Resistant hypertension: an overview.
Authors: Pedrinelli R, Dell' Omo G, Ambrosio G, Cameli M, Cerbai E, Coiro S, Emdin M, Liga R, Marcucci R, Morrone D, Palazzuoli A, Padeletti L, Savino K, Società Italiana di Cardiologia, Sezione Regionale Tosco-Umbra
Abstract
Despite the availability of anti-hypertensive medications with proven efficacy and good tolerability, many hypertensive patients have blood pressure levels(BP) not at the goals set by international societies. Some of these patients are either non-adherent to the prescribed drugs or not optimally treated. However, a proportion, despite adequate treatment, has resistant hypertension(RH...
Source: Minerva Cardioangiologica - September 9, 2017 Category: Cardiology Tags: Minerva Cardioangiol Source Type: research
Blood pressure –lowering efficacy of indapamide SR/amlodipine combination in older patients with hypertension: A post hoc analysis of the NESTOR trial (Natrilix SR vs Enalapril in Hypertensive Type 2 Diabetics With Microalbuminuria)
To examine the antihypertensive efficacy and safety of indapamide sustained‐release (SR)/amlodipine compared with enalapril/amlodipine in patients 65 years and older with uncontrolled blood pressure (BP) on monotherapy, a post hoc analysis of the NESTOR trial (Natrilix SR vs Enalapril in Hypertensive Type 2 Diabetics With Microalbuminuria) was conducted. NESTOR randomized 570 patients (n=197, aged ≥65 years) with hypertension (systolic BP 140–180/diastolic BP <110 mm Hg) to indapamide SR 1.5 mg or enalapril 10 mg. If target BP (<140/85 mm Hg) was not achieved at 6 weeks, amlodipine 5 mg was added with...
Source: The Journal of Clinical Hypertension - July 18, 2017 Category: Cardiology Authors: Olivier Hanon, Laure Caillard, Edouard Chaussade, Intza Hernandorena, Clemence Boully Tags: ORIGINAL PAPER Source Type: research
Comparison between the effects of hydrochlorothiazide and indapamide on the kidney in hypertensive patients inadequately controlled with losartan
& X Chen (Source: Journal of Human Hypertension)
Source: Journal of Human Hypertension - July 13, 2017 Category: Cardiology Authors: S Wang J Li X Zhou K Liu X Zhang Q Meng R Shi D Shi X Chen Source Type: research
Comparison between the effects of hydrochlorothiazide and indapamide on the kidney in hypertensive patients inadequately controlled with losartan
Journal of Human Hypertension, Published online: 13 July 2017; doi:10.1038/jhh.2017.51 (Source: Journal of Human Hypertension)
Source: Journal of Human Hypertension - July 13, 2017 Category: Cardiology Authors: S Wang J Li X Zhou K Liu X Zhang Q Meng R Shi D Shi X Chen Source Type: research
The Transition From Hypertension to Heart Failure
Publication date: Available online 12 July 2017 Source:JACC: Heart Failure Author(s): Franz H. Messerli, Stefano F. Rimoldi, Sripal Bangalore Longstanding hypertension ultimately leads to heart failure (HF), and as a consequence most patients with HF have a history of hypertension. Conversely, absence of hypertension in middle age is associated with lower risks for incident HF across the remaining life course. Cardiac remodeling to a predominant pressure overload consists of diastolic dysfunction and concentric left ventricular (LV) hypertrophy. When pressure overload is sustained, diastolic dysfunction progresses, f...
Source: JACC: Heart Failure - July 12, 2017 Category: Cardiology Source Type: research
Prospective direct comparison of antihypertensive effect and safety between high-dose amlodipine or indapamide in hypertensive patients uncontrolled by standard doses of angiotensin receptor blockers and amlodipine.
CONCLUSION: Although both regimens were effective for reducing BP, increasing amlodipine to 10 mg daily controlled hypertension without elevation of serum uric acid.
PMID: 28692311 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - July 10, 2017 Category: Cardiology Authors: Okamura K, Shirai K, Totake N, Okuda T, Urata H Tags: Clin Exp Hypertens Source Type: research
Erratum to: Full-dose Perindopril/Indapamide in the Treatment of Difficult-to-Control Hypertension: The FORTISSIMO Study
(Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - July 10, 2017 Category: Drugs & Pharmacology Source Type: research
The Antihypertensive Efficacy of the Triple Fixed Combination of Perindopril, Indapamide, and Amlodipine: The Results of the PETRA Study
ConclusionsDuring the 3 months of the PETRA study, the outstanding 24-h antihypertensive efficacy of the triple fixed combination of perindopril, indapamide, and amlodipine was confirmed both by office BP readings and by ABPM recordings. This combination may offer a new therapeutic option for hypertensive patients who ha ve failed to achieve the desired BP target on their previous dual combination therapy.FundingEGIS Pharmaceuticals PLC. (Source: Advances in Therapy)
Source: Advances in Therapy - June 23, 2017 Category: Drugs & Pharmacology Source Type: research
Comparison of thiazide-like diuretics versus thiazide-type diuretics: a meta-analysis.
In conclusion, using thiazide-like diuretics is superior to thiazide-type diuretics in reducing blood pressure without increasing the incidence of hypokalemia, hyponatraemia and any change of blood glucose and serum total cholesterol.
PMID: 28631393 [PubMed - as supplied by publisher] (Source: J Cell Mol Med)
Source: J Cell Mol Med - June 19, 2017 Category: Molecular Biology Authors: Liang W, Ma H, Cao L, Yan W, Yang J Tags: J Cell Mol Med Source Type: research
Comparison of thiazide ‐like diuretics versus thiazide‐type diuretics: a meta‐analysis
In conclusion, using thiazide‐like diuretics is superior to thiazide‐type diuretics in reducing blood pressure without increasing the incidence of hypokalemia, hyponatraemia and any change of blood glucose and serum total cholesterol. (Source: Journal of Cellular and Molecular Medicine)
Source: Journal of Cellular and Molecular Medicine - June 19, 2017 Category: Molecular Biology Authors: Wenjing Liang, Hui Ma, Luxi Cao, Wenjiang Yan, Jingjing Yang Tags: Review Source Type: research
Blood pressure-lowering efficacy and safety of perindopril/indapamide/amlodipine single-pill combination in patients with uncontrolled essential hypertension: a multicenter, randomized, double-blind, controlled trial
Objectives: This 4-month, double-blind, randomized, controlled trial was designed to demonstrate the superiority of perindopril/indapamide/amlodipine single pill over perindopril/indapamide after 1 month and to determine further up-titration efficacy and safety in patients with mild-to-moderate hypertension.
Methods: After a 1-month run-in period on perindopril/indapamide 5/1.25 mg, patients with SBP/DBP at least 150/95 mmHg and no diabetes or renal insufficiency received perindopril/indapamide/amlodipine 5/1.25/5 mg single pill or continued on the same treatment. At 1, 2, and 3 months, patients with uncontrolled bl...
Source: Journal of Hypertension - June 2, 2017 Category: Cardiology Tags: ORIGINAL PAPERS: Therapeutic aspects Source Type: research
Renal denervation decreases blood pressure and renal tyrosine hydroxylase but does not augment the effect of hypotensive drugs.
In conclusion, renal denervation decreases blood pressure in hypertensive rats. The hypotensive action of metoprolol, indapamide, and losartan is not augmented by renal denervation, suggesting the absence of synergy between renal denervation and the drugs investigated in this study.
PMID: 28448180 [PubMed - in process] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - April 29, 2017 Category: Cardiology Authors: Skrzypecki J, Gawlak M, Huc T, Szulczyk P, Ufnal M Tags: Clin Exp Hypertens Source Type: research
Fixed-Dose Triple Combination of Antihypertensive Drugs Improves Blood Pressure Control: From Clinical Trials to Clinical Practice
ConclusionFDTC of perindopril/indapamide/amlodipine was effective at reducing SBP and PP in previously treated patients with uncontrolled hypertension, and well tolerated, providing support for clinicians in choosing a fixed-dose triple combination over the free-combination of a RAAS inhibitor, a diuretic, and a calcium antagonist. (Source: Advances in Therapy)
Source: Advances in Therapy - March 14, 2017 Category: Drugs & Pharmacology Source Type: research
Single-Pill Combination of Perindopril/Indapamide/Amlodipine in Patients with Uncontrolled Hypertension: A Randomized Controlled Trial
ConclusionsIn adult patients with uncontrolled essential hypertension on treatment, single-pill triple-combination therapy with Per/Ind/Aml is as effective as the same dose dual-pill combination of Per/Ind + Aml. Both treatments were associated with clinically significant BP reductions compared with baseline and were well tolerated.Clinical trials number:http://www.controlled-trials.com ISRCTN: 16442558.Funding: Les Laboratoires Servier. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - February 7, 2017 Category: Cardiology Source Type: research
High-throughput NIR-chemometric methods for chemical and pharmaceutical characterization of sustained release tablets
Publication date: 10 May 2017 Source:Journal of Pharmaceutical and Biomedical Analysis, Volume 138 Author(s): Alina Porfire, Cristina Filip, Ioan Tomuta The aim of this study was the development and validation of methods based on near-infrared spectroscopy (NIRS) and chemometry, useful for characterization of sustained release (SR) tablets with indapamide, in terms of tablet composition (API and two excipients), in vitro drug release mechanism (k and n Peppas) and crushing strength. A calibration set consisting of 25 different tablets formulations containing API, HPMC and lactose at five different content levels in th...
Source: Journal of Pharmaceutical and Biomedical Analysis - February 4, 2017 Category: Drugs & Pharmacology Source Type: research
