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Diagnosis and management of hyponatraemia in the older patient
Abstract Hyponatraemia (serum sodium concentration below 135 mmol/L) is the most common electrolyte disturbance and occurs commonly in older people. The causes can be complex to diagnose and treat and many published guidelines do not focus on the issues in an older patient group. Here, we are principally concerned with diagnosis and management of euvolaemic and hypervolaemic hyponatraemia in hospitalised patients over 70 years old. We also aim to increase awareness of hyponatraemia in residential aged care facilities and the community. Hyponatraemia can have many causes; in older people, chronic hyponatraemia can often be ...
Source: Internal Medicine Journal - January 10, 2018 Category: Internal Medicine Authors: Michael Woodward, Peter Gonski, Mathis Grossmann, John Obeid, Ron Scholes, Duncan J. Topliss Tags: Review Source Type: research

Issue Information
(Source: Internal Medicine Journal)
Source: Internal Medicine Journal - January 10, 2018 Category: Internal Medicine Tags: Issue Information Source Type: research

Diabetic Ketoacidosis in Adult Patients: An Audit of Factors Influencing Time to Normalisation of Metabolic Parameters
Abstract BackgroundDiabetic ketoacidosis (DKA) is an acute life‐threatening metabolic complication of diabetes that imposes substantial burden on our healthcare system. There is a paucity of published data in Australia assessing factors influencing time to resolution of DKA and length of stay (LOS). AimsTo identify factors that predict a slower time to resolution of DKA in adults with diabetes. MethodsRetrospective audit of patients admitted to St Vincent's Hospital Melbourne between 2010 to 2014 coded with a diagnosis of ‘Diabetic Ketoacidosis’. The primary outcome was time to resolution of DKA based on norm...
Source: Internal Medicine Journal - January 8, 2018 Category: Internal Medicine Authors: Melissa H. Lee, Genevieve L. Calder, John D. Santamaria, Richard J. MacIsaac Tags: Original Article Source Type: research

Drug ‐induced Liver Injury is Frequently Associated with Severe Cutaneous Adverse Drug Reactions: Experience from Two Australian Tertiary Hospitals
ConclusionsDrug‐induced liver injury commonly occurs in patients with cutaneous adverse drug reactions and is associated with longer inpatient stay. Patients with Stevens‐Johnson/toxic epidermal necrolysis and peripheral lymphocytosis appear to be at higher risk for developing associated liver injury. (Source: Internal Medicine Journal)
Source: Internal Medicine Journal - January 8, 2018 Category: Internal Medicine Authors: Wendy C Fang, Nikki R Adler, Linda V Graudins, Caitlin Goldblatt, Michelle SY Goh, Stuart K Roberts, Jason A Trubiano, Ar Kar Aung Tags: Original Article Source Type: research

General practitioners require more support to prescribe direct acting antiviral therapy for hepatitis C
(Source: Internal Medicine Journal)
Source: Internal Medicine Journal - January 3, 2018 Category: Internal Medicine Authors: Rishi Sud, Neha Tiwari, Patrice Forner, Lisa Dowdell, John Freiman, Amany Zekry Tags: Letter to the Editor Source Type: research

Does obesity reduce risk for osteoporosis and fractures in older adults?
(Source: Internal Medicine Journal)
Source: Internal Medicine Journal - January 3, 2018 Category: Internal Medicine Authors: David Scott, Gustavo Duque, Peter R. Ebeling Tags: Letter to the Editor Source Type: research

Increasing awareness of addiction in palliative care: applying best practice in an area of limited management guidance
(Source: Internal Medicine Journal)
Source: Internal Medicine Journal - January 3, 2018 Category: Internal Medicine Authors: A. Sarah Dunlop Tags: Letter to the Editor Source Type: research

The strength of evidence: low dose morphine for chronic breathlessness
(Source: Internal Medicine Journal)
Source: Internal Medicine Journal - January 3, 2018 Category: Internal Medicine Authors: David C. Currow, Magnus Ekstr öm, Miriam J. Johnson Tags: Letter to the Editor Source Type: research

An increasing incidence of syphilis among young women in Japan
(Source: Internal Medicine Journal)
Source: Internal Medicine Journal - January 3, 2018 Category: Internal Medicine Authors: Tetsuya Tanimoto, Yuto Maeda, Tomohiro Morita, Eiji Kusumi, Kenzo Takahashi Tags: Letter to the Editor Source Type: research

Intra ‐abdominal sepsis following a Papanicolaou test
(Source: Internal Medicine Journal)
Source: Internal Medicine Journal - January 3, 2018 Category: Internal Medicine Authors: John Burston Tags: Letter to the Editor Source Type: research

Delayed ‐onset heparin‐induced thrombocytopenia complicated by arterial and venous thromboses
(Source: Internal Medicine Journal)
Source: Internal Medicine Journal - January 3, 2018 Category: Internal Medicine Authors: Shalini Balendran, Alexander Harrison, Marie ‐Christine Morel‐Kopp, Christopher Ward, Cecily Forsyth Tags: Letter to the Editor Source Type: research

Localisation of occult extra ‐pancreatic insulinoma using glucagon‐like peptide‐1 receptor molecular imaging
(Source: Internal Medicine Journal)
Source: Internal Medicine Journal - January 3, 2018 Category: Internal Medicine Authors: Anna K. Mossman, David A. Pattison, Rodney J. Hicks, Peter S. Hamblin, Christopher J. Yates Tags: Letter to the Editor Source Type: research

Looking to tomorrow ’s healthcare today: a participatory health perspective
Abstract Health systems around the world face the issue of financial and workforce sustainability. Mobile health technologies – those devices which connect health professionals, patients, payers and the many other contributors who make up the health system offer some solutions – not just as ‘add ons’ but as enablers of real system change. This paper presents a vision for what the health system of the future could be like and emphasises the opportunities for real patient participation in clinical decision‐making if the professions can engage the technologies and patients/community in a meaningful w...
Source: Internal Medicine Journal - January 3, 2018 Category: Internal Medicine Authors: Sheryl Coughlin, David Roberts, Kenneth O ’Neill, Peter Brooks Tags: Personal Viewpoint Source Type: research

Southcare Geriatric Flying Squad: an innovative Australian model providing acute care in residential aged care facilities
This study reviews the outcomes of a model developed to improve the quality of care of residents living within residential aged care facilities (RACF). The Southcare Geriatric Flying Squad saw a total of 640 acutely unwell RACF residents over an 18‐month period. Of these, 578 (90.3%) were managed in the RACF avoiding emergency department. Only 35 (5.5%) patients required emergency department transfer and 27 (4.2%) were directly admitted to a medical ward. The service may have reduced emergency presentations by offering rapid assessment and management, choice in place of treatment and level of interventions. (Source: Inte...
Source: Internal Medicine Journal - January 3, 2018 Category: Internal Medicine Authors: Shikha Jain, Peter N. Gonski, Jeannette Jarick, Sandra Frese, Sheena Gerrard Tags: Brief Communication Source Type: research

Acceptability of opt ‐out consent in a hospital patient population
Abstract Research has been slow to leverage digitalised medical records as a data resource. Our study assessed patient acceptability of opt‐out consent for secondary use of digital patient data. A questionnaire was distributed to patients in multiple languages and with an interpreter. Of 919 completed surveys, 33% were of non‐English speaking background, 15% self‐reported cognitive impairment and 3% were refugees. Opt‐out consent was accepted in this diverse population; 87% of participants approved, or were indifferent to opt‐out consent. Gender, employment and cognition status were not significant determinants o...
Source: Internal Medicine Journal - January 3, 2018 Category: Internal Medicine Authors: Daniel Boulos, Eric Morand, Michelle Foo, Janki Dhaval Trivedi, Ruth Lai, Rachel Huntersmith, Karen Zhang, Claire Brigid Stark, Suong Le Tags: Brief Communication Source Type: research

Pneumocystis jirovecii pneumonia in patients with acute myeloid leukaemia
Abstract The association of Pneumocystis jirovecii pneumonia (PJP) and acute myeloid leukaemia (AML) is not clearly defined. In our experience of 291 patients with AML, 20 (14 males and 6 females, median age 56) developed PJP (incidence 6.8%). Thirteen patients (65%) survived until discharge from hospital. We conclude that PJP is not uncommon among patients with AML. In clinical care of AML, awareness of PJP should be heightened and prophylaxis should be considered. (Source: Internal Medicine Journal)
Source: Internal Medicine Journal - January 3, 2018 Category: Internal Medicine Authors: Hung Chang, Ming ‐Chung Kuo, Tung‐Liang Lin, Jin‐Hou Wu, Po‐Nan Wang Tags: Brief Communication Source Type: research

Current lung cancer screening practice amongst general practitioners in Western Australia: a cross ‐sectional study
Abstract Lung cancer screening with low dose computed tomography (LDCT) is recommended in the USA and Canada for high‐risk smokers but not in Australia. We administered a cross‐sectional survey to Western Australian general practitioners (GP). The majority (64/93, 69%) reported requesting a screening chest X‐ray (42/93, 45%) and/or LDCT (38/93, 41%) in the past year. LDCT screening was more common if the GP had received education from radiology practices (odds ratio (OR) 2.81, P = 0.03) or if they believed screening is funded by the Medical Benefits Scheme (OR 3.57, P = 0.02). Lung cancer screening with LDCT is occur...
Source: Internal Medicine Journal - January 3, 2018 Category: Internal Medicine Authors: David Manners, Helen Wilcox, Annette McWilliams, Francesco Piccolo, Helena Liira, Fraser Brims Tags: Brief Communication Source Type: research

Non ‐immediate heparin and heparinoid cutaneous allergic reactions: a role for fondaparinux
Abstract Non‐immediate allergic cutaneous reactions to heparins have been increasingly reported, typically manifesting as large, eczematous plaques at sites of subcutaneous injection. Patients may demonstrate cross‐reactivity between unfractionated heparin, low molecular weight heparin and semi‐synthetic heparinoids, making finding an alternative difficult. Fondaparinux has been identified as a useful alternative in such patients; here we present the first two documented cases in Australia and a literature review. (Source: Internal Medicine Journal)
Source: Internal Medicine Journal - January 3, 2018 Category: Internal Medicine Authors: Elina Tan, Grace Thompson, Charlotta Ekstrom, Michaela Lucas Tags: Brief Communication Source Type: research

Type 2 diabetes in young adults in Central Auckland: demography and complications
Abstract BackgroundType 2 diabetes (T2D) in young adults is associated with a high risk of diabetes complications. AimsTo investigated the demography and the emergence of complications of young adults with T2D in the central Auckland region where there has been substantial immigration. MethodsIn total, 310 young adults with T2D (
Source: Internal Medicine Journal - January 3, 2018 Category: Internal Medicine Authors: Junaid Beig, Manish Khanolkar, Tim Cundy Tags: Original Article Source Type: research

Do medical oncology patients and their support persons agree about end ‐of‐life issues?
ConclusionRelying on support persons’ views does not guarantee that patients’ actual preferences will be followed. Strategies that make patient preferences known to healthcare providers and support persons while they still have the capacity to do so is a critical next step in improving quality cancer care. (Source: Internal Medicine Journal)
Source: Internal Medicine Journal - January 3, 2018 Category: Internal Medicine Authors: Amy Waller, Alix Hall, Rob Sanson ‐Fisher, Nicholas Zdenkowski, Charles Douglas, Justin Walsh Tags: Original Article Source Type: research

Predictive value of symptoms, signs and biomarkers on computed tomography pulmonary angiogram results
Abstract BackgroundPulmonary embolism (PE) is associated with significant morbidity and mortality. PE is a heterogeneous entity that causes a wide variety of clinical presentations, making it imperative to establish which clinical symptoms, signs and biomarkers can influence the pretest probability of PE to aid clinicians and reduce over testing. AimTo analyse the clinical parameters used by clinicians to order a computed tomography pulmonary angiogram (CTPA) and establish which were associated with the presence of PE. MethodsMedical records of patients who underwent CTPA from December 2015 to March 2016 were extracted. Pa...
Source: Internal Medicine Journal - January 3, 2018 Category: Internal Medicine Authors: Anver Sethwala, Xiaojie Wang, Emma E. Sturm, Kate L. Collins, Ronan O'Donnabhain, Nadia D. Friedman Tags: Original Article Source Type: research

Postural change in convulsive seizures: a retrospective review of video ‐electroencephalographic recordings
ConclusionThe incidence of patients attaining a prone position during a seizure was low. Given that no patient rolled more than 90°, patients are least likely to attain a prone position if they are supine at the beginning of a seizure. (Source: Internal Medicine Journal)
Source: Internal Medicine Journal - January 3, 2018 Category: Internal Medicine Authors: Jane Rigg, Kimberley Irwin, Fred Tremayne, David Reutens Tags: Original Article Source Type: research

Statin ‐associated immune‐mediated necrotising myopathy: a New Zealand case series showing possible overrepresentation in Pacific Islanders
ConclusionThis is the first case series of statin‐associated IMNM with a focus on Pacific Islanders and raises the possibility that Pacific Islanders exposed to statins may be at increased risk of developing an immune‐mediated myopathy. (Source: Internal Medicine Journal)
Source: Internal Medicine Journal - January 3, 2018 Category: Internal Medicine Authors: Michelle Woolley, Simon Stebbings, John Highton Tags: Original Article Source Type: research

Adult consequences of prenatal drug exposure
Abstract Maternal drug use is not new but over the last few decades, the number of mothers using drugs of addiction has escalated to epidemic levels. These drugs are both legal (e.g. prescription medication) and illegal (e.g. heroin) and all will cross the placental barrier into the developing infant. The most immediate and obvious consequence of intra‐uterine drug exposure is newborn withdrawal or the Neonatal Abstinence Syndrome (NAS) which is now, with prompt recognition and treatment, an uncommon cause of neonatal death. Thousands (if not millions) of adults most likely would have had a history of passive drug exposu...
Source: Internal Medicine Journal - January 3, 2018 Category: Internal Medicine Authors: Ju Lee Oei Tags: Clinical Perspectives Source Type: research

Dealing with the spiralling price of medicines: issues and solutions
Abstract Escalating cost of medicines is rapidly becoming a serious threat to patients and health systems. This trend has been documented to impact patient outcomes adversely. As clinicians and tax payers, it is our responsibility to be aware of the potential detrimental effects spiralling costs have on our patients, our community and our health system and to mitigate these effects by exposing this issue to our respective professional societies, representatives of the pharmaceutical companies that we interact with, government regulatory bodies and to patients who we are caring for. Only through understanding and constructi...
Source: Internal Medicine Journal - January 3, 2018 Category: Internal Medicine Authors: Chun K. K. Ma, Mark Danta, Richard Day, David D. F. Ma Tags: Review Source Type: research

Towards a cure for human immunodeficiency virus
(Source: Internal Medicine Journal)
Source: Internal Medicine Journal - January 3, 2018 Category: Internal Medicine Authors: Matthew C. Pitman, Sharon R. Lewin Tags: Editorial Source Type: research

2017 IMJ Reviewers
(Source: Internal Medicine Journal)
Source: Internal Medicine Journal - January 3, 2018 Category: Internal Medicine Tags: Reviewers List Source Type: research

The Journal in 2017
(Source: Internal Medicine Journal)
Source: Internal Medicine Journal - January 3, 2018 Category: Internal Medicine Authors: Jeff Szer Tags: Editorial Source Type: research

Issue Information
(Source: Internal Medicine Journal)
Source: Internal Medicine Journal - January 3, 2018 Category: Internal Medicine Tags: Issue Information Source Type: research

Multimorbidity, not HIV markers predicts unplanned admission among people with HIV in regional NSW
Abstract BackgroundMultimorbidity and unplanned admissions are common among people with HIV (PWH). AimsThe aim was to determine factors predictive of unplanned admission among PWH in regional NSW and compare care coordination between people with and without unplanned admissions. MethodA prospective cohort study of PWH attending a regional HIV service was conducted. Baseline HIV specific results and multimorbidity markers including Cumulative Illness Rating Scale (CIRS) were assessed as predictors of time to first unplanned admission using cox regression analysis. Care coordination markers were compared between people with ...
Source: Internal Medicine Journal - January 1, 2018 Category: Internal Medicine Authors: Natalie Edmiston, Kathy Petoumenos, David J Smith Tags: Original Article Source Type: research

Management of high risk chronic lymphocytic leukaemia (CLL) patients in Australia
ConclusionTesting for del(17p) and TP53 variants identifies high‐risk CLL that requires specialist management. (Source: Internal Medicine Journal)
Source: Internal Medicine Journal - December 17, 2017 Category: Internal Medicine Authors: Bryone J. Kuss, Constantine S. Tam Tags: Review Source Type: research

Issue Information
(Source: Internal Medicine Journal)
Source: Internal Medicine Journal - December 17, 2017 Category: Internal Medicine Tags: Issue Information Source Type: research

The full blood count as an ancillary test to support the diagnosis of giant cell arteritis
Abstract BackgroundTemporal artery biopsy is considered the investigation of choice to definitively diagnose giant cell arteritis in patients with compatible symptoms. However it is invasive and not completely sensitive. Serum markers, particularly ESR, can be supportive but are not definitive in individual cases. AimsWe sought to investigate whether indices derived from the full blood count including neutrophil‐to‐lymphocyte ratio (NLR) and platelet‐to‐lymphocyte ratio (PLR), were associated with a positive biopsy in patients with suspected giant cell arteritis. MethodsThe clinical and pathological details of 537 ...
Source: Internal Medicine Journal - December 13, 2017 Category: Internal Medicine Authors: Lawrence J. Oh, Eugene Wong, Juliana Andrici, Peter McCluskey, James E.H. Smith, Anthony J. Gill Tags: Original Article Source Type: research

Temporal changes in glycaemic thresholds for treatment intensification in type 2 diabetes in an urban Australian setting: The Fremantle Diabetes Study
ConclusionsHbA1c thresholds triggering treatment intensification fell between FDS Phases, suggesting a more proactive approach to management of glycaemia over time. (Source: Internal Medicine Journal)
Source: Internal Medicine Journal - December 12, 2017 Category: Internal Medicine Authors: Timothy M E Davis, Stephen A P Chubb, Bradley H Curtis, Helen Barraclough, Wendy A Davis Tags: Original Article Source Type: research

Volume 47 contents
(Source: Internal Medicine Journal)
Source: Internal Medicine Journal - December 10, 2017 Category: Internal Medicine Tags: Volume 47 contents Source Type: research

Author reply
(Source: Internal Medicine Journal)
Source: Internal Medicine Journal - December 10, 2017 Category: Internal Medicine Authors: Nicolette R. Holt, Matthew T. Naughton Tags: Letter to the Editor Source Type: research

Time to resurrect hypertension
(Source: Internal Medicine Journal)
Source: Internal Medicine Journal - December 10, 2017 Category: Internal Medicine Authors: Genevieve M. Gabb Tags: Letter to the Editor Source Type: research

Temporal artery biopsy: time matters!
(Source: Internal Medicine Journal)
Source: Internal Medicine Journal - December 10, 2017 Category: Internal Medicine Authors: Mohamed R. Sait, Mario Lepore, Richard Kwasnicki, Jonathan Allington, Narasimhaiah Srinivasaiah Tags: Letter to the Editor Source Type: research

Changing trends for diagnostic methods in Graves disease in Australia: an immunological diagnosis as the emerging preference
(Source: Internal Medicine Journal)
Source: Internal Medicine Journal - December 10, 2017 Category: Internal Medicine Authors: Albert Hsieh, Stephen M. Twigg, Elizabeth L. Chua Tags: Letter to the Editor Source Type: research

Pleuroperitoneal Denver shunt insertion for the treatment of refractory chylothorax in a patient with tuberous sclerosis complex and lymphangioleiomyomatosis
(Source: Internal Medicine Journal)
Source: Internal Medicine Journal - December 10, 2017 Category: Internal Medicine Authors: Richard Hanlon, Jonathan Lee, Doug Fenton ‐Lee, Deborah Yates Tags: Letter to the Editor Source Type: research

The utility of FDG ‐PET in complex neurological conditions
(Source: Internal Medicine Journal)
Source: Internal Medicine Journal - December 10, 2017 Category: Internal Medicine Authors: Zara A. Ioannides, Paul Thomas, Daman Langguth, Paul Kubler, Robert D. Henderson Tags: Letter to the Editor Source Type: research

Medical toxicology in the Old Testament. The poisonous pottage
(Source: Internal Medicine Journal)
Source: Internal Medicine Journal - December 10, 2017 Category: Internal Medicine Authors: Elias E. Mazokopakis, Christos G. Karagiannis Tags: History in Medicine Source Type: research

Collecting patient ‐reported outcome measures
Abstract Patient‐reported outcome measures (PROM) are potentially useful outcome measures that may be reported at the individual clinical, health service and/or health system level. PROM require clearly defined patient populations to enable comparisons, and are most meaningful when integrated with clinical data sets. Where possible PROM should be measured pre‐ and post‐intervention using reliable and validated tools. A variety of PROM collection methods exist which each have strengths and limitations, with selection depending on their purpose and patient factors. PROM programmes should be developed with high levels o...
Source: Internal Medicine Journal - December 10, 2017 Category: Internal Medicine Authors: Susannah Ahern, Rasa Ruseckaite, Ilana N. Ackerman Tags: Brief Communication Source Type: research

Acute kidney injury is under ‐recognised and under‐reported in hospitalised patients in Australia
Abstract Acute kidney injury (AKI) in hospitalised patients is associated with adverse outcomes; however, it remains unrecognised and under‐reported. A total of 48 045 serum creatinine results from 8129 tertiary hospital inpatients were reviewed. The prevalence of AKI was 4.33%. Mortality was significantly higher in patients with AKI (16.76%) compared to those without AKI (1.88%, P
Source: Internal Medicine Journal - December 10, 2017 Category: Internal Medicine Authors: Tim Mitchell, Elisabeth Feher, Gillian Mitchell, Aron Chakera Tags: Brief Communication Source Type: research

Interpreting insulin immunoassays during investigation of apparent spontaneous hypoglycaemia and insulin overdose
We report two cases of hypoglycaemia; one with apparently spontaneous hypoglycaemia and one with presumed insulin overdose. In both cases insulin concentration was normal when measured with the Roche immunoassay, but elevated when remeasured with the Advia Centaur immunoassay and a diagnosis of hypoglycaemia secondary to insulin analogue administration was made. These cases highlight that physicians need to understand the binding characteristics of the insulin immunoassay they use. (Source: Internal Medicine Journal)
Source: Internal Medicine Journal - December 10, 2017 Category: Internal Medicine Authors: Julie Chemmanam, Michelle Isaacs, Graham R. Jones, Jerry R. Greenfield, Morton G. Burt Tags: Brief Communication Source Type: research

Paradoxical psoriasiform reactions of anti ‐tumour necrosis factor therapy in inflammatory bowel disease patients
Abstract Anti‐tumour necrosis factor (TNF) agents have demonstrated efficacy in inflammatory bowel disease (IBD). Cutaneous reactions such as new onset psoriasis or psoriasiform‐like reactions are among the most common adverse reactions. We retrospectively identified cases of anti‐TNF‐induced psoriasis or psoriasiform manifestations in IBD patients at a tertiary centre in Australia. A total of 10 (six females) of 270 (3.7%) IBD patients treated with anti‐TNF therapy developed drug‐induced psoriatic or psoriasiform‐like reactions: five patients were treated with infliximab and five with adalimumab; nine had Cr...
Source: Internal Medicine Journal - December 10, 2017 Category: Internal Medicine Authors: Faseeha C. Peer, Andrew Miller, Paul Pavli, Kavitha Subramaniam Tags: Brief Communication Source Type: research

Medication reconciliation at two teaching hospitals in Australia: a missed opportunity?
Abstract Medication reconciliation prevents medication related harm at patient hospitalisation. This cross‐sectional study demonstrated that the Hunter New England Health Admission Medication History Form that supports the two processes is underutilised in two hospitals in New South Wales with many doctors unaware of the form and pharmacists facing understaffing and time constraints for completing it. Triaging of patients and, more collaboration between doctors and pharmacists are required for efficient in‐hospital medication reconciliation. (Source: Internal Medicine Journal)
Source: Internal Medicine Journal - December 10, 2017 Category: Internal Medicine Authors: Nimmi Athuraliya, Jasminka Sarunac, Jane Robertson Tags: Brief Communication Source Type: research

Mortality in acute non ‐invasive ventilation
Abstract A prospective study of non‐invasive ventilation at The Prince Charles Hospital outside of the intensive care unit from March 2015 to March 2016 was performed. Overall 69 patients were included. Acute hypercapnic respiratory failure was the most common indication (n = 59; 85%). 49 (71%) had multifactorial respiratory failure. 15 (22%) patients died. Premorbid inability to perform self‐care (P = 0.001) and the combination of mean pH
Source: Internal Medicine Journal - December 10, 2017 Category: Internal Medicine Authors: Dugal B. Smith, George T. P. Tay, Karen Hay, Jijo Antony, Brendan Bell, Frances B. Kinnear, Deanne L. Curtin, James Douglas Tags: Brief Communication Source Type: research

SIRCLE: a randomised controlled cost comparison of self ‐administered short‐course isoniazid and rifapentine for cost‐effective latent tuberculosis eradication
Abstract BackgroundCurrently, treatment of latent tuberculosis infection (LTBI) in Australia consists most commonly of a 9‐month course of isoniazid (9H). A 3‐month course of weekly isoniazid and rifapentine (3HP) has been shown to be as effective as 9 months of daily isoniazid, and associated with less hepatotoxicity; however, rifapentine is not currently available in Australia. Introduction of this regimen would have apparent advantages for people with LTBI in Victoria by safely shortening duration of LTBI therapy. However, the cost benefit of this new therapeutic approach is uncertain. AimCost‐analysis of standard...
Source: Internal Medicine Journal - December 10, 2017 Category: Internal Medicine Authors: Justin T. Denholm, Emma S. McBryde, Damon Eisen, Alan Street, Elizabeth Matchett, Caroline Chen, Thomas Shultz, Beverly Biggs, Karin Leder Tags: Original Article Source Type: research

Clinical outcomes in patients with advanced epidermal growth factor receptor ‐mutated non‐small‐cell lung cancer in South Western Sydney Local Health District
Abstract BackgroundEpidermal growth factor receptor (EGFR)‐mutated non‐small‐cell lung cancer (NSCLC) is a subgroup of oncogene addicted lung cancer that predicts response to tyrosine kinase inhibitors (TKI). However, there is variability in response and survival outcomes in patients with EGFR mutation treated with TKI. AimTo describe clinical characteristics, treatment patterns and factors influencing outcomes in patients with EGFR‐mutated NSCLC in South Western Sydney Local Health District. MethodsRetrospective review of patients with EGFR‐mutated NSCLC diagnosed between January 2010 and June 2016. ResultsA tot...
Source: Internal Medicine Journal - December 10, 2017 Category: Internal Medicine Authors: Pei N. Ding, Tara L. Roberts, Wei Chua, Therese M. Becker, Joseph Descallar, Po Y. Yip, Victoria Bray Tags: Original Article Source Type: research