The Antihypertensive Efficacy of the Triple Fixed Combination of Perindopril, Indapamide, and Amlodipine: The Results of the PETRA Study

AbstractIntroductionThe etiology of essential hypertension is multifactorial. Therefore, treatment with combinations of antihypertensive agents acting on multiple targets is necessary for successful therapy in the majority of patients. According to the experience and clinical data accumulated so far, combination therapy with three agents from different pharmacological classes is required in approx. 30% of patients in order to achieve long-term blood pressure control. The primary objective of the PETRA study was to evaluate the efficacy of blood pressure (BP) control with once daily administration of the different dosage strengths of the once-daily, triple fixed combination of perindopril, indapamide, and amlodipine. The evaluation was based on office BP readings and ambulatory blood pressure monitoring (ABPM) data gathered in routine clinical practice.MethodsData from 11,209 hypertensive patients (the proportion of female subjects was 47.6%) were processed and interpreted in a 3-month-long prospective, observational, non-interventional, open-label study conducted in 997 centers in Hungary.ResultsMean baseline office BP was 156.58  ± 16.10/91.56 ± 9.33 mmHg (mean ± SD), whereas the mean duration of hypertension was 9.48 ± 7.19 years. Mean office BP decreased by 24.81 ± 15.47/11.41 ± 9.90 mmHg after switching to the triple fixed combination of perindopril, indapa...
Source: Advances in Therapy - Category: Drugs & Pharmacology Source Type: research

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We report a case of ANCA-associated vasculitis coexisting with cholesterol emboli. A 76-year-old woman was diagnosed with ANCA-associated interstitial pneumonitis. She rapidly developed progressive glomerulonephritis, purpura, and peripheral sensory nerve disorder. A kidney biopsy revealed that renal dysfunction was caused by vasculitis of the interlobular arteries and cholesterol emboli. A skin biopsy revealed that purpura was caused by cholesterol emboli. Glucocorticoid and statin therapies were administered. Thereafter, the renal function and other symptoms improved and stabilized. The representative symptoms of ANCA-as...
Source: The Tohoku Journal of Experimental Medicine - Category: Research Authors: Tags: Tohoku J Exp Med Source Type: research
CONCLUSION: In hypertensive and diabetic patients, higher OPG values were associated with impaired LA function assessed by 2D-STE. In this high-risk patient group, serum OPG can be used as a risk predictor for LA mechanical dysfunction. PMID: 32462219 [PubMed - as supplied by publisher]
Source: Herz - Category: Cardiology Tags: Herz Source Type: research
AbstractChanges in neurovascular coupling are associated with both Alzheimer ’s disease and vascular dementia in later life, but this may be confounded by cerebrovascular risk. We hypothesized that hemodynamic latency would be associated with reduced cognitive functioning across the lifespan, holding constant demographic and cerebrovascular risk. In 387 adults aged 18–85 (mean = 48.82), dynamic causal modeling was used to estimate the hemodynamic response function in the left and right V1 and V3-ventral regions of the visual cortex in response to a simple checkerboard block design stimulus with mi...
Source: Anatomy and Embryology - Category: Anatomy Source Type: research
Abstract Changes in neurovascular coupling are associated with both Alzheimer's disease and vascular dementia in later life, but this may be confounded by cerebrovascular risk. We hypothesized that hemodynamic latency would be associated with reduced cognitive functioning across the lifespan, holding constant demographic and cerebrovascular risk. In 387 adults aged 18-85 (mean = 48.82), dynamic causal modeling was used to estimate the hemodynamic response function in the left and right V1 and V3-ventral regions of the visual cortex in response to a simple checkerboard block design stimulus with minim...
Source: Brain Structure and Function - Category: Neuroscience Authors: Tags: Brain Struct Funct Source Type: research
Time for a new edition of SharpBrains’ e‑newsletter! 1. Food for (nonpartisan) Thought: Should heads of state and candidates to high office pass a cognitive/ mental fitness test? 2. A school psychologist shares good tips to support our kids and, yes, manage our own stress. Three Ss to reduce the stress of “homeschooling” our kids: Simplify, Structure, Support. 3. Wow. Mindstrong Health raises $100M to transform how we measure and promote mental health. 4. Great partnership! Kaiser Permanente offers Calm mental fitness app at no cost to millions of members. 5. “Just as you can’t self-int...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Education & Lifelong Learning Health & Wellness Technology app brain health Brain Teasers brain-teaser Calm cognitive test FDA Headsafe Kaiser-Permanente Kernel mental health mental-fitness Mindstrong Source Type: blogs
AbstractDiabetes is a well ‐established risk factor for both ischemic and hemorrhagic stroke. Individuals with diabetes not only have a higher risk of stroke, they also have worse clinical outcomes after stroke, including poorer neurological recovery, higher rates of stroke recurrence and mortality. In addition to optimizin g glycemia, control of cardiovascular risk factors like hypertension and dyslipidemia is crucial in stroke prevention in subjects with diabetes.
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: EDITORIAL Source Type: research
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Source: Archives of Public Health - Category: International Medicine & Public Health Source Type: research
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Source: Journal of Tropical Medicine - Category: Tropical Medicine Tags: J Trop Med Source Type: research
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Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news
CONCLUSIONS: Prevention and treatment of CVD in American Indians and Alaska Natives should focus on control of risk factors and community-based interventions that address social determinants of health, particularly among individuals with diabetes mellitus. Accurate reporting of race/ethnicity is encouraged to address race-specific risk factors. PMID: 32460555 [PubMed - as supplied by publisher]
Source: Circulation - Category: Cardiology Authors: Tags: Circulation Source Type: research
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