Rationale and design of the steroids to reduce systemic inflammation after infant heart surgery (stress) trial
Publication date: Available online 9 December 2019Source: American Heart JournalAuthor(s): Kevin D. Hill, H. Scott Baldwin, David P. Bichel, Ryan J. Butts, Reid C. Chamberlain, Alicia M. Ellis, Eric M. Graham, Jesse Hickerson, Christoph P. Hornik, Jeffrey P. Jacobs, Marshall L. Jacobs, Robert DB Jaquiss, Prince J. Kannankeril, Sean M. O'Brien, Rachel Torok, Joseph W. Turek, Jennifer S. Li, For the STRESS Network InvestigatorsFor decades, physicians have administered corticosteroids in the perioperative period to infants undergoing heart surgery with cardiopulmonary bypass (CPB) to reduce the post-operative systemic inflamm...
Source: American Heart Journal - December 9, 2019 Category: Cardiology Source Type: research

Transesophageal echocardiography complications associated with interventional cardiology procedures
This study included 1249 consecutive patients undergoing either transcatheter aortic valve implantation (TAVI), Mitraclip, left atrial appendage occlusion (LAAO) or paravalvular leak closure (PVLC). Patients were divided into two cohorts based on the degree of probe manipulation required to guide the procedure and the risk of developing a TEE-related complication: low-risk (TAVI, n = 1037) and high-risk (Mitraclip, LAAO and PVLC, n = 212). Patients were further analyzed according to the occurrence of major and minor TEE-related complications.ResultsThe overall incidence of TEE-related complications was ...
Source: American Heart Journal - December 9, 2019 Category: Cardiology Source Type: research

Association between frequency of primary care provider visits and evidence-based statin prescribing and statin adherence: Findings from the veterans affairs system
Publication date: Available online 7 December 2019Source: American Heart JournalAuthor(s): Sarah T. Ahmed, Dhruv Mahtta, Hasan Rehman, Julia Akeroyd, Mahmoud Al Rifai, Fatima Rodriguez, Hani Jneid, Khurram Nasir, Zainab Samad, Mahboob Alam, Laura A. Petersen, Salim S. ViraniBackgroundStatin use remains suboptimal in patients with atherosclerotic cardiovascular disease (ASCVD). We assessed if the frequency of visits with primary care providers (PCPs) is associated with higher use of evidence-based statin prescriptions and adherence among patients with ASCVD.MethodsWe identified patients with ASCVD aged ≥18 years rec...
Source: American Heart Journal - December 7, 2019 Category: Cardiology Source Type: research

Estimating the prevalence of congenital heart disease among adolescents and adults in Colorado adjusted for incomplete case ascertainment
ConclusionThis statewide study yielded new information on the prevalence of CHDs in adolescents and adults. These high prevalence rates underscore the need for additional specialized care facilities for this population with CHDs. (Source: American Heart Journal)
Source: American Heart Journal - December 7, 2019 Category: Cardiology Source Type: research

Design, methodology and baseline characteristics of the Women's ischemia syndrome evaluation coronary vascular dysfunction (WISE-CVD)
Publication date: Available online 5 December 2019Source: American Heart JournalAuthor(s): Odayme Quesada, Ahmed AlBadri, Janet Wei, Chrisandra Shufelt, Puja K. Mehta, Jenna Maughan, Nissi Suppogu, Haider Aldiwani, Galen Cook-Wiens, Michael D. Nelson, Behzad Sharif, Eileen M. Handberg, David R. Anderson, John Petersen, Daniel S. Berman, Louise E.J. Thomson, Carl J. Pepine, C. Noel Bairey MerzBackgroundA significant number of women with signs and symptoms of ischemia with no obstructive coronary artery disease (INOCA) have coronary vascular dysfunction, detected by invasive coronary reactivity testing (CRT). However, the no...
Source: American Heart Journal - December 7, 2019 Category: Cardiology Source Type: research

High-throughput targeted proteomics discovery approach and spontaneous reperfusion in ST-segment elevation myocardial infarction
ConclusionsSpontaneous reperfusion prior to pPCI in STEMI was associated with a lower risk of adverse clinical events. These exploratory data from a targeted discovery proteomics platform identifies novel proteins across diverse, yet complementary, pathobiological axes that show promise in providing mechanistic insights into spontaneous reperfusion in STEMI.Condensed abstractSpontaneous reperfusion has been established with improved STEMI outcomes, yet its pathobiology is unclear and appears to involve diverse physiological processes. Using a 91-biomarker high-throughput proteomics platform, we studied 683 STEMI patients i...
Source: American Heart Journal - December 7, 2019 Category: Cardiology Source Type: research

Average daily ischemic versus bleeding risk in patients with ACS undergoing PCI: Insights from the BleeMACS and RENAMI registries
ConclusionsIn unselected ACS patients, ADIR and ADBR occurred at similar rates within 1 year after PCI. ADIR was greater than ADBR in the first 2 weeks, especially in ST-segment elevation myocardial infarction patients and those with incomplete revascularization. In the first year, ADIR was higher than ADBR in patients with incomplete revascularization, whereas ADBR was higher in non–ST-segment elevation ACS patients and in those discharged on ticagrelor. (Source: American Heart Journal)
Source: American Heart Journal - December 4, 2019 Category: Cardiology Source Type: research

Rationale and Design of the British Heart Foundation (BHF) coronary microvascular function and CT coronary angiogram (CorCTCA) study
Publication date: Available online 2 December 2019Source: American Heart JournalAuthor(s): Novalia P Sidik, Margaret McEntegart, Giles Roditi, Thomas J Ford, Michael McDermott, Andrew Morrow, John Byrne, Jacqueline Adams, Allister Hargreaves, Keith G Oldroyd, David Stobo, Olivia Wu, Claudia-Martina Messow, Alex McConnachie, Colin BerryBackgroundMicrovascular and/or vasospastic angina are relevant causes of ischemia and no obstructive coronary artery disease (INOCA) in patients after computed tomography coronary angiography (CTCA).ObjectivesOur research has two objectives. The first is to undertake a diagnostic study and th...
Source: American Heart Journal - December 3, 2019 Category: Cardiology Source Type: research

Association of plasma soluble ST2 and galectin-3 with cardiovascular events and mortality following cardiac surgery
ConclusionsHigher post-operative sST2 and gal-3 values were associated with increased incidence of cardiovascular event or mortality. These two biomarkers should be further studied for potential clinical utility for patients undergoing cardiac surgery.Graphical abstract (Source: American Heart Journal)
Source: American Heart Journal - December 3, 2019 Category: Cardiology Source Type: research

Variations in stepped-wedge cluster randomized trial design: Insights from the Patient-Centered Care Transitions in Heart Failure trial
Publication date: February 2020Source: American Heart Journal, Volume 220Author(s): Rudy R. Unni, Shun Fu Lee, Lehana Thabane, Stuart Connolly, Harriette GC Van SpallThe stepped-wedge (SW) cluster randomized controlled trial, in which clusters cross over in a randomized sequence from control to intervention, is ideal for the implementation and testing of complex health service interventions. In certain cases however, implementation of the intervention may pose logistical challenges, and variations in SW design may be required.We examine the logistical and statistical implications of variations in SW design using the optimi...
Source: American Heart Journal - December 3, 2019 Category: Cardiology Source Type: research

Impact of pre-procedural left ventricle hypertrophy and geometrical patterns on mortality following TAVR
ConclusionMild concentric LVH confers a protective effect among patients with severe aortic stenosis undergoing TAVR. However, hypertrophy becomes maladaptive and an increased baseline LVMI, eccentric pattern particularly, may be associated with all-cause mortality in this population. (Source: American Heart Journal)
Source: American Heart Journal - November 30, 2019 Category: Cardiology Source Type: research

Quantitative analysis of ablation technique predicts arrhythmia recurrence following atrial fibrillation ablation
ConclusionAblation lesion sequentiality measured by catheter inter-lesion distance and catheter stability measured by catheter excursion during lesion placement are potentially modifiable factors affecting arrhythmia recurrence after RF ablation for AF. (Source: American Heart Journal)
Source: American Heart Journal - November 29, 2019 Category: Cardiology Source Type: research

Validation of the all-comers design: Results of the TARGET-AC substudy
Publication date: Available online 27 November 2019Source: American Heart JournalAuthor(s): Gabor G Toth, Alexandra Lansky, Andreas Baumbach, Henning Kelbæk, Niels van Royen, Lene Holmvang, Luc Janssens, Salvatore Brugaletta, Emanuele Barbato, Luc Maillard, Ferdinand Kiemeneij, Christoph Kurt Naber, Felix Pucher, Peter Nørkjær Laursen, Koen Ameloot, Carlos Robles, Anastasios Milkas, Jose Sevilla, Christoph Jensen, William WijnsAbstractBackgroundResults of clinical trials are often criticized by low inclusion rate and potential sampling bias in patient recruitment. The aim of this validation registry is t...
Source: American Heart Journal - November 29, 2019 Category: Cardiology Source Type: research

Targeting all-comers – Are we doing as well as we can?
Publication date: Available online 23 November 2019Source: American Heart JournalAuthor(s): James M. Brophy (Source: American Heart Journal)
Source: American Heart Journal - November 24, 2019 Category: Cardiology Source Type: research

Safety and efficacy outcomes of left atrial Posterior Wall isolation compared to pulmonary vein isolation and pulmonary vein isolation with linear ablation for the treatment of persistent atrial fibrillation
ConclusionPVI + PWI does not appear to be as effective as PVI or PVI + linear ablation in reducing the recurrence of arrhythmia within 6 months of the index procedure in patients with persistent AF. A prospective, randomized controlled trial comparing these ablation techniques is needed to clarify the role of extensive substrate modification for treatment of persistent AF.Condensed AbstractPWI is increasingly used as an adjunctive lesion set to compliment PVI in patients with persistent AF. We performed a retrospective study of 558 patients who underwent de novo and repeat ablation for persistent A...
Source: American Heart Journal - November 23, 2019 Category: Cardiology Source Type: research

Grenada Heart Project–Community Health ActioN to EncouraGe healthy BEhaviors (GHP-CHANGE): A randomized control peer group–based lifestyle intervention
ConclusionsThe GHP-CHANGE trial showed that a peer-support lifestyle intervention program was feasible; however, it did not demonstrate a significant improvement in the FBS as compared to the control group. Further studies should assess the effects of low-cost lifestyle interventions in LMICs. (Source: American Heart Journal)
Source: American Heart Journal - November 23, 2019 Category: Cardiology Source Type: research

Major bleeding in patients with peripheral artery disease: Insights from the EUCLID trial
Publication date: Available online 18 November 2019Source: American Heart JournalAuthor(s): Rachael Ward, Zhen Huang, Frank W. Rockhold, Iris Baumgartner, Jeffrey S. Berger, Juuso I. Blomster, F. Gerry R. Fowkes, Brian G. Katona, Kenneth W. Mahaffey, Lars Norgren, Sreekanth Vemulapalli, Thomas J. Povsic, Rajendra Mehta, William R. Hiatt, Manesh R. Patel, W. Schuyler JonesBackgroundRates and predictors of major bleeding in patients with peripheral artery disease (PAD) treated with antiplatelets have not been well studied. This post-hoc analysis of EUCLID aimed to determine the incidence of major/minor bleeding, predictors o...
Source: American Heart Journal - November 20, 2019 Category: Cardiology Source Type: research

Ticagrelor-based antiplatelet regimens in patients with atherosclerotic artery disease—A meta-analysis of randomized clinical trials
Publication date: January 2020Source: American Heart Journal, Volume 219Author(s): Salvatore Cassese, Gjin Ndrepepa, Robert A. Byrne, Karl-Ludwig Laugwitz, Heribert Schunkert, Massimiliano Fusaro, Fernando Alfonso, Adnan KastratiBackgroundRandomized trials did not consistently support superiority of ticagrelor, as monotherapy or in combination with aspirin, in terms of efficacy or safety, in patients with atherosclerotic artery disease.MethodsMedline, EMBASE, the Cochrane Central Register of Controlled Trials, and scientific session abstracts were searched for trials of patients with coronary or peripheral artery disease (...
Source: American Heart Journal - November 20, 2019 Category: Cardiology Source Type: research

Are existing and emerging biomarkers associated with cardiorespiratory fitness in patients with chronic heart failure?
Publication date: Available online 16 November 2019Source: American Heart JournalAuthor(s): Marat Fudim, Jacob P. Kelly, Aaron D. Jones, Omar AbouEzzeddine, Andrew P. Ambrosy, Stephen J. Greene, Yogesh N.V. Reddy, Kevin J. Anstrom, Brooke Alhanti, Gregory D. Lewis, Adrian F. Hernandez, G. Michael FelkerAimsCardiorespiratory fitness (CRF) is closely linked to health status and clinical outcomes in heart failure (HF) patients. We aimed to test whether biomarkers can reflect CRF and its change over time.Methods and ResultsThis post-hoc analysis utilized data from ambulatory cohorts of heart failure with reduced ejection fract...
Source: American Heart Journal - November 16, 2019 Category: Cardiology Source Type: research

Risk score–guided multidisciplinary team-based Care for Heart Failure Inpatients is associated with lower 30-day readmission and lower 30-day mortality
Publication date: January 2020Source: American Heart Journal, Volume 219Author(s): Benjamin D. Horne, Colleen A. Roberts, Kismet D. Rasmusson, Jason Buckway, Rami Alharethi, Jalisa Cruz, R. Scott Evans, James F. Lloyd, Tami L. Bair, Abdallah G. Kfoury, Donald L. LappéObjectiveUsing augmented intelligence clinical decision tools and a risk score-guided multidisciplinary team-based care process (MTCP), this study evaluated the MTCP for heart failure (HF) patients' 30-day readmission and 30-day mortality across 20 Intermountain Healthcare hospitals.BackgroundHF inpatient care and 30-day post-discharge management requir...
Source: American Heart Journal - November 15, 2019 Category: Cardiology Source Type: research

The accuracy of self-reported blood pressure in the medication adherence improvement support app for engagement – Blood pressure (MedISAFE-BP) trial: Implications for pragmatic trials
In this study, we assessed the accuracy of self-reported poorly-controlled hypertension among adults in the community who were screened for participation in the MedISAFE-BP trial. Of individuals who self-reported poorly-controlled hypertension using the online trial enrollment platform, 64% had a systolic blood pressure less than 140 mmHg when measured at home. While we identified several characteristics associated with accurate self-report including older age (Odds Ratio [OR] 1.02 per year, 95% CI 1.01–1.03), diabetes (OR 1.59, 95% CI 1.17–2.14), and low health activation (OR 1.56 95% CI 1.17–2.07), we w...
Source: American Heart Journal - November 15, 2019 Category: Cardiology Source Type: research

Evolocumab treatment in patients with HIV and hypercholesterolemia/mixed dyslipidemia: BEIJERINCK study design and baseline characteristics
Publication date: Available online 12 November 2019Source: American Heart JournalAuthor(s): Franck Boccara, Princy Kumar, Bruno Caramelli, Alexandra Calmy, J. Antonio G. López, Sarah Bray, Marcoli Cyrille, Robert S. RosensonBackgroundPeople living with human immunodeficiency virus (PLHIV) are at higher risk of atherosclerotic cardiovascular disease (ASCVD) due to traditional and HIV- or antiretroviral treatment (ART)-related risk factors. The use of high-intensity statin therapy is often limited by comorbidities and drug–drug interactions with ART. Herein, we present the design and baseline characteristics of ...
Source: American Heart Journal - November 14, 2019 Category: Cardiology Source Type: research

Low-density lipoprotein cholesterol treatment and outcomes in patients with type 2 diabetes and established cardiovascular disease: Insights from TECOS
ConclusionsAlthough most high-risk patients with T2D and CV disease were on lipid-lowering therapy, only 1:3 had LDL-C 
Source: American Heart Journal - November 14, 2019 Category: Cardiology Source Type: research

The effect of METOPROLOL and aspirin on cardiovascular risk in bereavement: A randomized controlled trial
Publication date: Available online 13 November 2019Source: American Heart JournalAuthor(s): Geoffrey H Tofler, Marie-Christine Morel-Kopp, Monica Spinaze, Jill Dent, Christopher Ward, Sharon McKinley, Anastasia S Mihailidou, Jennifer Havyatt, Victoria Whitfield, Roger Bartrop, Judith Fethney, Holly G Prigerson, Thomas BuckleyBackgroundBereavement is associated with an increased risk of cardiovascular disease; however, no reports exist of interventions to reduce risk. In a randomized, double-blind, placebo-controlled trial of 85 recently bereaved participants, we determined whether beta-blocker (metoprolol 25 mg) and aspiri...
Source: American Heart Journal - November 14, 2019 Category: Cardiology Source Type: research

Average daily ischemic vs. bleeding risk in patients with ACS undergoing PCI: Insights from the Bleemacs and Renami registries
ConclusionsIn unselected ACS patients, ADIR and ADBR occurred at similar rates within 1 year after PCI. ADIR was greater than ADBR in the first 2 weeks, especially in STEMI patients and those with incomplete revascularization. In the first year ADIR was higher than ADBR in patients with incomplete revascularization, while ADBR was higher in NSTE-ACS patients and in those discharged on ticagrelor. (Source: American Heart Journal)
Source: American Heart Journal - November 12, 2019 Category: Cardiology Source Type: research

Primary outcomes should be of primary interest to readers
Publication date: Available online 11 November 2019Source: American Heart JournalAuthor(s): Bogdan Enache (Source: American Heart Journal)
Source: American Heart Journal - November 12, 2019 Category: Cardiology Source Type: research

Videos to reduce racial disparities in ICD therapy via innovative designs (VIVID) trial: Rational, design and methodology
ConclusionsIn addition to assessing the efficacy of decision support on ICD acceptance among black individuals, VIVID will provide insight into the role of racial concordance in medical decision-making. Given the similarities in the root causes of racial/ethnic disparities in care across health disciplines, our approach and findings may be generalizable to decision-making in other health care settings. (Source: American Heart Journal)
Source: American Heart Journal - November 12, 2019 Category: Cardiology Source Type: research

Primary Outcomes Should Be of Primary Interest to Readers
Publication date: Available online 11 November 2019Source: American Heart JournalAuthor(s): Matthew Budoff (Source: American Heart Journal)
Source: American Heart Journal - November 12, 2019 Category: Cardiology Source Type: research

Meta-analysis of short- and long-term efficacy of mononuclear cell transplantation in patients with myocardial infarction
Publication date: Available online 11 November 2019Source: American Heart JournalAuthor(s): Dan Yang, Connor Galen O'Brien, Gentaro Ikeda, Jay H. Traverse, Doris A. Taylor, Timothy D. Henry, Roberto Bolli, Phillip C. YangBackgroundMononuclear cells (MNCs) have been tested in clinical trials across multiple cardiovascular pathologies with mixed results. Major adverse cardiac events (MACE) and markers of cardiovascular capacity have been particularly challenging to interpret due to small size. This meta-analysis is aimed to assess the efficacy of MNC therapy in randomized clinical trials to identify the markers of efficiency...
Source: American Heart Journal - November 12, 2019 Category: Cardiology Source Type: research

Transcatheter InterAtrial shunt device for the treatment of heart failure: Rationale and Design of the Pivotal Randomized Trial to REDUCE elevated left atrial pressure in patients with heart failure II (REDUCE LAP-HF II)
ConclusionsREDUCE LAP-HF II is designed to evaluate the clinical efficacy of the IASD device in patients with symptomatic HF with elevated LA pressure and LVEF≥40%. (Source: American Heart Journal)
Source: American Heart Journal - November 12, 2019 Category: Cardiology Source Type: research

Claims-based cardiovascular outcome identification for clinical research: Results from 7 large randomized cardiovascular clinical trials
ConclusionsClaims- versus site-based (+CEC) follow-up identified similar overall cardiovascular event rates despite meaningful differences in the events detected. Randomized treatment effects were similar using the 2 methods, suggesting claims data could be used to support clinical research leveraging routinely collected data. This approach may lead to more effective evidence generation, synthesis, and appraisal of medical products and inform the strategic approaches toward the National Evaluation System for Health Technology. (Source: American Heart Journal)
Source: American Heart Journal - November 12, 2019 Category: Cardiology Source Type: research

Associations between β-blocker therapy and cardiovascular outcomes in patients with diabetes and established cardiovascular disease
ConclusionsIn this observational analysis of T2D and ASCVD, baseline β-blocker use was not associated with risks for severe hypoglycemia yet also was not associated with CV risk reduction over 3 years of follow-up, supporting a randomized examination of chronic β-blocker therapy in this patient population. (TECOS ClinicalTrials.gov number, NCT00790205). (Source: American Heart Journal)
Source: American Heart Journal - November 11, 2019 Category: Cardiology Source Type: research

The role of clinical assessment and electrophysiology study in Brugada Syndrome patients with syncope
Publication date: Available online 8 November 2019Source: American Heart JournalAuthor(s): Jaime Hernandez-Ojeda, Elena Arbelo, Paloma Jorda, Roger Borras, Oscar Campuzano, Georgia Sarquella-Brugada, Anna Iglesias, Lluis Mont, Ramon Brugada, Josep BrugadaAbstractBackgroundCardiogenic syncope in Brugada syndrome (BrS) increases the risk of major events. Nevertheless, clinical differentiation between cardiogenic and vasovagal syncope can be challenging. We characterized the long-term incidence of major events in a large cohort of BrS patients presented with syncope.MethodsFrom a total of 474 patients, syncope was the initial...
Source: American Heart Journal - November 10, 2019 Category: Cardiology Source Type: research

Diagnostic tools for early detection of cardiac dysfunction in childhood cancer survivors: Methodological aspects of the Dutch LATER cardiology study
ConclusionsThe LATER CARD study will provide knowledge on different surveillance modalities for detection of cardiac dysfunction in long-term CCS at risk for heart failure. The results of the study will enable us to improve long-term follow-up surveillance guidelines for CCS at risk for heart failure. (Source: American Heart Journal)
Source: American Heart Journal - November 10, 2019 Category: Cardiology Source Type: research

High throughout targeted proteomics discovery approach and spontaneous reperfusion in ST-segment elevation myocardial infarction
ConclusionSpontaneous reperfusion prior to pPCI in STEMI was associated with a lower risk of adverse clinical events. These exploratory data from a targeted discovery proteomics platform identifies novel proteins across diverse, yet complementary, pathobiological axes that show promise in providing mechanistic insights into spontaneous reperfusion in STEMI.Condensed abstractSpontaneous reperfusion has been established with improved STEMI outcomes, yet its pathobiology is unclear and appears to involve diverse physiological processes. Using a 91-biomarker high-throughput proteomics platform, we studied 683 STEMI patients in...
Source: American Heart Journal - November 10, 2019 Category: Cardiology Source Type: research

Four-year trends in oral anticoagulant use and declining rates of ischemic stroke among 194,030 atrial fibrillation patients drawn from a sample of 12 million people
Publication date: Available online 9 November 2019Source: American Heart JournalAuthor(s): Aldo P. Maggioni, Letizia Dondi, Felicita Andreotti, Antonella Pedrini, Silvia Calabria, Giulia Ronconi, Carlo Piccinni, Nello MartiniBackgroundAdministrative data were used to investigate changes in hospitalizations for atrial fibrillation (AF), AF-related stroke and treatment patterns between 2012 and 2016.MethodsFrom the ‘Ricerca e Salute’ database, a population- and patient-based repository involving>12 million inhabitants and linking demographics, prescriptions and hospital discharge records, all patients discharg...
Source: American Heart Journal - November 10, 2019 Category: Cardiology Source Type: research

Guideline-directed therapies for comorbidities and clinical outcomes among individuals with atrial fibrillation
ConclusionsIn AF patients, there is underuse of GDT for non-AF comorbidities. The association between GDT use and outcomes was strongest in heart failure and obstructive sleep apnea patients where use of GDT was associated with lower mortality and less AF progression. (Source: American Heart Journal)
Source: American Heart Journal - November 10, 2019 Category: Cardiology Source Type: research

Admission Society for Cardiovascular Angiography and Intervention shock stage stratifies post-discharge mortality risk in cardiac intensive care unit patients
Publication date: January 2020Source: American Heart Journal, Volume 219Author(s): Jacob C. Jentzer, David A. Baran, Sean van Diepen, Gregory W. Barsness, Timothy D. Henry, Srihari S. Naidu, Malcolm R. Bell, David R. HolmesBackgroundThe five-stage Society for Cardiovascular Angiography and Intervention (SCAI) cardiogenic shock classification scheme can stratify hospital mortality risk in patients admitted to the cardiac intensive care unit (CICU). We sought to evaluate the SCAI shock classification for prediction of post-discharge mortality in CICU survivors.MethodsWe retrospectively analyzed hospital survivors admitted to...
Source: American Heart Journal - November 10, 2019 Category: Cardiology Source Type: research

Clinical and regulatory landscape for cardiogenic shock: A report from the Cardiac Safety Research Consortium ThinkTank on cardiogenic shock
Publication date: January 2020Source: American Heart Journal, Volume 219Author(s): Marc Samsky, Mitchell Krucoff, Andrew D. Althouse, William T. Abraham, Philip Adamson, Fernando Aguel, Seth Bilazarian, George D. Dangas, Ian C Gilchrist, Timothy D. Henry, Judith S. Hochman, Navin K. Kapur, John Laschinger, Roy G. Masters, Eric Michelson, David A. Morrow, Valarie Morrow, E. Magnus Ohman, Ileana Pina, Alastair G. Proudfoot (Source: American Heart Journal)
Source: American Heart Journal - November 8, 2019 Category: Cardiology Source Type: research

Cardiovascular risk factor profiles in familial hypercholesterolemia patients with and without genetic mutation compared to a nationally representative sample of adults in a high-risk European country
ConclusionsThe FH(+) patients had significantly higher mean LDL-C, but the levels of nonlipid factors were lower or similar compared to the other groups. Both FH(+) and FH(−) were characterized by a heavy burden of ASCVD. This suggests that cholesterol, and no other risk factors, is a key contributor to cardiovascular risk in patients with FH, especially those with genetic mutation. (Source: American Heart Journal)
Source: American Heart Journal - November 7, 2019 Category: Cardiology Source Type: research

The effect of low-dose colchicine in patients with stable coronary artery disease: The LoDoCo2 trial rationale, design, and baseline characteristics
ConclusionThe LoDoCo2 Trial will provide information on the efficacy and safety of low-dose colchicine for secondary prevention in patients with stable coronary artery disease. (Source: American Heart Journal)
Source: American Heart Journal - November 7, 2019 Category: Cardiology Source Type: research

Gastrointestinal bleeding in patients with atrial fibrillation treated with Apixaban or warfarin: Insights from the ARISTOTLE trial
Publication date: Available online 31 October 2019Source: American Heart JournalAuthor(s): David A. Garcia, Deborah A. Fisher, Hillary Mulder, Lisa Wruck, Raffele De Caterina, Sigrun Halvorsen, Christopher B. Granger, Claes Held, Lars Wallentin, John H. Alexander, Renato D. LopesAbstractObjectivesA history of gastrointestinal bleeding (GIB) in patients with atrial fibrillation (AF) may impact decisions about anticoagulation treatment. To sought to determine whether prior GIB in patients with AF taking anticoagulants was associated with an increased risk of stroke or major hemorrhage.MethodsWe analyzed key efficacy and safe...
Source: American Heart Journal - November 2, 2019 Category: Cardiology Source Type: research

Getting to an improved understanding of low-density lipoprotein-cholesterol and dyslipidemia management (GOULD): Methods and baseline data of a registry of high cardiovascular risk patients in the United States
Publication date: Available online 31 October 2019Source: American Heart JournalAuthor(s): Christopher P. Cannon, James A. de Lemos, Robert S. Rosenson, Christie M. Ballantyne, Yuyin Liu, Daniel Yazdi, Mary Elliott-Davey, Katherine E. Mues, Deepak L. Bhatt, Mikhail N. Kosiborod, GOULD InvestigatorsAbstractBackgroundGuidelines for managing patients with atherosclerotic cardiovascular disease (ASCVD) recommend statin therapy initially. Target levels/goals for low-density lipoprotein-cholesterol (LDL-C) were initially included, subsequently de-emphasized in 2013, and then re-introduced as thresholds, leading to confusion in c...
Source: American Heart Journal - October 31, 2019 Category: Cardiology Source Type: research

Impact Of Initial Heart Failure Emergence On Clinical Outcomes Of Atrial Fibrillation Patients In the AFFIRM Trial
Publication date: Available online 28 October 2019Source: American Heart JournalAuthor(s): April Slee, Sanjeev SaksenaAbstractBackgroundHeart failure (HF) emergence in atrial fibrillation (AF) patients undergoing different treatment strategies has not been studied.MethodsAFFIRM trial subjects with no history of HF, without clinical HF & normal left ventricular ejection fraction at enrollment were identified. The principal outcome was time to development of a composite of NYHA class ≥II HF &/or cardiovascular (CV) death. It was compared for Rate and Rhythm strategies and correlated with ECG parameters on follow u...
Source: American Heart Journal - October 29, 2019 Category: Cardiology Source Type: research

Admission SCAI shock stage stratifies post-discharge mortality risk in cardiac intensive care unit patients
Publication date: Available online 27 October 2019Source: American Heart JournalAuthor(s): Jacob C. Jentzer, David A. Baran, Sean van Diepen, Gregory W. Barsness, Timothy D. Henry, Srihari S. Naidu, Malcolm R. Bell, David R. HolmesAbstractBackgroundThe five-stage Society for Cardiovascular Angiography and Intervention (SCAI) cardiogenic shock classification scheme can stratify hospital mortality risk in patients admitted to the cardiac intensive care unit (CICU). We sought to evaluate the SCAI shock classification for prediction of post-discharge mortality in CICU survivors.MethodsWe retrospectively analyzed hospital survi...
Source: American Heart Journal - October 28, 2019 Category: Cardiology Source Type: research

PREvention of Recurrent Arrhythmias with Mediterranean Diet (PREDIMAR) study in patients with atrial fibrillation: rationale, design and methods
ConclusionsIf our hypothesis is confirmed, the utility of the MedDiet enriched with EVOO in slowing the progression of AF will be proven, preventing recurrences and potentially reducing complications.ClinicalTrials.gov IdentifierNCT03053843 (Source: American Heart Journal)
Source: American Heart Journal - October 27, 2019 Category: Cardiology Source Type: research

ISCHEMIA trial update
Publication date: December 2019Source: American Heart Journal, Volume 218Author(s): John Spertus, Daniel Mark (Source: American Heart Journal)
Source: American Heart Journal - October 27, 2019 Category: Cardiology Source Type: research

ECG AI-guided screening for low ejection fraction (EAGLE): Rationale and design of a pragmatic cluster randomized trial
Publication date: Available online 25 October 2019Source: American Heart JournalAuthor(s): Xiaoxi Yao, Rozalina G. McCoy, Paul A. Friedman, Nilay D. Shah, Barbara A. Barry, Emma M. Behnken, Jonathan W. Inselman, Zachi I. Attia, Peter A. NoseworthyAbstractBackgroundA deep learning algorithm to detect low ejection fraction (EF) using routine 12-lead electrocardiogram (ECG) has recently been developed and validated. The algorithm was incorporated into the electronic health record (EHR) to automatically screen for low EF, encouraging clinicians to obtain a confirmatory transthoracic echocardiogram (TTE) for previously undiagno...
Source: American Heart Journal - October 27, 2019 Category: Cardiology Source Type: research

Age, knowledge, preferences, and risk tolerance for invasive cardiac care
Publication date: Available online 23 October 2019Source: American Heart JournalAuthor(s): Michael G. Nanna, Eric D. Peterson, Angie Wu, Tina Harding, Anthony N. Galanos, Lisa Wruck, Karen P. AlexanderAbstractBackground/objectivesThe extent to which individual knowledge, preferences, and priorities explain lower use of invasive cardiac care among older vs. younger adults presenting with acute coronary syndrome (ACS) is unknown. We directly surveyed a group of patients to ascertain their preferences and priorities for invasive cardiovascular care.DesignWe performed a prospective cohort study of adults hospitalized with ACS....
Source: American Heart Journal - October 24, 2019 Category: Cardiology Source Type: research

Care Optimization Through Patient and Hospital Engagement Clinical Trial for Heart Failure: Rationale and Design of CONNECT-HF
Publication date: Available online 23 October 2019Source: American Heart JournalAuthor(s): Adam D. DeVore, Bradi B. Granger, Gregg C. Fonarow, Hussein R. Al-Khalidi, Nancy M. Albert, Eldrin F. Lewis, Javed Butler, Ileana L. Piña, Paul A. Heidenreich, Larry A. Allen, Cyde W. Yancy, Lauren B. Cooper, G. Michael Felker, Lisa A. Kaltenbach, A. Thomas McRae, David E. Lanfear, Robert W. Harrison, Robb D. Kociol, Maghee Disch, Dan ArielyAbstractMany therapies have been shown to improve outcomes for patients with heart failure (HF) in controlled settings, but there are limited data available to inform best practices for hos...
Source: American Heart Journal - October 24, 2019 Category: Cardiology Source Type: research