Emergent Coronary Thrombectomy for Acute Myocardial Infarction Immediately Following Craniotomy with Tumor Resection
AbstractThe management of perioperative acute myocardial infarction (AMI) following oncologic neurosurgery requires balancing competing risks of myocardial ischemia and postoperative bleeding. There are limited human data to establish the safest timing of antiplatelet or anticoagulation therapy following neurosurgical procedures. For patients with malignancy experiencing AMI in the acute postoperative period, staged percutaneous coronary intervention (PCI) with upfront coronary aspiration thrombectomy followed by delayed completion PCI may offer an opportunity for myocardial salvage while minimizing postoperative bleeding ...
Source: Cardiology and Therapy - March 27, 2024 Category: Cardiology Source Type: research

Real-World Effectiveness of High-Dose Tafamidis on Neurologic Disease Progression in Mixed-Phenotype Variant Transthyretin Amyloid Cardiomyopathy
ConclusionThis is the first real-world study to demonstrate the potential value of high-dose tafamidis for delaying neurologic disease progression in patients with mixed-phenotype ATTRv-CM. The findings underscore the importance of multidisciplinary assessment for patients with ATTR amyloidosis.Trial registrationClinicalTrials.gov: NCT05139680. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - March 23, 2024 Category: Cardiology Source Type: research

Effects of Ivabradine on Myocardial Perfusion in Chronic Angina: A Prospective, Preliminary, Open-Label, Single-Arm Study
ConclusionIvabradine added to beta blockers was associated with a reduction in detectable myocardial ischemia by MPS in patients with CA.Infographic available for this article.Trial RegistrationThe trial has been retrospectively registered with the Brazilian Registry of Clinical Trials (REBEC) under the following number RBR-5fysqrh (date of registration: 30 November 2023).Graphical Abstract (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - March 22, 2024 Category: Cardiology Source Type: research

Macitentan in Pulmonary Arterial Hypertension Associated with Connective Tissue Disease (CTD-PAH): Real-World Evidence from the Combined OPUS/OrPHeUS Dataset
ConclusionsMacitentan was used in clinical practice in patients with CTD-PAH and its subgroups, including as combination therapy. The safety and tolerability profile of macitentan in patients with CTD-PAH was comparable to that of patients with I/HPAH.Trial RegistrationOPsumit ® Users Registry (OPUS): NCT02126943; Opsumit® Historical Users cohort (OrPHeUS): NCT03197688;www.clinicaltrials.govGraphical abstract available for this article.Graphical Abstract (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - March 7, 2024 Category: Cardiology Source Type: research

Targeting Lipoprotein(a): Can RNA Therapeutics Provide the Next Step in the Prevention of Cardiovascular Disease?
AbstractNumerous genetic and epidemiologic studies have demonstrated an association between elevated levels of lipoprotein(a) (Lp[a]) and cardiovascular disease. As a result, lowering Lp(a) levels is widely recognized as a promising strategy for reducing the risk of new-onset coronary heart disease, stroke, and heart failure. Lp(a) consists of a low-density lipoprotein-like particle with covalently linked apolipoprotein A  (apo[a]) and apolipoprotein B-100, which explains its pro-thrombotic, pro-inflammatory, and pro-atherogenic properties. Lp(a) serum concentrations are genetically determined by the apo(a) isoform, with ...
Source: Cardiology and Therapy - February 21, 2024 Category: Cardiology Source Type: research

The Clear Value of Coronary Artery Calcification Evaluation on Non-Gated Chest Computed Tomography for Cardiac Risk Stratification
In conclusion, the integration of CAC on non-gated chest CT in general cardiology should be promoted and research on this method should be encouraged. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - February 13, 2024 Category: Cardiology Source Type: research

Single-Pill, Triple Antihypertensive Therapy in Rural Sub-Saharan Africa: Preliminary Experience
ConclusionsThese results provide real-life evidence that hypertension management with a  once-daily, single-pill combination of olmesartan, amlodipine, and hydrochlorothiazide as initial treatment is feasible and effective also in a rural sub-Saharan setting. Single-pill combinations should be made available also in rural and remote areas in low- and middle-income countries as a reli able first-line treatment strategy. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - February 12, 2024 Category: Cardiology Source Type: research

Cerebral Embolic Protection in Transcatheter Aortic Valve Implantation Using the Sentinel Cerebral Protection System: A Systematic Review and Meta-Analysis
ConclusionsIn our analysis, there was no difference between TAVI with the Sentinel ™ CPS compared to TAVI without TCEP in regard to risk of periprocedural stroke; however, it was associated with a decreased risk of periprocedural disabling stroke. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - February 10, 2024 Category: Cardiology Source Type: research

Contemporary Management of Cardiomyopathy and Heart Failure in Pregnancy
AbstractCardiovascular disease is the primary cause of pregnancy-related mortality and morbidity in the United States, and maternal mortality has increased over the last decade. Pregnancy and the postpartum period are associated with significant vascular, metabolic, and physiologic adaptations that can unmask new heart failure or exacerbate heart failure symptoms in women with known underlying cardiomyopathy. There are unique management considerations for heart failure in women throughout pregnancy, and it is imperative that clinicians caring for pregnant women understand these important principles. Early involvement of mu...
Source: Cardiology and Therapy - February 10, 2024 Category: Cardiology Source Type: research

Real-World Heart Failure Burden in Thai Patients
ConclusionOur study demonstrated that the burden of HF in terms of hospitalization and in-hospital mortality was notably high when compared to similar studies conducted in Thailand and other countries. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - February 7, 2024 Category: Cardiology Source Type: research

Real-World Safety and Effectiveness of a 4-Factor Prothrombin Complex Concentrate in Japanese Patients Experiencing Major Bleeding: A Post-marketing Surveillance Study
ConclusionThe incidence of TEEs following treatment with 4F-PCC did not surpass those observed in phase  3 trials. No novel safety signals were identified. The safety and effectiveness of 4F-PCC in Japanese real-world practice were in harmony with the observations of prior studies. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - February 6, 2024 Category: Cardiology Source Type: research

Factor  XI Inhibitors: A New Horizon in Anticoagulation Therapy
AbstractAnticoagulation therapy has undergone significant evolution, marked by the emergence of direct oral anticoagulants with distinct advantages. Despite these advancements, challenges persist in managing residual thrombotic and bleeding risks, particularly among vulnerable populations. The pursuit of alternative drugs has honed in on factor  XI/XIa inhibitors. This comprehensive review delves into several key aspects regarding this new target: (i) the role of factor XI in the coagulation cascade; (ii) the genetic evidence and pathophysiologic rationale supporting factor XI inhibition as a therapeutic target; (iii) a...
Source: Cardiology and Therapy - February 2, 2024 Category: Cardiology Source Type: research

Prevalence of CYP2C19*2 and CYP2C19*3 Allelic Variants and Clopidogrel Use in Patients with Cardiovascular Disease in Trinidad & amp; Tobago
ConclusionsA large proportion of Trinidadian patients with CVD who are prescribed or may be prescribed clopidogrel carry genetic variants associated with clopidogrel resistance. These results emphasize the clinical need for further investigation into whetherCYP2C19*2 genotype should guide clopidogrel use for the cardiovascular disease population in Trinidad& Tobago.A slide deck is available for this article. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - January 29, 2024 Category: Cardiology Source Type: research

Real-World Risk of Recurrent Cardiovascular Events in Atherosclerotic Cardiovascular Disease Patients with LDL-C Above Guideline-Recommended Threshold: A Retrospective Observational Study
ConclusionThis real-world study confirms that statin-treated high-risk patients with ASCVD and above-threshold LDL-C levels have substantial incidence of recurrent CV events. These findings reinforce the opportunity for lipid-lowering therapy intensification in high-risk patients to levels below guideline-recommended threshold in order to reduce CV risk. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - January 29, 2024 Category: Cardiology Source Type: research

Effect of Macitentan in Pulmonary Arterial Hypertension and the Relationship Between Echocardiography and cMRI Variables: REPAIR Echocardiography Sub-study Results
ConclusionsA good relationship between relevant echo and cMRI parameters was shown. Improvements in RV structure and function with macitentan treatment was observed by echo, consistent with results observed by cMRI in the primary analysis of the REPAIR study. Echo is a valuable complementary method to cMRI, with the potential to non-invasively monitor treatment response at follow-up.Trial registration numberREPAIR NCT02310672.Graphical Abstract (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - January 28, 2024 Category: Cardiology Source Type: research