Safety and Effectiveness of Hydroxychloroquine and Azithromycin Combination Therapy for Treatment of Hospitalized Patients with COVID-19: A Propensity-Matched Study
AbstractIntroductionWe sought to determine the effectiveness and safety of hydroxychloroquine –azithromycin (HCQ-AZM) therapy in hospitalized patients with COVID-19.MethodsThis was a retrospective cohort study of 613 patients hospitalized (integrated health system involving three hospitals) for RT-PCR-confirmed COVID-19 infection between March  1, 2020 and April 25, 2020. Intervention was treatment with HCQ-AZM in hospitalized patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Outcomes of interest were in-hospital all-cause mortality, cardiovascular mortality, pulsele...
Source: Cardiology and Therapy - October 14, 2020 Category: Cardiology Source Type: research

Efficacy and Safety of Ivabradine Once-Daily Prolonged-Release versus Twice-Daily Immediate-Release Formulation in Patients with Stable Chronic Heart Failure with Systolic Dysfunction: A Randomized, Double-Blind, Phase 3 Non-Inferiority (PROFICIENT) Study
ConclusionIvabradine PR was found to be non-inferior to ivabradine IR in the management of patients with stable CHF, with a comparable safety profile. Once-daily ivabradine PR effectively maintained the HR in patients shifted from the ivabradine IR twice-daily regimen, and thus may aid in improving treatment compliance.Trial RegistrationCTRI/2018/04/013464  (Trial Registered Prospectively on 24/04/2018) (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - September 30, 2020 Category: Cardiology Source Type: research

Expansion of TAVR into Low-Risk Patients and Who to Consider for SAVR
AbstractTranscatheter aortic valve replacement (TAVR) has revolutionized the treatment of severe aortic stenosis (AS) over the last decade. The results of the Placement of Aortic Transcatheter Valves (PARTNER) 3 and Evolut Low Risk trials demonstrated the safety and efficacy of TAVR in low-surgical-risk patients and led to the approval of TAVR for use across the risk spectrum. Heart teams around the world will now be faced with evaluating a deluge of younger, healthier patients with severe AS. Prior to the PARTNER 3 and Evolut Low Risk studies, this heterogenous patient population would have undergone surgical aortic valve...
Source: Cardiology and Therapy - August 31, 2020 Category: Cardiology Source Type: research

Myocardial Fibrosis in Heart Failure: Anti-Fibrotic Therapies and the Role of Cardiovascular Magnetic Resonance in Drug Trials
AbstractAll heart muscle diseases that cause chronic heart failure finally converge into one dreaded pathological process that is myocardial fibrosis. Myocardial fibrosis predicts major adverse cardiovascular events and death, yet we are still missing the targeted therapies capable of halting and/or reversing its progression. Fundamentally it is a problem of disproportionate extracellular collagen accumulation that is part of normal myocardial ageing and accentuated in certain disease states. In this article we discuss the role of cardiovascular magnetic resonance (CMR) imaging biomarkers to track fibrosis and collate resu...
Source: Cardiology and Therapy - August 29, 2020 Category: Cardiology Source Type: research

A Phase 4, Open-Label, Single-Arm Study Assessing the Efficacy and Safety of Ivabradine in African American Patients with Heart Failure and Reduced Ejection Fraction
ConclusionThese data support ivabradine use in African American patients with HF with reduced ejection fraction who meet typical treatment criteria.Trial RegistrationClinicalTrials.gov identifier, NCT03456856 (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - August 16, 2020 Category: Cardiology Source Type: research

Dual Antiplatelet Therapy in Coronary Artery Disease
AbstractAcute coronary syndrome (ACS) is principally driven by platelet aggregation. Dual antiplatelet therapy (DAPT) has demonstrated a reduction in recurrent ischemic events. The newer antiplatelets ticagrelor and prasugrel have demonstrated superiority over clopidogrel. While prasugrel demonstrated benefit in patients scheduled for percutaneous intervention (PCI), benefits of ticagrelor were seen irrespective of the treatment strategy. Current guidelines recommend the use of DAPT for 1 year in all patients with ACS. Ticagrelor 60  mg is recommended for up to 3 years in high-risk patients. DAPT and Predicting B...
Source: Cardiology and Therapy - August 16, 2020 Category: Cardiology Source Type: research

Hypochloraemia in Patients with Heart Failure: Causes and Consequences
AbstractHypochloraemia is a common electrolyte abnormality in patients with heart failure (HF). It has a strong association with adverse outcome regardless of HF phenotype and independent of other prognostic markers. How hypochloraemia develops in a patient with HF and how it might influence outcome are not clear, and in this review we explore the possible mechanisms. Patients with HF and hypochloraemia almost invariably take higher doses of loop diuretic than patients with normal chloride levels. However, renal chloride and bicarbonate homeostasis are closely linked, and the latter may be influenced by neurohormonal activ...
Source: Cardiology and Therapy - August 8, 2020 Category: Cardiology Source Type: research

The Effect of Low-Dose Ticagrelor on Platelet Function Profiles in Patients With Stable Coronary Artery Disease in Trinidad: The TWIST Pilot Study
AbstractIntroductionThis prospective, pharmacodynamic study aimed to explore the potential applicability of a low-dose ticagrelor regimen in a heterogeneous Trinidadian subpopulation.MethodsPatients with stable coronary artery disease (n = 25) who were actively treated with dual antiplatelet therapy of aspirin 81 mg daily and clopidogrel 75 mg daily were recruited. Platelet function was measured with the VerifyNow P2Y12 assay (Accriva Diagnostics, San Diego, CA, USA) and assessed before initiation of and after 14  days of treatment with a low-dose ticagrelor 45 mg twice daily maintenance d...
Source: Cardiology and Therapy - August 5, 2020 Category: Cardiology Source Type: research

Vaccines Targeting PSCK9 for the Treatment of Hyperlipidemia
AbstractDespite progress in both primary and secondary prevention, cardiovascular diseases (CVD) are still the largest group of ailments contributing to morbidity and mortality worldwide. Atherosclerotic changes, the primary pathological substrate for CVD, are closely related to hypercholesterolemia. Therefore, the treatment of hypercholesterolemia is a key therapeutic strategy for CVD management. Statins, as the gold standard in the treatment of hypercholesterolemia, have shown enhanced cardiac outcomes in many randomized clinical trials. However, often despite the maximum allowed and tolerated dosage of statins, we are n...
Source: Cardiology and Therapy - July 30, 2020 Category: Cardiology Source Type: research

Massive Left Atrial Myxoma Presenting With Troponin-Positive Chest Pain
AbstractAtrial myxomas are the most prevalent primary cardiac tumors. The clinical presentation is variable and often poses a diagnostic challenge. Here we describe the case of a 52-year-old woman who presented with troponin-positive chest pain, exertional dizziness, and dyspnea as a consequence of a massive left atrial myxoma, which was successfully treated with surgical resection. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - July 26, 2020 Category: Cardiology Source Type: research

In-Hospital Outcomes of Patients With Pulmonary Hypertension and Cirrhosis: A 6-Year Population Cohort Study of Over One Million Patients
ConclusionsPatients with pulmonary hypertension and cirrhosis have increased mortality and hospital utilization compared to patients with only pulmonary hypertension. We identified key drivers for these outcomes. Targeted interventions, such as novel medications, right-to-left shunts, more evaluations for lung transplantation, and reversal of pulmonary vacular  remodeling, are needed for the subgroups identified in this study in order to improve outcomes. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - July 19, 2020 Category: Cardiology Source Type: research

Clinical Characteristics and In-Hospital Mortality for COVID-19 Across The Globe
AbstractIntroductionNumerous case series have reported on the baseline characteristics and in-hospital mortality of patients with COVID-19, however, these studies included patients localized in a specific geographic region. The purpose of our study was to identify differences in the clinical characteristics and the in-hospital mortality of patients with a laboratory-confirmed diagnosis of COVID-19 internationally.MethodsA comprehensive search of all published literature on adult patients with laboratory-confirmed diagnosis of COVID-19 that reported on the clinical characteristics and in-hospital mortality was performed. Gr...
Source: Cardiology and Therapy - July 17, 2020 Category: Cardiology Source Type: research

Overuse of Cardiac Troponin Among Hospitalized Patients: A Cohort Study of Biomarker “Superusers”
(Source: Cardiology and Therapy)
Source: Cardiology and Therapy - July 15, 2020 Category: Cardiology Source Type: research

A Call for a New Paradigm for Diabetes Care in the Era of Sodium –Glucose Cotransporter 2 Inhibitors (SGLT2i)
This article is based on previously conducted studies and the authors disclose  their roles in relevant trials in the Acknowledgements. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - July 12, 2020 Category: Cardiology Source Type: research

Use, Persistence, Efficacy, and Safety of Apixaban in Patients with Non-Valvular Atrial Fibrillation in Unselected Patients in Germany. Results of the Prospective Apixaban in Atrial Fibrillation (APAF) Registry
ConclusionsIn this prospective experience in unselected patients with atrial fibrillation, persistence to apixaban was high, and efficacy and safety were comparable to the results in clinical trials, supporting its use in clinical practice. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - July 7, 2020 Category: Cardiology Source Type: research

A Comparison of Ezetimibe and Evolocumab for Atherogenic Lipid Reduction in Four Patient Populations: A Pooled Efficacy and Safety Analysis of Three Phase 3 Studies
AbstractIntroductionClinicians, payers, guideline committees, and policymakers support the use of high-intensity statins in patients at high risk for complications of cardiovascular disease (CVD). Guidelines and recommendations provide guidance on next steps for patients with inadequate low-density lipoprotein cholesterol (LDL-C) control on maximally tolerated statin or for those who are statin-intolerant. Ezetimibe and evolocumab improve CV outcomes when added to statins in high-CV-risk populations. The aim of the study was to compare evolocumab and ezetimibe for lipid-lowering efficacy and safety.MethodsWe summarized dat...
Source: Cardiology and Therapy - June 19, 2020 Category: Cardiology Source Type: research

Optical Coherence Tomography: Current Applications for the Assessment of Coronary Artery Disease and Guidance of Percutaneous Coronary Interventions
AbstractIntroductionCoronary angiography (CAG) is the standard modality for assessment of coronary stenoses and intraprocedural guidance of percutaneous coronary interventions (PCI). However, the limitations of CAG are well recognized. Intracoronary imaging (ICI) can potentially overcome these limitations. Intravascular ultrasound (IVUS) and optical coherence tomography (OCT) are the main ICI techniques utilized in clinical practice.AimThis narrative literature review addresses the current clinical applications of OCT in relation to IVUS and CAG in patients with coronary artery disease (CAD). Items reviewed are: technical ...
Source: Cardiology and Therapy - June 19, 2020 Category: Cardiology Source Type: research

Home-Based Cardiac Rehabilitation (HBCR) In Post-TAVR Patients: A Prospective, Single-Center, Cohort, Pilot Study
ConclusionsIn conclusion, our pilot study offers novel insight into the role of HBCR in improving physical health and well-being in post-TAVR patients while eliminating the barriers of transportation and access to cardiac rehabilitation programs. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - June 12, 2020 Category: Cardiology Source Type: research

Cardiovascular Implications and Therapeutic Considerations in COVID-19 Infection
AbstractThe ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has profoundly impacted all fields of medicine. Infection with SARS-CoV-2 and the resulting coronavirus of 2019 (COVID-19) syndrome has multiorgan effects. The pandemic has united researchers from bench to bedside in attempts to understand the pathophysiology of the disease and define optimal treatment strategies. Cardiovascular disease is highly prevalent and a leading cause of death across gender, race, and ethnic groups. As the pandemic spreads, there is increasing concern about the cardiovascular effects of the viral infection and...
Source: Cardiology and Therapy - June 12, 2020 Category: Cardiology Source Type: research

Extrapolation of Survival Benefits in Patients with Transthyretin Amyloid Cardiomyopathy Receiving Tafamidis: Analysis of the Tafamidis in Transthyretin Cardiomyopathy Clinical Trial
ConclusionsThis extrapolation of survival data from ATTR-ACT further supports the efficacy of tafamidis in patients with ATTR-CM. Owing to the limitations of this analysis, these survival estimates should be interpreted with caution; however, they are consistent with recently presented findings from a combined analysis of data from ATTR-ACT and interim data from an ongoing long-term extension study (median follow-up 36  months; ClinicalTrials.gov number NCT02791230).Trial RegistrationClinicalTrials.gov: NCT01994889. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - June 9, 2020 Category: Cardiology Source Type: research

In-Hospital Outcomes of Patients with Acute Decompensated Heart Failure and Cirrhosis: An Analysis of the National Inpatient Sample
In this study, we aim to identify risk factors in a national population cohort from 2016.MethodsAll patients above 18 years old with cirrhosis and ADHF admitted in 2016 were identified from the Nationwide Inpatient Sample (NIS). Multivariate regression analysis was used to estimate the odds ratio of in-hospital mortality, average length of stay (LOS), and total hospital charges after adjusting for the following factors: age, gender, race, Charlson and Elixhauser scores, primary insurance payer  status, hospital type, hospital bed size, hospital region, and hospital teaching status. Statistical analysis was performed b...
Source: Cardiology and Therapy - June 7, 2020 Category: Cardiology Source Type: research

Anatomical Extent of Venous Reflux
This report addresses the most important aspects of the standard definitions of the anatomical extent of venous reflux, the differences between the three classes of reflux, and the challenges of implementing this classification in clinical practice. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - June 1, 2020 Category: Cardiology Source Type: research

A Qualitative Analysis of Patient-Related Factors Associated With Implantable Cardioverter Defibrillator Acceptance
ConclusionsPatients without ICDs perceived less benefit from ICDs and had less decision support. Participants viewed conversations with providers as insufficient. Needed interventions include the development and validation of processes for informed decisions about ICDs. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - May 30, 2020 Category: Cardiology Source Type: research

Acute Myocarditis After Black Widow Spider Bite: A Case Report
AbstractThe black widow spider (BWS) is a venomous spider whose bite can cause various clinical conditions that range from local damage to serious systemic complications, including death. Cases of myocarditis following a BWS bite are rare but they can be fatal on occasion. However, the prognostic significance of the bite and presentation of myocarditis is unknown. Our case involved a 50-year-old man who presented with myocarditis after being bitten by a BWS and subsequently admitted to the intensive care unit for cardiac monitoring. During the hospital stay, he showed worsening signs on both the electrocardiographic and ec...
Source: Cardiology and Therapy - May 26, 2020 Category: Cardiology Source Type: research

Perceptions and Experiences of Atrial Fibrillation Patients on Their Condition and Oral Anticoagulant Treatment
ConclusionsGPs and patients are waiting for the other to mention issues surrounding AF treatment such as switching, use of thrombosis service, and number of pills to take first. The perceptions and experiences of patients with AF regarding their disease and treatment highly influence the decisions GPs make, together with these patients, as well as considerations that patients have regarding their treatment; GPs need to be aware of their AF patients ’ perceptions and experiences with their condition and medication’ in order to facilitate discussions with patients and improve clinical outcomes. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - May 26, 2020 Category: Cardiology Source Type: research

Lipoprotein(a) and Cardiovascular Disease Prevention across Diverse Populations
AbstractLipoprotein(a) (Lp(a)) is a highly proatherogenic lipid fraction that is genetically determined and minimally responsive to lifestyle or behavior changes. Mendelian randomization studies have suggested a causal link between elevated Lp(a) and heart disease, stroke, and aortic stenosis. There is substantial inter-ethnic variation in Lp(a) levels, with persons of African descent having the highest median values. Monitoring of Lp(a) has historically been limited by lack of standardization of assays. With the advent of novel therapeutic modalities to lower Lp(a) levels including proprotein convertase subtilisin/kexin 9...
Source: Cardiology and Therapy - May 24, 2020 Category: Cardiology Source Type: research

Sex-Based Differences in Coronary and Structural Percutaneous Interventions
AbstractIn the current state of interventional cardiology, the ability to offer advanced therapies to patients who historically were not surgical candidates has grown exponentially in the last few decades. As therapies have expanded in complex coronary and structural interventions, the nuances of treating certain populations have emerged. In particular, the role of sex-based anatomic and outcome differences has been increasingly recognized. As guidelines for cardiovascular prevention and treatment for certain conditions may vary by sex, therapeutic interventions in the structural and percutaneous coronary areas may also va...
Source: Cardiology and Therapy - May 20, 2020 Category: Cardiology Source Type: research

Effectiveness of Trimetazidine in Patients with Stable Angina Pectoris of Various Durations: Results from ODA
AbstractIntroductionTrimetazidine (TMZ) is an antianginal agent that acts directly at the myocardial cell level and which is now available in a once-daily (od) formulation.MethodsODA, a 3-month, observational, multicenter study in Russia, assessed the effectiveness and tolerability of TMZ 80  mg od in patients with stable angina and persisting symptoms, in real-life settings. The present analysis explored the effects of adding TMZ to background antianginal treatment with respect to the duration of stable angina.ResultsA total of 3032 patients were divided into four groups according to stable angina pectoris duration s...
Source: Cardiology and Therapy - May 18, 2020 Category: Cardiology Source Type: research

The Physiologic Basis and Clinical Outcomes of Combined Impella and Veno-Arterial Extracorporeal Membrane Oxygenation Support in Cardiogenic Shock
AbstractVeno-arterial extracorporeal membrane oxygenation (VA-ECMO) provides effective hemodynamic support in cardiogenic shock, but in some cases may be complicated by left ventricular  (LV) distension and pulmonary edema. The Impella, a catheter-mounted microaxial pump has been used to unload the LV. Recent studies have compared the clinical outcomes of VA-ECMO to the combination of Impella and VA-ECMO. The purpose of this review is threefold: firstly, to discuss the physiologic al effects of Impella support in addition to VA-ECMO, secondly to review published studies on the outcome of this combined support, and thi...
Source: Cardiology and Therapy - May 17, 2020 Category: Cardiology Source Type: research

Incidence Rates of Bleeding and Emergency Surgery Due to Trauma or Fracture Among Japanese Patients with Non-valvular Atrial Fibrillation Receiving Oral Anticoagulation Therapy
ConclusionsFewer than one in 200 patients per year with NVAF receiving OACs experience emergency surgeries and major bleeding episodes associated with fractures and trauma; however, the IR of these events is markedly higher in patients of advanced age.Trial registrationClinicalTrials.gov 207, NCT03254147. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - May 10, 2020 Category: Cardiology Source Type: research

Proposal for New Classification and Practical Use of Diuretics According to Their Effects on the Serum Chloride Concentration: Rationale Based on the “Chloride Theory”
AbstractCurrently, diuretic therapy for heart failure (HF) pathophysiology is primarily focused on the sodium and water balance. Over the last several years, however, chloride (Cl) has been recognized to have an important role in HF pathophysiology, as both a prognostic marker and a possible central factor regulating the body fluid status. I recently proposed a unifying hypothesis for HF pathophysiology, called the “chloride theory”, during HF worsening and recovery, as follows. Chloride is the key electrolyte for regulating both reabsorption of tubular electrolytes and water in the kidney through the renin&nda...
Source: Cardiology and Therapy - May 5, 2020 Category: Cardiology Source Type: research

Prevalence of US Adults with Triglycerides  ≥ 150 mg/dl: NHANES 2007–2014
The objective of this analysis was to estimate the prevalence of triglyceride (TG) levels  ≥ 150 mg/dl in statin-treated adults with diabetes or ASCVD in the United States.MethodsLaboratory data, medical history, and prescription data from 40,617 subjects who participated in the US National Health and Nutrition Examination Survey (NHANES) spanning 8  years (four 2-year surveys; 2007–2014) were analyzed. Patients included were ≥ 20 years old and had morning fasting (at least 8.5 h) TG values available. The proportion and weighted number of individuals in the US pop...
Source: Cardiology and Therapy - April 22, 2020 Category: Cardiology Source Type: research

Diagnosis of Transthyretin Amyloid Cardiomyopathy
AbstractTransthyretin amyloid cardiomyopathy (ATTR-CM) continues to be an easily overlooked, life-threatening, yet treatable cause of heart failure. Furthermore, its elusive diagnosis leads to late or misdiagnosis. As therapeutic advancements such as tafamidis usher in a promising new era in the management of ATTR-CM, the need for disease awareness and efficient diagnostic evaluation is crucial. With newer inexpensive imaging modalities and techniques, such as longitudinal strain imaging, T1 mapping on cardiac magnetic resonance imaging, and cardiac scintigraphy, the diagnosis of ATTR-CM no longer requires invasive evaluat...
Source: Cardiology and Therapy - April 6, 2020 Category: Cardiology Source Type: research

Idarucizumab for Emergency Reversal of Anticoagulant Effects of Dabigatran: Interim Results of a Japanese Post-Marketing Surveillance Study
ConclusionsThe results of this interim analysis suggest that idarucizumab is safe and effective for the reversal of dabigatran in Japanese patients in a real-world setting, and support the continued use of idarucizumab.Trial RegistrationClinicalTrials.gov identifier, NCT02946931. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - March 8, 2020 Category: Cardiology Source Type: research

Cardiology and Therapy: A Summary of 2019 and Key Areas of Emerging Research in 2020
(Source: Cardiology and Therapy)
Source: Cardiology and Therapy - March 5, 2020 Category: Cardiology Source Type: research

Emergency Department Visits and Subsequent Hospital Admission Trends for Patients with Chest Pain and a History of Coronary Artery Disease
AbstractIntroductionHospitalization is the largest component of health care spending in the United States. Most hospitalized patients first visit the emergency department (ED), where hospitalization decisions are made. Optimal utilization of hospital resources is critical for all stakeholders.MethodsWe performed a population-based, cross-sectional study evaluating ED visits and subsequent inpatient admissions for patients with coronary artery disease (CAD) and chest pain (CP) suggestive of CAD from 2006 to 2013 using the Nationwide Emergency Department Sample database weighted for national estimates. We analyzed trends usi...
Source: Cardiology and Therapy - March 1, 2020 Category: Cardiology Source Type: research

Update on Transcatheter Aortic Valve Replacement
AbstractTranscatheter aortic valve replacement (TAVR) is a minimally invasive approach to treat symptomatic severe aortic stenosis. The patient populations that have been shown to benefit from this procedure continue to grow with time. Techniques and technology in TAVR persistently advance with a continued trend toward improved outcomes for patients. In this review, we highlight the advances in vascular access, TAVR valve design, progress in reducing procedural complications, and emerging evidence in the field. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - February 27, 2020 Category: Cardiology Source Type: research

What Lessons Have We Learned and What Remains to be Clarified for PCSK9 Inhibitors? A Review of FOURIER and ODYSSEY Outcomes Trials
AbstractFor more than half a century, low-density  lipoprotein cholesterol (LDL-C) has been recognized as a major risk factor for incident atherosclerotic cardiovascular disease. The discovery of proprotein convertase subtilisin-kexin type 9 (PCSK9) in 2003, which prevents LDL-C receptor recycling, identified a new target for drug intervention. Re cently, two large-scale randomized clinical outcomes trials involving fully human anti-PCSK9 monoclonal antibodies tested the hypothesis that targeting this pathway would reduce cardiovascular events. Both the FOURIER (Further cardiovascular OUtcomes Research with PCSK9 Inhi...
Source: Cardiology and Therapy - February 4, 2020 Category: Cardiology Source Type: research

Antihypertensive Effectiveness of Perindopril Arginine and Indapamide Single-Pill Combination According to Body Mass Index: Findings from the FORSAGE Study
AbstractIntroductionOverweight and obesity are increasing worldwide and are associated with an increased risk for cardiovascular disease (CVD). The aim of this study was to examine the burden of CVD risk factors among normal weight, overweight, and obese subjects with hypertension, and to evaluate the effectiveness of switching to a single-pill combination (SPC) of perindopril arginine/indapamide for blood pressure (BP) control in overweight and obese subjects treated in routine clinical practice.MethodsFORSAGE was a 3-month, multicenter, observational, open-label study conducted in Russian patients with uncontrolled arter...
Source: Cardiology and Therapy - January 31, 2020 Category: Cardiology Source Type: research

The Beneficial Effects of Cardiac Rehabilitation
AbstractCardiac rehabilitation (CR) is a combined range of measures aimed at providing patients with cardiovascular disease with the optimum psychological and physical conditions so that they themselves can prevent their disease from progressing or potentially reversing its course. The following measures are the three main parts of CR: exercise training, lifestyle modification, and psychological intervention. The course of cardiac rehabilitation generally takes 3 –4 weeks. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - January 28, 2020 Category: Cardiology Source Type: research

Relationship between Invasive and Echocardiographic Transvalvular Gradients after Transcatheter Aortic Valve Replacement
AbstractIntroductionLower transcatheter aortic valve replacement (TAVR) pressure gradients have been reported after implantation of self-expanding valves compared with balloon-expandable valves; however, there is a paucity of data on the relationship between invasively measured transvalvular pressure gradients and Doppler-derived measurements.MethodsFrom September 2013 to September 2018, patients with native aortic valve stenosis who had both intraoperative invasive and postoperative echocardiography transvalvular pressure gradients were included for analysis. We used parametric and nonparametric statistics to compare aort...
Source: Cardiology and Therapy - January 21, 2020 Category: Cardiology Source Type: research

Diagnosis of Amyloidosis: A Survey of Current Awareness and Clinical Challenges Among Cardiologists in Switzerland
ConclusionsSurvey results highlight that cardiologists in Switzerland would benefit from information on the latest advances in ATTR to support them in screening heart failure patients and ensure that patients benefit from treatment advances. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - January 19, 2020 Category: Cardiology Source Type: research

Facing the Challenge of Lowering Blood Pressure and Cholesterol in the Same Patient: Report of a Symposium at the European Society of Hypertension
AbstractA symposium held at the 29th European Meeting on Hypertension and Cardiovascular Protection in Milan, Italy, discussed the potential impact and long-term benefits of early active management of cardiovascular disease (CVD) risk in patients with hypertension, and potential barriers to this strategy. Hypertension often aggregates with other cardiovascular risk factors, exponentially increasing morbidity and mortality. While effective therapies to treat hypertension exist, a substantial number of patients still experience major cardiovascular events. Two major issues account for these disappointing results: interventio...
Source: Cardiology and Therapy - January 12, 2020 Category: Cardiology Source Type: research

Catheter Ablation of Atrial Fibrillation: State of the Art and Future Perspectives
ConclusionsPulmonary vein isolation is the treatment of choice for symptomatic patients with paroxysmal and persistent drug-refractory AF. The reconnection of previously isolated pulmonary veins remains the major cause of AF recurrence. Novel ablation tools, such as balloon technologies or alternative energy sources, might help to overcome this limitation. Patients with non-paroxysmal AF and with AF recurrence might benefit from alternative ablation strategies. However, further studies are warranted to further improve our knowledge of the underlying mechanisms of AF and to obtain long-term clinical outcomes on new ablation...
Source: Cardiology and Therapy - January 1, 2020 Category: Cardiology Source Type: research

Mitraclip Plus Medical Therapy Versus Medical Therapy Alone for Functional Mitral Regurgitation: A Meta-Analysis
ConclusionsMitraClip plus medical therapy improves overall mortality and reduces HF re-hospitalization rates compared to medical therapy alone in patients with FMR. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - December 8, 2019 Category: Cardiology Source Type: research

Effect of Methadone on Cardiac Repolarization in Japanese Cancer Patients: A Longitudinal Study
ConclusionsThe findings suggested that small or modest doses of methadone could exert dose-dependent effects on cardiac repolarization in cancer patients.Trial RegistrationUMIN Clinical Trials Registry, UMIN000034519. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - November 19, 2019 Category: Cardiology Source Type: research

Comparative Outcomes of Transapical Versus Transfemoral Access for Transcatheter Aortic Valve Replacement in Diabetics
AbstractIntroductionThe outcomes of transfemoral (TF) compared with transapical (TA) access for transcatheter aortic valve replacement (TAVR) in diabetics are unknown.MethodsWe queried the NIS database (2011 –2014) to identify diabetics who underwent TAVR. We performed a propensity matching analysis comparing TF-TAVR versus TA-TAVR.ResultsThe analysis included 14.555 diabetics who underwent TAVR. After matching, in-hospital mortality was not different between TF-TAVR and TA-TAVR. (3.5 vs. 4.4%,p = 0.11). TF-TAVR was associated with lower rates of cardiogenic shock (2.7 vs. 4.7%,p = 0.02), ...
Source: Cardiology and Therapy - November 10, 2019 Category: Cardiology Source Type: research

Comparison of Cardiac Repolarization After Transcatheter Aortic Valve Implantation and Surgical Aortic Valve Replacement: A Longitudinal Study
AbstractIntroductionTranscatheter aortic valve implantation (TAVI) has been established as an alternative to surgical aortic valve replacement (SAVR) for high-risk patients. To assess the impact of TAVI on cardiac repolarization, we compared QT dispersion (QTD) and the interval from the peak to the end of the T wave (Tpeak –Tend: TpTe) between the patients who underwent TAVI and those who underwent SAVR and TpTe between the patients who underwent TAVI or SAVR.MethodsThis retrospective study was approved by the ethics committee of Dokkyo Medical University Hospital. The study included 45 patients who underwent TAVI an...
Source: Cardiology and Therapy - November 5, 2019 Category: Cardiology Source Type: research

Complications of Temporary Percutaneous Mechanical Circulatory Support for Cardiogenic Shock: An Appraisal of Contemporary Literature
AbstractCardiogenic shock (CS) is associated with hemodynamic compromise and end-organ hypoperfusion due to a primary cardiac etiology. In addition to vasoactive medications, percutaneous mechanical circulatory support (MCS) devices offer the ability to support the hemodynamics and prevent acute organ failure. Despite the wide array of available MCS devices for CS, there are limited data on the complications from these devices. In this review, we seek to summarize the complications of MCS devices in the contemporary era. Using a systems-based approach, this review covers domains of hematological, neurological, vascular, in...
Source: Cardiology and Therapy - October 22, 2019 Category: Cardiology Source Type: research

A Review of Antithrombotic Treatment in Critical Limb Ischemia After Endovascular Intervention
AbstractEndovascular intervention is often used to treat critical limb ischemia (CLI). Post-intervention treatment with antiplatelet and/or anticoagulant therapy has reduced morbidity and mortality due to cardiovascular complications. The purpose of this review is to shed light on the various pharmacologic treatment protocols for treating CLI following endovascular procedures. We reviewed the literature comparing outcomes after antithrombotic treatment for patients with CLI. We characterized antithrombotic therapies into three categories: (1) mono-antiplatelet therapy (MAPT) vs. dual antiplatelet therapy (DAPT), (2) MAPT v...
Source: Cardiology and Therapy - October 18, 2019 Category: Cardiology Source Type: research