Idarucizumab for Emergency Reversal of Anticoagulant Effects of Dabigatran: Interim Results of a Japanese Post-Marketing Surveillance Study
ConclusionsThe results of this interim analysis suggest that idarucizumab is safe and effective for the reversal of dabigatran in Japanese patients in a real-world setting, and support the continued use of idarucizumab.Trial RegistrationClinicalTrials.gov identifier, NCT02946931. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - March 9, 2020 Category: Cardiology Source Type: research

Cardiology and Therapy: A Summary of 2019 and Key Areas of Emerging Research in 2020
(Source: Cardiology and Therapy)
Source: Cardiology and Therapy - March 6, 2020 Category: Cardiology Source Type: research

Emergency Department Visits and Subsequent Hospital Admission Trends for Patients with Chest Pain and a History of Coronary Artery Disease
AbstractIntroductionHospitalization is the largest component of health care spending in the United States. Most hospitalized patients first visit the emergency department (ED), where hospitalization decisions are made. Optimal utilization of hospital resources is critical for all stakeholders.MethodsWe performed a population-based, cross-sectional study evaluating ED visits and subsequent inpatient admissions for patients with coronary artery disease (CAD) and chest pain (CP) suggestive of CAD from 2006 to 2013 using the Nationwide Emergency Department Sample database weighted for national estimates. We analyzed trends usi...
Source: Cardiology and Therapy - March 2, 2020 Category: Cardiology Source Type: research

Update on Transcatheter Aortic Valve Replacement
AbstractTranscatheter aortic valve replacement (TAVR) is a minimally invasive approach to treat symptomatic severe aortic stenosis. The patient populations that have been shown to benefit from this procedure continue to grow with time. Techniques and technology in TAVR persistently advance with a continued trend toward improved outcomes for patients. In this review, we highlight the advances in vascular access, TAVR valve design, progress in reducing procedural complications, and emerging evidence in the field. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - February 28, 2020 Category: Cardiology Source Type: research

What Lessons Have We Learned and What Remains to be Clarified for PCSK9 Inhibitors? A Review of FOURIER and ODYSSEY Outcomes Trials
AbstractFor more than half a century, low-density  lipoprotein cholesterol (LDL-C) has been recognized as a major risk factor for incident atherosclerotic cardiovascular disease. The discovery of proprotein convertase subtilisin-kexin type 9 (PCSK9) in 2003, which prevents LDL-C receptor recycling, identified a new target for drug intervention. Re cently, two large-scale randomized clinical outcomes trials involving fully human anti-PCSK9 monoclonal antibodies tested the hypothesis that targeting this pathway would reduce cardiovascular events. Both the FOURIER (Further cardiovascular OUtcomes Research with PCSK9 Inhi...
Source: Cardiology and Therapy - February 5, 2020 Category: Cardiology Source Type: research

Antihypertensive Effectiveness of Perindopril Arginine and Indapamide Single-Pill Combination According to Body Mass Index: Findings from the FORSAGE Study
AbstractIntroductionOverweight and obesity are increasing worldwide and are associated with an increased risk for cardiovascular disease (CVD). The aim of this study was to examine the burden of CVD risk factors among normal weight, overweight, and obese subjects with hypertension, and to evaluate the effectiveness of switching to a single-pill combination (SPC) of perindopril arginine/indapamide for blood pressure (BP) control in overweight and obese subjects treated in routine clinical practice.MethodsFORSAGE was a 3-month, multicenter, observational, open-label study conducted in Russian patients with uncontrolled arter...
Source: Cardiology and Therapy - February 1, 2020 Category: Cardiology Source Type: research

The Beneficial Effects of Cardiac Rehabilitation
AbstractCardiac rehabilitation (CR) is a combined range of measures aimed at providing patients with cardiovascular disease with the optimum psychological and physical conditions so that they themselves can prevent their disease from progressing or potentially reversing its course. The following measures are the three main parts of CR: exercise training, lifestyle modification, and psychological intervention. The course of cardiac rehabilitation generally takes 3 –4 weeks. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - January 29, 2020 Category: Cardiology Source Type: research

Relationship between Invasive and Echocardiographic Transvalvular Gradients after Transcatheter Aortic Valve Replacement
AbstractIntroductionLower transcatheter aortic valve replacement (TAVR) pressure gradients have been reported after implantation of self-expanding valves compared with balloon-expandable valves; however, there is a paucity of data on the relationship between invasively measured transvalvular pressure gradients and Doppler-derived measurements.MethodsFrom September 2013 to September 2018, patients with native aortic valve stenosis who had both intraoperative invasive and postoperative echocardiography transvalvular pressure gradients were included for analysis. We used parametric and nonparametric statistics to compare aort...
Source: Cardiology and Therapy - January 22, 2020 Category: Cardiology Source Type: research

Diagnosis of Amyloidosis: A Survey of Current Awareness and Clinical Challenges Among Cardiologists in Switzerland
ConclusionsSurvey results highlight that cardiologists in Switzerland would benefit from information on the latest advances in ATTR to support them in screening heart failure patients and ensure that patients benefit from treatment advances. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - January 20, 2020 Category: Cardiology Source Type: research

Facing the Challenge of Lowering Blood Pressure and Cholesterol in the Same Patient: Report of a Symposium at the European Society of Hypertension
AbstractA symposium held at the 29th European Meeting on Hypertension and Cardiovascular Protection in Milan, Italy, discussed the potential impact and long-term benefits of early active management of cardiovascular disease (CVD) risk in patients with hypertension, and potential barriers to this strategy. Hypertension often aggregates with other cardiovascular risk factors, exponentially increasing morbidity and mortality. While effective therapies to treat hypertension exist, a substantial number of patients still experience major cardiovascular events. Two major issues account for these disappointing results: interventio...
Source: Cardiology and Therapy - January 13, 2020 Category: Cardiology Source Type: research

Catheter Ablation of Atrial Fibrillation: State of the Art and Future Perspectives
ConclusionsPulmonary vein isolation is the treatment of choice for symptomatic patients with paroxysmal and persistent drug-refractory AF. The reconnection of previously isolated pulmonary veins remains the major cause of AF recurrence. Novel ablation tools, such as balloon technologies or alternative energy sources, might help to overcome this limitation. Patients with non-paroxysmal AF and with AF recurrence might benefit from alternative ablation strategies. However, further studies are warranted to further improve our knowledge of the underlying mechanisms of AF and to obtain long-term clinical outcomes on new ablation...
Source: Cardiology and Therapy - January 2, 2020 Category: Cardiology Source Type: research

Mitraclip Plus Medical Therapy Versus Medical Therapy Alone for Functional Mitral Regurgitation: A Meta-Analysis
ConclusionsMitraClip plus medical therapy improves overall mortality and reduces HF re-hospitalization rates compared to medical therapy alone in patients with FMR. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - December 9, 2019 Category: Cardiology Source Type: research

Effect of Methadone on Cardiac Repolarization in Japanese Cancer Patients: A Longitudinal Study
ConclusionsThe findings suggested that small or modest doses of methadone could exert dose-dependent effects on cardiac repolarization in cancer patients.Trial RegistrationUMIN Clinical Trials Registry, UMIN000034519. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - November 20, 2019 Category: Cardiology Source Type: research

Comparative Outcomes of Transapical Versus Transfemoral Access for Transcatheter Aortic Valve Replacement in Diabetics
AbstractIntroductionThe outcomes of transfemoral (TF) compared with transapical (TA) access for transcatheter aortic valve replacement (TAVR) in diabetics are unknown.MethodsWe queried the NIS database (2011 –2014) to identify diabetics who underwent TAVR. We performed a propensity matching analysis comparing TF-TAVR versus TA-TAVR.ResultsThe analysis included 14.555 diabetics who underwent TAVR. After matching, in-hospital mortality was not different between TF-TAVR and TA-TAVR. (3.5 vs. 4.4%,p = 0.11). TF-TAVR was associated with lower rates of cardiogenic shock (2.7 vs. 4.7%,p = 0.02), ...
Source: Cardiology and Therapy - November 11, 2019 Category: Cardiology Source Type: research

Comparison of Cardiac Repolarization After Transcatheter Aortic Valve Implantation and Surgical Aortic Valve Replacement: A Longitudinal Study
AbstractIntroductionTranscatheter aortic valve implantation (TAVI) has been established as an alternative to surgical aortic valve replacement (SAVR) for high-risk patients. To assess the impact of TAVI on cardiac repolarization, we compared QT dispersion (QTD) and the interval from the peak to the end of the T wave (Tpeak –Tend: TpTe) between the patients who underwent TAVI and those who underwent SAVR and TpTe between the patients who underwent TAVI or SAVR.MethodsThis retrospective study was approved by the ethics committee of Dokkyo Medical University Hospital. The study included 45 patients who underwent TAVI an...
Source: Cardiology and Therapy - November 6, 2019 Category: Cardiology Source Type: research

Complications of Temporary Percutaneous Mechanical Circulatory Support for Cardiogenic Shock: An Appraisal of Contemporary Literature
AbstractCardiogenic shock (CS) is associated with hemodynamic compromise and end-organ hypoperfusion due to a primary cardiac etiology. In addition to vasoactive medications, percutaneous mechanical circulatory support (MCS) devices offer the ability to support the hemodynamics and prevent acute organ failure. Despite the wide array of available MCS devices for CS, there are limited data on the complications from these devices. In this review, we seek to summarize the complications of MCS devices in the contemporary era. Using a systems-based approach, this review covers domains of hematological, neurological, vascular, in...
Source: Cardiology and Therapy - October 23, 2019 Category: Cardiology Source Type: research

A Review of Antithrombotic Treatment in Critical Limb Ischemia After Endovascular Intervention
AbstractEndovascular intervention is often used to treat critical limb ischemia (CLI). Post-intervention treatment with antiplatelet and/or anticoagulant therapy has reduced morbidity and mortality due to cardiovascular complications. The purpose of this review is to shed light on the various pharmacologic treatment protocols for treating CLI following endovascular procedures. We reviewed the literature comparing outcomes after antithrombotic treatment for patients with CLI. We characterized antithrombotic therapies into three categories: (1) mono-antiplatelet therapy (MAPT) vs. dual antiplatelet therapy (DAPT), (2) MAPT v...
Source: Cardiology and Therapy - October 19, 2019 Category: Cardiology Source Type: research

Electrocardiographic Detection of Left Ventricular Hypertrophy; Adding Body Mass Index and Spatial QRS-T Angle: A Cross-Sectional Study
ConclusionsElectrocardiographic detection of LVH improved by adding BMI and SA to a model with conventional electrocardiographic criteria. This approach would require little extra effort and application in clinical practice is feasible. However, results should first be replicated in high-risk populations. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - October 16, 2019 Category: Cardiology Source Type: research

Losartan for Preventing Aortic Root Dilatation in Patients with Marfan Syndrome: A Meta-Analysis of Randomized Trials
ConclusionIn this meta-analysis including seven randomized trials, the use of losartan was associated with a significantly smaller change in aortic root diameter in patients with Marfan syndrome. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - October 13, 2019 Category: Cardiology Source Type: research

A Review of the Role of Bradykinin and Nitric Oxide in the Cardioprotective Action of Angiotensin-Converting Enzyme Inhibitors: Focus on Perindopril
AbstractThe functional integrity of the endothelium is essential for vascular health. In addition to maintaining a delicate balance between vasodilation and vasoconstriction, the endothelium has numerous other complex roles involved in the maintenance of vascular homeostasis. Chronic exposure to cardiovascular risk factors and oxidative stress results in an imbalance in these functions, creating an environment that favors reduced vasodilation and a proinflammatory and prothrombic state. The involvement of endothelial dysfunction in all stages of the cardiovascular continuum makes it an important target for treatment. One o...
Source: Cardiology and Therapy - October 1, 2019 Category: Cardiology Source Type: research

Current Evidence on Oral Antibiotics for Infective Endocarditis: A Narrative Review
AbstractInfective endocarditis (IE) continues to be associated with high morbidity and mortality, even  when treated with optimal antibiotic regimens. The selection of treatment depends on the causative pathogen, its antibiotic susceptibility profile, local and systemic complications and the presence of prosthetic materials or devices. Standard therapy typically involves 4–6 weeks of intravenous (IV) bactericidal therapy. However, there are instances in which IV antibiotic administration may be challenging due to cost, complications of IV access, adverse side-effects of the medication or concerns for misuse...
Source: Cardiology and Therapy - September 18, 2019 Category: Cardiology Source Type: research

Cardiovascular Risk Factors and Secondary Events Among Acute and Chronic Stable Myocardial Infarction Patients: Findings from a Managed Care Database
ConclusionsGreater understanding of differences in the CVD risk profiles and the transition from acute to chronic stable phase may help identify high-risk patients and inform clinical risk stratification and long-term disease management in MI patients.FundingMerck& Co., Inc., Kenilworth, NJ, USA. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - August 20, 2019 Category: Cardiology Source Type: research

Effectiveness and Impact on Adherence of a New Fixed-Dose Combination of Ivabradine and Metoprolol in a Wide Range of Stable Angina Patients in Real-Life Practice
ConclusionsTreatment with metoprolol/ivabradine FDC significantly improved angina symptoms and adherence, with an excellent tolerability profile, in stable angina patient subgroups relevant to real-life clinical practice, regardless of age, CAD duration, CCS class, comorbidities, previous MI, or history of revascularization.Trial registrationISRCTN51906157.FundingThis study was sponsored by Servier Deutschland GmbH. Editorial assistance and the Rapid Service Fee were funded by Servier, France.Plain Language SummaryPlain language summary available for this article. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - August 13, 2019 Category: Cardiology Source Type: research

Estimating the Prevalence of Transthyretin Amyloid Cardiomyopathy in a Large In-Hospital Database in Japan
ConclusionThis retrospective study provides an estimate of the number of patients diagnosed with ATTR-CM in a large in-hospital database in Japan over a period of 9  years. Improving awareness of disease prevalence may improve diagnosis and treatment.FundingPfizer. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - August 2, 2019 Category: Cardiology Source Type: research

Patient-Reported Satisfaction and Study Drug Discontinuation: Post-Hoc Analysis of Findings from ROCKET AF
ConclusionsStudy drug satisfaction did not predict rate of study drug discontinuation. No significant difference was observed between satisfaction with warfarin and rivaroxaban, as expected given the double-blind trial design. Although these results are negative, the importance of PRO data will only increase, and these analyses may inform future studies that explore the relationship between drug-satisfaction PROs, adherence, and clinical outcomes.ClinicalTrials.govNCT00403767.FundingThe ROCKET AF trial was funded by Johnson& Johnson and Bayer. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - August 2, 2019 Category: Cardiology Source Type: research

New American and European Hypertension Guidelines, Reconciling the Differences
AbstractIn November 2017, the American College of Cardiology and the American Heart Association released hypertension guidelines for the first time, replacing the Joint National Committee periodical reports, appearing from 1977 to 2003. In parallel, the European Society of Cardiology and the European Society of Hypertension updated their own recommendations with a new document released in August 2018. While both documents contain similar recommendations concerning several aspects of detection, prevention, and management of hypertension, they differ in some sensitive characteristics, which specifically affect diagnostic and...
Source: Cardiology and Therapy - July 30, 2019 Category: Cardiology Source Type: research

Acute and Long-Term Outcomes of Patients with Impaired Left Ventricular Systolic Function Undergoing Rotational Atherectomy: A Single-Center Observational Retrospective Study
AbstractIntroductionRotational atherectomy (RA) historically was contraindicated in patients with impaired left ventricular (LV) function due to inherent cardio-depressive effects. Contemporary RA practice is less aggressive than traditional RA and no longer withheld from patients with reduced ejection fraction (EF). The aim of this analysis is to explore the outcomes of rotational atherectomy (RA) in patients with reduced left ventricular ejection fraction (LVEF).MethodsPatients undergoing RA (n = 644) were divided into three groups according to LVEF (severely reduced ≤ 35%,n =&thinsp...
Source: Cardiology and Therapy - July 27, 2019 Category: Cardiology Source Type: research

Implications of Left Bundle Branch Block in Takotsubo Cardiomyopathy: Propensity Match Analysis from the National Inpatient Sample
ConclusionsThe incidence of arrhythmia and shock in patients with TTC does not correlate with the extent of myocardium involvement. The presence of LBBB in such cases can help recognize at-risk populations, and with timely intervention, life-threatening complications can be avoided. Despite limitations of the dataset and inability to establish causality, prospective studies with longer follow-up are warranted. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - July 17, 2019 Category: Cardiology Source Type: research

TRimetazidine as an Agent to affeCt clopidogrEl Response: The TRACER Study
ConclusionHigher platelet reactivity was seen in patients on TMZ, suggesting that TMZ attenuated the PD effects of clopidogrel in this study of a predominantly South Asian diabetic subpopulation. Alternative therapies should be considered and further research is warranted.Trial RegistrationClinicalTrials.gov number, NCT03603249. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - July 10, 2019 Category: Cardiology Source Type: research

Insulin Resistance is Associated with Longitudinal Changes of Cardiac Repolarization Heterogeneity in Apparently Healthy Subjects
ConclusionInsulin resistance may be involved in the longitudinal increase of ventricular repolarization heterogeneity in apparently healthy subjects. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - July 4, 2019 Category: Cardiology Source Type: research

Ethnic and Gender Disparities in the Uptake of Transcatheter Aortic Valve Replacement in the United States
We described the temporal trends in the uptake of TAVR procedures among various ethnicities and genders.ResultsOur analysis identified 39,253 records; 20,497 (52.2%) were men and 18,756 (47.8%) were women. Among all TAVRs, 87.2% were Caucasians, 3.9% were African Americans (AA), 3.7% were Hispanics, and 5.2% were of other ethnicities. We found a significant rise in the trend of TAVRs in all groups: in Caucasian men (coefficient  = 0.946,p 
Source: Cardiology and Therapy - June 25, 2019 Category: Cardiology Source Type: research

The Association between Transcatheter Aortic Valve Replacement (TAVR) Approach and New-Onset Bundle Branch Blocks
ConclusionsRelative to transfemoral TAVR, patients undergoing transapical TAVR are at increased risk for new-onset bundle branch block, peri-procedural myocardial infarction, rehospitalization, TAV-in-TAV deployment, and all-cause mortality at 1  year. Interventional cardiologists and cardiothoracic surgeons alike should take these findings into consideration when choosing which approach is most suitable for patients undergoing TAVR for severe aortic stenosis. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - May 23, 2019 Category: Cardiology Source Type: research

Adverse Outcomes Associated with Pre-Existing and New-Onset Atrial Fibrillation in Patients with Acute Coronary Syndrome: A Retrospective Cohort Study
ConclusionsNew-onset AF during ACS was associated with a significantly increased risk of adverse outcomes, especially in the elderly patients. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - April 17, 2019 Category: Cardiology Source Type: research

Development and Psychometric Evaluation of Coronary Artery Disease Treatment Adherence Scale
ConclusionsThe Coronary Artery Disease Treatment Adherence Scale is a valid and reliable tool and can be used in different healthcare settings for the assessment of treatment adherence among patients ’ with coronary artery disease.Trial RegistrationTehran University of Medical Sciences, identifier, 35456. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - April 10, 2019 Category: Cardiology Source Type: research

Effects of Evolocumab on the ApoA1 Remnant Ratio: A Pooled Analysis of Phase 3 Studies
AbstractIntroductionThe apolipoprotein A1 (apoA1) remnant ratio has been identified as an independent cardiovascular (CV) risk factor. Higher apoA1 remnant ratios may predict lower CV risk in some patients. This analysis aimed to evaluate the effects of evolocumab on the change from baseline in the apoA1 remnant ratio compared with placebo.MethodsThis pooled post hoc analysis included 2464 patients with mixed dyslipidemia treated with evolocumab 140  mg every 2 weeks (Q2W) or 420 mg once monthly (QM) in three phase 3 evolocumab trials. The apoA1 remnant ratio was calculated by dividing apoA1 by the differenc...
Source: Cardiology and Therapy - March 9, 2019 Category: Cardiology Source Type: research

Left Ventricular Diastolic Dysfunction and Transcatheter Aortic Valve Replacement Outcomes: A Review
AbstractAortic stenosis (AS) is the most common valvular disease that can lead to increased afterload, left ventricular (LV) remodeling, and myocardial fibrosis. We reviewed the literature addressing the impact of transcatheter aortic valve replacement (TAVR) on LV remodeling and patients ’ outcomes by elimination of AS-related high afterload. TAVR reduces afterload and improves LV remodeling recovery. However, myocardial fibrosis may not completely reverse after the TAVR. The LV diastolic dysfunction (LVDD) induced by AS is an independent predictor of post-TAVR mortality, and mort ality increases with severity of LV...
Source: Cardiology and Therapy - March 7, 2019 Category: Cardiology Source Type: research

Identifying Outcome Measures for Coronary Artery Disease Value-Based Contracting Using the Delphi Method
ConclusionsOur study results verify the utility of a widely used clinical CAD outcome measure, myocardial infarction events, for the purpose of pharmaceutical value-based contracting. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - March 1, 2019 Category: Cardiology Source Type: research

Icosapent Ethyl Effects on Fatty Acid Profiles in Statin-Treated Patients With High Triglycerides: The Randomized, Placebo-controlled ANCHOR Study
AbstractIntroductionFatty acid content in plasma and red blood cells (RBCs) may provide insight into potential physiologic benefits of omega-3 fatty acids. Icosapent ethyl is a pure prescription form of eicosapentaenoic acid (EPA) ethyl ester approved by the US Food and Drug Administration at a dose of 4  g/day as an adjunct to diet to reduce triglyceride levels in adults with severe (≥ 500 mg/dl) hypertriglyceridemia.MethodsThis was a prespecified exploratory subset analysis of the ANCHOR study, which randomized 702 statin-treated patients at increased cardiovascular risk with triglycerides 200 –...
Source: Cardiology and Therapy - February 20, 2019 Category: Cardiology Source Type: research

Effectiveness of Long-acting Trimetazidine in Different Clinical Situations in Patients with Stable Angina Pectoris: Findings from ODA Trial
AbstractIntroductionTrimetazidine (TMZ) has been shown to be efficacious for angina treatment. The TMZ 80-mg formulation allows one-daily (od) dosage, which could improve symptom control and adherence.MethodsThe 3-month, observational, multicenter, prospective ODA (antianginal effectiveness and tolerability of trimetazidine modified release 80 mg Once Daily in stable Angina patients in real-world practice) study assessed TMZ 80  mg od effectiveness in stable angina patients with persistent symptoms despite therapy. Two clinical situations were compared: patients who initiated treatment with TMZ 80 mg od (initiati...
Source: Cardiology and Therapy - February 18, 2019 Category: Cardiology Source Type: research

Dynamic Piston Function of the Mitral Annulus to Assess Early Left Ventricular Diastolic Filling: A Proof of Concept Study
AbstractIntroductionEarly left ventricular (LV) filling has been described as an asymmetric toroidal vortex ring of blood entering the LV upon opening of the mitral valve. This phenomenon is in part responsible for cyclical changes in LV volumes during the cardiac cycle and also contributes to the apical and basal longitudinal displacements of the mitral annulus (MA). Although MA early diastolic (e ’) velocities have been used to assess early LV filling characteristics, accurate distinction between normal aging and pathological diastolic dysfunction (DD) might be challenging at times.MethodsIn this pilot study, echoc...
Source: Cardiology and Therapy - February 16, 2019 Category: Cardiology Source Type: research

Plasma LDL-Cholesterol Level at Admission is Independently Associated with Infarct Size in Patients with ST-Segment Elevation Myocardial Infarction Treated with Primary Percutaneous Coronary Intervention
AbstractIntroductionHypercholesterolemia is a well-known risk factor for developing atherosclerosis and subsequently for the risk of a myocardial infarction (MI). Moreover, it might also be related to the extent of damaged myocardium in the event of a MI. The aim of this study was to evaluate the association of baseline low density lipoprotein-cholesterol (LDL-c) level with infarct size in patients with ST-segment elevation myocardial infarction (STEMI) after primary percutaneously coronary intervention (pPCI).MethodsBaseline blood samples were obtained from all patients admitted between 2004 and 2014 with STEMI who underw...
Source: Cardiology and Therapy - February 13, 2019 Category: Cardiology Source Type: research

Characteristics of Japanese Patients with Nonvalvular Atrial Fibrillation on Anticoagulant Treatment: A Descriptive Analysis of J-dabigatran Surveillance and JAPAF Study
ConclusionsIn Japan, physicians who attempt stroke prevention in patients with atrial fibrillation choose appropriate anticoagulant treatment, taking into consideration the individual patient backgrounds as well as the features of each antithrombotic agent.Trial RegistrationClinicalTrials.gov Identifier, NCT01491178 and University Hospital Medical Information Network (UMIN) Clinical Trial Registry Identifier, UMIN000009644.FundingNippon Boehringer Ingelheim Co., Ltd.Plain Language SummaryPlain language summary available for this article. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - February 11, 2019 Category: Cardiology Source Type: research

Growth Differentiation Factor-15 Levels at Admission Provide Incremental Prognostic Information on All-Cause Long-term Mortality in ST-Segment Elevation Myocardial Infarction Patients Treated with Primary Percutaneous Coronary Intervention
ConclusionGDF-15 levels at admission in STEMI patients are independently associated with 10-year all-cause mortality rates and could improve risk stratification on top of clinical variables and other cardiac biomarkers. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - January 30, 2019 Category: Cardiology Source Type: research

Cardiology and Therapy: A Summary of 2018 and Key Areas of Emerging Research in 2019
(Source: Cardiology and Therapy)
Source: Cardiology and Therapy - January 25, 2019 Category: Cardiology Source Type: research

Treatment of Orthostatic Hypotension Due to Autonomic Dysfunction (Neurogenic Orthostatic Hypotension) in a Patient with Cardiovascular Disease and Parkinson's Disease
ConclusionDroxidopa is approved by the US Food and Drug Administration to treat symptomatic nOH and is not contraindicated in patients with cardiovascular conditions. In this case, treatment with droxidopa improved the patient ’s orthostatic tolerance and, importantly, did not change the patient’s rate-controlled AF or his symptoms of class IV heart failure. Because symptoms associated with nOH can be detrimental to patient safety and mobility, it is critical to screen for and treat patients with nOH, even when there are cardiovascular comorbidities.FundingEditorial support and article processing charges were f...
Source: Cardiology and Therapy - January 9, 2019 Category: Cardiology Source Type: research

Pharmacological Options in Atherosclerosis: A Review of the Existing Evidence
AbstractCoronary heart disease (CHD) is the leading cause of mortality worldwide and high low-density lipoprotein (LDL) cholesterol levels have been shown to be key in the pathogenesis of this condition. Lipid control has therefore been the subject of decades of research and has led to many large and robust randomized controlled trials, as well as the highest grossing drug of all time —Lipitor (atorvastatin). Statin therapy has long been indicated for secondary and more recently primary prevention. However, despite the large-scale use of statins, CHD prevalence remains high, and some patients do not respond to statin...
Source: Cardiology and Therapy - December 12, 2018 Category: Cardiology Source Type: research

Drug-Coated Balloon-Only Percutaneous Coronary Intervention for the Treatment of De Novo Coronary Artery Disease: A Systematic Review
In this study, we performed a systematic review of stentless DCB-only angioplasty in de novo coronary artery disease. We identified 41 studies examining the effects of DCB-only PCI in a variety of clinical scenarios including small vessels, bifurcations, calcified lesions, and primary PCI. DCB-only PCI appears to be associated with comparable clinical outcomes to DESs and superior angiographic outcomes to plain-old balloon angioplasty. Although current data are promising, there is still a need for further long-term randomized control trial data comparing a DCB-only approach specifically against a second- or third-generatio...
Source: Cardiology and Therapy - October 27, 2018 Category: Cardiology Source Type: research

27-Year-Old Man with a Positive Troponin: A Case Report
AbstractIn this case report, we describe a young athletic male with a family history of early sudden cardiac death who presented with atypical chest pain and was found to have a positive serum troponin. Although his symptoms resolved without intervention, workup revealed hypertension, hyperlipidemia, mild left ventricular hypertrophy, non-obstructive coronary artery disease, and the presence of serum heterophile antibodies. Ultimately, it was concluded that his rigorous exercise regimen as well as the presence of heterophile antibodies may have contributed to his positive serum troponin. This case serves as a reminder of t...
Source: Cardiology and Therapy - October 26, 2018 Category: Cardiology Source Type: research

Effect of Erythropoietin Administration on Myocardial Viability and Coronary Microvascular Dysfunction in Anterior Acute Myocardial Infarction: Randomized Controlled Trial in the Japanese Population
ConclusionsA single medium dose of EPO could have a favorable effect on CMD and LA remodeling in the chronic phase of anterior AMI.Trial RegistrationThe institutional ethics committee of Wakayama Medical University, identifier, 1125. (Source: Cardiology and Therapy)
Source: Cardiology and Therapy - October 23, 2018 Category: Cardiology Source Type: research

Effects of Neostigmine and Sugammadex for Reversal of Neuromuscular Blockade on QT Dispersion Under Propofol Anesthesia: A Randomized Controlled Trial
AbstractIntroductionReversal of non-depolarizing neuromuscular blocking agent neostigmine is associated with QT prolongation under general anesthesia. To clarify the effects of neostigmine and sugammadex on hemodynamic status, the QT interval and QT dispersion after reversal of neuromuscular blockade were evaluated with a 12-lead electrocardiogram. To exclude QT prolongation due to sevoflurane, the present study was performed under propofol anesthesia.MethodsAfter receiving approval from the ethics committee of Dokkyo Medical University Hospital, 40 patients with American Society of Anesthesiologists physical status I or I...
Source: Cardiology and Therapy - September 14, 2018 Category: Cardiology Source Type: research