Frequency of Transition From Stage A to Stage B Heart Failure After Initiating Potentially Cardiotoxic Chemotherapy
This study sought to determine the prevalence of American Heart Association/American College of Cardiology Foundation (AHA/ACCF) heart failure (HF) Stages after potentially cardiotoxic chemotherapy was initiated.BackgroundFor individuals receiving potentially cardiotoxic chemotherapy, the frequency of transitioning from Stage A to more advanced HF Stages is not well described.MethodsIn 143 Stage A HF patients with breast cancer, lymphoma and leukemia, renal cell carcinoma, or sarcoma prior to and then at 3, 6, and 12 to 24 months after potentially cardiotoxic chemotherapy was initiated, we obtained blinded cardiac mag...
Source: JACC: Heart Failure - November 8, 2018 Category: Cardiology Source Type: research

Initiation, Continuation, Switching, and Withdrawal of Heart Failure Medical Therapies During Hospitalization
Publication date: Available online 7 November 2018Source: JACC: Heart FailureAuthor(s): Aditi A. Bhagat, Stephen J. Greene, Muthiah Vaduganathan, Gregg C. Fonarow, Javed ButlerAbstractPatients with worsening heart failure with reduced ejection fraction (HFrEF) spend a large proportion of time in the hospital and other health care facilities. The benefits of guideline-directed medical therapy (GDMT) in the outpatient setting have been shown in large randomized controlled trials. However, the decision to initiate, continue, switch, or withdraw HFrEF medications in the inpatient setting is often based on multiple factors and ...
Source: JACC: Heart Failure - November 8, 2018 Category: Cardiology Source Type: research

“To B or Not to B”…That Is the Question: Whether We Can Identify Those at Risk for Cardiac Dysfunction During Cancer Therapy∗
Publication date: Available online 7 November 2018Source: JACC: Heart FailureAuthor(s): Daniel J. LenihanCorresponding Author (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - November 8, 2018 Category: Cardiology Source Type: research

History of Atrial Fibrillation and Trajectory of Decongestion in Acute Heart Failure
This study sought to characterize the course of decongestion among patients hospitalized for acute heart failure (AHF) by history of atrial fibrillation (AF) and/or atrial flutter (AFL).BackgroundAF/AFL and chronic heart failure (HF) commonly coexist. Little is known regarding impact of AF/AFL on relief of congestion among patients who develop AHF.MethodsWe pooled patients from 3 randomized trials of AHF conducted within the Heart Failure Network, the DOSE (Diuretic Optimization Strategies) trial, the ROSE (Renal Optimization Strategies) trial, and the CARRESS-HF (Cardiorenal Rescue Study in Acute Decompensated Heart Failu...
Source: JACC: Heart Failure - November 6, 2018 Category: Cardiology Source Type: research

Obesity Is a Culprit in Heart Failure: Do NOT Miss HFpEF, Especially in Obese Women
Publication date: November 2018Source: JACC: Heart Failure, Volume 6, Issue 11Author(s): Atsushi Tanaka, Koichi Node (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - October 30, 2018 Category: Cardiology Source Type: research

Safety of Alpha-Adrenergic Receptor Antagonists in Heart Failure
This study evaluated whether alpha-blocker (AB) use following an admission for heart failure (HF) was associated with an increased risk of HF readmission or death.BackgroundABs, found to increase the risk of HF in the ALLHAT (Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial) trial, are commonly used for prostatic hypertrophy, including in those with or at risk for HF.MethodsThis propensity score–matched cohort study included patients discharged from a Veterans Affairs hospital between January 2002 and September 2015 with a primary diagnosis of HF and ascertained AB use at discharge. Cox pro...
Source: JACC: Heart Failure - October 30, 2018 Category: Cardiology Source Type: research

Reply: The Role of the Clinical Examination in Patients With Heart Failure
Publication date: November 2018Source: JACC: Heart Failure, Volume 6, Issue 11Author(s): Jennifer T. Thibodeau, Mark H. Drazner (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - October 30, 2018 Category: Cardiology Source Type: research

Can Blood Volume Analysis–Guided Acute Heart Failure Therapy Improve Clinical Outcomes?∗
Publication date: November 2018Source: JACC: Heart Failure, Volume 6, Issue 11Author(s): W.H. Wilson Tang, Kartik S. Telukuntla, Kenneth A. MayugaCorresponding Author (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - October 30, 2018 Category: Cardiology Source Type: research

Aortic Insufficiency During Contemporary Left Ventricular Assist Device Support: Analysis of the INTERMACS Registry
ConclusionsDevelopment of moderate to severe AI has a negative impact on hemodynamics, hospitalizations, and survival on CF-LVAD support. Pre- and post-implantation management strategies should be developed to prevent and treat this complication.Graphical abstract (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - October 30, 2018 Category: Cardiology Source Type: research

Is it Time to Get More Aggressive With Aortic Valve Insufficiency During LVAD Implantation?∗
Publication date: November 2018Source: JACC: Heart Failure, Volume 6, Issue 11Author(s): Jacob N. Schroder, Carmelo A. MilanoCorresponding Author (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - October 30, 2018 Category: Cardiology Source Type: research

Everybody Has a Story, and I Am Lucky!
Publication date: November 2018Source: JACC: Heart Failure, Volume 6, Issue 11Author(s): Cindy Tenner (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - October 30, 2018 Category: Cardiology Source Type: research

COAPTing Heart Failure Physicians, Interventional Cardiologists, and CardioThoracic Surgeons: A New Opportunity for Patients
Publication date: November 2018Source: JACC: Heart Failure, Volume 6, Issue 11Author(s): Christopher M. O’Connor (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - October 30, 2018 Category: Cardiology Source Type: research

The Role of Bedside Ultrasound in Patients With Heart Failure
Publication date: November 2018Source: JACC: Heart Failure, Volume 6, Issue 11Author(s): Paul Wallace, Richard L. Weiss (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - October 30, 2018 Category: Cardiology Source Type: research

Diagnosing Heart Failure by the Valsalva Maneuver: Isn't it Finally Time?
Publication date: November 2018Source: JACC: Heart Failure, Volume 6, Issue 11Author(s): Michael J. Zema (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - October 30, 2018 Category: Cardiology Source Type: research

The Role of the Clinical Examination in Patients With Heart Failure: E-Z CVP
Publication date: November 2018Source: JACC: Heart Failure, Volume 6, Issue 11Author(s): Donald M. Rocklin (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - October 30, 2018 Category: Cardiology Source Type: research

Caregivers of Patients Considering a Destination Therapy Left Ventricular Assist Device and a Shared Decision-Making Intervention: The DECIDE-LVAD Trial
ConclusionsAn SDM intervention improved concordance between caregiver values and treatment choice for their loved ones but did not significantly impact knowledge. Caregivers found the DAs less acceptable than more biased educational materials and exposure to DAs led to higher conflict initially. These findings highlight the complexity of SDM involving caregivers of patients with chronic illness. (PCORI-1310-06998 Trial of a Decision Support Intervention for Patients and Caregivers Offered Destination Therapy Heart Assist Device [DECIDE-LVAD]; NCT02344576)Graphical abstract (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - October 11, 2018 Category: Cardiology Source Type: research

Living Unhappily on Left Ventricular Assist Device Support: The Impetus for Shared Decision Making∗
Publication date: Available online 10 October 2018Source: JACC: Heart FailureAuthor(s): Jennifer Cowger (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - October 11, 2018 Category: Cardiology Source Type: research

Are Alpha-Adrenergic Receptor Antagonists Beneficial to Prevent Heart Failure?: Alpha-Adrenergic Receptor Antagonists Revisited∗
Publication date: Available online 10 October 2018Source: JACC: Heart FailureAuthor(s): Seung Yong Shin, Gregory Y.H. LipCorresponding Author (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - October 11, 2018 Category: Cardiology Source Type: research

Forgotten No More: A Focused Update on the Right Ventricle in Cardiovascular Disease
Publication date: Available online 10 October 2018Source: JACC: Heart FailureAuthor(s): Myriam Amsallem, Olaf Mercier, Yukari Kobayashi, Kegan Moneghetti, Francois HaddadAbstractIn the last decade, there has been renewed interest in the study of the right ventricle. It is now well established that right ventricular function is a strong predictor of mortality, not only in heart failure but also in pulmonary hypertension, congenital heart disease, and cardiothoracic surgery. The right ventricle is part of a cardiopulmonary unit with connections to the pulmonary circulation, venous return, atria, and left ventricle. In this c...
Source: JACC: Heart Failure - October 11, 2018 Category: Cardiology Source Type: research

Short- and Long-Term Prognostic Relevance of Cardiogenic Shock in Takotsubo Syndrome: Results From the RETAKO Registry
ConclusionsCS is not uncommon and is associated with worse short- and long-term prognosis in TTS. CS complicating TTS may constitute a marker of underlying disease severity and could identify a masked heart failure phenotype with increased vulnerability to catecholamine-mediated myocardial stunning.Graphical abstract (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - October 11, 2018 Category: Cardiology Source Type: research

Adiposity and Incident Heart Failure and its Subtypes: MESA (Multi-Ethnic Study of Atherosclerosis)
ConclusionsIn a multiethnic cohort free of cardiovascular disease, CT-measured VAT was independently associated with incident hospitalized HFpEF but not HFrEF. Measuring visceral fat at the time of CT imaging for other indications may offer additional prognostication of HF risk. (Multi-Ethnic Study of Atherosclerosis [MESA]; NCT00005487) (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - October 11, 2018 Category: Cardiology Source Type: research

Pivotal Role of Excess Intra-Abdominal Adipose in the Pathogenesis of Metabolic/Obese HFpEF∗
Publication date: Available online 10 October 2018Source: JACC: Heart FailureAuthor(s): Dalane W. Kitzman, Barbara J. NicklasCorresponding Author (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - October 11, 2018 Category: Cardiology Source Type: research

Can Blood Volume Analysis-Guided Acute Heart Failure Therapy Improve Clinical Outcomes?∗
Publication date: Available online 10 October 2018Source: JACC: Heart FailureAuthor(s): W.H. Wilson Tang, Kartik S. Telukuntla, Kenneth A. MayugaCorresponding Author (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - October 11, 2018 Category: Cardiology Source Type: research

Cardiogenic Shock Complicating Takotsubo Events∗
Publication date: Available online 10 October 2018Source: JACC: Heart FailureAuthor(s): Scott W. SharkeyCorresponding Author (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - October 11, 2018 Category: Cardiology Source Type: research

Safety of Alpha Adrenergic Receptor Antagonists in Heart Failure
This study evaluated whether alpha-blocker (AB) use following an admission for heart failure (HF) was associated with an increased risk of HF readmission or death.BackgroundABs, found to increase the risk of HF in the ALLHAT (Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial) trial, are commonly used for prostatic hypertrophy, including in those with or at risk for HF.MethodsThis propensity score–matched cohort study included patients discharged from a Veterans Affairs hospital between January 2002 and September 2015 with a primary diagnosis of HF and ascertained AB use at discharge. Cox pro...
Source: JACC: Heart Failure - October 11, 2018 Category: Cardiology Source Type: research

Heart Failure Outcomes With Volume-Guided Management
This study performed a retrospective outcome analyses of a large cohort of mixed ejection fraction patients admitted for acute heart failure (HF), whose inpatient care was guided by individual quantitative blood volume analysis (BVA) results.BackgroundDecongestion strategies in patients hospitalized for HF are based on clinical assessment of volume and have not integrated a quantitative intravascular volume metric.MethodsPropensity score control matching analysis was performed in 245 consecutive HF admissions to a community hospital (September 2007 to April 2014; 78 ± 10 years of age; 50% with HF with reduced e...
Source: JACC: Heart Failure - October 11, 2018 Category: Cardiology Source Type: research

What Is the Ideal Blood Pressure Goal for Heart Failure Patients?
Publication date: October 2018Source: JACC: Heart Failure, Volume 6, Issue 10Author(s): Mostafa Ghanim, Maxwell Eyram Afari, Lana Tsao (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - October 4, 2018 Category: Cardiology Source Type: research

Reply: Cognitive Deficit in Heart Failure Patients
Publication date: October 2018Source: JACC: Heart Failure, Volume 6, Issue 10Author(s): Anna Frey, Stefan Störk, Guido Stoll (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - October 4, 2018 Category: Cardiology Source Type: research

Heart Failure From a Caregiver’s Point of View
Publication date: October 2018Source: JACC: Heart Failure, Volume 6, Issue 10Author(s): Amy Lingenfelter (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - October 4, 2018 Category: Cardiology Source Type: research

Depression in Heart Failure: Beyond a SADHART
Publication date: October 2018Source: JACC: Heart Failure, Volume 6, Issue 10Author(s): Christopher M. O'Connor (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - October 4, 2018 Category: Cardiology Source Type: research

Venoarterial Extracorporeal Membrane Oxygenation in Cardiogenic Shock
Publication date: October 2018Source: JACC: Heart Failure, Volume 6, Issue 10Author(s): Prashant Rao, Richard Smith, Zain Khalpey (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - October 4, 2018 Category: Cardiology Source Type: research

Comparison of Prognostic Scores in Chronic Heart Failure
Publication date: October 2018Source: JACC: Heart Failure, Volume 6, Issue 10Author(s): Pedro Freitas, António M. Ferreira, Carlos Aguiar (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - October 4, 2018 Category: Cardiology Source Type: research

Cognitive Deficit in Heart Failure Patients
Publication date: October 2018Source: JACC: Heart Failure, Volume 6, Issue 10Author(s): Ibrahim El-Battrawy, Martin Borggrefe, Ibrahim Akin (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - October 4, 2018 Category: Cardiology Source Type: research

Reply: What Is the Ideal Blood Pressure Goal for Heart Failure Patients?
Publication date: October 2018Source: JACC: Heart Failure, Volume 6, Issue 10Author(s): Franz H. Messerli, Stefano F. Rimoldi, Sripal Bangalore (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - October 4, 2018 Category: Cardiology Source Type: research

Comparison of New Glucose-Lowering Drugs on Risk of Heart Failure in Type 2 Diabetes: A Network Meta-Analysis
ConclusionsCurrent evidence suggests that SGLT-2 inhibitors are more effective than either GLP-1 agonists or DPP-4 inhibitors for reducing the risk of hospitalization for HF in type 2 diabetes mellitus.Graphical abstract (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - September 6, 2018 Category: Cardiology Source Type: research

Physical Activity and Incidence of Heart Failure in Postmenopausal Women
This study prospectively examined physical activity levels and the incidence of heart failure (HF) in 137,303 women, ages 50 to 79 years, and examined a subset of 35,272 women who, it was determined, had HF with preserved ejection fraction (HFpEF) and HF with reduced EF (HFrEF).BackgroundThe role of physical activity in HF risk among older women is unclear, particularly for incidence of HFpEF or HFrEF.MethodsWomen were free of HF and reported ability to walk at least 1 block without assistance at baseline. Recreational physical activity was self-reported. The study documented 2,523 cases of total HF, and 451 and 734 cases ...
Source: JACC: Heart Failure - September 6, 2018 Category: Cardiology Source Type: research

Preventing Heart Failure in Diabetes: Glycemic Targets or Class Effect?∗
Publication date: Available online 5 September 2018Source: JACC: Heart FailureAuthor(s): Adam D. DeVore, Jennifer B. GreenCorresponding Author (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - September 6, 2018 Category: Cardiology Source Type: research

Walking Away From Heart Failure∗
Publication date: Available online 5 September 2018Source: JACC: Heart FailureAuthor(s): Mariell Jessup, Nosheen RezaCorresponding Author (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - September 6, 2018 Category: Cardiology Source Type: research

Reply: The Barcelona Bio-HF Calculator: A Contemporary Web-Based Heart Failure Risk Score
Publication date: September 2018Source: JACC: Heart Failure, Volume 6, Issue 9Author(s): Marco Canepa, Luigi Tavazzi, Aldo P. Maggioni, ESC HF Long Term Registry Investigators (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - August 28, 2018 Category: Cardiology Source Type: research

The Barcelona Bio-HF Calculator: A Contemporary Web-Based Heart Failure Risk Score
Publication date: September 2018Source: JACC: Heart Failure, Volume 6, Issue 9Author(s): Antoni Bayés-Genís, Josep Lupón (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - August 28, 2018 Category: Cardiology Source Type: research

Discussing Prognosis in Heart Failure: A Questionnaire-Based Study of the Patient’s View
Publication date: September 2018Source: JACC: Heart Failure, Volume 6, Issue 9Author(s): Prithwish Banerjee, Catherine Watson, Danish Ali (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - August 28, 2018 Category: Cardiology Source Type: research

Politically Correct Heart Failure Research in America to Avoid Geographic Variation
Publication date: September 2018Source: JACC: Heart Failure, Volume 6, Issue 9Author(s): Christopher M. O’Connor (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - August 28, 2018 Category: Cardiology Source Type: research

Atrial Fibrillation in Hypertrophic Cardiomyopathy
Publication date: September 2018Source: JACC: Heart Failure, Volume 6, Issue 9Author(s): Ibrahim El-Battrawy, Martin Borggrefe, Ibrahim Akin (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - August 28, 2018 Category: Cardiology Source Type: research

Reply: Atrial Fibrillation in Hypertrophic Cardiomyopathy
Publication date: September 2018Source: JACC: Heart Failure, Volume 6, Issue 9Author(s): Martin S. Maron, James E. Udelson, Ethan J. Rowin, Barry J. Maron (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - August 28, 2018 Category: Cardiology Source Type: research

Correction
Publication date: September 2018Source: JACC: Heart Failure, Volume 6, Issue 9Author(s): (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - August 28, 2018 Category: Cardiology Source Type: research

Vaccination Trends in Patients With Heart Failure: Insights From Get With The Guidelines–Heart Failure
This study sought to evaluate and contribute to the limited data on U.S. hospital practice patterns with respect to respiratory vaccination in patients hospitalized with heart failure (HF).BackgroundRespiratory infection is a major driver of morbidity in patients with HF, and many influenza and pneumococcal infections may be prevented by vaccination.MethodsWe evaluated patients hospitalized at centers participating in the Get With The Guidelines–HF (GWTG-HF) registry from October 2012 to March 2017. The proportion of patients receiving vaccination was described for influenza and pneumococcal vaccination, respectively...
Source: JACC: Heart Failure - August 9, 2018 Category: Cardiology Source Type: research

Long-Chain Omega-3 Fatty Acid Supplements in Depressed Heart Failure Patients: Results of the OCEAN Trial
ConclusionsOmega-3 supplementation resulted in significant increases in omega-3 levels in red blood cell counts, corresponding to a particular compound of omega-3. Changes in cognitive depressive symptoms and social function were in favor of the omega-3 supplementation. Further studies with larger sample sizes are necessary to confirm the benefits of omega-3 supplementation on modifying psychosocial factors for patients with CHF. (Omega-3 Supplementation for Co-Morbid Depression and Heart Failure Treatment [OCEAN]; NCT02057406)Graphical abstract (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - August 9, 2018 Category: Cardiology Source Type: research

Predictors of Hospice Enrollment for Patients With Advanced Heart Failure and Effects on Health Care Use
This study sought to: 1) identify the predictors of hospice enrollment for patients with heart failure (HF); and 2) determine the impact of hospice enrollment on health care use.BackgroundPatients with HF rarely enroll in hospice. Little is known about how hospice affects this group’s health care use.MethodsUsing a propensity score–matched sample of Medicare decedents with ≥2 HF discharges within 6 months, an Outcome and Assessment Information Set (OASIS) assessment, and subsequent death, we used Medicare administrative, claims, and patient assessment data to compare hospitalizations, intensive care unit sta...
Source: JACC: Heart Failure - August 9, 2018 Category: Cardiology Source Type: research

Antihyperglycemic Therapies to Treat Patients With Heart Failure and Diabetes Mellitus
Publication date: Available online 8 August 2018Source: JACC: Heart FailureAuthor(s): Abhinav Sharma, Lauren B. Cooper, Mona Fiuzat, Robert J. Mentz, João Pedro Ferreira, Javed Butler, David Fitchett, Alan Charles Moses, Christopher O’Connor, Faiez ZannadAbstractThere is increasing recognition of the relationship between diabetes and heart failure (HF). Comorbid diabetes is associated with worse outcomes in patients with HF, and death from HF forms a large burden of mortality among patients with diabetes and atherosclerotic cardiovascular disease. However, there is evidence of harm relating to the risk of HF o...
Source: JACC: Heart Failure - August 9, 2018 Category: Cardiology Source Type: research

INTERMACS Profiles and Outcomes Among Non–Inotrope-Dependent Outpatients With Heart Failure and Reduced Ejection Fraction
ConclusionsINTERMACS profiles strongly predict subsequent mortality and hospitalization burden in non–inotrope-dependent outpatients with HFrEF. These simple profiles could therefore facilitate and promote advanced HF awareness among clinicians and planning for advanced HF therapies.Graphical abstract (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - August 9, 2018 Category: Cardiology Source Type: research