Hydrochlorothiazide and alternative diuretics versus renin–angiotensin system inhibitors for the regression of left ventricular hypertrophy: a head-to-head meta-analysis

Background: Found in 36–41% of hypertension, elevated left ventricular mass (LVM) independently predicts cardiovascular events and total mortality. Conversely, drug-induced regression of LVM predicts improved outcomes. Previous studies have favored renin–angiotensin system inhibitors (RASIs) over other antihypertensives for reducing LVM but ignored differences among thiazide-type diuretics. From evidence regarding potency, cardiovascular events, and electrolytes, we hypothesized a priori that ‘CHIP’ diuretics [CHlorthalidone, Indapamide and Potassium-sparing Diuretic/hydrochlorothiazide (PSD/HCTZ)] would rival RASIs for reducing LVM. Method and results: Systematic review yielded 12 relevant double-blind randomized trials. CHIPs were more closely associated with reduced LVM than HCTZ (P = 0.004), indicating that RASIs must be compared with each diuretic separately. Publication bias favoring RASIs was corrected by cumulative analysis. For reducing LVM, HCTZ tended to be less effective than RASIs. However, the following surpassed RASIs: chlorthalidone Hedge's G: −0.37 (95% CI −0.72 to −0.02), P = 0.036; indapamide −0.20 (−0.39 to −0.01), P = 0.035; all CHIPs combined (with 61% of patients in one trial) −0.25 (−0.41to −0.09), P = 0.002. Statistical significance (P 
Source: Journal of Hypertension - Category: Cardiology Tags: Reviews Source Type: research

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Publication date: Available online 4 June 2020Source: Pharmacological ResearchAuthor(s): Ying Huang, Changming Xie, Xiaoke Chen, Qianhui Hong, Hui Huang
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
This study used nationally representative data from demographic and health surveys (DHS) in Namibia, Kenya and Sierra Leone. A direct sisterhood method was used to estimate pregnancy-related deaths based on 7 years of recollection. Findings of the study reveal that death during the antenatal period was the commonest time of death in mothers aged 15-19, while death during delivery and two months after delivery were the leading causes of death for mothers aged 20-24. Pregnancy-related deaths were more prevalent among women with no schooling or primary education than their counterparts with secondary and higher education.Impa...
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Tags: J Obstet Gynaecol Source Type: research
United Therapeutics Corp. has filed a lawsuit against Morrisville, North Carolina-based Liquidia Technologies Inc. for allegedly violating a patent for one of its pulmonary arterial hypertension drugs. The suit, filed Thursday in U.S. District Court for Delaware, alleges that Liquidia infringed on the Silver Spring biotech’s two patents for Tyvaso, an inhalation system that uses active ingredient treprostinil, when it filed a new drug application with the Food and Drug Administration for an in haled,…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
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Source: European Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: Revista Brasileira de Epidemiologia - Category: Epidemiology Source Type: research
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Source: Revista Brasileira de Epidemiologia - Category: Epidemiology Source Type: research
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Source: Revista Brasileira de Epidemiologia - Category: Epidemiology Source Type: research
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Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Conditions:   Aortic Stenosis;   Hypertension Intervention:   Device: Biological prosthesis in the aortc valve Sponsor:   Haukeland University Hospital Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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Source: Medscape Today Headlines - Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news
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