I-CARE randomized clinical trial integrating depression and acute coronary syndrome care in low-resource hospitals in China: Design and rationale
Publication date: August 2018 Source:American Heart Journal, Volume 202 Author(s): Shenshen Li, James A. Blumenthal, Chuan Shi, Danielle Millican, Xian Li, Xin Du, Anushka Patel, Pei Gao, Elizabeth Delong, Pallab K. Maulik, Runlin Gao, Xin Yu, Yangfeng Wu Depression and acute coronary syndromes (ACS) are both common public health challenges. Patients with ACS often develop depression, which in turn adversely affects prognosis. Low-cost, sustainable, and effective service models that integrate depression care into the management of ACS patients to reduce depression and improve ACS outcomes are critically needed. Integratin...
Source: American Heart Journal - June 20, 2018 Category: Cardiology Source Type: research

Patterns of glucose-lowering medication use in patients with type 2 diabetes and heart failure. Insights from the diabetes collaborative registry (DCR)
Conclusion In a large US-based outpatient registry, we found that a quarter of adults with T2D had a diagnosis of HF, which was predominantly HFpEF. Although certain T2D medication use in patients with HF appeared consistent with evidence (less use of thiazolidinediones), others appeared contrary to evidence (less use of metformin and SGLT2 inhibitors). (Source: American Heart Journal)
Source: American Heart Journal - June 19, 2018 Category: Cardiology Source Type: research

Ultrasound-guided versus palpation-guided radial artery catheterization in adult population: A systematic review and meta-analysis of randomized controlled trials
Conclusions Ultrasound-guided technique for RA access has higher first attempt success and lower failure rate compared with palpation alone with no significant differences in access site hematoma or time to a successful attempt. These findings support the routine use of ultrasound guidance for radial artery access. (Source: American Heart Journal)
Source: American Heart Journal - June 19, 2018 Category: Cardiology Source Type: research

The Second Annual Think Tank on Prevention of Sudden Cardiac Death in the Young: Developing a rational, reliable, and sustainable national health care resource. A report from the Cardiac Safety Research Consortium
Publication date: August 2018 Source:American Heart Journal, Volume 202 Author(s): Peter F. Aziz, Stuart Berger, Peter Kowey, Mitchell Krucoff, Martha Lopez-Anderson, Eric Michelson, Silvana Molossi, Valarie Morrow, Ignacio Rodriguez, Tess (Elizabeth) Saarel, Colette Strnadova, Victoria Vetter, Theressa J. Wright, Salim F. Idriss Sudden cardiac death in the young (SCDY) spans gender, race, ethnicity, and socioeconomic class. The loss of any pediatric patient is a matter of national and international public health concern, and focused efforts should be aimed at preventing these burdensome tragedies. Prepared by members of ...
Source: American Heart Journal - June 17, 2018 Category: Cardiology Source Type: research

Stroke type and severity in patients with subclinical atrial fibrillation: An analysis from the Asymptomatic Atrial Fibrillation and Stroke Evaluation in Pacemaker Patients and the Atrial Fibrillation Reduction Atrial Pacing Trial (ASSERT)
Conclusions In patients with SCAF and stroke, SCAF seems probably causal in many cases; however, in more than 40%, it seems to be acting only as a risk marker. (Source: American Heart Journal)
Source: American Heart Journal - June 15, 2018 Category: Cardiology Source Type: research

Atrial fibrillation and stroke: The more we learn, the less we understand
Publication date: July 2018 Source:American Heart Journal, Volume 201 Author(s): Rod Passman (Source: American Heart Journal)
Source: American Heart Journal - June 15, 2018 Category: Cardiology Source Type: research

Hemodynamic effects of short-term infusion of a vasopressin V1A/V2 receptor antagonist conivaptan in patients with chronic heart failure during submaximal exercise
Publication date: Available online 14 June 2018 Source:American Heart Journal Author(s): L Balling, J.H Thomsen, E Wolsk, C Hassager, S Boesgaard, S Goldsmith, F Gustafsson Heart failure (HF) is associated with a reduced exercise capacity. Our aim was to investigate if infusion with a V1A/V2-receptor antagonist, conivaptan, leads to an increase in cardiac output (CO) at a constant or reduced filling pressure (PCWP) during submaximal exercise. (Source: American Heart Journal)
Source: American Heart Journal - June 14, 2018 Category: Cardiology Source Type: research

High-dose influenza vaccine to reduce clinical outcomes in high-risk cardiovascular patients: Rationale and design of the INVESTED trial
Conclusion INVESTED is the largest and longest study to assess whether high-dose influenza vaccine is superior to standard-dose influenza vaccine in reducing cardiopulmonary events in a high-risk cardiovascular population (ClinicalTrials.gov Identifier: NCT02787044). (Source: American Heart Journal)
Source: American Heart Journal - June 14, 2018 Category: Cardiology Source Type: research

A clinical decision instrument to predict 30-day death & amp; cardiovascular hospitalizations following an emergency department visit for atrial fibrillation: The atrial fibrillation in the emergency room, part 2 (AFTER2) study
Conclusions Using a population-based sample, we derived and validated a tool that predicts the risk of early death and re-hospitalization for a cardiovascular reason in emergency department AF patients. The tool can offer information to managing physicians about the risk of death and re-hospitalization AF patients seen in the in emergency department, as well as identify patient groups for future targeted interventions aimed at preventing these outcomes. Graphical abstract (Source: American Heart Journal)
Source: American Heart Journal - June 13, 2018 Category: Cardiology Source Type: research

Harmony Outcomes: A randomized, double blind, placebo-controlled trial of the effect of albiglutide on major cardiovascular events in patients with type 2 diabetes mellitus —rationale, design, and baseline characteristics
Conclusions Harmony Outcomes will assess the CV safety of albiglutide in patients with T2DM and CV disease. Trials of other agents in the GLP-1 RA class have shown CV benefit for only some of these medications, possibly due to differences in trial design or instead due to differences in drug structure or metabolism. Harmony Outcomes will provide information critical to our understanding of this heterogenous class of glucose-lowering agents. (Source: American Heart Journal)
Source: American Heart Journal - June 13, 2018 Category: Cardiology Source Type: research

Safety and efficacy of non-vitamin K oral anticoagulant for atrial fibrillation patients following percutaneous coronary intervention: A bivariate analysis of the PIONEER AF-PCI and RE-DUAL PCI trial
Conclusions A bivariate analysis that simultaneously characterizes both risk and benefit demonstrates that rivaroxaban- and dabigatran-based regimens were both favorable over VKA plus dual antiplatelet therapy among patients with AF undergoing PCI. (Source: American Heart Journal)
Source: American Heart Journal - June 13, 2018 Category: Cardiology Source Type: research

ALLiance for sEcondary PREvention after an acute coronary syndrome. The ALLEPRE trial: a multicentre fully nurse-coordinated intensive intervention programme
Publication date: Available online 12 June 2018 Source:American Heart Journal Author(s): Giorgia Paoli, Notarangelo Maria Francesca, Maria Mattioli, Rachele La Sala, Chiara Foà, Emilia Solinas, Sara Fusco, Cristian Fava, Caterina Caminiti, Giovanna Artioli, Giovanna Maria Pelà, Elisabetta Dall’Aglio, Antonio Manari, Stefano Tondi, Antonio Rizzo, Gaia Trapolin, Giampiero Patrizi, Stefano Cappelli, Giovanni Quinto Villani, Massimo Piepoli, Gianni Zobbi, Elisa Nicosia, Diego Ardissino The main objective of cardiovascular disease prevention is to reduce morbidity and mortality by promoting a healthy lifest...
Source: American Heart Journal - June 12, 2018 Category: Cardiology Source Type: research

Telephone-based mindfulness training to reduce stress in women with myocardial infarction: Rationale and design of a multicenter randomized controlled trial
Conclusions If found to be effective, this innovative, scalable intervention may be a promising secondary prevention strategy for women with MI experiencing elevated perceived stress. (Source: American Heart Journal)
Source: American Heart Journal - June 1, 2018 Category: Cardiology Source Type: research

Influence of hospital volume on outcomes for patients with heart failure: Evidence from a Canadian national cohort study
Publication date: Available online 27 May 2018 Source:American Heart Journal Author(s): Finlay A. McAlister, Erik Youngson, Sean van Diepen, Justin A. Ezekowitz, Padma Kaul Although the Get with the Guidelines-Heart Failure (GWTG-HF) group recently reported no association between hospital volume and 30-day outcomes in their registry, GWTG-HF hospitals are self-selected and tend to be higher volume hospitals with active quality improvement departments. Thus, we explored the volume-outcome relationship for HF in an unselected population-based cohort of 241,533 adults admitted with HF as the most responsible diagnosis to any...
Source: American Heart Journal - May 28, 2018 Category: Cardiology Source Type: research

Assessment of left ventricular size and function by three-dimensional transthoracic echocardiography: Impact of the echocardiography platform and analysis software
Conclusions The echocardiography platform and analysis software significantly affects the values of LV parameters obtained by 3DE. Intervendor standardization and improvements in 3DE modalities are needed to broaden the use of LV parameters obtained by 3DE in clinical practice. (Source: American Heart Journal)
Source: American Heart Journal - May 28, 2018 Category: Cardiology Source Type: research

The CardiAMP Heart Failure trial: A randomized controlled pivotal trial of high-dose autologous bone marrow mononuclear cells using the CardiAMP cell therapy system in patients with post –myocardial infarction heart failure: Trial rationale and study design
Conclusions This novel approach may lead to a new treatment for those with ischemic heart disease suffering from medically refractory heart failure. (Source: American Heart Journal)
Source: American Heart Journal - May 26, 2018 Category: Cardiology Source Type: research

International Study of Comparative Health Effectiveness with Medical and Invasive Approaches (ISCHEMIA) trial: Rationale and design
Conclusions ISCHEMIA will provide new scientific evidence regarding whether an invasive management strategy improves clinical outcomes when added to optimal medical therapy in patients with SIHD and moderate or severe ischemia. (Source: American Heart Journal)
Source: American Heart Journal - May 26, 2018 Category: Cardiology Source Type: research

Revival of transcatheter PFO closure: A meta-analysis of randomized controlled trials - impact of shunt size and age
Conclusion According to our meta-analysis TPC plus antiplatelets was superior in terms of stroke prevention when compared to Med-Tx. Furthermore, patients with moderate to severe shunts and those younger than 45 years of age were found to benefit most from TPC. (Source: American Heart Journal)
Source: American Heart Journal - May 26, 2018 Category: Cardiology Source Type: research

Heart failure and readmissions: Research in the public eye
Publication date: Available online 25 May 2018 Source:American Heart Journal Author(s): Mubeen Shakir, Jason H. Wasfy (Source: American Heart Journal)
Source: American Heart Journal - May 25, 2018 Category: Cardiology Source Type: research

Analysis of outcomes for 15,259 US patients with acute myocardial infarction cardiogenic shock (AMICS) supported with the Impella device
Conclusions In this early clinical experience with Impella support for AMICS, wide variation in outcomes existed across centers. Survival was higher when Impella was used as first support strategy, when invasive hemodynamic monitoring was used, and at centers with higher Impella implantation volume. (Source: American Heart Journal)
Source: American Heart Journal - May 25, 2018 Category: Cardiology Source Type: research

The 2nd annual think tank on prevention of sudden cardiac death in the young: Developing a rational, reliable and sustainable National Health Care Resource. A report from the cardiac safety research consortium
Publication date: Available online 23 May 2018 Source:American Heart Journal Author(s): Peter F. Aziz, Stuart Berger, Peter Kowey, Mitchell Krucoff, Martha Lopez-Anderson, Eric Michelson, Silvana Molossi, Valarie Morrow, Ignacio Rodriguez, Tess (Elizabeth) Saarel, Colette Strnadova, Victoria Vetter, Theressa J. Wright, Salim F. Idriss Sudden cardiac death in the young (SCDY) spans gender, race, ethnicity and socioeconomic class. The loss of any pediatric patient is a matter of national and international public health concern and focused efforts should be aimed at preventing these burdensome tragedies. Prepared by members ...
Source: American Heart Journal - May 24, 2018 Category: Cardiology Source Type: research

High-dose influenza vaccine to reduce clinical outcomes in high risk cardiovascular patients: Rationale and design of the INVESTED trial
Conclusion INVESTED is the largest and longest study to assess whether high-dose influenza vaccine is superior to standard-dose influenza vaccine in reducing cardiopulmonary events in a high-risk cardiovascular population patients with heart failure and/or myocardial infarction (ClinicalTrials.gov Identifier: NCT02787044). (Source: American Heart Journal)
Source: American Heart Journal - May 24, 2018 Category: Cardiology Source Type: research

The AUStralian MEDiterranean diet heart trial (AUSMED heart trial): A randomized clinical trial in secondary prevention of coronary heart disease in a multi-ethnic Australian population: Study protocol
Publication date: Available online 24 May 2018 Source:American Heart Journal Author(s): Catherine Itsiopoulos, Teagan Kucianski, Hannah L. Mayr, William J. van Gaal, Miguel Angel Martinez-Gonzalez, Hassan Vally, Michael Kingsley, Antigone Kouris-Blazos, Jessica Radcliffe, Leonie Segal, Laima Brazionis, Agus Salim, Audrey C. Tierney, Kerin O'Dea, Andrew Wilson, Colleen J. Thomas The Mediterranean diet was first characterized as a heart-protective diet in the 1960s. The significant cardio-protective effects of the Mediterranean diet in comparison to the standard care low-fat diet have been established in the primary prevent...
Source: American Heart Journal - May 24, 2018 Category: Cardiology Source Type: research

10-year nationwide trends of the incidence, prevalence, and adverse outcomes of non-valvular atrial fibrillation nationwide health insurance data covering the entire Korean population
Conclusions The burden of AF among Asian patients is increasing. Although the overall risks of cardiovascular events and death following AF onset have decreased over a decade, the event rates are still high. Optimized management of any associated comorbidities should be part of the holistic management approach for patients with AF. (Source: American Heart Journal)
Source: American Heart Journal - May 24, 2018 Category: Cardiology Source Type: research

Analysis of clinical and candidate genetic risk factors for postoperative atrial tachycardia after congenital heart surgery in infants
Conclusion AT occurs in 15% of infants after CHD surgery and is associated with increased morbidity and mortality. Risk factors include use of 2 or more inotropes, neonatal age, and higher surgical complexity score. We observed no association between common genetic variants in PITX2 and IL6 and AT in infants after CHD surgery. (Source: American Heart Journal)
Source: American Heart Journal - May 24, 2018 Category: Cardiology Source Type: research

Leveraging electronic health records for clinical research
We report the proceedings from this think tank meeting in the following paper. (Source: American Heart Journal)
Source: American Heart Journal - May 24, 2018 Category: Cardiology Source Type: research

Rationale and design of the comparison of 3 combination therapies in lowering blood pressure in black Africans (CREOLE study): 2 × 3 factorial randomized single-blind multicenter trial
Conclusions The CREOLE trial will provide unique information as to the most efficacious 2-drug combination in blacks residing in SSA and thereby inform the development of clinical guidelines for the treatment of hypertension in this subregion. (Source: American Heart Journal)
Source: American Heart Journal - May 24, 2018 Category: Cardiology Source Type: research

Challenges of Evaluating Chronic Heart Failure and Acute Heart Failure Events in Research Studies Using Large Healthcare Databases
Publication date: Available online 21 May 2018 Source:American Heart Journal Author(s): Miguel Cainzos-Achirica, Cristina Rebordosa, Emili Vela, Montse Cleries, Kunihiro Matsushita, Estel Plana, Elena Rivero-Ferrer, Cristina Enjuanes, Santiago Jimenez-Marrero, Luis Alberto Garcia-Rodriguez, Josep Comin-Colet, Susana Perez-Gutthann Epidemiological studies on heart failure (HF) using large healthcare databases are becoming increasingly frequent, as they represent an invaluable opportunity to characterize the importance and risk factors of HF from a population perspective. Nevertheless, because of its complex diagnosis and n...
Source: American Heart Journal - May 22, 2018 Category: Cardiology Source Type: research

I-CARE randomized clinical trial integrating depression and acute coronary syndrome Care in low Resource Hospitals in China: Design and rationale
Publication date: Available online 21 May 2018 Source:American Heart Journal Author(s): Shenshen Li, James A. Blumenthal, Chuan Shi, Danielle Millican, Xian Li, Xin Du, Anushka Patel, Pei Gao, Elizabeth Delong, Pallab K. Maulik, Runlin Gao, Xin Yu, Yangfeng Wu Depression and acute coronary syndromes (ACS) are both common public health challenges. Patients with ACS often develop depression, which in turn adversely affects prognosis. Low-cost, sustainable, and effective service models that integrated depression care into the management of ACS patients to reduce depression and improve ACS outcomes are critically needed. Inte...
Source: American Heart Journal - May 22, 2018 Category: Cardiology Source Type: research

The Role of Gas Exchange Variables in Cardiopulmonary Exercise Testing for Risk Stratification and Management of Heart Failure with Reduced Ejection Fraction
Publication date: Available online 22 May 2018 Source:American Heart Journal Author(s): Jonathan Wagner, Piergiuseppe Agostoni, Ross Arena, Romualdo Belardinelli, Daniel Dumitrescu, Alfred Hager, Jonathan Myers, Rainer Rauramaa, Marshall Riley, Tim Takken, Arno Schmidt-Trucksäss Heart failure with reduced ejection fraction (HFrEF) is common in the developed world and results in significant morbidity and mortality. Accurate risk assessment methods and prognostic variables are therefore needed to guide clinical decision making for medical therapy and surgical interventions with the ultimate goal of decreasing risk and ...
Source: American Heart Journal - May 22, 2018 Category: Cardiology Source Type: research

Immediate coronary intervention in prehospital cardiac arrest - aiming to save lives
Publication date: Available online 22 May 2018 Source:American Heart Journal Author(s): Johan Holmén, Johan Herlitz, Christer Axelsson (Source: American Heart Journal)
Source: American Heart Journal - May 22, 2018 Category: Cardiology Source Type: research

A randomized controlled cross-over trial evaluating differential responses to antihypertensive drugs (used as mono- or dual-therapy) on the basis of ethnicity: The - comparIsoN oF optimal hypertension RegiMens; part of the ancestry informative markers in HYpertension programme – AIM-HY INFORM trial
Conclusion AIM-HY INFORM is a prospective, open-label, randomized trial which aims to evaluate first and second-line anti-hypertensive therapies for multi-ethnic populations. (Source: American Heart Journal)
Source: American Heart Journal - May 21, 2018 Category: Cardiology Source Type: research

Progressive right ventricular enlargement due to pulmonary regurgitation: Clinical characteristics of a “low-risk” group
Conclusions Patients with PR without RVEDVi >130 mL/m2 and/or ≥moderate tricuspid regurgitation represent a low-risk subgroup that may be appropriate for clinical and echo follow-up but may potentially require infrequent CMRI follow-up. (Source: American Heart Journal)
Source: American Heart Journal - May 21, 2018 Category: Cardiology Source Type: research

First spot urine sodium after initial diuretic identifies patients at high risk for adverse outcome after heart failure hospitalization
Conclusions Assessment of spot UNa after initial intravenous loop diuretic administration may facilitate identification and triage of a population of HF patients at increased risk for adverse events and prolonged hospitalization. (Source: American Heart Journal)
Source: American Heart Journal - May 20, 2018 Category: Cardiology Source Type: research

The high cost of critical care unit over-utilization for patients with NSTE ACS
Conclusions In a population-based contemporary cohort, CCU utilization for patients with NSTE ACS varied widely and in-hospital mortality was similar between low, medium and high utilization centers. CCU care accounted for 45% of hospitalization costs; thus, implementing policies and admission practices to align hospital resources with patient care needs have the potential to reduce overall health care costs. (Source: American Heart Journal)
Source: American Heart Journal - May 20, 2018 Category: Cardiology Source Type: research

Driving with the headlights on: Measuring adequate urinary sodium excretion on the road to precision diuresis
Publication date: Available online 19 May 2018 Source:American Heart Journal Author(s): Justin L. Grodin, W.H. Wilson Tang (Source: American Heart Journal)
Source: American Heart Journal - May 20, 2018 Category: Cardiology Source Type: research

Long-term outcomes of mitral regurgitation by type and severity
Conclusions Although MR severity is independently associated with increased all-cause death risk for most forms of MR, the absolute mortality rates associated with worse MR severity are much higher for primary myxomatous, non-myxomatous, and secondary ischemic MR. The findings from this study support carefully defining MR by type and severity. (Source: American Heart Journal)
Source: American Heart Journal - May 19, 2018 Category: Cardiology Source Type: research

Mechanical circulatory support costs in children bridged to heart transplantation — analysis of a linked database
Conclusions MCS as a bridge to HT in children is associated with greater total costs. While costs are similar between VAD and ECMO groups, the majority of costs associated with VAD support is incurred pre-HT while ECMO costs are incurred primarily post-HT. Discharging patients on VAD support awaiting HT may represent a strategy to reduce costs in this population. (Source: American Heart Journal)
Source: American Heart Journal - May 18, 2018 Category: Cardiology Source Type: research

Importance of geriatric nutritional risk index assessment in patients undergoing transcatheter aortic valve replacement
Conclusions GNRI is related to both frailty components and the STS score and is an important surrogate marker for predicting worse clinical outcomes following TAVR. GNRI assessment may be considered when deciding on TAVR. (Source: American Heart Journal)
Source: American Heart Journal - May 16, 2018 Category: Cardiology Source Type: research

Validation of the Seattle angina questionnaire in women with ischemic heart disease
Conclusion The SAQ demonstrates similar psychometric properties in men and women with CAD. These findings provide evidence for validity of the SAQ in assessing women with IHD. (Source: American Heart Journal)
Source: American Heart Journal - May 15, 2018 Category: Cardiology Source Type: research

Discharge timing and outcomes after uncomplicated non –ST-segment elevation acute myocardial infarction
Conclusions Patients with NSTEMI who had no serious complications during the first 2 hospital days were at low risk of subsequent short- and intermediate-term death or ischemic events. (Source: American Heart Journal)
Source: American Heart Journal - May 11, 2018 Category: Cardiology Source Type: research

Implications of a recurrent in-hospital cardiac arrest on survival and neurological outcomes
Conclusions Nearly 1 in 8 patients with an IHCA has a recurrent IHCA, and these patients have worse outcomes than patients with only a single IHCA and those with an IHCA after being hospitalized for an OHCA. Despite worse survival, rates of DNAR and withdrawal of care were lowest for patients with recurrent IHCA. These findings provide important prognostic information for clinicians caring for patients with recurrent IHCA and suggest the need to better align resuscitation and end-of-life decisions with patients' prognoses after IHCA. (Source: American Heart Journal)
Source: American Heart Journal - May 10, 2018 Category: Cardiology Source Type: research

Cardiac arrest: A recurrent problem
Publication date: Available online 9 May 2018 Source:American Heart Journal Author(s): Jacob C. Jentzer (Source: American Heart Journal)
Source: American Heart Journal - May 10, 2018 Category: Cardiology Source Type: research

Randomized clinical comparison of the dual-therapy CD34 antibody-covered sirolimus-eluting combo stent with the sirolimus-eluting Orsiro stent in patients treated with percutaneous coronary intervention: Rationale and study design of the Scandinavian Organization for Randomized Trials with clinical outcome (SORT OUT) X trial
Conclusion The SORT OUT X trial will determine whether the dual-therapy Combo stent is non-inferior to the Orsiro stent with respect to clinically driven events. (ClinicalTrials.gov NCT03216733). (Source: American Heart Journal)
Source: American Heart Journal - May 8, 2018 Category: Cardiology Source Type: research

The Association of Duration of participation in get with the guidelines-resuscitation with quality of Care for in-Hospital Cardiac Arrest
Conclusions GWTG-R participation duration was associated with a significant improvement in IHCA quality of care, yet significant opportunities remain to find ways to maximize quality of care in this high-risk patient group. (Source: American Heart Journal)
Source: American Heart Journal - May 8, 2018 Category: Cardiology Source Type: research

Safety of Ticagrelor in patients with baseline conduction abnormalities: A PLATO (study of platelet inhibition and patient outcomes) analysis
Conclusions Ticagrelor compared to clopidogrel did not increase arrhythmic events, even in subjects with ACS who present with mild conduction abnormalities on their baseline ECG. (Source: American Heart Journal)
Source: American Heart Journal - May 8, 2018 Category: Cardiology Source Type: research

Impact of polyvascular disease on patients with atrial fibrillation: Insights from ROCKET AF
Conclusion The use of rivaroxaban compared with warfarin was associated with a higher risk of stroke and bleeding in patients with polyvascular disease enrolled in ROCKET AF. Further studies are needed to understand the optimal management of this high-risk population. (Source: American Heart Journal)
Source: American Heart Journal - May 8, 2018 Category: Cardiology Source Type: research

Coronary angiography in out-of-hospital cardiac arrest without ST elevation on ECG —Short- and long-term survival
Conclusion In this population of bystander-witnessed cases of out-of-hospital cardiac arrest with shockable rhythm and ECG without ST elevation, early coronary angiography may be associated with improved short and long term survival. (Source: American Heart Journal)
Source: American Heart Journal - May 8, 2018 Category: Cardiology Source Type: research

Randomized placebo controlled trial evaluating the safety and efficacy of single low-dose intracoronary insulin-like growth factor following percutaneous coronary intervention in acute myocardial infarction (RESUS-AMI)
Conclusions In this pilot trial, low-dose IGF1, given after optimal mechanical reperfusion in STEMI, is safe but does not improve LVEF. However, there is a signal for a dose-dependent benefit on post-MI remodeling that may warrant further study. (Source: American Heart Journal)
Source: American Heart Journal - May 8, 2018 Category: Cardiology Source Type: research

The design and rationale for the Dapagliflozin Effect on Cardiovascular Events (DECLARE) –TIMI 58 Trial
Conclusion The DECLARE–TIMI 58 trial is testing the hypotheses that dapagliflozin is safe (does not increase) and may reduce the occurrence of major CV events. DECLARE–TIMI 58 is the largest study to address this question with an SGLT-2 inhibitor in patients with T2DM and with established CV disease and without CV disease but with multiple risk factors. (Source: American Heart Journal)
Source: American Heart Journal - May 8, 2018 Category: Cardiology Source Type: research