One database, two studies and a trebling of Atherectomy rates
Publication date: Available online 19 March 2019Source: American Heart JournalAuthor(s): Paul Bamford, GT Lau, Becky Hines (Source: American Heart Journal)
Source: American Heart Journal - March 19, 2019 Category: Cardiology Source Type: research

Comparison of the polymer-free biolimus-coated BioFreedom stent with the thin strut biodegradable polymer sirolimus-eluting Orsiro stent in an all-comers population treated with percutaneous coronary intervention: Rationale and design of the randomized SORT OUT IX trial
ConclusionThe SORT OUT IX trial will determine whether the drug-coated BioFreedom stent is non-inferior to a modern biodegradable polymer Orsiro stent. (Source: American Heart Journal)
Source: American Heart Journal - March 15, 2019 Category: Cardiology Source Type: research

Rationale and design of the randomized, controlled early valve replacement guided by biomarkers of left ventricular decompensation in asymptomatic patients with severe aortic stenosis (EVOLVED) trial
ConclusionThe EVOLVED trial is the first multicenter randomized controlled trial to compare early aortic valve replacement to routine care in asymptomatic patients with severe aortic stenosis and mid-wall LGE. (Source: American Heart Journal)
Source: American Heart Journal - March 15, 2019 Category: Cardiology Source Type: research

Apixaban versus warfarin in evaluation of progression of atherosclerotic and calcified plaques (prospective randomized trial)
Publication date: Available online 13 March 2019Source: American Heart JournalAuthor(s): Theingi Tiffany Win, Rine Nakanishi, Kazuhiro Osawa, Dong Li, Shriraj S. Susaria, Eranthi Jayawardena, Sajad Hamal, Michael Kim, Alexander Broersen, Pieter H. Kitslaar, Christopher Dailing, Matthew J. BudoffAbstractWarfarin has been showed to increase vascular calcification. Apixaban, a direct factor Xa inhibitor, has no interaction with vitamin K and its effect on coronary plaques is unknown. We randomized and compared warfarin and apixaban on progression of coronary atherosclerotic plaques measured by coronary computed tomographic an...
Source: American Heart Journal - March 13, 2019 Category: Cardiology Source Type: research

Pre-hospital statin use and low-density lipoprotein cholesterol levels at admission in acute coronary syndrome patients with history of myocardial infarction or revascularization: Findings from the improving Care for Cardiovascular Disease in China (CCC) project
This study aimed to assess use of pre-hospital statins and LDL-C levels at admission in ACS patients with history of MI or revascularization.MethodsImproving Care for Cardiovascular Disease in China project was a nationwide registry, with 192 participating hospitals reporting details of clinical information of ACS patients from November 2014. By May 2018, 80,282 patients with ACS were included. LDL-C levels were obtained from the initial admission lipid testing.ResultsOf the 80,282 ACS patients, 6523 with a history of MI or revascularization were enrolled. Among them, 50.8% were receiving lipid-lowering therapy before hosp...
Source: American Heart Journal - March 13, 2019 Category: Cardiology Source Type: research

Randomized controlled trial of influenza vaccine in patients with heart failure to reduce adverse vascular events (IVVE): Rationale and design
ConclusionThis is the largest randomized trial to test if influenza vaccine compared to control reduces adverse vascular events in high risk individuals.Trial registration number:Clinicaltrials.govNCT02762851 (Source: American Heart Journal)
Source: American Heart Journal - March 12, 2019 Category: Cardiology Source Type: research

Neck circumference and cardiovascular outcomes: Insights from the Jackson heart study
ConclusionsIn this large cohort of African American individuals, a larger NC was associated with increased risk for HF hospitalization following adjustment for age and sex, but this risk was not statistically significant after adjusting for other clinical variables. Although NC is not independently associated with increased risk for cardiovascular events, it may offer prognostic information particularly related to HF hospitalization. (Source: American Heart Journal)
Source: American Heart Journal - March 9, 2019 Category: Cardiology Source Type: research

Randomized evaluation of ticagrelor monotherapy after 3-month dual-antiplatelet therapy in patients with acute coronary syndrome treated with new-generation sirolimus-eluting stents: TICO trial rationale and design
ConclusionsThe TICO trial is an ongoing trial evaluating the efficacy and safety of ticagrelor monotherapy following 3-month DAPT exclusively in ACS patients treated with uniform BP-SES. It may provide novel insights regarding the need for adjusted use of DAPT for rebalancing risk–benefit in current practice and changing from the conventional concept of aspirin maintenance to a ticagrelor-based regimen in the management of ACS. (Source: American Heart Journal)
Source: American Heart Journal - March 9, 2019 Category: Cardiology Source Type: research

Validating the Use of Registries and Claims Data to Support Randomized Trials: Rationale and Design of the Extending Trial-Based Evaluations of Medical Therapies Using Novel Sources of Data (EXTEND) Study
ConclusionsLinkage of trials to registries and claims data represents an opportunity to utilize alternative data sources in place of and as adjuncts to randomized clinical trial data, but requires further validation. The results of this research will help determine how these data sources can be used to improve our present and future understanding of new medical treatments. (Source: American Heart Journal)
Source: American Heart Journal - March 7, 2019 Category: Cardiology Source Type: research

Association of Access to exercise opportunities and cardiovascular mortality
Publication date: Available online 7 March 2019Source: American Heart JournalAuthor(s): Suveen Angraal, Aakriti Gupta, Rohan Khera, Khurram Nasir, Nihar R. DesaiAbstractWe sought to examine the patterns of cardiovascular diseases (CVD) mortality in varying degrees of access to exercise opportunities at county level in the U.S. Access to exercise opportunities was significantly associated with adjusted CVD mortality (P 
Source: American Heart Journal - March 7, 2019 Category: Cardiology Source Type: research

Performance on management strategies with class I recommendation and a level of evidence among hospitalized patients with non-ST-segment elevation acute coronary syndrome in China: Findings from the improving Care for Cardiovascular Disease in China-acute coronary syndrome project
ConclusionsAbout one in six NSTE-ACS patients received defect-free care, and the performance varied across hospitals. (Source: American Heart Journal)
Source: American Heart Journal - March 5, 2019 Category: Cardiology Source Type: research

Rationale and Design of the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE)
Publication date: Available online 4 March 2019Source: American Heart JournalAuthor(s): Steven K. Grinspoon, Kathleen V. Fitch, Edgar Turner Overton, Carl J. Fichtenbaum, Markella V. Zanni, Judith A. Aberg, Carlos Malvestutto, Michael T. Lu, Judith S. Currier, Craig A. Sponseller, Myron Waclawiw, Beverly Alston-Smith, Katharine Cooper-Arnold, Karin L. Klingman, Patrice Desvigne-Nickens, Udo Hoffmann, Heather J. Ribaudo, Pamela S. Douglas, on behalf of the REPRIEVE InvestigatorsBackgroundCardiovascular disease (CVD) is more frequent among people with HIV (PWH) and may relate to traditional and nontraditional factors, includ...
Source: American Heart Journal - March 5, 2019 Category: Cardiology Source Type: research

Myocardial constructive work and cardiac mortality in resynchronization therapy candidates
ConclusionsThe estimation of left ventricular CW by PSLs is a relatively novel tool that allows for the prediction of cardiac outcome in CRT candidates. (Source: American Heart Journal)
Source: American Heart Journal - March 5, 2019 Category: Cardiology Source Type: research

Rationale and Design of the Mechanistic Substudy of REPRIEVE: Effects of Pitavastatin on Coronary Artery Disease and Inflammatory Biomarkers
ConclusionThis study represents the first large, randomized, CCTA-based assessment of the effects of a primary prevention strategy for CVD on high-risk CAD, immune activation and inflammation among PWH. The study will assess pitavastatin’s effects on coronary plaque, and the interrelationship of these changes with biomarkers of immune activation and inflammation in PWH to determine mechanisms of CVD prevention and improved outcomes in this population. (Source: American Heart Journal)
Source: American Heart Journal - March 5, 2019 Category: Cardiology Source Type: research

Trends and predictors of recurrent acute coronary syndrome hospitalizations and unplanned revascularization after index acute myocardial infarction treated with percutaneous coronary intervention
Publication date: Available online 5 March 2019Source: American Heart JournalAuthor(s): Matias B. Yudi, David J. Clark, Omar Farouque, Nick Andrianopoulos, Andrew E. Ajani, Angela Brennan, Jeffrey Lefkovits, Melanie Freeman, Chin Hiew, Laura A. Selkrig, Jessica O’Brien, Anthony M. Dart, Christopher M. Reid, Stephen J. Duffy, Melbourne Interventional GroupSTRUCTURED ABSTRACTBackgroundRepeat hospitalizations for recurrent acute coronary syndrome (ACS) or unplanned revascularization after acute myocardial infarction (MI) are common, costly and potentially preventable. We aim to describe 10-year trends and identify indep...
Source: American Heart Journal - March 5, 2019 Category: Cardiology Source Type: research

Relationship of stroke and bleeding risk profiles to efficacy and safety of dabigatran dual therapy versus warfarin triple therapy in atrial fibrillation after PCI: An ancillary analysis from the RE-DUAL PCI trial
ConclusionDabigatran dual therapy reduced bleeding events irrespective of bleeding risk category and demonstrated similar efficacy regardless of stroke risk category when compared with warfarin triple therapy. (Source: American Heart Journal)
Source: American Heart Journal - March 4, 2019 Category: Cardiology Source Type: research

Rationale and design for AMPLATZER Amulet Left Atrial Appendage Occluder IDE randomized controlled trial (Amulet IDE Trial)
Publication date: May 2019Source: American Heart Journal, Volume 211Author(s): Dhanunjaya Lakkireddy, Stephan Windecker, David Thaler, Lars Søndergaard, John Carroll, Michael R Gold, Hongfei Guo, Kyle J Brunner, James B Hermiller, Hans-Christoph Diener, Boris Schmidt, Lee MacDonald, Moussa Mansour, Brijeshwar Maini, Joseph LevineAimsThe Amulet IDE Trial is an ongoing, prospective, randomized, multi-national trial, designed to evaluate the safety and effectiveness of the AMPLATZER Amulet Left Atrial Appendage Occluder for stroke prevention in comparison to the WATCHMAN Left Atrial Appendage Closure Device in patients...
Source: American Heart Journal - March 4, 2019 Category: Cardiology Source Type: research

In response to letter to the editor: “Ultrasound guided radial artery catheterization: A superior technique for expert clinicians?
Publication date: Available online 23 February 2019Source: American Heart JournalAuthor(s): Homam Moussa Pacha, M. Chadi Alraies (Source: American Heart Journal)
Source: American Heart Journal - February 23, 2019 Category: Cardiology Source Type: research

Ultrasound guided radial artery catheterization: A superior technique for expert clinicians?
Publication date: Available online 23 February 2019Source: American Heart JournalAuthor(s): Leigh White, Ruan Vlok, Thomas Melhuish (Source: American Heart Journal)
Source: American Heart Journal - February 23, 2019 Category: Cardiology Source Type: research

Mineralocorticoid receptor antagonist pre-treatment and early post-treatment to minimize reperfusion injury after ST-elevation myocardial infarction: The MINIMIZE STEMI trial
ConclusionThis pilot study showed no benefit of MRA therapy to reduce acute MI size in STEMI patients when initiated prior to reperfusion, but there was an improvement in LV remodeling at 3 months. Adequately powered studies are warranted to confirm our findings. (Source: American Heart Journal)
Source: American Heart Journal - February 21, 2019 Category: Cardiology Source Type: research

Comparative effectiveness, safety, and costs of rivaroxaban and warfarin among morbidly obese patients with atrial fibrillation
Publication date: Available online 20 February 2019Source: American Heart JournalAuthor(s): Eric D. Peterson, Veronica Ashton, Yen-Wen Chen, Bingcao Wu, Alex C. SpyropoulosBackgroundThere are limited data regarding clinical outcomes and healthcare resource utilization of direct oral anticoagulants (DOACs) in patients with atrial fibrillation (AF) who are morbidly obese (body mass index>40 kg/m2 or body weight> 120 kg).MethodsUsing data from 2 US healthcare claims databases, we identified patients initiating rivaroxaban or warfarin who had ≥1 medical claim with an AF diagnosis, a diagnostic code for ...
Source: American Heart Journal - February 21, 2019 Category: Cardiology Source Type: research

Adverse events in patients with high platelet reactivity following successful chronic Total occlusion PCI: The ADAPT-DES study
ConclusionsIn ADAPT-DES, HPR was associated with an increased 2-year risk of TVF after PCI, an association that was at least as strong after CTO PCI compared with non-CTO PCI. (Source: American Heart Journal)
Source: American Heart Journal - February 20, 2019 Category: Cardiology Source Type: research

Peripheral blood metabolite profiles associated with new onset atrial fibrillation
ConclusionMetabolite profiles were associated with new onset AF among patients referred for coronary angiography. Validation of these observations in broader patient populations may provide better mechanistic insight into the development of AF, and may provide new opportunities for prevention and treatment. (Source: American Heart Journal)
Source: American Heart Journal - February 14, 2019 Category: Cardiology Source Type: research

Performance of atherosclerotic cardiovascular risk prediction models in a rural northern Chinese population: Results from the Fangshan cohort study
Publication date: Available online 5 February 2019Source: American Heart JournalAuthor(s): Xun Tang, Dudan Zhang, Liu He, Na Wu, Yaqin Si, Yang Cao, Shaoping Huang, Na Li, Jingrong Li, Huidong Dou, Pei Gao, Yonghua HuAbstractBackgroundPerformance of Pooled Cohort Equations (PCE) for atherosclerotic cardiovascular disease (ASCVD) risks varied across populations. Whether recent developed Prediction for ASCVD Risk in China (China-PAR) model could accurately predict cardiovascular risks in real practice remains unclear.MethodsA population-based cohort study in rural Beijing in the “stroke-belt” in North China was u...
Source: American Heart Journal - February 5, 2019 Category: Cardiology Source Type: research

Outcomes after STEMI in old multimorbid patients with complex health needs and the effect of invasive management
ConclusionsMultimorbid older people with complex health needs and STEMI had high rates of new ischemic events and death. In this cohort of older, high risk STEMI patients, an invasive strategy was associated with lower event rates. Randomized studies are needed to clarify whether these high risk patients who might benefit from invasive care are being managed too conservatively. (Source: American Heart Journal)
Source: American Heart Journal - February 1, 2019 Category: Cardiology Source Type: research

Rationale and design of the SI! Program for health promotion in elementary students aged 6 to 11 years: A cluster randomized trial
Publication date: April 2019Source: American Heart Journal, Volume 210Author(s): Gloria Santos-Beneit, Patricia Bodega, Mercedes de Miguel, Carla Rodríguez, Vanesa Carral, Xavier Orrit, Domènech Haro, Isabel Carvajal, Amaya de Cos-Gandoy, José Luis Peñalvo, Emilia Gómez-Pardo, Belén Oliva, Borja Ibañez, Juan Miguel Fernández-Alvira, Rodrigo Fernández-Jiménez, Valentin FusterUnhealthy habits in children are increasing at an alarming rate. The school provides a promising setting for effective preventive strategies to improve children's lifestyle behaviors....
Source: American Heart Journal - February 1, 2019 Category: Cardiology Source Type: research

Utilizing mobile technologies to improve physical activity and medication adherence in patients with heart failure and diabetes mellitus: Rationale and design of the TARGET-HF-DM trial
Publication date: Available online 31 January 2019Source: American Heart JournalAuthor(s): Abhinav Sharma, Robert J. Mentz, Bradi B. Granger, John F. Heitner, Lauren B. Cooper, Dipanjan Banerjee, Cynthia L. Green, Maulik D. Majumdar, Zubin Eapen, Lori Hudson, G. Michael FelkerAbstractHeart failure (HF) and diabetes mellitus (DM) are major public health issues that place significant burden on patients and healthcare systems. Patients with both HF and DM are at higher risk of adverse cardiovascular and HF outcomes than those with either disease in isolation. Different anti-hyperglycemic medications (even within the same medi...
Source: American Heart Journal - January 31, 2019 Category: Cardiology Source Type: research

Association of Frailty and Cognitive Impairment with benefits of Oral anticoagulation in patients with atrial fibrillation
We examined the prevalence of clinically recognized cognitive impairment and frailty (as defined by the American Geriatric Society Criteria) in the Outcomes Registry for Better Informed Care in AF (ORBIT AF) and associated adjusted outcomes via multivariable Cox regression. The interaction between cognitive impairment and frailty and oral anticoagulation (OAC) in determining outcomes was examined.ResultsAmong 9749 patients with AF [median (IQR) age 75 (67–82) y, 57% male], cognitive impairment and frailty was identified in 293 (3.0%) and 575 (5.9%) patients respectively. Frail patients (68 vs 77%, P 
Source: American Heart Journal - January 30, 2019 Category: Cardiology Source Type: research

Long-term outcomes for heart failure patients with and without diabetes: From the get with the guidelines-heart failure registry
Publication date: Available online 27 January 2019Source: American Heart JournalAuthor(s): Boback Ziaeian, Adrian F. Hernandez, Adam D. DeVore, Jingjing Wu, Haolin Xu, Paul A. Heidenreich, Roland A. Matsouaka, Deepak L. Bhatt, Clyde W. Yancy, Gregg C. Fonarow (Source: American Heart Journal)
Source: American Heart Journal - January 28, 2019 Category: Cardiology Source Type: research

Design and rationale of a randomized noninferiority trial to evaluate the SurVeil drug-coated balloon in subjects with stenotic lesions of the femoropopliteal artery — the TRANSCEND study
ConclusionThe Randomized And Controlled Noninferiority Trial to Evaluate Safety and Clinical Efficacy of the SurVeil DCB in the Treatment of Subjects with Stenotic Lesions of the Femoropopliteal Artery Compared to the Medtronic IN.PACT Admiral (TRANSCEND) study will assess safety and efficacy of the SurVeil DCB relative to a commonly used DCB. (Source: American Heart Journal)
Source: American Heart Journal - January 25, 2019 Category: Cardiology Source Type: research

Differences in statin utilization and lipid lowering by race, ethnicity, and HIV status in a real-world cohort of persons with human immunodeficiency virus and uninfected persons
Publication date: March 2019Source: American Heart Journal, Volume 209Author(s): Robert A. Riestenberg, Andrew Furman, Avery Cowen, Anna Pawlowksi, Daniel Schneider, Alana A. Lewis, Sean Kelly, Babafemi Taiwo, Chad Achenbach, Frank Palella, Neil J. Stone, Donald M. Lloyd-Jones, Matthew J. FeinsteinBackgroundRisks for cardiovascular diseases, including myocardial infarction and stroke, are elevated in people with HIV infection (PWH). However, no trials of statin utilization with clinical cardiovascular disease (CVD) end points have been completed in PWH, and there are sparse real-world data regarding statin use and lipid-lo...
Source: American Heart Journal - January 25, 2019 Category: Cardiology Source Type: research

Association between the timing of surgery for complicated, left-sided infective endocarditis and survival
Publication date: Available online 17 January 2019Source: American Heart JournalAuthor(s): Andrew Wang, Vivian H. Chu, Eugene Athan, Francois Delahaye, Tomas Freiberger, Cristiane Lamas, Jose M. Miro, Jacob Strahilevitz, Christophe Tribouilloy, Emanuele Durante-Mangoni, Juan M. Pericas, Nuria Fernández-Hidalgo, Francisco Nacinovich, Bruno Barsic, Efthymia Giannitsioti, John P. Hurley, Margaret M. Hannan, Lawrence P. Park, ICE-PLUS InvestigatorsAbstractBackgroundIn patients with active infective endocarditis (IE), the relationship between timing of surgery and survival is uncertain.ObjectivesTo evaluate clinical char...
Source: American Heart Journal - January 18, 2019 Category: Cardiology Source Type: research

Trends in cardiorespiratory fitness: The evolution of exercise treadmill testing at a single Academic Medical Center from 1970 to 2012
Publication date: Available online 16 January 2019Source: American Heart JournalAuthor(s): Jacob P. Kelly, Brian J. Andonian, Mahesh J. Patel, Zhen Huang, Linda K. Shaw, Robert W. McGarrah, Salvador Borges-Neto, Eric J. Velazquez, William E. KrausAbstractObjectiveTo identify temporal trends in the use of exercise treadmill testing (ETT) and cardiorespiratory fitness (CRF) estimated by ETT in metabolic equivalents (METs). (Source: American Heart Journal)
Source: American Heart Journal - January 16, 2019 Category: Cardiology Source Type: research

Radial versus femoral vascular access in ST-elevation myocardial infarction: Are the results of femoral operators unfairly represented in observational research?
Publication date: Available online 16 January 2019Source: American Heart JournalAuthor(s): Sarah R Blake, Adeel Shahzad, Suneil K Aggarwal, Abhishek Kumar, Adnan Khan, Rod H StablesAbstractBackgroundRecent randomized controlled trials comparing femoral and radial access in primary percutaneous coronary intervention (PPCI) have shown conflicting results regarding the incidence of major adverse cardiovascular events (MACE) and major bleeding.MethodsUsing data from the HEAT-PPCI trial, we compared the primary efficacy (all-cause mortality, stroke, new myocardial infarction or unplanned repeat revascularisation) and safety (ma...
Source: American Heart Journal - January 16, 2019 Category: Cardiology Source Type: research

Knowledge of myocardial infarction symptoms and perceptions of self-risk in Tanzania
Publication date: Available online 15 January 2019Source: American Heart JournalAuthor(s): Julian T Hertz, Deng B Madut, Revogatus A Tesha, Gwamaka William, Ryan A Simmons, Sophie W Galson, Francis M Sakita, Venance P Maro, Gerald S Bloomfield, John A Crump, Matthew P RubachAbstractBackgroundLittle is known about community knowledge of myocardial infarction symptoms and perceptions of self-risk in sub-Saharan Africa.MethodsA community survey was conducted in northern Tanzania, where the prevalence of cardiovascular risk factors is high. Households were selected randomly in a population-weighted fashion and surveys were adm...
Source: American Heart Journal - January 15, 2019 Category: Cardiology Source Type: research

A randomized, double-blind, placebo-controlled trial to assess the efficAcy and safety of Trimetazidine in patients with angina pectoris having been treated by percutaneous coronary intervention (ATPCI study): Rationale, design, and baseline characteristics
ConclusionThe ATPCI study will shed further light on the management of contemporary angina patients after PCI. Results are expected in 2019. (Source: American Heart Journal)
Source: American Heart Journal - January 15, 2019 Category: Cardiology Source Type: research

Heart failure and adverse heart failure outcomes among persons living with HIV in a US tertiary medical center
Publication date: Available online 11 January 2019Source: American Heart JournalAuthor(s): Raza M. Alvi, Maryam Afshar, Anne M. Neilan, Noor Tariq, Malek Hassan, Jaime Gerber, Magid Awadalla, Connor P. Mulligan, Adam Rokicki, Virginia A. Triant, Markella V. Zanni, Tomas G. NeilanAbstractBackgroundPersons living with HIV (PLHIV) have an increased risk of heart failure (HF). However, little is known about outcomes among PLHIV with HF. The study aim was to compare HF outcomes among PLHIV with HF vs. individuals without HIV with HF.MethodsOur cohort included 2308 individuals admitted with decompensated HF. We compared baseline...
Source: American Heart Journal - January 12, 2019 Category: Cardiology Source Type: research

C-reactive protein and prognosis after percutaneous coronary intervention and bypass graft surgery for left Main coronary artery disease: Analysis from the EXCEL trial
Publication date: Available online 11 January 2019Source: American Heart JournalAuthor(s): Ioanna Kosmidou, Björn Redfors, Shmuel Chen, Aaron Crowley, Nicholas J. Lembo, Dimitri Karmpaliotis, W. Morris Brown, Eric Maupas, Nicolas Durrleman, Alpesh Shah, Michael J. Reardon, Ovidiu Dressler, Ori Ben-Yehuda, Arie Pieter Kappetein, Joseph F. Sabik, Patrick W. Serruys, Gregg W. StoneAbstractBackgroundThe prognostic impact of high-sensitivity C-reactive protein (CRP) levels in patients with left main coronary artery disease (LMCAD) treated with percutaneous coronary intervention (PCI) and coronary artery bypass grafting (CA...
Source: American Heart Journal - January 12, 2019 Category: Cardiology Source Type: research

Radial versus femoral approach for saphenous vein grafts angiography and interventions
This study aimed to investigate the feasibility and safety of the radial approach compared to femoral access in a large cohort of patients undergoing SVG angiography and intervention.Methods and resultsData from 1481 patients from Canada, United States and Spain who underwent procedures between 2010 and 2016 were collected. Patients must have undergone SVG coronary angiography and/or intervention. Demographics, procedural data and in-hospital complications were recorded. Procedures were undertaken by either the radial (n = 863, 211 intervention) or femoral (n = 618, 260 intervention) approach. The mean ...
Source: American Heart Journal - January 12, 2019 Category: Cardiology Source Type: research

Blood kidney injury molecule–1 predicts short and longer term kidney outcomes in patients undergoing diagnostic coronary and/or peripheral angiography—Results from the Catheter Sampled Blood Archive in Cardiovascular Diseases (CASABLANCA) study
Publication date: March 2019Source: American Heart Journal, Volume 209Author(s): Nasrien E. Ibrahim, Cian P. McCarthy, Shreya Shrestha, Asya Lyass, Yiwei Li, Hanna K. Gaggin, Mandy L. Simon, Joseph M. Massaro, Ralph B. D'Agostino, Joseph M. Garasic, Roland RJ van Kimmenade, James L. JanuzziBackgroundKidney injury is common in patients with cardiovascular disease.ObjectivesWe determined whether blood measurement of kidney injury molecule-1 (KIM-1), would predict kidney outcomes in patients undergoing angiographic procedures for various indications.MethodsOne thousand two hundred eight patients undergoing coronary and/or per...
Source: American Heart Journal - January 12, 2019 Category: Cardiology Source Type: research

Comparative effectiveness and safety of statins as a class and of specific statins for primary prevention of cardiovascular disease: A systematic review, meta-analysis and network meta-analysis of randomized trials with 94,283 participants
ConclusionsAll statins showed statistically significant risk reduction of CVD and all-cause mortality in primary prevention populations while increasing the risk for some harm risks. However, the benefit-harm profile differed by statin type. A quantitative assessment of the benefit-harm balance is thus needed since meta-analyses alone are insufficient to inform whether statins provide net benefit. (Source: American Heart Journal)
Source: American Heart Journal - January 11, 2019 Category: Cardiology Source Type: research

Rationale and design of the SI! Program for health promotion in elementary students aged 6 to 11 years: A cluster randomized trial
Publication date: Available online 8 January 2019Source: American Heart JournalAuthor(s): Gloria Santos-Beneit, Patricia Bodega, Mercedes de Miguel, Carla Rodríguez, Vanesa Carral, Xavier Orrit, Domènech Haro, Isabel Carvajal, Amaya de Cos-Gandoy, José Luis Peñalvo, Emilia Gómez-Pardo, Belén Oliva, Borja Ibañez, Juan Miguel Fernández-Alvira, Rodrigo Fernández-Jiménez, Valentin FusterAbstractUnhealthy habits in children are increasing at an alarming rate. The school provides a promising setting for effective preventive strategies to improve children's lif...
Source: American Heart Journal - January 8, 2019 Category: Cardiology Source Type: research

Design and rationale of a randomized noninferiority trial to evaluate the SurVeil™ drug-coated balloon in subjects with stenotic lesions of the Femoropopliteal artery - the TRANSCEND study
ConclusionThe Randomized And Controlled Noninferiority Trial to Evaluate Safety and Clinical Efficacy of the SurVeil DCB in the Treatment of Subjects with Stenotic Lesions of the Femoropopliteal Artery Compared to the Medtronic IN.PACT Admiral (TRANSCEND) study will assess safety and efficacy of the SurVeil DCB relative to a commonly used DCB. (Source: American Heart Journal)
Source: American Heart Journal - December 29, 2018 Category: Cardiology Source Type: research

A prospective 5-year study of exercise performance following melody valve implant
Publication date: Available online 29 December 2018Source: American Heart JournalAuthor(s): Bryant Priromprintr, Michael J Silka, Jonathan Rhodes, Anjan S BatraAbstractIntroductionThe long-term benefits of Melody valve implant for right ventricular outflow tract conduit obstruction or insufficiency on exercise capacity are undefined.MethodsAs part of the Melody valve clinical trial, 136 patients with congenital heart disease underwent serial cardiopulmonary exercise testing prior to, 6 months after, and annually for up to 5 years post-implant.ResultsMean age at Melody valve implantation was 22.4 ±&nbs...
Source: American Heart Journal - December 29, 2018 Category: Cardiology Source Type: research

Rationale and design for AMPLATZER™ amulet™ left atrial appendage Occluder IDE randomized controlled trial (amulet IDE trial)
Publication date: Available online 21 December 2018Source: American Heart JournalAuthor(s): Dhanunjaya Lakkireddy, Stephan Windecker, David Thaler, Lars Sondergaard, John Carroll, Michael R Gold, Hongfei Guo, Kyle J Brunner, James B Hermiller, Hans-Christoph Diener, Boris Schmidt, Lee MacDonald, Moussa Mansour, Brijeshwar Maini, Joseph LevineAbstractAimsThe Amulet IDE Trial is an ongoing, prospective, randomized, multi-national trial, designed to evaluate the safety and effectiveness of the AMPLATZER™ Amulet™ Left Atrial Appendage Occluder for stroke prevention in comparison to the WATCHMAN Left Atrial Appendag...
Source: American Heart Journal - December 21, 2018 Category: Cardiology Source Type: research

The CSL112-2001 trial: Safety and tolerability of multiple doses of CSL112 (apolipoprotein A-I [human]), an intravenous formulation of plasma-derived apolipoprotein A-I, among subjects with moderate renal impairment after acute myocardial infarction
ConclusionsThese results demonstrate the acceptable safety of the 6-g dose of CSL112 among AMI subjects with moderate stage 3 CKD and support inclusion of these patients in a phase 3 cardiovascular outcomes trial powered to assess efficacy. (Source: American Heart Journal)
Source: American Heart Journal - December 21, 2018 Category: Cardiology Source Type: research

Differences in Statin Utilization and Lipid-Lowering by Race, Ethnicity, and HIV Status in a Real-World Cohort of Persons with Human Immunodeficiency Virus and Uninfected Persons
Publication date: Available online 20 December 2018Source: American Heart JournalAuthor(s): Robert A. Riestenberg, Andrew Furman, Avery Cowen, Anna Pawlowksi, Daniel Schneider, Alana A. Lewis, Sean Kelly, Babafemi Taiwo, Chad Achenbach, Frank Palella, Neil J. Stone, Donald M. Lloyd-Jones, Matthew J. FeinsteinAbstractBackgroundRisks for cardiovascular diseases, including myocardial infarction and stroke, are elevated in people with HIV infection (PWH). However, no trials of statin utilization with clinical cardiovascular disease (CVD) endpoints have been completed in PWH, and there are sparse real-world data regarding stati...
Source: American Heart Journal - December 21, 2018 Category: Cardiology Source Type: research

The association of pre- and posthospital medication adherence in myocardial infarction patients
ConclusionsPrior medication adherence predicts post-MI adherence to P2Y12 inhibitors. Increasing accessibility of medication adherence data in the medical record may be an important tool to identify patients at higher risk for post-MI medication nonadherence and target efforts to improve adherence. (Source: American Heart Journal)
Source: American Heart Journal - December 21, 2018 Category: Cardiology Source Type: research

Generalizability of the FOURIER Trial to Routine Clinical Care: Do Trial Participants Represent Patients in Everyday Practice?
Publication date: Available online 16 December 2018Source: American Heart JournalAuthor(s): Xiaoxi Yao, Bernard J Gersh, Francisco Lopez-Jimenez, Nilay D Shah, Peter A NoseworthyAbstractBackgroundIn the FOURIER trial, evolocumab, a proprotein convertase subtilisin–kexin type 9 inhibitor (PCSK9i), reduced cardiovascular events in patients with atherosclerotic cardiovascular disease (ASCVD). We aimed to examine how closely patients in routine practice resemble the FOURIER trial participants, and to assess the observed cardiovascular risks based on trial eligibility and under-representativeness.MethodsUsing a large U.S....
Source: American Heart Journal - December 19, 2018 Category: Cardiology Source Type: research

Development of a cardiac inherited disease service and clinical registry: A 15-year perspective
We describe the establishment of this registry and discuss the key features, including dedicated coordinators, links to a multidisciplinary and collaborative clinical service, a translational research program, a secure web-based database, and governance encompassing ethical and cultural approval. (Source: American Heart Journal)
Source: American Heart Journal - December 19, 2018 Category: Cardiology Source Type: research