Combination Antihypertensive Therapy with Perindopril and Indapamide in Patients with Essential Hypertension: Effect on Endothelial and Cognitive Markers of Vascular Improvement
ConclusionSPC PER/IND at full doses for 12 months improves endothelial function, structural and functional parameters of the microcirculation, as well as cognitive function in patients with arterial hypertension at high cardiovascular risk.FundingLes Laboratoires Servier. (Source: Advances in Therapy)
Source: Advances in Therapy - October 1, 2018 Category: Drugs & Pharmacology Source Type: research
Hydrochlorothiazide vs chlorthalidone, indapamide, and potassium ‐sparing/hydrochlorothiazide diuretics for reducing left ventricular hypertrophy: A systematic review and meta‐analysis
The Journal of Clinical Hypertension, EarlyView. (Source: The Journal of Clinical Hypertension)
Source: The Journal of Clinical Hypertension - September 25, 2018 Category: Cardiology Authors: George C. Roush,
Ramy Abdelfattah,
Steven Song,
Michael E. Ernst,
Domenic A. Sica,
John B. Kostis Source Type: research
Combination Antihypertensive Therapy with Perindopril and Indapamide in Patients with Essential Hypertension: Effect on Endothelial and Cognitive Markers of Vascular Improvement
ConclusionSPC PER/IND at full doses for 12 months improves endothelial function, structural and functional parameters of the microcirculation, as well as cognitive function in patients with arterial hypertension at high cardiovascular risk.FundingLes Laboratoires Servier. (Source: Advances in Therapy)
Source: Advances in Therapy - August 20, 2018 Category: Drugs & Pharmacology Source Type: research
Role of hydrogen bonding in cocrystals and coamorphous solids: indapamide as a case study
CrystEngComm, 2018, Advance Article DOI: 10.1039/C8CE01075G, CommunicationSuryanarayana Allu, Kuthuru Suresh, Geetha Bolla, M. K. Chaitanya Mannava, Ashwini Nangia Crystalline and amorphous stable binary compounds of indapamide for high solubility and permeability. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - CrystEngComm latest articles)
Source: RSC - CrystEngComm latest articles - August 17, 2018 Category: Chemistry Authors: Suryanarayana Allu Source Type: research
Role of hydrogen bonding in cocrystal and coamorphous solids: Indapamide as a case study
CrystEngComm, 2018, Accepted Manuscript DOI: 10.1039/C8CE01075G, CommunicationAshwini Nangia, Suryanarayana Allu, Kuthuru Suresh, Geetha Bolla, Chaitanya Mannava The stronger sulfonamide-pyridine (SO2NH2 •••N-Py) and sulfonamide-carboxamide (SO2NH2•••O=C-NH) hydrogen bonding directs the formation of cocrystals while weaker sulfonamide-amine (SO2NH2•••N-H) hydrogen bond results in coamorphous products. IDP-PIP and IDP-ARG coamorphous solids exhibit... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - CrystEngComm latest articles)
Source: RSC - CrystEngComm latest articles - August 7, 2018 Category: Chemistry Authors: Ashwini Nangia Source Type: research
Contribution of Volume Overload to Progression of Cardiovascular Diseases in Rat Model of Chronic Kidney Disease.
In conclusion, salt induced volume overload in a rat model of CKD had an adverse cardiovascular outcome and it was associated with inflammatory activation and decrease in renal klotho expression.
PMID: 30079760 [PubMed - as supplied by publisher] (Source: Canadian Journal of Physiology and Pharmacology)
Source: Canadian Journal of Physiology and Pharmacology - August 4, 2018 Category: Drugs & Pharmacology Authors: Mahmoud MM, Shamseldeen A, Rashed LA, Fares AE, Shamaa A, Gharib DM Tags: Can J Physiol Pharmacol Source Type: research
Simultaneous determination of indapamide, perindopril and perindoprilat in human plasma or whole blood by UPLC-MS/MS and its pharmacokinetic application
Publication date: Available online 19 May 2018Source: Journal of Pharmaceutical AnalysisAuthor(s): Yi Tao, Sheng Wang, Lei Wang, Min Song, Taijun HangAbstractSimple and sensitive methods were developed for the determination of indapamide, perindopril and its active metabolite perindoprilat in human plasma or whole blood by hyphenated ultra-performance liquid chromatography-mass spectrometry (UPLC-MS/MS). Indapamide-d3, perindopril-d4 and perindoprilat-d4 were used as the internal standards. The separation was performed on a Thermo BDS Hypersil C18 column (4.6 mm×100 mm, 2.4 μm) for indapamide and perindopril si...
Source: Journal of Pharmaceutical Analysis - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
Simultaneous determination of indapamide, perindopril and perindoprilat in human plasma or whole blood by UPLC-MS/MS and its pharmacokinetic application
Publication date: Available online 19 May 2018 Source:Journal of Pharmaceutical Analysis Author(s): Yi Tao, Sheng Wang, Lei Wang, Min Song, Taijun Hang Simple and sensitive methods were developed for the determination of indapamide, perindopril and its active metabolite perindoprilat in human plasma or whole blood by hyphenated ultra-performance liquid chromatography-mass spectrometry (UPLC-MS/MS). Indapamide-d3, perindopril-d4 and perindoprilat-d4 were used as the internal standards. The separation was performed on a Thermo BDS Hypersil C18 column (4.6mm×100mm, 2.4 μm) for indapamide and perindopril simultaneousl...
Source: Journal of Pharmaceutical Analysis - May 20, 2018 Category: Drugs & Pharmacology Source Type: research
Efficacy and Tolerability of Fixed-Dose Combination Perindopril/Indapamide in Hypertensive Patients with a History of Stroke or Transient Ischemic Attack: PICASSO Trial
ConclusionThis study suggests that fixed combination perindopril 10 mg/indapamide 2.5 mg is an effective and well-tolerated treatment for patients with a history of stroke or transient ischemic attack.FundingEGIS Pharmaceuticals Plc. (Source: Advances in Therapy)
Source: Advances in Therapy - May 10, 2018 Category: Drugs & Pharmacology Source Type: research
Hydrochlorothiazide and alternative diuretics versus renin–angiotensin system inhibitors for the regression of left ventricular hypertrophy: a head-to-head meta-analysis
Background:
Found in 36–41% of hypertension, elevated left ventricular mass (LVM) independently predicts cardiovascular events and total mortality. Conversely, drug-induced regression of LVM predicts improved outcomes. Previous studies have favored renin–angiotensin system inhibitors (RASIs) over other antihypertensives for reducing LVM but ignored differences among thiazide-type diuretics. From evidence regarding potency, cardiovascular events, and electrolytes, we hypothesized a priori that ‘CHIP’ diuretics [CHlorthalidone, Indapamide and Potassium-sparing Diuretic/hydrochlorothiazide (PSD/HCTZ)] would rival RA...
Source: Journal of Hypertension - May 1, 2018 Category: Cardiology Tags: Reviews Source Type: research
Type 2 Diabetes and Thiazide Diuretics
AbstractPurpose of ReviewIn patients with prediabetes or type 2 diabetes, the use of thiazides as antihypertensive agents has been challenged because associated metabolic adverse events, including new-onset diabetes.Recent FindingsThese metabolic disturbances are less marked with low-dose thiazides and, in most but not all studies, with thiazide-like diuretics (chlorthalidone, indapamide) than with thiazide-type diuretics (hydrochlorothiazide). In post hoc analyses of subgroups of patients with hypertension and type 2 diabetes, thiazides resulted in a significant reduction in cardiovascular events, all-cause mortality, and...
Source: Current Diabetes Reports - February 5, 2018 Category: Endocrinology Source Type: research
Vascular legacy beyond blood pressure control: benefits of perindopril/indapamide combination in hypertensive patients with diabetes.
CONCLUSION: Moving forward, understanding the pathophysiological bases of the effects that extend beyond those of blood pressure control, will help us differentiate between anti-hypertensive choices.
PMID: 29307229 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - January 10, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research
Diagnosis and management of hyponatraemia in the older patient
Abstract
Hyponatraemia (serum sodium concentration below 135 mmol/L) is the most common electrolyte disturbance and occurs commonly in older people. The causes can be complex to diagnose and treat and many published guidelines do not focus on the issues in an older patient group. Here, we are principally concerned with diagnosis and management of euvolaemic and hypervolaemic hyponatraemia in hospitalised patients over 70 years old. We also aim to increase awareness of hyponatraemia in residential aged care facilities and the community. Hyponatraemia can have many causes; in older people, chronic hyponatraemia can often be ...
Source: Internal Medicine Journal - January 10, 2018 Category: Internal Medicine Authors: Michael Woodward, Peter Gonski, Mathis Grossmann, John Obeid, Ron Scholes, Duncan J. Topliss Tags: Review Source Type: research
