Efficacy of Single-Pill, Triple Antihypertensive Therapy in Patients with Uncontrolled Hypertension: A Systematic Review and Meta-analysis
Conclusionperindopril/indapamide/amlodipine is effective in reducing systolic and diastolic blood pressures by 24 and 12 mmHg respectively. Over 24 h, the combination reduced systolic and diastolic blood pressures by 14 and 7 mmHg respectively. (Source: High Blood Pressure and Cardiovascular Prevention)
Source: High Blood Pressure and Cardiovascular Prevention - March 24, 2022 Category: Cardiology Source Type: research
Perindopril/Indapamide/Amlodipine in Hypertension: A Profile of Its Use
AbstractThe single-pill combination (SPC) of perindopril (PER)/indapamide (IND)/amlodipine (AML) is a valuable and convenient treatment option for patients with hypertension controlled with two-drug SPC of PER/IND + AML given as two separate pills at the same dose level. PER [an angiotensin-converting enzyme (ACE) inhibitor], IND (a thiazide-like diuretic) and AML (a calcium channel blocker) are well established antihypertensive agents, which have been available for a long time as monotherapies and dual SPCs and have complementary mechanisms of action. Once-daily PER/IND/AML provided effective BP control, with good tolerab...
Source: American Journal of Cardiovascular Drugs - March 8, 2022 Category: Cardiology Source Type: research
Effectiveness of indapamide/amlodipine single-pill combination in patients with isolated systolic hypertension: post-hoc analysis of the ARBALET study
This study evaluated the effectiveness of treatment with an indapamide/amlodipine single-pill combination (SPC) in outpatients with uncontrolled isolated systolic hypertension (ISH) aged over 55 years in real-... (Source: BMC Cardiovascular Disorders)
Source: BMC Cardiovascular Disorders - March 4, 2022 Category: Cardiology Authors: Zh. D. Kobalava, Eteri L. Kolesnik, E. K. Shavarova, L. A. Goreva and L. V. Karapetyan Tags: Original Research Source Type: research
Assessment of the genotoxic effects of antihypertensive drug active ingredient indapamide in human lymphocytes
. (Source: Drug and Chemical Toxicology)
Source: Drug and Chemical Toxicology - January 12, 2022 Category: Toxicology Authors: Ece Avuloglu-Yilmaz Deniz Yuzbasioglu Fatma Unal Source Type: research
Multimodal imaging of indapamide-induced bilateral choroidal effusion: a case report
Indapamide, a sulfonamide diuretic used to treat hypertension, has been reported to have ocular side effects of acute angle-closure glaucoma, transient myopia and choroidal effusion whose immediate etiology is... (Source: BMC Ophthalmology)
Source: BMC Ophthalmology - November 4, 2021 Category: Opthalmology Authors: Shizuka Takahashi, Shinichi Usui, Noriyasu Hashida, Hiroshi Kubota, Kentaro Nishida, Hirokazu Sakaguchi and Kohji Nishida Tags: Case report Source Type: research
Shone syndrome revealed by treatment-resistant hypertension
CONCLUSION: Treatment required the coordinated efforts of a team of specialists. It could be either surgical with different method or by Trans catheter treatments.PMID:34729182 | PMC:PMC8545662 | DOI:10.1016/j.amsu.2021.102955 (Source: Annals of Medicine)
Source: Annals of Medicine - November 3, 2021 Category: Internal Medicine Authors: Soumia Boulouiz Amine Kossir Fadoua Mouedder Chaimae Miri Nabila Ismaili Noha El Ouafi Source Type: research
A Randomized, Double-blind, Active-controlled, Two Parallel-Group, Optional Titration, Multicenter, Phase IIIb Study to Evaluate the Efficacy and Safety of Fimasartan Versus Perindopril Monotherapy With and Without a Diuretic Combination in Elderly Patients With Essential Hypertension
This study was therefore conducted to determine the efficacy and tolerability of fimasartan compared with perindopril in elderly Korean patients aged >70 years with essential hypertension (defined by a mean sitting systolic blood pressure [SBP] ≥140 mm Hg).METHODS: This randomized, double-blind, active-controlled, 2 parallel-group, optional titration, multicenter, Phase IIIb trial (FITNESS [Fimasartan in the Senior Subjects]) enrolled 241 patients from 23 cardiac centers in the Republic of Korea between August 2017 and December 2019. After the placebo run-in period, treatment started with fimasartan 30 mg or perindopr...
Source: Clinical Therapeutics - September 10, 2021 Category: Drugs & Pharmacology Authors: Hae-Young Lee Kwang-Il Kim Sang Hyun Ihm Moo-Yong Rhee Il Suk Sohn Sungha Park Eun-Seok Jeon Jong-Min Song Wook Bum Pyun Ki-Chul Sung Moo Hyun Kim Sang-Hyun Kim Seok-Yeon Kim Shin-Jae Kim Eung Ju Kim Jinho Shin Sung Yun Lee Kook-Jin Chun Jin-Ok Jeong Shun Source Type: research
A Randomized, Double-blind, Active-controlled, Two Parallel-Group, Optional Titration, Multicenter, Phase IIIb Study to Evaluate the Efficacy and Safety of Fimasartan Versus Perindopril Monotherapy With and Without a Diuretic Combination in Elderly Patients With Essential Hypertension
This study was therefore conducted to determine the efficacy and tolerability of fimasartan compared with perindopril in elderly Korean patients aged >70 years with essential hypertension (defined by a mean sitting systolic blood pressure [SBP] ≥140 mm Hg).METHODS: This randomized, double-blind, active-controlled, 2 parallel-group, optional titration, multicenter, Phase IIIb trial (FITNESS [Fimasartan in the Senior Subjects]) enrolled 241 patients from 23 cardiac centers in the Republic of Korea between August 2017 and December 2019. After the placebo run-in period, treatment started with fimasartan 30 mg or perindopr...
Source: Clinical Therapeutics - September 10, 2021 Category: Drugs & Pharmacology Authors: Hae-Young Lee Kwang-Il Kim Sang Hyun Ihm Moo-Yong Rhee Il Suk Sohn Sungha Park Eun-Seok Jeon Jong-Min Song Wook Bum Pyun Ki-Chul Sung Moo Hyun Kim Sang-Hyun Kim Seok-Yeon Kim Shin-Jae Kim Eung Ju Kim Jinho Shin Sung Yun Lee Kook-Jin Chun Jin-Ok Jeong Shun Source Type: research
A Randomized, Double-blind, Active-controlled, Two Parallel-Group, Optional Titration, Multicenter, Phase IIIb Study to Evaluate the Efficacy and Safety of Fimasartan Versus Perindopril Monotherapy With and Without a Diuretic Combination in Elderly Patients With Essential Hypertension
This study was therefore conducted to determine the efficacy and tolerability of fimasartan compared with perindopril in elderly Korean patients aged >70 years with essential hypertension (defined by a mean sitting systolic blood pressure [SBP] ≥140 mm Hg).METHODS: This randomized, double-blind, active-controlled, 2 parallel-group, optional titration, multicenter, Phase IIIb trial (FITNESS [Fimasartan in the Senior Subjects]) enrolled 241 patients from 23 cardiac centers in the Republic of Korea between August 2017 and December 2019. After the placebo run-in period, treatment started with fimasartan 30 mg or perindopr...
Source: Clinical Therapeutics - September 10, 2021 Category: Drugs & Pharmacology Authors: Hae-Young Lee Kwang-Il Kim Sang Hyun Ihm Moo-Yong Rhee Il Suk Sohn Sungha Park Eun-Seok Jeon Jong-Min Song Wook Bum Pyun Ki-Chul Sung Moo Hyun Kim Sang-Hyun Kim Seok-Yeon Kim Shin-Jae Kim Eung Ju Kim Jinho Shin Sung Yun Lee Kook-Jin Chun Jin-Ok Jeong Shun Source Type: research
Isolated tongue angioedema after alteplase infusion in acute ischemic stroke
CONCLUSION: Although the incidence of alteplase-induced angiodema in these patients is rare, this case report suggests the need for routine inspection of the tongue in acute ischemic patient in treatment with alteplase infusion, especially in female patients in treatment with ACE inhibitors.PMID:34323196 | DOI:10.2174/1574886316666210728104331 (Source: Current Drug Safety)
Source: Current Drug Safety - July 29, 2021 Category: Drugs & Pharmacology Authors: Ermanno Pisani Carmen Gaudiano Alfredo Petrone Furio Stancati Antonio Siniscalchi Source Type: research
