Instructions For Authors
Publication date: May 2021Source: JACC: Heart Failure, Volume 9, Issue 5Author(s): (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - April 28, 2021 Category: Cardiology Source Type: research

The Vexing Problem of HFpEF Therapeutics: Inching Toward Success∗
Publication date: May 2021Source: JACC: Heart Failure, Volume 9, Issue 5Author(s): Sheldon E. Litwin, Michael R. Zile (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - April 28, 2021 Category: Cardiology Source Type: research

Burden of Heart Failure Signs and Symptoms, Prognosis, and Response to Therapy: The PARAGON-HF Trial
Publication date: May 2021Source: JACC: Heart Failure, Volume 9, Issue 5Author(s): Karola Jering, Brian Claggett, Margaret M. Redfield, Sanjiv J. Shah, Inder S. Anand, Felipe Martinez, Shalini V. Sabarwal, Petar M. Seferović, Jose F. Kerr Saraiva, Tzvetana Katova, Marty P. Lefkowitz, Marc A. Pfeffer, John J.V. McMurray, Scott D. Solomon (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - April 28, 2021 Category: Cardiology Source Type: research

Insights From the History and Physical Examination in HFpEF or HFrEF: Similarities and Differences∗
Publication date: May 2021Source: JACC: Heart Failure, Volume 9, Issue 5Author(s): Mark H. Drazner (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - April 28, 2021 Category: Cardiology Source Type: research

Promoting Diversity in Clinical Trial Leadership: A Call to Action
Publication date: May 2021Source: JACC: Heart Failure, Volume 9, Issue 5Author(s): JoAnn Lindenfeld, Mona Fiuzat, Christopher O’Connor (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - April 28, 2021 Category: Cardiology Source Type: research

Reply: Optimal Positioning of Novel Heart Failure Pharmacotherapies: The Case of Vericiguat
Publication date: May 2021Source: JACC: Heart Failure, Volume 9, Issue 5Author(s): Paul W. Armstrong, Justin A. Ezekowitz (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - April 28, 2021 Category: Cardiology Source Type: research

Bio-Profiling of Transthyretin Amyloid Cardiomyopathy
Publication date: May 2021Source: JACC: Heart Failure, Volume 9, Issue 5Author(s): Muddassir Mehmood (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - April 28, 2021 Category: Cardiology Source Type: research

Reply: Bio-Profiling of Transthyretin Amyloid Cardiomyopathy
Publication date: May 2021Source: JACC: Heart Failure, Volume 9, Issue 5Author(s): Claudio Rapezzi, Marla B. Sultan, Mathew S. Maurer (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - April 28, 2021 Category: Cardiology Source Type: research

Mitral Regurgitation in Heart Failure: Prognostic Significance and Impact on Evaluation of Left Ventricular Function
Publication date: May 2021Source: JACC: Heart Failure, Volume 9, Issue 5Author(s): Michael Dandel, Roland Hetzer (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - April 28, 2021 Category: Cardiology Source Type: research

Reply: Mitral Regurgitation in Heart Failure: Prognostic Significance and Impact on Evaluation of Left Ventricular Function
Publication date: May 2021Source: JACC: Heart Failure, Volume 9, Issue 5Author(s): Sameer Arora, John P. Vavalle (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - April 28, 2021 Category: Cardiology Source Type: research

Neprilysin and Corin in HF: Does Combining 2 Biomarkers Double Our Insights?
Publication date: May 2021Source: JACC: Heart Failure, Volume 9, Issue 5Author(s): Inna P. Gladysheva, Ryan D. Sullivan, Guy L. Reed (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - April 28, 2021 Category: Cardiology Source Type: research

Soluble Neprilysin, Corin Concentrations, and Clinical Outcome in Chronic Heart Failure: The miRNAs Role
Publication date: May 2021Source: JACC: Heart Failure, Volume 9, Issue 5Author(s): Salvatore Patanè (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - April 28, 2021 Category: Cardiology Source Type: research

Reply: Neprilysin and Corin in HF: Does Combining 2 Biomarkers Double Our Insights?
Publication date: May 2021Source: JACC: Heart Failure, Volume 9, Issue 5Author(s): D.H. Frank Gommans, Elena Revuelta-Lopez, Antoni Bayés-Genis, Roland R.J. van Kimmenade (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - April 28, 2021 Category: Cardiology Source Type: research

Levosimendan Improves Hemodynamics and Exercise Tolerance in PH-HFpEF: Results of the Randomized Placebo-Controlled HELP Trial
Publication date: Available online 7 April 2021Source: JACC: Heart FailureAuthor(s): Daniel Burkhoff, Barry A. Borlaug, Sanjiv J. Shah, Ronald Zolty, Ryan J. Tedford, Thenappan Thenappan, Roham T. Zamanian, Jeremy A. Mazurek, Jonathan D. Rich, Marc A. Simon, Eugene S. Chung, Farhan Raza, David T. Majure, Gregory D. Lewis, Ioana R. Preston, Stuart Rich (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - April 8, 2021 Category: Cardiology Source Type: research

Worsening Heart Failure Events in HFpEF: Underlying Biology Not Treatment Location∗
Publication date: Available online 7 April 2021Source: JACC: Heart FailureAuthor(s): Robert J. Mentz, Vishal N. Rao (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - April 8, 2021 Category: Cardiology Source Type: research

Worsening Heart Failure Episodes Outside a Hospital Setting in Heart Failure with Preserved Ejection Fraction: The PARAGON-HF Trial
Publication date: Available online 7 April 2021Source: JACC: Heart FailureAuthor(s): Muthiah Vaduganathan, Jonathan W. Cunningham, Brian L. Claggett, Finnian Mc Causland, Ebrahim Barkoudah, Peter Finn, Faiez Zannad, Marc A. Pfeffer, Adel R. Rizkala, Shalini Sabarwal, John J.V. McMurray, Scott Solomon, Akshay S. Desai (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - April 8, 2021 Category: Cardiology Source Type: research

Global Differences in Burden and Treatment of Ischemic Heart Disease in Acute Heart Failure: REPORT-HF
Publication date: Available online 7 April 2021Source: JACC: Heart FailureAuthor(s): Jasper Tromp, Wouter Ouwerkerk, John G.F. Cleland, Christiane E. Angermann, Ulf Dahlstrom, Katherine Tiew-Hwa Teng, Sahiddah Bamadhaj, Georg Ertl, Mahmoud Hassanein, Sergio V. Perrone, Mathieu Ghadanfar, Anja Schweizer, Achim Obergfell, Gerasimos Filippatos, Sean P. Collins, Carolyn S.P. Lam, Kenneth Dickstein (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - April 8, 2021 Category: Cardiology Source Type: research

Left Ventricular Assist Devices Versus Heart Transplantation for End Stage Heart Failure is a Misleading Equivalency∗
Publication date: April 2021Source: JACC: Heart Failure, Volume 9, Issue 4Author(s): Clancy W. Mullan, Sounok Sen, Tariq Ahmad (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - March 30, 2021 Category: Cardiology Source Type: research

Everolimus for the Prevention of Calcineurin-Inhibitor-Induced Left Ventricular Hypertrophy After Heart Transplantation (RADTAC Study)
Publication date: April 2021Source: JACC: Heart Failure, Volume 9, Issue 4Author(s): Chris Anthony, Muhammad Imran, Jim Pouliopoulos, Sam Emmanuel, James W. Iliff, Kirsten J. Moffat, Joanne Ross, Robert M. Graham, Eugene Kotlyar, Kavitha Muthiah, Anne M. Keogh, Christopher S. Hayward, Peter Macdonald, Andrew Jabbour (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - March 30, 2021 Category: Cardiology Source Type: research

Reverse Remodeling the Transplanted Heart by Remodeling Immunosuppression?∗
Publication date: April 2021Source: JACC: Heart Failure, Volume 9, Issue 4Author(s): Amrut V. Ambardekar, David S. Raymer (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - March 30, 2021 Category: Cardiology Source Type: research

Heart Failure Leadership, Culture, and Governance: Lessons Learned From Tom Brady
Publication date: April 2021Source: JACC: Heart Failure, Volume 9, Issue 4Author(s): Christopher M. O’Connor (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - March 30, 2021 Category: Cardiology Source Type: research

Transitioning HFrEF Patients on ACE Inhibitors to Modern Medical Therapy: What Is the Next Step?
Publication date: April 2021Source: JACC: Heart Failure, Volume 9, Issue 4Author(s): Nishi H. Patel, Amarinder S. Bindra (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - March 30, 2021 Category: Cardiology Source Type: research

Improving Heart Failure Therapeutics: Thinking Outside the Pillbox
Publication date: April 2021Source: JACC: Heart Failure, Volume 9, Issue 4Author(s): Muddassir Mehmood (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - March 30, 2021 Category: Cardiology Source Type: research

Reply: Improving Heart Failure Therapeutics: Thinking Outside the Pillbox?
Publication date: April 2021Source: JACC: Heart Failure, Volume 9, Issue 4Author(s): Ankeet S. Bhatt, Mona Fiuzat, JoAnn Lindenfeld, Christopher M. O’Connor, Javed Butler (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - March 30, 2021 Category: Cardiology Source Type: research

Mitral Regurgitation in Acute Decompensated Heart Failure
Publication date: April 2021Source: JACC: Heart Failure, Volume 9, Issue 4Author(s): Muddassir Mehmood (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - March 30, 2021 Category: Cardiology Source Type: research

Reply: Mitral Regurgitation in Acute Decompensated Heart Failure
Publication date: April 2021Source: JACC: Heart Failure, Volume 9, Issue 4Author(s): Sameer Arora, John P. Vavalle (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - March 30, 2021 Category: Cardiology Source Type: research

Pulmonary Artery Catheter in Cardiogenic Shock: Will the Benefits Finally Outweigh the Costs and Complications?
Publication date: April 2021Source: JACC: Heart Failure, Volume 9, Issue 4Author(s): Federico Fortuni, Guido Tavazzi, Gaetano M. De Ferrari (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - March 30, 2021 Category: Cardiology Source Type: research

Reply: Pulmonary Artery Catheter in Cardiogenic Shock: Will the Benefits Finally Outweigh the Costs and Complications?
Publication date: April 2021Source: JACC: Heart Failure, Volume 9, Issue 4Author(s): A. Reshad Garan, Manreet Kanwar, Jaime Hernandez-Montfort, Claudius Mahr, Shashank S. Sinha, Daniel Burkhoff, Navin K. Kapur (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - March 30, 2021 Category: Cardiology Source Type: research

Changes in Use of Left Ventricular Assist Devices as Bridge to Transplantation With New Heart Allocation Policy
Publication date: Available online 10 March 2021Source: JACC: Heart FailureAuthor(s): Clancy W. Mullan, Fouad Chouairi, Sounok Sen, Makoto Mori, Katherine A.A. Clark, Samuel W. Reinhardt, P. Elliott Miller, Michael A. Fuery, Daniel Jacoby, Christopher Maulion, Muhammad Anwer, Arnar Geirsson, David Mulligan, Richard Formica, Joseph G. Rogers, Nihar R. Desai, Tariq Ahmad (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - March 11, 2021 Category: Cardiology Source Type: research

Pragmatic Design of Randomized Clinical Trials for Heart Failure: Rationale and Design of the TRANSFORM-HF Trial
Publication date: Available online 10 March 2021Source: JACC: Heart FailureAuthor(s): Stephen J. Greene, Eric J. Velazquez, Kevin J. Anstrom, Eric L. Eisenstein, Shelly Sapp, Shelby Morgan, Tina Harding, Vandana Sachdev, Fassil Ketema, Dong-Yun Kim, Patrice Desvigne-Nickens, Bertram Pitt, Robert J. Mentz, Kirkwood Adams, Tammy Long, Kunal Bhatt, Brandon Walker, Tracy DeWald, Kim Biever, Kelly Axsom (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - March 11, 2021 Category: Cardiology Source Type: research

Improving Health-Related Quality of Life for Women With Acute Heart Failure: Chronically Undertreated∗
Publication date: Available online 10 March 2021Source: JACC: Heart FailureAuthor(s): Ersilia M. DeFilippis, Harriette G.C. Van Spall (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - March 11, 2021 Category: Cardiology Source Type: research

Sex Differences in Clinical Course and Patient-Reported Outcomes Among Patients Hospitalized for Heart Failure
Publication date: Available online 10 March 2021Source: JACC: Heart FailureAuthor(s): Vanessa Blumer, Stephen J. Greene, Angie Wu, Javed Butler, Justin A. Ezekowitz, JoAnn Lindenfeld, Brooke Alhanti, Adrian F. Hernandez, Christopher M. O’Connor, Robert J. Mentz (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - March 11, 2021 Category: Cardiology Source Type: research

Splanchnic Nerve Block Mediated Changes in Stressed Blood Volume in Heart Failure
Publication date: Available online 10 March 2021Source: JACC: Heart FailureAuthor(s): Marat Fudim, Manesh R. Patel, Richard Boortz-Marx, Barry A. Borlaug, Adam D. DeVore, Arun Ganesh, Cynthia L. Green, Renato D. Lopes, Robert J. Mentz, Chetan B. Patel, Joseph G. Rogers, G. Michael Felker, Adrian F. Hernandez, Kenji Sunagawa, Daniel Burkhoff (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - March 11, 2021 Category: Cardiology Source Type: research

Burden of Heart Failure Signs and Symptoms, Prognosis, and Response to Therapy: The PARAGON-HF Trial
Publication date: Available online 10 March 2021Source: JACC: Heart FailureAuthor(s): Karola Jering, Brian Claggett, Margaret M. Redfield, Sanjiv J. Shah, Inder S. Anand, Felipe Martinez, Shalini V. Sabarwal, Petar M. Seferović, Jose F. Kerr Saraiva, Tzvetana Katova, Marty P. Lefkowitz, Marc A. Pfeffer, John J.V. McMurray, Scott D. Solomon (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - March 11, 2021 Category: Cardiology Source Type: research

ECMO as a Bridge to Left Ventricular Assist Device or Heart Transplantation
Publication date: Available online 10 March 2021Source: JACC: Heart FailureAuthor(s): Ersilia M. DeFilippis, Kevin Clerkin, Lauren K. Truby, Michael Francke, Justin Fried, Amirali Masoumi, A. Reshad Garan, Maryjane A. Farr, Hiroo Takayama, Koji Takeda, Nir Uriel, Veli K. Topkara (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - March 11, 2021 Category: Cardiology Source Type: research

Thromboembolism in Heart Failure Patients in Sinus Rhythm: Epidemiology, Pathophysiology, Clinical Trials, and Future Direction
Publication date: Available online 10 March 2021Source: JACC: Heart FailureAuthor(s): Andrew Y. Lin, Elisabetta Dinatolo, Marco Metra, Marco Sbolli, Nicolò Dasseni, Javed Butler, Barry H. Greenberg (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - March 11, 2021 Category: Cardiology Source Type: research

Mineralocorticoid Receptor Antagonists and SGLT2 Inhibitor Therapy: The Best of Both Worlds in HFrEF∗
Publication date: Available online 10 March 2021Source: JACC: Heart FailureAuthor(s): Faiez Zannad, Patrick Rossignol (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - March 11, 2021 Category: Cardiology Source Type: research

Reviewers Hall of Fame: 2020 Top Reviewers
Publication date: March 2021Source: JACC: Heart Failure, Volume 9, Issue 3Author(s): Christopher M. O’Connor (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - February 23, 2021 Category: Cardiology Source Type: research

Instructions For Authors
Publication date: March 2021Source: JACC: Heart Failure, Volume 9, Issue 3Author(s): (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - February 23, 2021 Category: Cardiology Source Type: research

The Impact of Patients With Cardiac Amyloidosis in HFpEF Trials
Publication date: March 2021Source: JACC: Heart Failure, Volume 9, Issue 3Author(s): Silvia Oghina, Wulfran Bougouin, Mélanie Bézard, Mounira Kharoubi, Michel Komajda, Alain Cohen-Solal, Alexandre Mebazaa, Thibaud Damy, Diane Bodez (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - February 23, 2021 Category: Cardiology Source Type: research

Cardiopulmonary Exercise Testing-Based Risk Stratification in the Modern Era of Advanced Heart Failure Management∗
Publication date: March 2021Source: JACC: Heart Failure, Volume 9, Issue 3Author(s): Gregory D. Lewis, Daniel A. Zlotoff (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - February 23, 2021 Category: Cardiology Source Type: research

Setting the Stage for a Multimarker-Based Heart Failure Prevention Trial?∗
Publication date: March 2021Source: JACC: Heart Failure, Volume 9, Issue 3Author(s): Tariq Ahmad, G. Michael Felker (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - February 23, 2021 Category: Cardiology Source Type: research

Optimal Positioning of Novel Heart Failure Pharmacotherapies: The Case of Vericiguat
Publication date: March 2021Source: JACC: Heart Failure, Volume 9, Issue 3Author(s): Muddassir Mehmood (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - February 23, 2021 Category: Cardiology Source Type: research

Proteomics as a Path to More Refined Heart Failure Therapeutics∗
Publication date: Available online 3 February 2021Source: JACC: Heart FailureAuthor(s): James L. Januzzi, Sean P. Murphy (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - February 4, 2021 Category: Cardiology Source Type: research

Predictive Value of Cardiopulmonary Exercise Testing Parameters in Ambulatory Advanced Heart Failure
Publication date: Available online 3 February 2021Source: JACC: Heart FailureAuthor(s): Anuradha Lala, Keyur B. Shah, David E. Lanfear, Jennifer T. Thibodeau, Maryse Palardy, Amrut V. Ambardekar, Dennis M. McNamara, Wendy C. Taddei-Peters, J. Timothy Baldwin, Neal Jeffries, Shokoufeh Khalatbari, Cathie Spino, Blair Richards, Douglas L. Mann, Garrick C. Stewart, Keith D. Aaronson, Donna M. Mancini, REVIVAL Investigatocrs (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - February 4, 2021 Category: Cardiology Source Type: research

Dapagliflozin in HFrEF Patients Treated With Mineralocorticoid Receptor Antagonists: An Analysis of DAPA-HF
Publication date: Available online 3 February 2021Source: JACC: Heart FailureAuthor(s): Li Shen, Søren Lund Kristensen, Olof Bengtsson, Michael Böhm, Rudolf A. de Boer, Kieran F. Docherty, Silvio E. Inzucchi, Tzvetana Katova, Lars Køber, Mikhail N. Kosiborod, Anna Maria Langkilde, Daniel Lindholm, M. Felipe A. Martinez, Eileen O’Meara, Jose C. Nicolau, Mark C. Petrie, Piotr Ponikowski, Marc S. Sabatine, Morten Schou, Mikaela Sjöstrand (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - February 4, 2021 Category: Cardiology Source Type: research

The Battle for Enrollment: Preventing Collateral Damage on Clinical Trial Outcomes∗
Publication date: Available online 3 February 2021Source: JACC: Heart FailureAuthor(s): Marvin A. Konstam (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - February 4, 2021 Category: Cardiology Source Type: research

Impact of Geographic Region on the COMMANDER-HF Trial
Publication date: Available online 3 February 2021Source: JACC: Heart FailureAuthor(s): João Pedro Ferreira, John G.F. Cleland, Carolyn S.P. Lam, Dirk van Veldhuisen, William M. Byra, David A. La Police, Stefan D. Anker, Mandeep R. Mehra, Céline Leroy, Valerie Eschwege, Marie Toussaint-Hacquard, Patrick Rossignol, Barry Greenberg, Faiez Zannad (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - February 4, 2021 Category: Cardiology Source Type: research

The “Burden” of Secondary Mitral Regurgitation in Acute Decompensated Heart Failure∗
Publication date: Available online 3 February 2021Source: JACC: Heart FailureAuthor(s): Paul A. Grayburn (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - February 4, 2021 Category: Cardiology Source Type: research

The Impact of Patients With Cardiac Amyloidosis in HFpEF Trials
Publication date: Available online 3 February 2021Source: JACC: Heart FailureAuthor(s): Silvia Oghina, Wulfran Bougouin, Mélanie Bézard, Mounira Kharoubi, Michel Komajda, Alain Cohen-Solal, Alexandre Mebazaa, Thibaud Damy, Diane Bodez (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - February 4, 2021 Category: Cardiology Source Type: research