Hydrochlorothiazide and alternative diuretics versus renin–angiotensin system inhibitors for the regression of left ventricular hypertrophy: a head-to-head meta-analysis
Background: Found in 36–41% of hypertension, elevated left ventricular mass (LVM) independently predicts cardiovascular events and total mortality. Conversely, drug-induced regression of LVM predicts improved outcomes. Previous studies have favored renin–angiotensin system inhibitors (RASIs) over other antihypertensives for reducing LVM but ignored differences among thiazide-type diuretics. From evidence regarding potency, cardiovascular events, and electrolytes, we hypothesized a priori that ‘CHIP’ diuretics [CHlorthalidone, Indapamide and Potassium-sparing Diuretic/hydrochlorothiazide (PSD/HCTZ)] would rival RASIs for reducing LVM. Method and results: Systematic review yielded 12 relevant double-blind randomized trials. CHIPs were more closely associated with reduced LVM than HCTZ (P = 0.004), indicating that RASIs must be compared with each diuretic separately. Publication bias favoring RASIs was corrected by cumulative analysis. For reducing LVM, HCTZ tended to be less effective than RASIs. However, the following surpassed RASIs: chlorthalidone Hedge's G: −0.37 (95% CI −0.72 to −0.02), P = 0.036; indapamide −0.20 (−0.39 to −0.01), P = 0.035; all CHIPs combined (with 61% of patients in one trial) −0.25 (−0.41to −0.09), P = 0.002. Statistical significance (P
Publication date: Available online 4 June 2020Source: Pharmacological ResearchAuthor(s): Ying Huang, Changming Xie, Xiaoke Chen, Qianhui Hong, Hui Huang
This study used nationally representative data from demographic and health surveys (DHS) in Namibia, Kenya and Sierra Leone. A direct sisterhood method was used to estimate pregnancy-related deaths based on 7 years of recollection. Findings of the study reveal that death during the antenatal period was the commonest time of death in mothers aged 15-19, while death during delivery and two months after delivery were the leading causes of death for mothers aged 20-24. Pregnancy-related deaths were more prevalent among women with no schooling or primary education than their counterparts with secondary and higher education.Impa...
United Therapeutics Corp. has filed a lawsuit against Morrisville, North Carolina-based Liquidia Technologies Inc. for allegedly violating a patent for one of its pulmonary arterial hypertension drugs. The suit, filed Thursday in U.S. District Court for Delaware, alleges that Liquidia infringed on the Silver Spring biotech’s two patents for Tyvaso, an inhalation system that uses active ingredient treprostinil, when it filed a new drug application with the Food and Drug Administration for an in haled,…
ConclusionsAccording to our study, use of SSRI does not change the risk of cataract in the overall population.
Conclusion: The prevalence of self-reported hypertension increased significantly in the study period. Considering this disease ’ s impact on society, knowing its current prevalence and identifying its main associated factors, the need to intensify the efforts to prevent it disease is evident in order to mitigate damage to individuals and impact on public expenditure.
Conclusion: Worst indicators among women receiving BF reflect social inequalities inherent in this most vulnerable group. The study also shows that BF is being targeted at the most vulnerabl e women.
RESUMO: Objetivos: Identificar a preval ência da doença renal crônica (DRC) autorreferida no Brasil e caracterizar os fatores associados a essa enfermidade. Métodos: Trata-se de um inquérito epidemiológico de base domiciliar, a Pesquisa Nacional de Saúde (PNS) realizada em 2013. O desfecho analisado foi a prevalência de DRC. Os grupos de variáveis explicativas foram: características sociodemográficas, estilos de vida, doenças crônicas autorreferidas, antropometria e avaliação de saúde. Foram estimadas as prevalê...
HIGH blood pressure affects the whole body offering clues and signs that something is not quite right. Feeling this sensation in your ears could mean you're at risk.
Conditions: Aortic Stenosis; Hypertension Intervention: Device: Biological prosthesis in the aortc valve Sponsor: Haukeland University Hospital Completed
A new study sheds light on the frequency and reproducibility of white coat and masked uncontrolled hypertension.European Heart Journal