—Rationale and design of the ENVISAGE-TAVI AF trial
Publication date: November 2018Source: American Heart Journal, Volume 205Author(s): Nicolas M. Van Mieghem, Martin Unverdorben, Marco Valgimigli, Roxana Mehran, Eric Boersma, Usman Baber, Christian Hengstenberg, Minggao Shi, Cathy Chen, Shigeru Saito, Roland Veltkamp, Pascal Vranckx, George D. DangasTranscatheter aortic valve implantation, also called transcatheter aortic valve replacement (TAVR), is the treatment of choice for patients with severe aortic stenosis and intermediate to high operative risk. A significant portion of TAVR patients have atrial fibrillation (AF) requiring chronic oral anticoagulation. In moderate...
Source: American Heart Journal - August 30, 2018 Category: Cardiology Source Type: research

Ventricular arrhythmia and death among atrial fibrillation patients using anti-arrhythmic drugs
ConclusionsDronedarone was the only anti-arrhythmic drug with signficantly lower risk for arrhythmic death, sustained ventricular arrhythmia or ICD implantation than sotalol among patients with atrial fibrillation. Both dronedarone and flecainide were associated with lower all-cause mortality than sotalol. (Source: American Heart Journal)
Source: American Heart Journal - August 26, 2018 Category: Cardiology Source Type: research

The impact of incomplete revascularization on early and late outcomes in ST-elevation myocardial infarction
This study examined associations between incomplete revascularization, determined by the rSS, and the combined outcome of cardiac death and myocardial infarction (MI). Patients were divided into groups: rSS = 0 (complete revascularization), rSS = 1-8 (incomplete revascularization with a low burden of residual disease), or rSS>8 (incomplete revascularization with a high burden of residual disease).ResultsThe rSS score was calculated in 589 consecutive patients; 25% had an rSS of 0, 42% rSS 1-8, and 33% rSS>8. At median follow-up of 3.5 years, cardiac death and MI occurred in 5% of rSS = 0 patients, 15% rSS = 1-8, and ...
Source: American Heart Journal - August 26, 2018 Category: Cardiology Source Type: research

Ticagrelor versus clopidogrel for recovery of vascular function immediately after successful chronic coronary total occlusion recanalization: A randomized clinical trial
Publication date: Available online 2 August 2018Source: American Heart JournalAuthor(s): Salvatore Brugaletta, Josep Gomez-Lara, Juan Caballero, Luis Ortega-Paz, Luis Teruel, Miriam Jimenez Fernandez, Rafael Romaguera, Vicente Alcalde Martinez, Marcos Ñato, Eduardo Molina Navarro, Joan-Antoni Gomez-Hospital, Concepcion Correa Vilches, Maria Joyera, Angel Cequier, Dominick J Angiolillo, Manel SabateAbstractCoronary vascular function of a chronic coronary total occlusion (CTO) immediately after recanalization is known to be poor. We sought if ticagrelor may augment adenosine-induced coronary blood flow vs. clopidogrel...
Source: American Heart Journal - August 25, 2018 Category: Cardiology Source Type: research

The authors reply: Treatment of patients with restenosis of drug-eluting stents
Publication date: Available online 23 August 2018Source: American Heart JournalAuthor(s): Do-Yoon Kang, Yiu Tung Anthony Wong, Duk-Woo Park, Seung-Jung Park (Source: American Heart Journal)
Source: American Heart Journal - August 24, 2018 Category: Cardiology Source Type: research

Randomized trial of rivaroxaban versus warfarin in the evaluation of progression of coronary atherosclerosis
Publication date: Available online 24 August 2018Source: American Heart JournalAuthor(s): Juhwan Lee, Rine Nakanishi, Dong Li, Kashif Shaikh, Chandana Shekar, Kazuhiro Osawa, Negin Nezarat, Eranthi Jayawardena, Maja Blanco, Matthew Chen, Matthew Sieckert, Eric Nelson, Darius Billingsley, Sajad Hamal, Matthew J. BudoffWarfarin, a vitamin K antagonist, is associated with systemic vascular calcification. We evaluated that rivaroxaban (a direct oral factor Xa inhibitor with no interaction with vitamin K) will slow the progression in coronary plaque volumes compared with warfarin in patients with non-valvular atrial fibrillatio...
Source: American Heart Journal - August 24, 2018 Category: Cardiology Source Type: research

Treatment of patients with restenosis of drug-eluting stents
Publication date: Available online 24 August 2018Source: American Heart JournalAuthor(s): Fernando Alfonso, Javier Cuesta, Marcos García-Guimaraes, Esther Gonzalez-Barthol, Paula Antuña, Teresa Bastante, Fernando Rivero (Source: American Heart Journal)
Source: American Heart Journal - August 24, 2018 Category: Cardiology Source Type: research

Accuracy of blinded clinician interpretation of single-lead smartphone electrocardiograms and a proposed clinical workflow
Publication date: Available online 23 August 2018Source: American Heart JournalAuthor(s): Anoop N Koshy, Jithin K Sajeev, Kazuaki Negishi, Michael C Wong, Christopher B Pham, Sumudu P Cooray, Yeganeh Khavar, Louise Roberts, Jennifer C Cooke, Andrew W TehDespite the appeal of smartphone-based electrocardiograms (ECG) for arrhythmia screening, a paucity of data exists on the accuracy of primary care physicians' and cardiologists' interpretation of tracings compared with the device's automated diagnosis. Utilizing 408 ECGs in 51 patients, we demonstrate a variable accuracy in clinician interpretation of smartphone-based ECGs ...
Source: American Heart Journal - August 23, 2018 Category: Cardiology Source Type: research

The Relationship Between Pharmacy Benefit Managers(PBMs)and the Cost of Therapies in the U.S. Pharmaceutical Market: A Policy Primer for Clinicians
Publication date: Available online 23 August 2018Source: American Heart JournalAuthor(s): Kevin A. Schulman, Matan DaboraAbstractPharmaceutical benefit managers (PBM’s)are playing an increasingly important role in establishing access to pharmaceutical products for patients. PBM’s set retail prices for pharmaceutical products, negotiate “rebates” from manufacturers based on total sales volume of products, and achieve several types of post-sale price concessions and payments from pharmacies. All of these activities describe a complex flow of funds that has not been transparent to clinicians nor to pat...
Source: American Heart Journal - August 23, 2018 Category: Cardiology Source Type: research

Rationale and design of the EVOLVE short DAPT study to assess 3-month dual antiplatelet therapy in subjects at high risk for bleeding undergoing percutaneous coronary intervention
ConclusionThe EVOLVE Short DAPT study will prospectively define the safety of DAPT discontinuation at 3 months in high bleeding risk patients treated with the SYNERGY stent. (Source: American Heart Journal)
Source: American Heart Journal - August 17, 2018 Category: Cardiology Source Type: research

Rationale and Design of the Study of dietary intervention under 100 MMOL in heart failure (SODIUM-HF)
Publication date: Available online 16 August 2018Source: American Heart JournalAuthor(s): Eloisa Colin-Ramirez, Justin A. Ezekowitz, on behalf of the SODIUM-HF investigatorsBackgroundPatients with heart failure (HF) remain at high risk for future events despite medical and device therapy. Dietary sodium reduction is often recommended based on limited evidence. However, it is not known whether dietary sodium reduction reduces the morbidity or mortality associated with HF.MethodsThe SODIUM study is a pragmatic, randomized, open-label trial assessing the efficacy of dietary sodium reduction to
Source: American Heart Journal - August 16, 2018 Category: Cardiology Source Type: research

Rational and Design of the European Randomized Optical Coherence Tomography Optimized Bifurcation Event Reduction Trial (OCTOBER)
Publication date: Available online 16 August 2018Source: American Heart JournalAuthor(s): Niels Ramsing Holm, Lene Nyhus Andreasen, Simon Walsh, Olli A. Kajander, Nils Witt, Christian Eek, Paul Knaapen, Lukasz Koltowski, Juan Luis Gutiérrez-Chico, Francesco Burzotta, Janusz Kockman, John Ormiston, Irene Santos-Pardo, Peep Laanmets, Darren Mylotte, Morten Madsen, Jakob Hjort, Indulis Kumsars, Truls Råmunddal, Evald Høj ChristiansenBackgroundPercutaneous coronary intervention (PCI) in complex bifurcation lesions is prone to suboptimal implantation results and is associated with increased risk of subsequen...
Source: American Heart Journal - August 16, 2018 Category: Cardiology Source Type: research

Mortality differences in acute myocardial infarction patients in the Netherlands: The weekend-effect
Publication date: Available online 16 August 2018Source: American Heart JournalAuthor(s): Daniëlle C. Eindhoven, Hoi W. Wu, Stijn W.F. Kremer, Judith A. van Erkelens, Suzanne C. Cannegieter, Martin J. Schalij, C. Jan Willem BorleffsObjectiveSeveral studies have shown that patients admitted with an acute myocardial infarction during the weekends have a higher mortality rate than those admitted during weekdays, possibly attributable to less trained personnel available and a lower use of medical procedures. The current study aimed to assess this ‘weekend-effect’ in a nationwide registry.MethodsIn the Netherla...
Source: American Heart Journal - August 16, 2018 Category: Cardiology Source Type: research

Impact of high on-aspirin platelet reactivity on outcomes following successful percutaneous coronary intervention with drug-eluting stents
ConclusionsHAPR was infrequently present in a large registry of patients undergoing PCI. There was no clear relationship between HAPR and 2-year clinical outcomes. Investigation of antiplatelet regimens without aspirin after DES implantation are ongoing and should inform future management of patients undergoing PCI. (Source: American Heart Journal)
Source: American Heart Journal - August 15, 2018 Category: Cardiology Source Type: research

Relationships among clinic, home, and ambulatory blood pressures with small vessel disease of the brain and functional status in older people with hypertension
ConclusionThese data demonstrate that ambulatory BP measurements in older people are more strongly associated with WMH and certain measures of functional status compared to home BP measurements. Hence, home BP may not be a useful substitute for ambulatory BP for assessing subcortical small vessel disease and its consequences. Further longitudinal analyses comparing clinic and various types of out-of-office BP measures with small vessel brain disease are needed.Clinicaltrials.gov identifier - NCT01650402. (Source: American Heart Journal)
Source: American Heart Journal - August 11, 2018 Category: Cardiology Source Type: research

Comparison between patients included in randomized controlled trials of ischemic heart disease and real-world data. A nationwide study
The objective was to compare patients with ischemic heart disease (IHD) undergoing percutaneous coronary intervention (PCI) who were included in randomized controlled trials (RCTs) (trial participants) with patients who were not included (nonparticipants) on a trial-by-trial basis and according to indication for PCI.MethodsIn this cohort study, we compared patients with IHD who were randomized in RCTs in relation to undergoing PCI in Denmark between 2011 and 2015 were considered as RCT-participants in this study. The RCT-participants were compared with contemporary nonparticipants with IHD undergoing PCI in the same period...
Source: American Heart Journal - August 11, 2018 Category: Cardiology Source Type: research

Association of N-terminal pro B-type natriuretic peptide (NT-proBNP) change with the risk of atrial fibrillation in the ARIC cohort
ConclusionPositive NT-proBNP change is associated with an increased incidence rate of AF. Adding NT-proBNP change into the prediction model modestly improved incident AF prediction. Future studies should assess the value of monitoring NT-proBNP concentration among individuals at high risk of developing AF. (Source: American Heart Journal)
Source: American Heart Journal - August 10, 2018 Category: Cardiology Source Type: research

Rationale and design of: A Randomized tRial of Expedited transfer to a cardiac arrest center for non-ST elevation out-of-hospital cardiac arrest: The ARREST randomized controlled trial
ConclusionPost-arrest care is time-critical, requires a multi-disciplinary approach and may be more optimally delivered in centers with greater provider experience. This trial would help to demonstrate if regionalization of post-arrest care to CACs reduces mortality in patients without STE, which could dramatically reshape emergency care provision. (Source: American Heart Journal)
Source: American Heart Journal - August 7, 2018 Category: Cardiology Source Type: research

A randomized controlled crossover trial evaluating differential responses to antihypertensive drugs (used as mono- or dual therapy) on the basis of ethnicity: The comparIsoN oF Optimal Hypertension RegiMens; part of the Ancestry Informative Markers in HYpertension program—AIM-HY INFORM trial
ConclusionAIM-HY INFORM is a prospective, open-label, randomized trial which aims to evaluate first- and second-line antihypertensive therapies for multiethnic populations. (Source: American Heart Journal)
Source: American Heart Journal - August 6, 2018 Category: Cardiology Source Type: research