Empirical Antimicrobial Therapy and QTc Interval Prolongation in Emergency Medicine
CONCLUSION: This analysis shows the relevance of the empirical therapy established at the admission, in particular for infective diseases, as an important risk factor for the prolongation of QTc. Other factors that can increase the risk are electrolytes alterations, advanced age, cardiovascular diseases, and drug-drug interaction.PMID:34212831 | DOI:10.2174/1574886316666210629150105 (Source: Current Drug Safety)
Source: Current Drug Safety - July 2, 2021 Category: Drugs & Pharmacology Authors: Marianna Suppa Luca Marino Source Type: research

Empirical Antimicrobial Therapy and QTc Interval Prolongation in Emergency Medicine
CONCLUSION: This analysis shows the relevance of the empirical therapy established at the admission, in particular for infective diseases, as an important risk factor for the prolongation of QTc. Other factors that can increase the risk are electrolytes alterations, advanced age, cardiovascular diseases, and drug-drug interaction.PMID:34212831 | DOI:10.2174/1574886316666210629150105 (Source: Current Drug Safety)
Source: Current Drug Safety - July 2, 2021 Category: Drugs & Pharmacology Authors: Marianna Suppa Luca Marino Source Type: research

Empirical Antimicrobial Therapy and QTc Interval Prolongation in Emergency Medicine
CONCLUSION: This analysis shows the relevance of the empirical therapy established at the admission, in particular for infective diseases, as an important risk factor for the prolongation of QTc. Other factors that can increase the risk are electrolytes alterations, advanced age, cardiovascular diseases, and drug-drug interaction.PMID:34212831 | DOI:10.2174/1574886316666210629150105 (Source: Current Drug Safety)
Source: Current Drug Safety - July 2, 2021 Category: Drugs & Pharmacology Authors: Marianna Suppa Luca Marino Source Type: research

Empirical Antimicrobial Therapy and QTc Interval Prolongation in Emergency Medicine
CONCLUSION: This analysis shows the relevance of the empirical therapy established at the admission, in particular for infective diseases, as an important risk factor for the prolongation of QTc. Other factors that can increase the risk are electrolytes alterations, advanced age, cardiovascular diseases, and drug-drug interaction.PMID:34212831 | DOI:10.2174/1574886316666210629150105 (Source: Current Drug Safety)
Source: Current Drug Safety - July 2, 2021 Category: Drugs & Pharmacology Authors: Marianna Suppa Luca Marino Source Type: research

Empirical Antimicrobial Therapy and QTc Interval Prolongation in Emergency Medicine
CONCLUSION: This analysis shows the relevance of the empirical therapy established at the admission, in particular for infective diseases, as an important risk factor for the prolongation of QTc. Other factors that can increase the risk are electrolytes alterations, advanced age, cardiovascular diseases, and drug-drug interaction.PMID:34212831 | DOI:10.2174/1574886316666210629150105 (Source: Current Drug Safety)
Source: Current Drug Safety - July 2, 2021 Category: Drugs & Pharmacology Authors: Marianna Suppa Luca Marino Source Type: research

Empirical Antimicrobial Therapy and QTc Interval Prolongation in Emergency Medicine
CONCLUSION: This analysis shows the relevance of the empirical therapy established at the admission, in particular for infective diseases, as an important risk factor for the prolongation of QTc. Other factors that can increase the risk are electrolytes alterations, advanced age, cardiovascular diseases, and drug-drug interaction.PMID:34212831 | DOI:10.2174/1574886316666210629150105 (Source: Current Drug Safety)
Source: Current Drug Safety - July 2, 2021 Category: Drugs & Pharmacology Authors: Marianna Suppa Luca Marino Source Type: research

Empirical Antimicrobial Therapy and QTc Interval Prolongation in Emergency Medicine
CONCLUSION: This analysis shows the relevance of the empirical therapy established at the admission, in particular for infective diseases, as an important risk factor for the prolongation of QTc. Other factors that can increase the risk are electrolytes alterations, advanced age, cardiovascular diseases, and drug-drug interaction.PMID:34212831 | DOI:10.2174/1574886316666210629150105 (Source: Current Drug Safety)
Source: Current Drug Safety - July 2, 2021 Category: Drugs & Pharmacology Authors: Marianna Suppa Luca Marino Source Type: research

Empirical Antimicrobial Therapy and QTc Interval Prolongation in Emergency Medicine
CONCLUSION: This analysis shows the relevance of the empirical therapy established at the admission, in particular for infective diseases, as an important risk factor for the prolongation of QTc. Other factors that can increase the risk are electrolytes alterations, advanced age, cardiovascular diseases, and drug-drug interaction.PMID:34212831 | DOI:10.2174/1574886316666210629150105 (Source: Current Drug Safety)
Source: Current Drug Safety - July 2, 2021 Category: Drugs & Pharmacology Authors: Marianna Suppa Luca Marino Source Type: research

Empirical Antimicrobial Therapy and QTc Interval Prolongation in Emergency Medicine
CONCLUSION: This analysis shows the relevance of the empirical therapy established at the admission, in particular for infective diseases, as an important risk factor for the prolongation of QTc. Other factors that can increase the risk are electrolytes alterations, advanced age, cardiovascular diseases, and drug-drug interaction.PMID:34212831 | DOI:10.2174/1574886316666210629150105 (Source: Current Drug Safety)
Source: Current Drug Safety - July 2, 2021 Category: Drugs & Pharmacology Authors: Marianna Suppa Luca Marino Source Type: research

Empirical Antimicrobial Therapy and QTc Interval Prolongation in Emergency Medicine
CONCLUSION: This analysis shows the relevance of the empirical therapy established at the admission, in particular for infective diseases, as an important risk factor for the prolongation of QTc. Other factors that can increase the risk are electrolytes alterations, advanced age, cardiovascular diseases, and drug-drug interaction.PMID:34212831 | DOI:10.2174/1574886316666210629150105 (Source: Current Drug Safety)
Source: Current Drug Safety - July 2, 2021 Category: Drugs & Pharmacology Authors: Marianna Suppa Luca Marino Source Type: research

Empirical Antimicrobial Therapy and QTc Interval Prolongation in Emergency Medicine
CONCLUSION: This analysis shows the relevance of the empirical therapy established at the admission, in particular for infective diseases, as an important risk factor for the prolongation of QTc. Other factors that can increase the risk are electrolytes alterations, advanced age, cardiovascular diseases, and drug-drug interaction.PMID:34212831 | DOI:10.2174/1574886316666210629150105 (Source: Current Drug Safety)
Source: Current Drug Safety - July 2, 2021 Category: Drugs & Pharmacology Authors: Marianna Suppa Luca Marino Source Type: research

Empirical Antimicrobial Therapy and QTc Interval Prolongation in Emergency Medicine
CONCLUSION: This analysis shows the relevance of the empirical therapy established at the admission, in particular for infective diseases, as an important risk factor for the prolongation of QTc. Other factors that can increase the risk are electrolytes alterations, advanced age, cardiovascular diseases, and drug-drug interaction.PMID:34212831 | DOI:10.2174/1574886316666210629150105 (Source: Current Drug Safety)
Source: Current Drug Safety - July 2, 2021 Category: Drugs & Pharmacology Authors: Marianna Suppa Luca Marino Source Type: research

Empirical Antimicrobial Therapy and QTc Interval Prolongation in Emergency Medicine
CONCLUSION: This analysis shows the relevance of the empirical therapy established at the admission, in particular for infective diseases, as an important risk factor for the prolongation of QTc. Other factors that can increase the risk are electrolytes alterations, advanced age, cardiovascular diseases, and drug-drug interaction.PMID:34212831 | DOI:10.2174/1574886316666210629150105 (Source: Current Drug Safety)
Source: Current Drug Safety - July 2, 2021 Category: Drugs & Pharmacology Authors: Marianna Suppa Luca Marino Source Type: research

Empirical Antimicrobial Therapy and QTc Interval Prolongation in Emergency Medicine
CONCLUSION: This analysis shows the relevance of the empirical therapy established at the admission, in particular for infective diseases, as an important risk factor for the prolongation of QTc. Other factors that can increase the risk are electrolytes alterations, advanced age, cardiovascular diseases, and drug-drug interaction.PMID:34212831 | DOI:10.2174/1574886316666210629150105 (Source: Current Drug Safety)
Source: Current Drug Safety - July 2, 2021 Category: Drugs & Pharmacology Authors: Marianna Suppa Luca Marino Source Type: research

Empirical Antimicrobial Therapy and QTc Interval Prolongation in Emergency Medicine
CONCLUSION: This analysis shows the relevance of the empirical therapy established at the admission, in particular for infective diseases, as an important risk factor for the prolongation of QTc. Other factors that can increase the risk are electrolytes alterations, advanced age, cardiovascular diseases, and drug-drug interaction.PMID:34212831 | DOI:10.2174/1574886316666210629150105 (Source: Current Drug Safety)
Source: Current Drug Safety - July 2, 2021 Category: Drugs & Pharmacology Authors: Marianna Suppa Luca Marino Source Type: research

Empirical Antimicrobial Therapy and QTc Interval Prolongation in Emergency Medicine
CONCLUSION: This analysis shows the relevance of the empirical therapy established at the admission, in particular for infective diseases, as an important risk factor for the prolongation of QTc. Other factors that can increase the risk are electrolytes alterations, advanced age, cardiovascular diseases, and drug-drug interaction.PMID:34212831 | DOI:10.2174/1574886316666210629150105 (Source: Current Drug Safety)
Source: Current Drug Safety - July 2, 2021 Category: Drugs & Pharmacology Authors: Marianna Suppa Luca Marino Source Type: research

Empirical Antimicrobial Therapy and QTc Interval Prolongation in Emergency Medicine
CONCLUSION: This analysis shows the relevance of the empirical therapy established at the admission, in particular for infective diseases, as an important risk factor for the prolongation of QTc. Other factors that can increase the risk are electrolytes alterations, advanced age, cardiovascular diseases, and drug-drug interaction.PMID:34212831 | DOI:10.2174/1574886316666210629150105 (Source: Current Drug Safety)
Source: Current Drug Safety - July 2, 2021 Category: Drugs & Pharmacology Authors: Marianna Suppa Luca Marino Source Type: research

Empirical Antimicrobial Therapy and QTc Interval Prolongation in Emergency Medicine
CONCLUSION: This analysis shows the relevance of the empirical therapy established at the admission, in particular for infective diseases, as an important risk factor for the prolongation of QTc. Other factors that can increase the risk are electrolytes alterations, advanced age, cardiovascular diseases, and drug-drug interaction.PMID:34212831 | DOI:10.2174/1574886316666210629150105 (Source: Current Drug Safety)
Source: Current Drug Safety - July 2, 2021 Category: Drugs & Pharmacology Authors: Marianna Suppa Luca Marino Source Type: research

Adr In Journals: Are They Translated Into Regulatory Frameworks?
CONCLUSION: Depending upon our observation, we have noticed that there is a deficiency in reporting of suspected ADR to the regulatory authorities. Reporting can be included as mandatory criteria for ADR case reports. Also, there is an increased need for various healthcare workers to be aware about reporting ADR.PMID:34151768 | DOI:10.2174/1574886316666210609115148 (Source: Current Drug Safety)
Source: Current Drug Safety - June 21, 2021 Category: Drugs & Pharmacology Authors: Annapurna Kolupoti Ananya Chakraborty None Shahistha K Source Type: research

Adr In Journals: Are They Translated Into Regulatory Frameworks?
CONCLUSION: Depending upon our observation, we have noticed that there is a deficiency in reporting of suspected ADR to the regulatory authorities. Reporting can be included as mandatory criteria for ADR case reports. Also, there is an increased need for various healthcare workers to be aware about reporting ADR.PMID:34151768 | DOI:10.2174/1574886316666210609115148 (Source: Current Drug Safety)
Source: Current Drug Safety - June 21, 2021 Category: Drugs & Pharmacology Authors: Annapurna Kolupoti Ananya Chakraborty None Shahistha K Source Type: research

Adr In Journals: Are They Translated Into Regulatory Frameworks?
CONCLUSION: Depending upon our observation, we have noticed that there is a deficiency in reporting of suspected ADR to the regulatory authorities. Reporting can be included as mandatory criteria for ADR case reports. Also, there is an increased need for various healthcare workers to be aware about reporting ADR.PMID:34151768 | DOI:10.2174/1574886316666210609115148 (Source: Current Drug Safety)
Source: Current Drug Safety - June 21, 2021 Category: Drugs & Pharmacology Authors: Annapurna Kolupoti Ananya Chakraborty None Shahistha K Source Type: research

Adr In Journals: Are They Translated Into Regulatory Frameworks?
CONCLUSION: Depending upon our observation, we have noticed that there is a deficiency in reporting of suspected ADR to the regulatory authorities. Reporting can be included as mandatory criteria for ADR case reports. Also, there is an increased need for various healthcare workers to be aware about reporting ADR.PMID:34151768 | DOI:10.2174/1574886316666210609115148 (Source: Current Drug Safety)
Source: Current Drug Safety - June 21, 2021 Category: Drugs & Pharmacology Authors: Annapurna Kolupoti Ananya Chakraborty None Shahistha K Source Type: research

Adr In Journals: Are They Translated Into Regulatory Frameworks?
CONCLUSION: Depending upon our observation, we have noticed that there is a deficiency in reporting of suspected ADR to the regulatory authorities. Reporting can be included as mandatory criteria for ADR case reports. Also, there is an increased need for various healthcare workers to be aware about reporting ADR.PMID:34151768 | DOI:10.2174/1574886316666210609115148 (Source: Current Drug Safety)
Source: Current Drug Safety - June 21, 2021 Category: Drugs & Pharmacology Authors: Annapurna Kolupoti Ananya Chakraborty None Shahistha K Source Type: research

Adr In Journals: Are They Translated Into Regulatory Frameworks?
CONCLUSION: Depending upon our observation, we have noticed that there is a deficiency in reporting of suspected ADR to the regulatory authorities. Reporting can be included as mandatory criteria for ADR case reports. Also, there is an increased need for various healthcare workers to be aware about reporting ADR.PMID:34151768 | DOI:10.2174/1574886316666210609115148 (Source: Current Drug Safety)
Source: Current Drug Safety - June 21, 2021 Category: Drugs & Pharmacology Authors: Annapurna Kolupoti Ananya Chakraborty None Shahistha K Source Type: research

Adr In Journals: Are They Translated Into Regulatory Frameworks?
CONCLUSION: Depending upon our observation, we have noticed that there is a deficiency in reporting of suspected ADR to the regulatory authorities. Reporting can be included as mandatory criteria for ADR case reports. Also, there is an increased need for various healthcare workers to be aware about reporting ADR.PMID:34151768 | DOI:10.2174/1574886316666210609115148 (Source: Current Drug Safety)
Source: Current Drug Safety - June 21, 2021 Category: Drugs & Pharmacology Authors: Annapurna Kolupoti Ananya Chakraborty None Shahistha K Source Type: research

Adr In Journals: Are They Translated Into Regulatory Frameworks?
CONCLUSION: Depending upon our observation, we have noticed that there is a deficiency in reporting of suspected ADR to the regulatory authorities. Reporting can be included as mandatory criteria for ADR case reports. Also, there is an increased need for various healthcare workers to be aware about reporting ADR.PMID:34151768 | DOI:10.2174/1574886316666210609115148 (Source: Current Drug Safety)
Source: Current Drug Safety - June 21, 2021 Category: Drugs & Pharmacology Authors: Annapurna Kolupoti Ananya Chakraborty None Shahistha K Source Type: research

Adr In Journals: Are They Translated Into Regulatory Frameworks?
CONCLUSION: Depending upon our observation, we have noticed that there is a deficiency in reporting of suspected ADR to the regulatory authorities. Reporting can be included as mandatory criteria for ADR case reports. Also, there is an increased need for various healthcare workers to be aware about reporting ADR.PMID:34151768 | DOI:10.2174/1574886316666210609115148 (Source: Current Drug Safety)
Source: Current Drug Safety - June 21, 2021 Category: Drugs & Pharmacology Authors: Annapurna Kolupoti Ananya Chakraborty None Shahistha K Source Type: research

Agreement among different scales for causality assessment in drug-induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
CONCLUSION: Discrepancies were observed among four different CATs in assessing drug-induced SJS and TEN. A CAT that is more specific to drug-induced SJS and TEN, simple, user-friendly with limited subjective interpretation, incorporating new immunological and pharmacogenetic markers is necessary.PMID:34126908 | DOI:10.2174/1574886316666210611160123 (Source: Current Drug Safety)
Source: Current Drug Safety - June 15, 2021 Category: Drugs & Pharmacology Authors: Kiruthika Sivagourounadin Priyadharsini Rajendran Sandhiya Selvarajan Mahalakshmi Ganesapandian Source Type: research

Agreement among different scales for causality assessment in drug-induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
CONCLUSION: Discrepancies were observed among four different CATs in assessing drug-induced SJS and TEN. A CAT that is more specific to drug-induced SJS and TEN, simple, user-friendly with limited subjective interpretation, incorporating new immunological and pharmacogenetic markers is necessary.PMID:34126908 | DOI:10.2174/1574886316666210611160123 (Source: Current Drug Safety)
Source: Current Drug Safety - June 15, 2021 Category: Drugs & Pharmacology Authors: Kiruthika Sivagourounadin Priyadharsini Rajendran Sandhiya Selvarajan Mahalakshmi Ganesapandian Source Type: research

Agreement among different scales for causality assessment in drug-induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
CONCLUSION: Discrepancies were observed among four different CATs in assessing drug-induced SJS and TEN. A CAT that is more specific to drug-induced SJS and TEN, simple, user-friendly with limited subjective interpretation, incorporating new immunological and pharmacogenetic markers is necessary.PMID:34126908 | DOI:10.2174/1574886316666210611160123 (Source: Current Drug Safety)
Source: Current Drug Safety - June 15, 2021 Category: Drugs & Pharmacology Authors: Kiruthika Sivagourounadin Priyadharsini Rajendran Sandhiya Selvarajan Mahalakshmi Ganesapandian Source Type: research

Agreement among different scales for causality assessment in drug-induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
CONCLUSION: Discrepancies were observed among four different CATs in assessing drug-induced SJS and TEN. A CAT that is more specific to drug-induced SJS and TEN, simple, user-friendly with limited subjective interpretation, incorporating new immunological and pharmacogenetic markers is necessary.PMID:34126908 | DOI:10.2174/1574886316666210611160123 (Source: Current Drug Safety)
Source: Current Drug Safety - June 15, 2021 Category: Drugs & Pharmacology Authors: Kiruthika Sivagourounadin Priyadharsini Rajendran Sandhiya Selvarajan Mahalakshmi Ganesapandian Source Type: research

Agreement among different scales for causality assessment in drug-induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
CONCLUSION: Discrepancies were observed among four different CATs in assessing drug-induced SJS and TEN. A CAT that is more specific to drug-induced SJS and TEN, simple, user-friendly with limited subjective interpretation, incorporating new immunological and pharmacogenetic markers is necessary.PMID:34126908 | DOI:10.2174/1574886316666210611160123 (Source: Current Drug Safety)
Source: Current Drug Safety - June 15, 2021 Category: Drugs & Pharmacology Authors: Kiruthika Sivagourounadin Priyadharsini Rajendran Sandhiya Selvarajan Mahalakshmi Ganesapandian Source Type: research

The effect of levothyroxine in comparison with placebo on serum osteocalcin levels in patients with subclinical hypothyroidism
This study aimed to investigate the effect of levothyroxine vs. placebo on serum osteocalcin levels in patients with subclinical hypothyroidism.METHODS: This randomized clinical trial was performed on 30 patients with subclinical hypothyroidism who were referred to the endocrine clinics of Ghaem and Imam Reza hospitals in Mashhad, Iran. After giving informed consent, patients were randomly divided into intervention (50 µg/day levothyroxine for 2 months) and control (placebo) groups. Serum levels of osteocalcin, thyroid hormones, lipid profile, insulin, and fasting glucose, as well as other clinical and anthropometric...
Source: Current Drug Safety - May 26, 2021 Category: Drugs & Pharmacology Authors: Reihaneh Rezaee Masoud Mohebbi Mozhgan Afkhamizadeh Mohammad Ali Yaghoubi Mona Najaf Najafi Mansoureh Hoseinzadeh Amirhossein Sahebkar Source Type: research

The effect of levothyroxine in comparison with placebo on serum osteocalcin levels in patients with subclinical hypothyroidism
This study aimed to investigate the effect of levothyroxine vs. placebo on serum osteocalcin levels in patients with subclinical hypothyroidism.METHODS: This randomized clinical trial was performed on 30 patients with subclinical hypothyroidism who were referred to the endocrine clinics of Ghaem and Imam Reza hospitals in Mashhad, Iran. After giving informed consent, patients were randomly divided into intervention (50 µg/day levothyroxine for 2 months) and control (placebo) groups. Serum levels of osteocalcin, thyroid hormones, lipid profile, insulin, and fasting glucose, as well as other clinical and anthropometric...
Source: Current Drug Safety - May 26, 2021 Category: Drugs & Pharmacology Authors: Reihaneh Rezaee Masoud Mohebbi Mozhgan Afkhamizadeh Mohammad Ali Yaghoubi Mona Najaf Najafi Mansoureh Hoseinzadeh Amirhossein Sahebkar Source Type: research

The effect of levothyroxine in comparison with placebo on serum osteocalcin levels in patients with subclinical hypothyroidism
This study aimed to investigate the effect of levothyroxine vs. placebo on serum osteocalcin levels in patients with subclinical hypothyroidism.METHODS: This randomized clinical trial was performed on 30 patients with subclinical hypothyroidism who were referred to the endocrine clinics of Ghaem and Imam Reza hospitals in Mashhad, Iran. After giving informed consent, patients were randomly divided into intervention (50 µg/day levothyroxine for 2 months) and control (placebo) groups. Serum levels of osteocalcin, thyroid hormones, lipid profile, insulin, and fasting glucose, as well as other clinical and anthropometric...
Source: Current Drug Safety - May 26, 2021 Category: Drugs & Pharmacology Authors: Reihaneh Rezaee Masoud Mohebbi Mozhgan Afkhamizadeh Mohammad Ali Yaghoubi Mona Najaf Najafi Mansoureh Hoseinzadeh Amirhossein Sahebkar Source Type: research

The effect of levothyroxine in comparison with placebo on serum osteocalcin levels in patients with subclinical hypothyroidism
This study aimed to investigate the effect of levothyroxine vs. placebo on serum osteocalcin levels in patients with subclinical hypothyroidism.METHODS: This randomized clinical trial was performed on 30 patients with subclinical hypothyroidism who were referred to the endocrine clinics of Ghaem and Imam Reza hospitals in Mashhad, Iran. After giving informed consent, patients were randomly divided into intervention (50 µg/day levothyroxine for 2 months) and control (placebo) groups. Serum levels of osteocalcin, thyroid hormones, lipid profile, insulin, and fasting glucose, as well as other clinical and anthropometric...
Source: Current Drug Safety - May 26, 2021 Category: Drugs & Pharmacology Authors: Reihaneh Rezaee Masoud Mohebbi Mozhgan Afkhamizadeh Mohammad Ali Yaghoubi Mona Najaf Najafi Mansoureh Hoseinzadeh Amirhossein Sahebkar Source Type: research

The effect of levothyroxine in comparison with placebo on serum osteocalcin levels in patients with subclinical hypothyroidism
This study aimed to investigate the effect of levothyroxine vs. placebo on serum osteocalcin levels in patients with subclinical hypothyroidism.METHODS: This randomized clinical trial was performed on 30 patients with subclinical hypothyroidism who were referred to the endocrine clinics of Ghaem and Imam Reza hospitals in Mashhad, Iran. After giving informed consent, patients were randomly divided into intervention (50 µg/day levothyroxine for 2 months) and control (placebo) groups. Serum levels of osteocalcin, thyroid hormones, lipid profile, insulin, and fasting glucose, as well as other clinical and anthropometric...
Source: Current Drug Safety - May 26, 2021 Category: Drugs & Pharmacology Authors: Reihaneh Rezaee Masoud Mohebbi Mozhgan Afkhamizadeh Mohammad Ali Yaghoubi Mona Najaf Najafi Mansoureh Hoseinzadeh Amirhossein Sahebkar Source Type: research

The effect of levothyroxine in comparison with placebo on serum osteocalcin levels in patients with subclinical hypothyroidism
This study aimed to investigate the effect of levothyroxine vs. placebo on serum osteocalcin levels in patients with subclinical hypothyroidism.METHODS: This randomized clinical trial was performed on 30 patients with subclinical hypothyroidism who were referred to the endocrine clinics of Ghaem and Imam Reza hospitals in Mashhad, Iran. After giving informed consent, patients were randomly divided into intervention (50 µg/day levothyroxine for 2 months) and control (placebo) groups. Serum levels of osteocalcin, thyroid hormones, lipid profile, insulin, and fasting glucose, as well as other clinical and anthropometric...
Source: Current Drug Safety - May 26, 2021 Category: Drugs & Pharmacology Authors: Reihaneh Rezaee Masoud Mohebbi Mozhgan Afkhamizadeh Mohammad Ali Yaghoubi Mona Najaf Najafi Mansoureh Hoseinzadeh Amirhossein Sahebkar Source Type: research

The effect of levothyroxine in comparison with placebo on serum osteocalcin levels in patients with subclinical hypothyroidism
This study aimed to investigate the effect of levothyroxine vs. placebo on serum osteocalcin levels in patients with subclinical hypothyroidism.METHODS: This randomized clinical trial was performed on 30 patients with subclinical hypothyroidism who were referred to the endocrine clinics of Ghaem and Imam Reza hospitals in Mashhad, Iran. After giving informed consent, patients were randomly divided into intervention (50 µg/day levothyroxine for 2 months) and control (placebo) groups. Serum levels of osteocalcin, thyroid hormones, lipid profile, insulin, and fasting glucose, as well as other clinical and anthropometric...
Source: Current Drug Safety - May 26, 2021 Category: Drugs & Pharmacology Authors: Reihaneh Rezaee Masoud Mohebbi Mozhgan Afkhamizadeh Mohammad Ali Yaghoubi Mona Najaf Najafi Mansoureh Hoseinzadeh Amirhossein Sahebkar Source Type: research

The effect of levothyroxine in comparison with placebo on serum osteocalcin levels in patients with subclinical hypothyroidism
This study aimed to investigate the effect of levothyroxine vs. placebo on serum osteocalcin levels in patients with subclinical hypothyroidism.METHODS: This randomized clinical trial was performed on 30 patients with subclinical hypothyroidism who were referred to the endocrine clinics of Ghaem and Imam Reza hospitals in Mashhad, Iran. After giving informed consent, patients were randomly divided into intervention (50 µg/day levothyroxine for 2 months) and control (placebo) groups. Serum levels of osteocalcin, thyroid hormones, lipid profile, insulin, and fasting glucose, as well as other clinical and anthropometric...
Source: Current Drug Safety - May 26, 2021 Category: Drugs & Pharmacology Authors: Reihaneh Rezaee Masoud Mohebbi Mozhgan Afkhamizadeh Mohammad Ali Yaghoubi Mona Najaf Najafi Mansoureh Hoseinzadeh Amirhossein Sahebkar Source Type: research

The effect of levothyroxine in comparison with placebo on serum osteocalcin levels in patients with subclinical hypothyroidism
This study aimed to investigate the effect of levothyroxine vs. placebo on serum osteocalcin levels in patients with subclinical hypothyroidism.METHODS: This randomized clinical trial was performed on 30 patients with subclinical hypothyroidism who were referred to the endocrine clinics of Ghaem and Imam Reza hospitals in Mashhad, Iran. After giving informed consent, patients were randomly divided into intervention (50 µg/day levothyroxine for 2 months) and control (placebo) groups. Serum levels of osteocalcin, thyroid hormones, lipid profile, insulin, and fasting glucose, as well as other clinical and anthropometric...
Source: Current Drug Safety - May 26, 2021 Category: Drugs & Pharmacology Authors: Reihaneh Rezaee Masoud Mohebbi Mozhgan Afkhamizadeh Mohammad Ali Yaghoubi Mona Najaf Najafi Mansoureh Hoseinzadeh Amirhossein Sahebkar Source Type: research

The effect of levothyroxine in comparison with placebo on serum osteocalcin levels in patients with subclinical hypothyroidism
This study aimed to investigate the effect of levothyroxine vs. placebo on serum osteocalcin levels in patients with subclinical hypothyroidism.METHODS: This randomized clinical trial was performed on 30 patients with subclinical hypothyroidism who were referred to the endocrine clinics of Ghaem and Imam Reza hospitals in Mashhad, Iran. After giving informed consent, patients were randomly divided into intervention (50 µg/day levothyroxine for 2 months) and control (placebo) groups. Serum levels of osteocalcin, thyroid hormones, lipid profile, insulin, and fasting glucose, as well as other clinical and anthropometric...
Source: Current Drug Safety - May 26, 2021 Category: Drugs & Pharmacology Authors: Reihaneh Rezaee Masoud Mohebbi Mozhgan Afkhamizadeh Mohammad Ali Yaghoubi Mona Najaf Najafi Mansoureh Hoseinzadeh Amirhossein Sahebkar Source Type: research

The effect of levothyroxine in comparison with placebo on serum osteocalcin levels in patients with subclinical hypothyroidism
This study aimed to investigate the effect of levothyroxine vs. placebo on serum osteocalcin levels in patients with subclinical hypothyroidism.METHODS: This randomized clinical trial was performed on 30 patients with subclinical hypothyroidism who were referred to the endocrine clinics of Ghaem and Imam Reza hospitals in Mashhad, Iran. After giving informed consent, patients were randomly divided into intervention (50 µg/day levothyroxine for 2 months) and control (placebo) groups. Serum levels of osteocalcin, thyroid hormones, lipid profile, insulin, and fasting glucose, as well as other clinical and anthropometric...
Source: Current Drug Safety - May 26, 2021 Category: Drugs & Pharmacology Authors: Reihaneh Rezaee Masoud Mohebbi Mozhgan Afkhamizadeh Mohammad Ali Yaghoubi Mona Najaf Najafi Mansoureh Hoseinzadeh Amirhossein Sahebkar Source Type: research

The effect of levothyroxine in comparison with placebo on serum osteocalcin levels in patients with subclinical hypothyroidism
This study aimed to investigate the effect of levothyroxine vs. placebo on serum osteocalcin levels in patients with subclinical hypothyroidism.METHODS: This randomized clinical trial was performed on 30 patients with subclinical hypothyroidism who were referred to the endocrine clinics of Ghaem and Imam Reza hospitals in Mashhad, Iran. After giving informed consent, patients were randomly divided into intervention (50 µg/day levothyroxine for 2 months) and control (placebo) groups. Serum levels of osteocalcin, thyroid hormones, lipid profile, insulin, and fasting glucose, as well as other clinical and anthropometric...
Source: Current Drug Safety - May 26, 2021 Category: Drugs & Pharmacology Authors: Reihaneh Rezaee Masoud Mohebbi Mozhgan Afkhamizadeh Mohammad Ali Yaghoubi Mona Najaf Najafi Mansoureh Hoseinzadeh Amirhossein Sahebkar Source Type: research

The effect of levothyroxine in comparison with placebo on serum osteocalcin levels in patients with subclinical hypothyroidism
This study aimed to investigate the effect of levothyroxine vs. placebo on serum osteocalcin levels in patients with subclinical hypothyroidism.METHODS: This randomized clinical trial was performed on 30 patients with subclinical hypothyroidism who were referred to the endocrine clinics of Ghaem and Imam Reza hospitals in Mashhad, Iran. After giving informed consent, patients were randomly divided into intervention (50 µg/day levothyroxine for 2 months) and control (placebo) groups. Serum levels of osteocalcin, thyroid hormones, lipid profile, insulin, and fasting glucose, as well as other clinical and anthropometric...
Source: Current Drug Safety - May 26, 2021 Category: Drugs & Pharmacology Authors: Reihaneh Rezaee Masoud Mohebbi Mozhgan Afkhamizadeh Mohammad Ali Yaghoubi Mona Najaf Najafi Mansoureh Hoseinzadeh Amirhossein Sahebkar Source Type: research

The effect of levothyroxine in comparison with placebo on serum osteocalcin levels in patients with subclinical hypothyroidism
This study aimed to investigate the effect of levothyroxine vs. placebo on serum osteocalcin levels in patients with subclinical hypothyroidism.METHODS: This randomized clinical trial was performed on 30 patients with subclinical hypothyroidism who were referred to the endocrine clinics of Ghaem and Imam Reza hospitals in Mashhad, Iran. After giving informed consent, patients were randomly divided into intervention (50 µg/day levothyroxine for 2 months) and control (placebo) groups. Serum levels of osteocalcin, thyroid hormones, lipid profile, insulin, and fasting glucose, as well as other clinical and anthropometric...
Source: Current Drug Safety - May 26, 2021 Category: Drugs & Pharmacology Authors: Reihaneh Rezaee Masoud Mohebbi Mozhgan Afkhamizadeh Mohammad Ali Yaghoubi Mona Najaf Najafi Mansoureh Hoseinzadeh Amirhossein Sahebkar Source Type: research

The effect of levothyroxine in comparison with placebo on serum osteocalcin levels in patients with subclinical hypothyroidism
This study aimed to investigate the effect of levothyroxine vs. placebo on serum osteocalcin levels in patients with subclinical hypothyroidism.METHODS: This randomized clinical trial was performed on 30 patients with subclinical hypothyroidism who were referred to the endocrine clinics of Ghaem and Imam Reza hospitals in Mashhad, Iran. After giving informed consent, patients were randomly divided into intervention (50 µg/day levothyroxine for 2 months) and control (placebo) groups. Serum levels of osteocalcin, thyroid hormones, lipid profile, insulin, and fasting glucose, as well as other clinical and anthropometric...
Source: Current Drug Safety - May 26, 2021 Category: Drugs & Pharmacology Authors: Reihaneh Rezaee Masoud Mohebbi Mozhgan Afkhamizadeh Mohammad Ali Yaghoubi Mona Najaf Najafi Mansoureh Hoseinzadeh Amirhossein Sahebkar Source Type: research

Medication Without Harm: Developing optimal medication error reporting systems
Curr Drug Saf. 2021 Apr 22. doi: 10.2174/1574886316666210423115029. Online ahead of print.ABSTRACTMedication errors are amongst the most frequently occurring health care related incidents and have the potential to lead to life-threatening harm to patients. An incident reporting system is a traditional approach to improvement of patient safety and entails the retrieval of information from incident reports. This not only provides a better understanding of causes and contributing factors but also enables the collection of data on the severity of incidents, system deficiencies and the role of human factors in safety incidents....
Source: Current Drug Safety - April 27, 2021 Category: Drugs & Pharmacology Authors: Yuko Shiima Muzaffar Malik Michael Okorie Source Type: research

Prevalence And Predictors Of Potentially Inappropriate Medication Use Among Elderly Patients Using Updated Beers Criteria 2019: A Single Centered Retrospective Analysis
Curr Drug Saf. 2021 Apr 22. doi: 10.2174/1574886316666210423113916. Online ahead of print.ABSTRACTBACKGROUND: Inappropriate medication use poses a sizable health safety hazard in the elderly owing to aging-associated physiological and anatomic changes. Inappropriate drug prescribing and polypharmacy in this population elevates the risk of adverse drug reactions (ADR). To assess the prevalence and predictors of Potentially Inappropriate Medication (PIM) use in elderly patients according to updated Beers Criteria 2019.METHOD: Medical Records of 402 patients aged ≥65 years admitted a tertiary care hospital from June 2018 t...
Source: Current Drug Safety - April 27, 2021 Category: Drugs & Pharmacology Authors: Sreedharan Nair Syam Sundar Srilakshmi Cheeti Aditi Bajpai S Deepika Girish Thunga Muhammed Rashid Raviraja V Acharya Source Type: research

Medication Without Harm: Developing optimal medication error reporting systems
Curr Drug Saf. 2021 Apr 22. doi: 10.2174/1574886316666210423115029. Online ahead of print.ABSTRACTMedication errors are amongst the most frequently occurring health care related incidents and have the potential to lead to life-threatening harm to patients. An incident reporting system is a traditional approach to improvement of patient safety and entails the retrieval of information from incident reports. This not only provides a better understanding of causes and contributing factors but also enables the collection of data on the severity of incidents, system deficiencies and the role of human factors in safety incidents....
Source: Current Drug Safety - April 27, 2021 Category: Drugs & Pharmacology Authors: Yuko Shiima Muzaffar Malik Michael Okorie Source Type: research