Screening for Transthyretin Amyloid Cardiomyopathy in Everyday Practice
Publication date: Available online 10 July 2019Source: JACC: Heart FailureAuthor(s): Ronald M. Witteles, Sabahat Bokhari, Thibaud Damy, Perry M. Elliott, Rodney H. Falk, Nowell M. Fine, Mariana Gospodinova, Laura Obici, Claudio Rapezzi, Pablo Garcia-PaviaAbstractTransthyretin amyloid cardiomyopathy (ATTR-CM) is a life-threatening, progressive, infiltrative disease caused by the deposition of transthyretin amyloid fibrils in the heart, and can often be overlooked as a common cause of heart failure. Delayed diagnosis due to lack of disease awareness and misdiagnosis results in a poorer prognosis. Early accurate diagnosis is ...
Source: JACC: Heart Failure - July 11, 2019 Category: Cardiology Source Type: research

Omega-3 Fatty Acids and Heart Failure: Evidence and Still Open Questions∗
Publication date: Available online 10 July 2019Source: JACC: Heart FailureAuthor(s): Aldo P. MaggioniCorresponding Author (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - July 11, 2019 Category: Cardiology Source Type: research

Risk Models for Prediction of Implantable Cardioverter-Defibrillator Benefit: Insights From the DANISH Trial
This study aims to identify patients with nonischemic heart failure who are more likely to benefit from implantable cardioverter-defibrillator (ICD) implantation by use of established risk prediction models.BackgroundIt has been debated whether an ICD for primary prevention reduces mortality in patients with nonischemic heart failure.MethodsThe Seattle Heart Failure Model (SHFM) predicts all-cause mortality whereas the Seattle Proportional Risk Model (SPRM) predicts the proportion of sudden cardiac death (SCD) versus nonsudden death, with a higher score indicating a greater proportion of SCD. We report the effect of I...
Source: JACC: Heart Failure - July 11, 2019 Category: Cardiology Source Type: research

Primary Prevention Implantable Cardioverter-Defibrillators in Patients With Nonischemic Cardiomyopathy∗
Publication date: Available online 10 July 2019Source: JACC: Heart FailureAuthor(s): James P. Daubert, Adam S. BarnettCorresponding Author (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - July 11, 2019 Category: Cardiology Source Type: research

Hemodynamic Effects of Weight Loss in Obesity: A Systematic Review and Meta-Analysis
Publication date: Available online 10 July 2019Source: JACC: Heart FailureAuthor(s): Yogesh N.V. Reddy, Mahesh Anantha-Narayanan, Masaru Obokata, Katlyn E. Koepp, Patricia Erwin, Rickey E. Carter, Barry A. BorlaugAbstractObjectivesThe authors aimed to explore whether weight loss may improve central hemodynamics in obesity.BackgroundHemodynamic abnormalities in obese heart failure with preserved ejection fraction patients are correlated with the amount of excess body mass, suggesting a possible causal relationship.MethodsRelevant databases were systematically searched from inception to May 2018, without language restriction...
Source: JACC: Heart Failure - July 11, 2019 Category: Cardiology Source Type: research

Predicting Risk for Incident Heart Failure With Omega-3 Fatty Acids: From MESA
Publication date: Available online 10 July 2019Source: JACC: Heart FailureAuthor(s): Robert C. Block, Linxi Liu, David M. Herrington, Shue Huang, Michael Y. Tsai, Timothy D. O’Connell, Gregory C. ShearerAbstractObjectivesThe aim of this study was to determine if plasma eicosapentaenoic acid (EPA) abundance (%EPA) is associated with reduced hazard for primary heart failure (HF) events in the MESA (Multi-Ethnic Study of Atherosclerosis) trial.BackgroundClinical trials suggest that omega-3 polyunsaturated fatty acids (ω3 PUFAs) prevent sudden death in coronary heart disease and HF, but this is controversial. In mi...
Source: JACC: Heart Failure - July 11, 2019 Category: Cardiology Source Type: research

Health-Related Quality of Life in Heart Failure With Preserved Ejection Fraction: The PARAGON-HF Trial
This study sought to describe baseline health-related quality of life (HRQL) in the PARAGON-HF (Prospective Comparison of ARNI with ARB Global Outcomes in HFpEF) trial, the largest heart failure with preserved ejection fraction (HFpEF) trial to date.BackgroundThere are limited data characterizing HRQL in patients with HFpEF using validated metrics.MethodsThe PARAGON-HF trial randomized symptomatic patients with HFpEF (≥45%) ≥50 years of age to either sacubitril/valsartan or valsartan. The study reports comprehensive baseline HRQL using Kansas City Cardiomyopathy Questionnaire (KCCQ) administered at randomization...
Source: JACC: Heart Failure - July 11, 2019 Category: Cardiology Source Type: research

Risk for Heart Failure: The Opportunity for Prevention With the American Heart Association’s Life’s Simple 7
ConclusionsA healthy lifestyle, as reflected in an ideal LS7 score, was associated with a 55% lower risk for HF compared with an inadequate LS7 score. Preventive strategies that target combinations of specific LS7 components could have a significant impact on decreasing incident HF in the population at large.Central Illustration (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - July 11, 2019 Category: Cardiology Source Type: research

Impact of Malnutrition Using Geriatric Nutritional Risk Index in Heart Failure With Preserved Ejection Fraction
This study sought to investigate the relationship between malnutrition and adverse cardiovascular (CV) events in heart failure with preserved ejection fraction (HFpEF).BackgroundMalnutrition is associated with poor prognosis in a wide range of illnesses, however, the prognostic impact of malnutrition in HFpEF patients is not well known.MethodsBaseline malnutrition risk was determined in 1,677 patients with HFpEF enrolled in the Americas regions of the TOPCAT (Aldosterone Antagonist Therapy for Adults With Heart Failure and Preserved Systolic Function) trial, according to 3 categories of the geriatric nutritional risk ...
Source: JACC: Heart Failure - July 11, 2019 Category: Cardiology Source Type: research

Treating Obesity in Heart Failure: A Big, Fat Void∗
Publication date: Available online 10 July 2019Source: JACC: Heart FailureAuthor(s): Michael E. Hall, Daisuke KamimuraCorresponding Author (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - July 11, 2019 Category: Cardiology Source Type: research

Exercise-Based Rehabilitation for Heart Failure: Cochrane Systematic Review, Meta-Analysis, and Trial Sequential Analysis
ConclusionsThis review supports the beneficial effects of ExCR on patient outcomes. These benefits appear to be consistent across ExCR program characteristics. GRADE and TSA assessments indicated that further high-quality randomized trials are needed.Central Illustration (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - July 11, 2019 Category: Cardiology Source Type: research

Exercise Rehabilitation for Heart Failure: The Neglected Stepchild∗
Publication date: Available online 10 July 2019Source: JACC: Heart FailureAuthor(s): Jerome L. FlegCorresponding Author (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - July 11, 2019 Category: Cardiology Source Type: research

Impact of Malnutrition Using Geriatric Nutritional Risk Index in Heart Failure With Preserved Ejection Fraction∗
Publication date: Available online 10 July 2019Source: JACC: Heart FailureAuthor(s): Andrew L. Clark, Shirley SzeCorresponding Author (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - July 11, 2019 Category: Cardiology Source Type: research

Seven Metrics That Will Determine Your Cardiovascular Success or Failure∗
Publication date: Available online 10 July 2019Source: JACC: Heart FailureAuthor(s): Christie M. Ballantyne, Vijay NambiCorresponding Author (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - July 11, 2019 Category: Cardiology Source Type: research

Instructions For Authors
Publication date: July 2019Source: JACC: Heart Failure, Volume 7, Issue 7Author(s): (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - June 26, 2019 Category: Cardiology Source Type: research

Burden and Causes of Hospital Admissions in Heart Failure During the Last Year of Life
This study aimed to evaluate the incidence and causes of hospitalization in the year preceding death of patients with heart failure (HF).BackgroundHospitalizations in HF are common, especially in the last period of the lives of patients with HF, but little is known about hospitalization burden and causes during this phase of the disease.MethodsFrom Danish nationwide registries, we identified patients who died in the period 2001–2016 after having experienced HF for at least 1 year, and examined hospitalizations during the last year of life in age- and sex-stratified analyses.ResultsWe included 32,157 patients. Median ...
Source: JACC: Heart Failure - June 26, 2019 Category: Cardiology Source Type: research

The Last Year in Patients With Heart Failure: More Than Just Heart∗
Publication date: July 2019Source: JACC: Heart Failure, Volume 7, Issue 7Author(s): Patricia P. ChangCorresponding Author (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - June 26, 2019 Category: Cardiology Source Type: research

The Role of the Pericardium in Heart Failure: Implications for Pathophysiology and Treatment
Publication date: July 2019Source: JACC: Heart Failure, Volume 7, Issue 7Author(s): Barry A. Borlaug, Yogesh N.V. ReddyAbstractThe elastic pericardium exerts a compressive contact force on the surface of the myocardium that becomes more substantial when heart volume increases, as in patients with various forms of heart failure (HF). Pericardial restraint plays an important role in determining hemodynamics and ventricular function in both health and disease. This review discusses the physiology of pericardial restraint in HF and explores the question of whether it can be targeted indirectly through medical in...
Source: JACC: Heart Failure - June 26, 2019 Category: Cardiology Source Type: research

Bucindolol for the Maintenance of Sinus Rhythm in a Genotype-Defined HF Population: The GENETIC-AF Trial
Publication date: July 2019Source: JACC: Heart Failure, Volume 7, Issue 7Author(s): Jonathan P. Piccini, William T. Abraham, Christopher Dufton, Ian A. Carroll, Jeff S. Healey, Dirk J. van Veldhuisen, William H. Sauer, Inder S. Anand, Michel White, Stephen B. Wilton, Ryan Aleong, Michiel Rienstra, Steven K. Krueger, Felix Ayala-Paredes, Yaariv Khaykin, Bela Merkely, Vladimir Miloradović, Jerzy K. Wranicz, Leonard Ilkhanoff, Paul D. ZieglerAbstractObjectivesThe purpose of this study was to compare the effectiveness of bucindolol with that of metoprolol succinate for the maintenance of sinus rhythm in a genetically defined ...
Source: JACC: Heart Failure - June 26, 2019 Category: Cardiology Source Type: research

GENETIC-AF: Digging Deeper Into Genotype-Phenotype and Heart Failure-Atrial Fibrillation Interactions∗
Publication date: July 2019Source: JACC: Heart Failure, Volume 7, Issue 7Author(s): Palak Shah, Marco MetraGraphical abstractCorresponding AuthorFirst Author (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - June 26, 2019 Category: Cardiology Source Type: research

The Importance of Educating First Responders
Publication date: July 2019Source: JACC: Heart Failure, Volume 7, Issue 7Author(s): Charlie Liggett (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - June 26, 2019 Category: Cardiology Source Type: research

N-of-1 Clinical Trials
Publication date: July 2019Source: JACC: Heart Failure, Volume 7, Issue 7Author(s): Christopher M. O’Connor (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - June 26, 2019 Category: Cardiology Source Type: research

Heart Failure With Preserved Ejection Fraction: Types 1 and 2?
Publication date: July 2019Source: JACC: Heart Failure, Volume 7, Issue 7Author(s): Steven R. Goldsmith, Mengistu Simegn (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - June 26, 2019 Category: Cardiology Source Type: research

Reply: Heart Failure With Preserved Ejection Fraction: Types 1 and 2?
Publication date: July 2019Source: JACC: Heart Failure, Volume 7, Issue 7Author(s): Dalane W. Kitzman, Bharathi Upadhya, Peter H. Brubaker, Mark J. Haykowsky, Michael D. Nelson (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - June 26, 2019 Category: Cardiology Source Type: research

Physical Activity and Fitness in Heart Failure With Preserved Ejection Fraction: Ready for Prime Time?
Publication date: July 2019Source: JACC: Heart Failure, Volume 7, Issue 7Author(s): Massimo Leggio, Cristina Tiberti, Massimo Armeni, Giorgio Limongelli, Andrea Mazza (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - June 26, 2019 Category: Cardiology Source Type: research

Reply: Physical Activity and Fitness in Heart Failure With Preserved Ejection Fraction: Ready for Prime Time?
Publication date: July 2019Source: JACC: Heart Failure, Volume 7, Issue 7Author(s): Emil Wolsk, Finn Gustafsson (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - June 26, 2019 Category: Cardiology Source Type: research

Correction
Publication date: July 2019Source: JACC: Heart Failure, Volume 7, Issue 7Author(s): (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - June 26, 2019 Category: Cardiology Source Type: research

PROmises to Keep∗
Publication date: Available online 5 June 2019Source: JACC: Heart FailureAuthor(s): D. Marshall Brinkley, Lynne W. StevensonCorresponding Author (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - June 6, 2019 Category: Cardiology Source Type: research

Association of Changes in Heart Failure Treatment With Patients’ Health Status: Real-World Evidence From CHAMP-HF
Publication date: Available online 5 June 2019Source: JACC: Heart FailureAuthor(s): Merrill Thomas, Yevgeniy Khariton, Gregg C. Fonarow, Suzanne V. Arnold, Larry Hill, Michael E. Nassif, Puza P. Sharma, Javed Butler, Laine Thomas, Carol I. Duffy, Adam D. DeVore, Adrian Hernandez, Nancy M. Albert, J. Herbert Patterson, Fredonia B. Williams, Kevin McCague, John A. SpertusAbstractObjectivesThe aim of this study was to use a multicenter, observational outpatient registry of patients with heart failure with reduced ejection fraction (HFrEF) to describe the association between changes in patients’ medications with changes ...
Source: JACC: Heart Failure - June 6, 2019 Category: Cardiology Source Type: research

The Importance of Baseline Physical Activity Level in Heart Failure With Preserved Ejection Fraction
Publication date: June 2019Source: JACC: Heart Failure, Volume 7, Issue 6Author(s): Massimo Leggio, Cristina Tiberti, Massimo Armeni, Giorgio Limongelli, Andrea Mazza (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - May 29, 2019 Category: Cardiology Source Type: research

Heart Failure and Atrial Fibrillation, Like Fire and Fury
Publication date: June 2019Source: JACC: Heart Failure, Volume 7, Issue 6Author(s): Matthew A. Carlisle, Marat Fudim, Adam D. DeVore, Jonathan P. PicciniAbstractHeart failure and atrial fibrillation are 2 common cardiovascular disorders that frequently complicate one another and exert a significant detrimental effect on cardiovascular health and well-being. Both heart failure and atrial fibrillation continue to increase in prevalence as the risk factors underlying each condition become more common. This review encompasses what is currently known about the epidemiology and pathophysiology of these comorbidities along with i...
Source: JACC: Heart Failure - May 29, 2019 Category: Cardiology Source Type: research

Reply: Clinical Context of Dyskalemias Across the Heart Failure Spectrum and Their Associated Adverse Outcomes
Publication date: June 2019Source: JACC: Heart Failure, Volume 7, Issue 6Author(s): Gianluigi Savarese, Lars H. Lund, Juan J. Carrero (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - May 29, 2019 Category: Cardiology Source Type: research

Too Different or Too Late?: Gender Differences in Outcomes After Mitral Valve Surgery∗
Publication date: June 2019Source: JACC: Heart Failure, Volume 7, Issue 6Author(s): Brent C. Lampert, JoAnn Lindenfeld, William T. AbrahamCorresponding Author (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - May 29, 2019 Category: Cardiology Source Type: research

Sex-Based Differences in Heart Failure Across the Ejection Fraction Spectrum: Phenotyping, and Prognostic and Therapeutic Implications
ConclusionsMales and females with HF showed different characteristics across the EF spectrum. Males reported a lower crude risk of mortality/morbidity in HFpEF and HFmrEF but higher risk of HFrEF, although after adjustments, prognosis was better in females regardless of EF. The observed sex-related differences highlight the need for an adequate representation of females in HF randomized controlled trials to improve generalizability.Central Illustration (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - May 29, 2019 Category: Cardiology Source Type: research

Dare to Achieve Health Equity∗
Publication date: June 2019Source: JACC: Heart Failure, Volume 7, Issue 6Author(s): Khadijah BreathettCorresponding Author (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - May 29, 2019 Category: Cardiology Source Type: research

When the Doctor Becomes the Patient
Publication date: June 2019Source: JACC: Heart Failure, Volume 7, Issue 6Author(s): Serena-Lynn Brown (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - May 29, 2019 Category: Cardiology Source Type: research

Better Quality of Life Over More Quantity of Life: How We View Time Trade-Off
Publication date: June 2019Source: JACC: Heart Failure, Volume 7, Issue 6Author(s): Christopher M. O’Connor (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - May 29, 2019 Category: Cardiology Source Type: research

Clinical Context of Dyskalemias Across the Heart Failure Spectrum and Their Associated Adverse Outcomes
Publication date: June 2019Source: JACC: Heart Failure, Volume 7, Issue 6Author(s): Janani Rangaswami, Peter A. McCullough (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - May 29, 2019 Category: Cardiology Source Type: research

Reply: The Importance of Baseline Physical Activity Level in Heart Failure With Preserved Ejection Fraction
Publication date: June 2019Source: JACC: Heart Failure, Volume 7, Issue 6Author(s): Anna L. Beale, Shane Nanayakkara, David M. Kaye (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - May 29, 2019 Category: Cardiology Source Type: research

Sex-Based Differences in Outcomes After Mitral Valve Surgery for Severe Ischemic Mitral Regurgitation: From the Cardiothoracic Surgical Trials Network
ConclusionsWomen with SIMR displayed different echocardiographic features and experienced higher mortality and worse QOL after MV surgery than men. There were no significant differences in the degree of reverse LV remodeling between sexes. (Comparing the Effectiveness of Repairing Versus Replacing the Heart's Mitral Valve in People With Severe Chronic Ischemic Mitral Regurgitation [Severe Ischemic Mitral Regurgitation]; NCT00807040)Central Illustration (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - May 29, 2019 Category: Cardiology Source Type: research

Getting Paid to Participate: Financial Incentives to Improve Adherence to Cardiac Rehabilitation∗
Publication date: Available online 8 May 2019Source: JACC: Heart FailureAuthor(s): Gordon R. Reeves, David J. WhellanCorresponding Author (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - May 9, 2019 Category: Cardiology Source Type: research

Failure Is Not an Option: Optimizing Care for Heart Failure Patients at the End of Life∗
Publication date: Available online 8 May 2019Source: JACC: Heart FailureAuthor(s): Haider J. Warraich, Clyde W. YancyCorresponding Author (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - May 9, 2019 Category: Cardiology Source Type: research

Factors Associated With Live Discharge of Heart Failure Patients From Hospice: A Multimethod Study
ConclusionsLive discharge from hospice, especially due to acute hospitalization, is common with heart failure. Greater attention is needed for patients’ knowledge of and readiness for hospice care, especially among younger and diverse populations, and for factors related to the social and family context in which hospice care is provided. (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - May 9, 2019 Category: Cardiology Source Type: research

Importance of Nonobstructive Coronary Artery Disease in the Prognosis of Patients With Heart Failure
ConclusionsAmong HF patients with reduced ejection fraction, the presence of nonobstructive CAD was independently associated with an increased hazard of the primary composite outcome and death of any cause.Graphical abstract (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - May 9, 2019 Category: Cardiology Source Type: research

Secondary Mitral Regurgitation: Is it Time for a Paradigm Shift in Treatment?
Publication date: Available online 8 May 2019Source: JACC: Heart FailureAuthor(s): Wayne Batchelor, Randall C. Starling, Gregg W. Stone (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - May 9, 2019 Category: Cardiology Source Type: research

Cardiogenic Shock in Takotsubo Cardiomyopathy Versus Acute Myocardial Infarction: An 8-Year National Perspective on Clinical Characteristics, Management, and Outcomes
This study sought to evaluate the clinical characteristics and outcomes of Takotusbo cardiomyopathy cardiogenic shock (TC-CS) in comparison to those of acute myocardial infarction cardiogenic shock (AMI-CS) among patients hospitalized in the United States. We additionally sought to compare the incidence of multiorgan failure and use of supportive therapies as well as the trends over time, given the increasing awareness and diagnosis of TC.BackgroundCS is a major complication of TC; however, there are limited data, especially as to how TC-CS compares to AMI-CS.MethodsThe National Inpatient Sample Database was used to identi...
Source: JACC: Heart Failure - May 9, 2019 Category: Cardiology Source Type: research

Ambulatory Advanced Heart Failure in Women: A Report From the REVIVAL Registry
ConclusionsThis study represents the largest report to date of women with ambulatory advanced HF receiving contemporary therapies. Systematic elicitation of patient-reported outcome measures uncovered an added burden of HF in women and may be an appropriate target of augmented support and intervention.Central Illustration (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - May 9, 2019 Category: Cardiology Source Type: research

Heart Failure With Obstructive, Nonobstructive, and No Coronary Artery Disease∗
Publication date: Available online 8 May 2019Source: JACC: Heart FailureAuthor(s): Leslee J. Shaw, Eloisa Arbustini, Jagat NarulaCorresponding Author (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - May 9, 2019 Category: Cardiology Source Type: research

Not All Shock Is Created Equal: Developing a Standardized Treatment Approach for Cardiogenic Shock∗
Publication date: Available online 8 May 2019Source: JACC: Heart FailureAuthor(s): Behnam N. Tehrani, Carolyn Rosner, Shashank S. SinhaCorresponding Author (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - May 9, 2019 Category: Cardiology Source Type: research

Outcomes and Effect of Treatment According to Etiology in HFrEF: An Analysis of PARADIGM-HF
ConclusionsJust under half of patients in this global trial had nonischemic HF with reduced ejection fraction, with idiopathic and hypertensive the most commonly ascribed etiologies. Adjusted outcomes were similar across etiologic categories, as was the benefit of sacubitril/valsartan over enalapril. (Efficacy and Safety of LCZ696 Compared to Enalapril on Morbidity and Mortality of Patients With Chronic Heart Failure; NCT01035255)Central Illustration (Source: JACC: Heart Failure)
Source: JACC: Heart Failure - May 9, 2019 Category: Cardiology Source Type: research