Central Nervous System Depressants and Risk of Hospitalization due to Community Acquired Pneumonia in the Very Old.
CONCLUSION: The use of antipsychotics in the very old adults was associated with an increased risk of hospital admission due to CAP. This suggests that use of these medications in this population should be done with caution. No association was observed with opioids, benzodiazepines and zolpidem with the latter outcome. PMID: 32189596 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - March 19, 2020 Category: Drugs & Pharmacology Authors: Espinosa J, Alvarez P, Castro V, Caceres M, Soler-Riera M, Bril F Tags: Curr Drug Saf Source Type: research

Ustekinumab-induced sarcoidosis in a patient with psoriatic arthritis.
Abstract Psoriatic arthritis(PsA) is a chronic inflammatory disease which may affect many different joints. Sarcoidosis is a Th-1 cell related chronic granulomatous disease characterized by non-caseating granuloma formation. The coexistence of both diseases is a rare entity. In addition to conventional DMARDs, biological agents are also used in the treatment of PsA. One of these drugs is ustekinumab, an IL12 / 23 inhibitor that control both skin lesions and locomotor system findings. In this paper, we report the development of sarcoidosis in a 52 years old female patient treated with ustekinumab for PsA. PMID...
Source: Current Drug Safety - March 16, 2020 Category: Drugs & Pharmacology Authors: Kobak S, Semiz H Tags: Curr Drug Saf Source Type: research

Inappropriate Medication Use and cost comparison analysis of Proton pump inhibitors: Evidence from an Indian tertiary care facility.
CONCLUSION: The study inferred that irrational drug use of PPI still prevalent, that too without considering the economic impact of it on general populations. Healthcare practitioners should be aware and cautious while prescribing the PPI to identify the actual need and to choose with the most cost-effective alternative. PMID: 32160850 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - March 11, 2020 Category: Drugs & Pharmacology Authors: Venkataraman R, Rashid M, Shrestha H Tags: Curr Drug Saf Source Type: research

Impact of clinical audit on adherence to the guidelines directed medical therapy in patients admitted with heart failure.
CONCLUSION: This study reveals that periodic clinical audit improves adherence to GDMT in patients admitted with heart failure with reduced ejection fraction. PMID: 32156240 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - March 10, 2020 Category: Drugs & Pharmacology Authors: Ahamed A, George N, Radhakrishnan S, Velusamy S, Kaliappan T, Gopalan R, Anandan P, Palanimuthu R, Balasubramanian VR Tags: Curr Drug Saf Source Type: research

Delirium Secondary to Lamotrigine Toxicity.
CONCLUSION: Clinicians should use caution interpreting lamotrigine levels when working up delirium, as normal levels may not rule out the development of lamotrigine toxicity. PMID: 32096747 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - February 24, 2020 Category: Drugs & Pharmacology Authors: Sanchez DL, Fusick AJ, Gunther SR, Hernandez MJ, Sullivan GA, Catalano MC, Catalano G Tags: Curr Drug Saf Source Type: research

Integrating Regulatory Drug Label Information to Facilitate Evaluation of Adverse Events in Pharmacovigilance.
CONCLUSION: In addition to providing standalone KIM table as reference, adoption of this concept and automation may also be fully integrated into commercial signal detection and management software packages for easy use and accessibility and may even lead to reduced False Positive rate in signal detection within the PV space. PMID: 32091345 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - February 23, 2020 Category: Drugs & Pharmacology Authors: Hui TZ Tags: Curr Drug Saf Source Type: research

Analysis of QTc Interval during Levofloxacin Prescription in Cardiac Patients with Pneumonia: A Comparative Study.
Abstract BACKGROUND: Medications induced QT prolongation could cause ventricular arrhythmia, torsade de pointes, and death. OBJECTIVE: The purpose of this study was to evaluate the magnitude of QTc interval prolongation as a result of levofloxacin treatment in patients admitted to cardiology wards. METHODS: This was a cross-sectional study conducted in the coronary care units and general wards of the Imam Ali Heart Hospital in Kermanshah, Iran. The QTc interval was determined at baseline and after 72 hours of levofloxacin administration. Changes in the QTc interval before and after the levofloxacin presc...
Source: Current Drug Safety - February 12, 2020 Category: Drugs & Pharmacology Authors: Shojaei L, Ruzbahani M, Khajavian S, Shahsavari S, Tamasoki N, Rajabian M, Moradi F, Shahbazi F Tags: Curr Drug Saf Source Type: research

A Rare Case Report Of Dabigatran Induced Oral Ulcers.
CONCLUSION: Patient education and counselling should be done regarding this side effect of dabigatran and proper intake of this medicine. PMID: 32048978 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - February 11, 2020 Category: Drugs & Pharmacology Authors: Singh A, Prabha N, Yadav H Tags: Curr Drug Saf Source Type: research

Treatment of psoriasis: A comprehensive review of entire therapies.
CONCLUSION: A rationalized cost effective patient compliant therapy is required for effective management and complete cure of psoriasis. PMID: 31994468 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - January 27, 2020 Category: Drugs & Pharmacology Authors: Bakshi H, Nagpal M, Singh M, Dhingra GA, Aggarwal G Tags: Curr Drug Saf Source Type: research

Self-Medication Pattern and Prevalence among Iranian Medical Sciences Students.
CONCLUSIONS: Although medical sciences students have information about treatment of illnesses but they should be more informed about negative results and side-effects of self-medication. They should also transfer their knowledge to the society to decrease self-medication behavior. PMID: 31642791 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - October 21, 2019 Category: Drugs & Pharmacology Authors: Niroomand N, Bayati M, Seif M, Delavari S, Delavari S Tags: Curr Drug Saf Source Type: research

Disposal Practices of Unused and Expired Medicines among General Public in Delhi & National Capital Region, India.
CONCLUSION: The knowledge and practices of consumers towards disposal of unused and expired medicines needs to be improved. Health care professionals, government and policy makers should offer training to educate and guide the general public on safe and proper disposal practices of expired or unused medicines. PMID: 31593533 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - October 7, 2019 Category: Drugs & Pharmacology Authors: Manocha S, Suranagi UD, Sah RK, Chandane RD, Kulhare S, Goyal N, Tanwar K Tags: Curr Drug Saf Source Type: research

Drug withdrawal due to safety reasons: A review of the data supporting the withdrawal decision.
CONCLUSION: According to available and published evidence, there is no gold standard to identify risks associated with drug exposure. These findings strengthen the role of different information sources within the drug safety review process. PMID: 31584381 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - October 3, 2019 Category: Drugs & Pharmacology Authors: Craveiro NS, Lopes BS, Tomás L, Almeida SF Tags: Curr Drug Saf Source Type: research

Analysis of ADRs from oral anticoagulants: Clinical pictures, preventability and need for clinical and laboratory monitoring. A pilot study in an Internal Medicine Department.
CONCLUSIONS: This study highlights the large percentage of adverse reactions from oral anticoagulants that can be avoided with more careful patient management. A clinical picture of cardiac failure often leads to a diagnosis of hemorrhage/anemia; Periodic check up of cardiac and renal function and of blood count may be very useful, especially in older patients and in those in therapy with DOACs. A larger study, including patients from different hospitals, could yeld a higher general value. PMID: 31580253 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - October 3, 2019 Category: Drugs & Pharmacology Authors: Spada G, Vighi GVGV, Pagani S, Vighi GD, Venegoni M, Ruocco M Tags: Curr Drug Saf Source Type: research

Ledipasvir/Sofosbuvir versus Daclatasvir/Sofosbuvir for the Treatment of Chronic Hepatitis C Genotype 4 Patients.
Abstract BACKGROUND: Chronic hepatitis C (CHC) is a common progressive healthcare challenge that leads to liver cirrhosis, liver failure, and hepatocellular carcinoma. The optimum therapy was a combination of pegylated interferon and ribavirin, which was associated with moderate response and severe side effects. Sofosbuvir revolutionized CHC treatment, especially in combination with other antiviral agents. OBJECTIVE: The aim of this study was to compare and evaluate the safety and efficacy of sofosbuvir/daclatasvir versus sofosbuvir/ledipasvir for treatment of non-cirrhotic naïve patients for 12 weeks in...
Source: Current Drug Safety - October 1, 2019 Category: Drugs & Pharmacology Authors: Abdelaty LN, Elnaggar AA, Said AA, Hussein RRS Tags: Curr Drug Saf Source Type: research

Impact of Abuse of Topical Corticosteroids and Counterfeit Cosmetic Products for the Face: Prospective Demographic Study in Basrah City, Iraq.
CONCLUSION: The causes behind corticosteroid abuse for various indications are many but lack of education, lack of restriction, get quick profit for sellers and low price are the main factors responsible for the rampant in our Basrah city. PMID: 31573892 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - September 30, 2019 Category: Drugs & Pharmacology Authors: Jaccob AA, Yaqoub AA, Rahmani MA Tags: Curr Drug Saf Source Type: research

Olmesartan Associated Enteropathy: Usefulness of Video Capsule Endoscopy in a Case With Doubtful Upper Endoscopic/Histological Picture.
CONCLUSIONS: Our case could give new insights in the field of Olmesartan associated enteropathy and highlights the usefulness of video capsule endoscopy in the presence of doubtful diagnostic features and/or to obtain information regarding the whole small bowel involvement. PMID: 31549594 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - September 23, 2019 Category: Drugs & Pharmacology Authors: Abbruzzi F, Loconte I, Carparelli S, Ierardi E, Di Leo A, Principi M Tags: Curr Drug Saf Source Type: research

Bilateral sub-deltoid bursitis in a patient receiving infliximab for Crohn's disease.
CONCLUSIONS: Musculoskeletal side effects of infliximab infusion are uncommonly reported. Among them bursitis has been reported in only few cases. Ultrasonography can help early diagnosis of bursitis. The time of occurring of this reaction regarding to infliximab infusion, screening of ATI and clinical outcome after drug discontinuation are the main helpful arguments. PMID: 31483235 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - September 4, 2019 Category: Drugs & Pharmacology Authors: Bellakhal S, Abbes M, Jomni MT, Abdelaali I, Charfi M, Douggui MH Tags: Curr Drug Saf Source Type: research

Knowledge of Pharmacists about Anti-epileptic Drugs in a Developing Country.
CONCLUSIONS: Majority of the pharmacists in Khartoum State have poor knowledge about anti-epileptic drugs. Further research is needed to investigate the actual factors behind this knowledge gap and to propose interventions to improve the pharmacist's knowledge and practice aiming to improve the quality of health care provided to the patients. PMID: 31362679 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - July 29, 2019 Category: Drugs & Pharmacology Authors: Ali MAO, Mahgoub EAA, Nimir M, Ali KM Tags: Curr Drug Saf Source Type: research

Evaluation of Different Sedatives for Colonoscopy.
CONCLUSION: Sedation with propofol ketamine during colonoscopy was found to be safe and efficacious and to achieve hemodynamic stability with fewer complications than propofol fentanyl. PMID: 31362661 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - July 26, 2019 Category: Drugs & Pharmacology Authors: Seleem WM, El Hossieny KM, Abd-Elsalam S Tags: Curr Drug Saf Source Type: research

A Rare Case of Drug-Induced Erectile Dysfunction with Secukinumab Solved After Switch to Ixekizumab in A Psoriatic Patient: A Case Report.
CONCLUSION: We describe for the first time a sexual dysfunction possibly due to secukinumab and his resolution after switch to another similar but different drug, highlighting the potential difference between anti-IL17A drugs. PMID: 31362662 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - July 26, 2019 Category: Drugs & Pharmacology Authors: Dastoli S, Iannone LF, Bennardo L, Silvestri M, Palleria C, Nisticò SP, De Sarro G, Russo E Tags: Curr Drug Saf Source Type: research

Levofloxacin induced Desquamation: A Rare Case Report.
We present a case report of levofloxacin-induced desquamation in an India patient. CASE REPORT: - A-38-year old female patient presented to outpatient department, with chief complaints of peeling of her epidermal skin. Initially, Desquamation started on her greater figure, slowly evolved her hand, feet, lower limbs as well as upper limb and neck region. She was prescribed Levofloxacin for respiratory tract infection. RESULT: - Considering temporal relationship, upon causality assessment, (Adverse Drug Reaction) ADR was found to be likely, moderate and probable. Drug was withdrawn along with initiation of supporti...
Source: Current Drug Safety - July 8, 2019 Category: Drugs & Pharmacology Authors: Gill GK, Chhabra M, Chawla SPS Tags: Curr Drug Saf Source Type: research

Intercycle Unplanned Hospital Admissions Due to Cisplatin-based Chemotherapy Regimen-induced Adverse Reactions: A Retrospective Analysis.
Abstract BACKGROUND: Cisplatin is a commonly used chemotherapy agent known to induce serious adverse reactions that may require hospital readmission. We aimed to analyze the extent and factors associated with unplanned hospital admissions due to cisplatin-based chemotherapy regimen-induced adverse reactions. METHOD: Retrospective review of medical records of those patients who received at least one cycle of chemotherapy with cisplatin-based regimen during a six-month period from March to August 2017. RESULTS: Of the 458 patients who received cisplatin during the study period, 142 patients did not meet in...
Source: Current Drug Safety - June 19, 2019 Category: Drugs & Pharmacology Authors: Bright HR, Chandy SJ, Chacko RT, Backianathan S Tags: Curr Drug Saf Source Type: research

Antibiotic Abuse Induced Histopathological And Neurobehavioral Disorders In Mice.
In conclusion, antibiotic abuse is a neurotoxic factor that works by both local and more prominent systemic mechanisms. It can be said that antibiotic abuse is a cofactor behind the rise of neuropsychiatric diseases in Egypt. PMID: 31195950 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - June 12, 2019 Category: Drugs & Pharmacology Authors: Helaly AMN, El-Attar YA, Khalil M, Ahmed Ghorab DSED, El-Mansoury AM Tags: Curr Drug Saf Source Type: research

Pembrolizumab-Induced Seronegat ıve Arthrıtıs And Fascııtıs In A Patıent Wıth Lung Adenocarcınoma.
Pembrolizumab-Induced Seronegatıve Arthrıtıs And Fascııtıs In A Patıent Wıth Lung Adenocarcınoma. Curr Drug Saf. 2019 May 28;: Authors: Kobak S Abstract Immune checkpoint inhibitors (CPIs) are a new promising anti-cancer drugs that block negative costimulation of T-cells leading to an enhanced anti-tumor immune response. Pembrolizumab, an a monoclonal antibody, targeting the programmed cell death protein 1 (PD-1) pathway. CPIs have been associated with a number of immune-related adverse events (AEs), including musculoskeletal and rheumatic disease. Herein we report a patient with lung adenoca...
Source: Current Drug Safety - May 28, 2019 Category: Drugs & Pharmacology Authors: Kobak S Tags: Curr Drug Saf Source Type: research

The effects of hemocoagulase on coagulation factors in an elderly patient with upper gastrointestinal hemorrhage: A case report.
CONCLUSION: So intravenous administration of hemocoagulase should be cautiously used for the treatment of gastrointestinal bleeding. PMID: 31124425 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - May 23, 2019 Category: Drugs & Pharmacology Authors: Zhang H Tags: Curr Drug Saf Source Type: research

Panitumumab Induced Forearm Panniculitis In Two Women With Metastatic Colon Cancer.
CONCLUSION: We reported for the first time the development of panniculitis during the treatment with Panitumumab and we documented that beta-lactams with fluoroquinolones or with thiazolidinedione may be useful to improve symptoms in young patients with mCRC without the development of drug interactions. PMID: 31113346 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - May 21, 2019 Category: Drugs & Pharmacology Authors: Domenico C, Antonella I, Benedetto C, Luigi S, Antonio C, Lidia C, Giuseppe S, Luca G Tags: Curr Drug Saf Source Type: research

Adverse drug reaction (ADR) as a cause of hospitalization at a government hospital in Saudi Arabia: A prospective observational study.
CONCLUSION: Our study shows that ADRs as a cause of hospitalization in Qassim population are considerably low. However, ADRs may contribute to morbidity and mortality and result in a considerable financial burden. PMID: 31109277 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - May 19, 2019 Category: Drugs & Pharmacology Authors: Alayed N, Alkhalifah B, Alharbi M, Alwohaibi N, Farooqui M Tags: Curr Drug Saf Source Type: research

Protective effect of edaravone on cyclophoshamide induced oxidative stress and neurotoxicity in rats.
This study aimed to investigate the effect of edaravone on neurobehavioral and neuropathological alteration induced by cyclophosphamide in male rats. Twenty eight Sprague-Dawley rats were equally divided into four groups of seven rats in each. The control group received saline, and other groups were given CPA intraperitoneally (100 mg/kg), CPA (100 mg/kg) intraperitoneally + Edaravone (10 mg/kg) orally, or Edaravone (10 mg/kg) orally for one month. Our data showed that CPA significantly elevated brain AChE activity in the hippocampal region. A decrease in the total antioxidant capacity, reduced CAT, SOD, and GPX activity ...
Source: Current Drug Safety - May 5, 2019 Category: Drugs & Pharmacology Authors: Singh S, Kumar A Tags: Curr Drug Saf Source Type: research

A "crazy paving" pattern on CT scan in a patient treated with Pembrolizumab.
CONCLUSIONS: Oncologists, pulmonologists, radiologists and general practitioners have to consider PD-1 and PD-L1 inhibitor pneumonitis as a potentially disabling and fatal event. PMID: 30864509 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - March 11, 2019 Category: Drugs & Pharmacology Authors: Marvisi M, Ramponi S, Balzarini L, Mancini C Tags: Curr Drug Saf Source Type: research

Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome associated with Ethambutol use: A Case Report.
Abstract Among the first line anti-tubercular drugs (ATDs), ethambutol has been rarely associated to cause drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome. A 34-year-old woman presented in out-patient department of Dermatology with fever, skin eruptions, eosinophilia, hyperinflated lung fields and deranged liver enzymes after 35 days of the initiation of ATDs. The patient recovered completely after stopping ethambutol and administration of topical and systemic corticosteroids. Based on available evidences of de-challenge and re-challenge of suspected drugs, ethambutol was certainly implicate...
Source: Current Drug Safety - March 7, 2019 Category: Drugs & Pharmacology Authors: Kapur A, Rehan HS Tags: Curr Drug Saf Source Type: research

Significant Weight Loss In A Patient Taking Olmesartan: An Unusual Case Report.
Abstract OBJECTIVE: Olmesartan-induced enteropathy consists a syndrome that mimics celiac disease both clinically and histologically. Cases of this entity have sporadically been reported since 2012 and are usually characterized by severe diarrhea and malabsorption, followed by significant weight loss. CASE REPORT: Herein, we report an uncommon case of this syndrome, where weight loss preceded several months the onset of gastrointestinal symptoms. Physicians should be aware of unexplained weight loss in patients taking olmesartan, as prompt discontinuation of the drug may prevent the deleterious consequences o...
Source: Current Drug Safety - March 7, 2019 Category: Drugs & Pharmacology Authors: Makri A, Florentin M, Elisaf MS, Liamis G Tags: Curr Drug Saf Source Type: research

Postoperative clinical monitoring after morphine administration: a retrospective multicenter practice survey.
CONCLUSION: This survey emphazises an important disparity in the prescription of medical monitoring and a lack of use of protocols when morphine is administred. It demonstrates the need for a standardization of protocols according to the existing guidelines. PMID: 30843492 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - March 5, 2019 Category: Drugs & Pharmacology Authors: Raft J, Podrez K, Baumann C, Richebé P, Bouaziz H Tags: Curr Drug Saf Source Type: research

Non-uremic calciphylaxis: a rare and late adverse reaction of warfarin.
We present a case of a 48-year male with a history of paroxysmal atrial fibrillation and hypertension taking amlodipine 5 mg and warfarin 5 mg daily for the last 26 month. The patient had a 6-month history of painful swelling followed by necrotic skin ulcer over the right leg. His remarkable examination findings were right leg tender ulcer with surrounding erythema and secondary sepsis. His hemogram, metabolic profile and connective tissue diseases work up were unremarkable except leucocytosis and raised inflammatory markers. His local part radiological and skin biopsy findings were suggestive of calciphylaxis. In our case...
Source: Current Drug Safety - March 3, 2019 Category: Drugs & Pharmacology Authors: Patel DM, Patel MV, Patel AD, Kaklotar JC, Patel GR, Patel MM Tags: Curr Drug Saf Source Type: research

Positive and negative effects of antipsychotic medication: an international online survey of 832 recipients.
Conclusions Clinical implications are discussed, with a particular focus on the principles of informed consent, and involving patients in decision making about their own lives. PMID: 30827259 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - March 1, 2019 Category: Drugs & Pharmacology Authors: Read J, Williams J Tags: Curr Drug Saf Source Type: research

Treatment with paracetamol is not associated with increased airway sensitivity and risk of asthma in rats.
Conclusion despite increased oxidative stress and reduced antioxidant defense, chronic treatment with PAR does not induce airway hypersensitivity or risk of asthma in rats. PMID: 30806323 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - February 22, 2019 Category: Drugs & Pharmacology Authors: Lacerda Ribeiro MT, Paes Porto HK, de Oliveira DF, da Silva Castro PF, Rocha ML Tags: Curr Drug Saf Source Type: research

Citalopram-Associated Alopecia: A Case Report and Brief Literature Review.
Abstract BACKGROUND: Selective Serotonin Reuptake Inhibitors (SSRIs) are the first-line treatments for various psychiatric disorders. SSRIs offer improved side effect profile compared to older treatments, which improve patient adherence and quality of life. CASE REPORT: Here we discuss a case of an uncommon, but distressing side effect of citalopram. A 76-year old woman was referred to the psychiatry clinic for bizarre behavior. Patient was diagnosed with behavioral variant frontotemporal dementia, and was started on citalopram 20 mg and aripiprazole 5 mg daily. At 3.5 months the patient complained of diffuse...
Source: Current Drug Safety - February 14, 2019 Category: Drugs & Pharmacology Authors: Hekmatjah J, Tareen K, Tareen RS Tags: Curr Drug Saf Source Type: research

Drug-induced idiosyncratic acute liver failure: A challenging and distressing scenario.
Abstract Idiosyncratic drug induced liver injury (DILI) is a rare adverse event to drugs that occasionally leads to severe liver damage, being one of the leading causes of acute liver failure (ALF) in developed countries. DILI is largely a diagnosis of exclusion. Thus, careful history of drug taking and ruling out other competing etiologies is mandatory given that DILI can present with an extremely variable phenotype. Several prognostic scores have been developed to promptly identify patients with potential risk of developing ALF. New biomarkers to diagnose and predict DILI evolution are under study and hopefully ...
Source: Current Drug Safety - February 14, 2019 Category: Drugs & Pharmacology Authors: Colaci CS, Mendizabal M, Bessone F Tags: Curr Drug Saf Source Type: research

Safety of SGLT2 Inhibitors in Patients with Diabetes Mellitus.
CONCLUSION: In conclusion, Marketing Authorization Holder (MAH) and Regulatory Authorities (RA) should monitor various adverse drug reactions such as diabetic ketoacidosis and urinary tract infection with the use of SGLT2 inhibitor. PMID: 30727912 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - February 6, 2019 Category: Drugs & Pharmacology Authors: Singh M, Sharma R, Kumar A Tags: Curr Drug Saf Source Type: research

New indices for ethnotoxicological assessment of medicinal plants: example of Tafilalet region, Morocco.
CONCLUSION: novel indices established in this investigation (DT, DFT and RLT) have been demonstrated to be useful for interpreting data collected in Tafilalet region and could serve for other ethnopharmacological surveys of toxic medicinal plants. PMID: 30727913 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - February 6, 2019 Category: Drugs & Pharmacology Authors: Eddouks M, Ajebli M, Hebi M Tags: Curr Drug Saf Source Type: research

Metronidazole induced cerebellar dysfunction: A dose related phenomenon or a pharmacogenetic outcome?
Abstract Metronidazole, a widely used antibacterial and antiprotozoal drug, is often the drug of choice in amoebic liver abscess. The drug, otherwise safe, can cause serious central nervous disturbances in rare circumstances. Here we report a case of cerebellar dysfunction in the form of slurring of speech and episodes of falls, in an elderly male following a three-week course of metronidazole therapy. The patient manifested classic radiologic features of metronidazole neurotoxicity. Marked improvement in clinical symptoms were seen following drug discontinuation. PMID: 30727914 [PubMed - as supplied by publi...
Source: Current Drug Safety - February 6, 2019 Category: Drugs & Pharmacology Authors: Kaur U, Kumar I, Singh A, Kumar M, Chakrabarti SS Tags: Curr Drug Saf Source Type: research

Preface.
Abstract PMID: 30698108 [PubMed - in process] (Source: Current Drug Safety)
Source: Current Drug Safety - January 31, 2019 Category: Drugs & Pharmacology Authors: Dodd S Tags: Curr Drug Saf Source Type: research

Adverse drug reactions to radiographic contrast media in a teaching hospital in North India: An observational study.
Abstract BACKGROUND: Radiocontrast media are used extensively nowadays to visualize internal organs. Currently, non ionic iodinated contrast media are used which are generally considered to be safe but some adverse reactions have been reported. Thus, the present study was carried out to analyze the nature and incidence of adverse drug reactions (ADRs) to radiographic contrast media in a teaching hospital. METHODS: An observational study carried out for a period of six months in a teaching hospital. Contrast media induced adverse reactions were analyzed in terms of affected organs, rate, causality assessment, ...
Source: Current Drug Safety - January 21, 2019 Category: Drugs & Pharmacology Authors: Chopra D, Jain A, Garg R, Dhingra S Tags: Curr Drug Saf Source Type: research

Depression, Antidepressants and Hypertensive Disorders of Pregnancy: A Systematic Review.
CONCLUSION: Review of the literature suggests a possible association between depression and antihypertensive medications with pregnancy-related hypertension, but further studies are needed. PMID: 30666916 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - January 21, 2019 Category: Drugs & Pharmacology Authors: Youash S, Sharma V Tags: Curr Drug Saf Source Type: research

Aripiprazole overdose and transient 2:1 second degree atrioventricular block: only a coincidence?
Abstract Atypical antipsychotics, unlike traditional antipsychotics, are considered to have limited cardiovascular side effects, but recent evidence drew attention to potential cardiac rhythm disturbances during aripiprazole therapy. Prolonged QT-interval and increased heart rate were described during treatment with therapeutic doses of aripiprazole, and some reports have even shown relevant arrhythmias, such as ventricular trigeminy and supraventricular tachycardia, in patients treated with this drug. Here we report a case of a young female who attempted suicide with aripiprazole overdose presenting with a concom...
Source: Current Drug Safety - January 19, 2019 Category: Drugs & Pharmacology Authors: Lucia R, Di Vincenzo A, Alessandro R, Marco R, Roberto V Tags: Curr Drug Saf Source Type: research

A Novel Desensitization Protocol for Infliximab hypersensitivity in a 13-Year Old Patient with Pustular Psoriasis.
CONCLUSION: Although our desensitization protocol was safe and effective, we recommend the entire desensitization procedure to be performed under supervision of experienced personnel in a pediatric intensive care unit. Future studies with larger sample size are needed to confirm our findings. PMID: 30659548 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - January 18, 2019 Category: Drugs & Pharmacology Authors: Behera SK, Selvarajan S, Mathews J, Shajil C, Das S, Munisamy M, Xavier AS Tags: Curr Drug Saf Source Type: research

Double infection in a patient with psoriatic arthritis under TNF-alpha blockers therapy: a case report.
CONCLUSION: This case highlights the importance to consider the possibility to develop leishmaniasis and/or non-tubercular mycobacterial infection in patients treated with TNF-apha inhibitors. PMID: 30648521 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - January 14, 2019 Category: Drugs & Pharmacology Authors: Caroleo B, Migliore A, Cione E, Zampogna S, Perticone F, Sarro G, Gallelli L Tags: Curr Drug Saf Source Type: research

Evaluation of Hospital Discharge Prescriptions in the Elderly and Younger Adults Using the Medication Regimen Complexity Index.
Abstract BACKGROUND: Advances in the clinical management of diseases have been accompanied by increasing complexity of treatment regimens. The complexity of medication regimen is of concern for patients as well as doctors as it may adversely affect patient compliance and treatment outcomes. It may result in medication errors, increased utilization of health resources owing to a reduction in treatment effectiveness, and increased risk of therapeutic failure. OBJECTIVE: To assess the complexity of medication regimen prescribed to patients on hospital discharge using the medication regimen complexity index (MRCI...
Source: Current Drug Safety - December 6, 2018 Category: Drugs & Pharmacology Authors: Balodiya S, Kamath A Tags: Curr Drug Saf Source Type: research

Pibrentasvir / Glecaprevir - induced cholestatic jaundice in a HCV patient with renal failure. A case presentation.
Abstract Direct-acting a antiviral (DAA) are currently used in the treatment of chronic HCV infection. In patients with renal failure with Elbasvir/Grazoprevir (genotype 1 and 4) or Pibrentasvir/Glecaprevir (genotype 1-6) is advised and these documented both good safety and efficacy. In this manuscript we reported the development of cholestatic jaundice, during Pibrentasvir/Glecaprevir treatment, in a 86-year-old male with chronic HCV (genotype 2) infection and renal failure. At examination patient was jaundiced and suffered of a severe itch. Ultrasound and laboratory findings excluded a liver failure (e.g. liver ...
Source: Current Drug Safety - November 15, 2018 Category: Drugs & Pharmacology Authors: Caroleo B, Caroleo MC, Cimellaro A, Colangelo L, Perticone M, Di Mizio G, De Sarro G, Gallelli L Tags: Curr Drug Saf Source Type: research

Delayed Hemolytic Anemia after Treatment with Artesunate: Case Report and Literature Review.
CONCLUSION: Considering clinical course and base on a reliable causality assessment scale, post artesunate delay hemolytic anemia was possible. PMID: 30411691 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - November 9, 2018 Category: Drugs & Pharmacology Authors: Salehi M, Masoumi-Asl H, Assarian M, Rad NK, Haghi AM, Nikbakht M, Khalili H Tags: Curr Drug Saf Source Type: research

Report Of Adverse Events In Colombia: A Successful Case.
This article summarizes the strategies implemented by INVIMA to strengthen the National Pharmacovigilance Program, including the expansion of the National Pharmacovigilance Network and the implementation of the electronic submission of adverse events. Results: the number of adverse events reported in Colombia increased from 5,447 in 2013 to 95,658 in 2017, reaching a population-based reporting ratio within international standards. PMID: 30411692 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - November 9, 2018 Category: Drugs & Pharmacology Authors: Moreno-Mattar O, Ramírez R, Alvarado A, Sierra F Tags: Curr Drug Saf Source Type: research