A review of the Efficacy and Cardiovascular Safety of Amylin Analogues.
Abstract A large proportion of persons with type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) do not reach the glycosylated haemoglobin (HbA1c) target of
Source: Current Drug Safety - November 5, 2020 Category: Drugs & Pharmacology Authors: Koshy RM, Fernandez CJ, Jacob K Tags: Curr Drug Saf Source Type: research

Efficacy and Cardiovascular Safety of Insulins.
Abstract Insulin is a lifesaving drug in patients with type 1 diabetes mellitus. Many type 2 diabetes mellitus patients will eventually require insulin. The rapid-acting and long-acting insulin analogues (RAIAs and LAIAs) have a pharmacological profile that closely mimic normal human physiology when compared to Neutral Protamine Hagedorn (NPH) insulin and regular human insulin, respectively. Glucagon-like peptide 1 receptor agonists (GLP-1RAs) were found to have a proven cardiovascular safety. They are preferred over insulin in many recent guidelines. Fixed-ratio combinations of GLP-1RAs and insulin are also recom...
Source: Current Drug Safety - November 5, 2020 Category: Drugs & Pharmacology Authors: Fernandez CJ, Radhakrishnan C Tags: Curr Drug Saf Source Type: research

Comparative Safety Assessment study for Drospirenone Induced Gallbladder Diseases using the Adverse Drug Reaction Database of USA, Europe, and Canada.
CONCLUSION: From our study, it is clear that the risk between drospirenone and gallbladder diseases is very low among three databases. There is no harm in prescribing this drug for a contraceptive action. PMID: 33109050 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - October 27, 2020 Category: Drugs & Pharmacology Authors: Shah M, Kothari C Tags: Curr Drug Saf Source Type: research

Severe Pancytopenia Following Single Dose Methotrexate In Psoriasis: A Rare And Potentially Lethal Manifestation.
Abstract Methotrexate is an antimetabolite anticancer drug frequently used in the treatment of extensive chronic plaque psoriasis. Psoriatic plaque erosion is a rare toxic side effect of single-dose methotrexate and is described as a sign of the impending pancytopenia. Here, we report a case of a 48-year-old male, presented with multiple oral and genital erosions, fissuring over palm and soles for 5 days. His laboratory tests revealed severe pancytopenia and nephropathy. He had a history of chronic plaque psoriasis for which he took a single dose of 15 mg methotrexate. During the hospital stay, the patient needed ...
Source: Current Drug Safety - October 26, 2020 Category: Drugs & Pharmacology Authors: Singh A, Choudhary R, Chhabra N, Ganguly S, Rathore V Tags: Curr Drug Saf Source Type: research

Efficacy and cardiovascular safety of Thiazolidinediones.
Abstract Type 2 diabetes mellitus (T2DM) is characterized by a progressive beta cell dysfunction in the setting of peripheral insulin resistance. Insulin resistance in subjects with type 2 diabetes and metabolic syndrome is primarily caused by an ectopic fat accumulation in liver and skeletal muscle. Insulin sensitizers are particularly important in the management of T2DM. Though, thiazolidinediones (TZDs) are principally insulin sensitizers, they possess an ability to preserve pancreatic β-cell function and thereby exhibit durable glycemic control. Cardiovascular outcome trials (CVOTs) have shown that Glucag...
Source: Current Drug Safety - October 26, 2020 Category: Drugs & Pharmacology Authors: Veettil RA, Fernandez CJ, Jacob K Tags: Curr Drug Saf Source Type: research

Efficacy and Cardiovascular Safety of Meglitinides.
This article is an attempt to review the efficacy and cardiovascular (CV) safety of Meglitinides to help clinicians to use this class of oral hypoglycaemic agents prudently. PMID: 33106149 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - October 26, 2020 Category: Drugs & Pharmacology Authors: Philip J, Fernandez CJ Tags: Curr Drug Saf Source Type: research

Anticholinergic Burden among Hospitalised Older Adults with Psychiatric Illnesses- A retrospective study.
CONCLUSION: Nearly half of the older adults in psychiatry in-patient setting had clinically relevant anticholinergic burden, which was associated with higher use of psychotropics. Our study highlights the importance of monitoring for anticholinergic effects of psychotropics in older adults. PMID: 33106150 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - October 26, 2020 Category: Drugs & Pharmacology Authors: Mukku SSR, Sinha P, Sivakumar PT, Varghese M Tags: Curr Drug Saf Source Type: research

Screening and Preponderance of Peptic ulcer and its Contributing risk factors Among Basrah City Residents in Iraq.
CONCLUSION: The risk of peptic ulcer disease appeared to increase with chronic medication use and smoking, which aggravatethe contributing risk by H-pylori infections. PMID: 33050865 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - October 13, 2020 Category: Drugs & Pharmacology Authors: Jaccob A, Kadhim S, Hassan A, Mohsin A, Muslim S Tags: Curr Drug Saf Source Type: research

Desogestrel and severe psychiatric disorders, a retrospective analysis of Federal Adverse Event Reporting System and Eudravigilance.
CONCLUSION: From this study, we conclude that there is no new emerging signal for the drug-event pair studied. Further study and continuous monitoring is required in future to know more about this drug-event pair association, as severe psychiatric disorders is not yet mentioned or included in SmPC and patient leaflet of desogestrel. PMID: 33019938 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - October 3, 2020 Category: Drugs & Pharmacology Authors: Shah M, Kothari C Tags: Curr Drug Saf Source Type: research

A case of quinacrine-induced psychosis: case report.
We report a patient with no prior psychiatric history who developed mild, prodromal psychiatric symptoms when treated with quinacrine for treatment resistant giardiasis. Symptoms resolved when the drug was stopped, recurred with greater severity (requiring involuntary psychiatric hospitalization) when restarted and promptly resolved again when finally stopped. Although quinacrine remains in use today, providers may be unaware of its potential for serious neuropsychiatric toxicity. PMID: 33019939 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - October 3, 2020 Category: Drugs & Pharmacology Authors: Pedapudi A, Stewart J, Patel A Tags: Curr Drug Saf Source Type: research

Factors Associated with Self-Reported Drug Allergies in a Large Chronic Spontaneous Urticaria Cohort.
CONCLUSION: In CSU, the prevalence of self-reported drug allergies was higher than the general population. Drug allergy associated with older age, white race and higher BMI while multiple drug allergy also associated with asthma. These CSU sub-populations should be studied to avoid the potential for morbidity associated with less efficacious and more costly drugs. PMID: 33006537 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - October 1, 2020 Category: Drugs & Pharmacology Authors: Rauscher C, Petrov AA, Fajt ML Tags: Curr Drug Saf Source Type: research

Efficacy and cardiovascular safety of SGLT2 Inhibitors.
Abstract Patients with diabetes continued to exhibit a high risk for cardiovascular and renal events despite achieving satisfactory glycemic, blood pressure and lipid targets. Studies evaluating new diabetes medications focused on cardiovascular events, largely overlooking heart failure (HF). The latter has recently been recognised as a major cause of morbidity and mortality in patients with diabetes mellitus. There had been an unmet need for drugs with cardiovascular (including HF) and renal protection, with an expectation that an ideal diabetic drug should improve these end points. Moreover, an ideal drug should...
Source: Current Drug Safety - October 1, 2020 Category: Drugs & Pharmacology Authors: Fernandez CJ, Nevins AG, Nawaz S, Nazir T, Hanna FWF Tags: Curr Drug Saf Source Type: research

Role and Services of Pharmacist in the Prevention of Medication Errors: A Systematic Review.
CONCLUSION: This systematic review suggests multiple pharmacist-centered strategies that have been implemented in several studies showing the positive impact in the reduction and prevention of medication errors commenced by not only the pharmacist but the rest of the healthcare team. PMID: 33006539 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - October 1, 2020 Category: Drugs & Pharmacology Authors: Gillani SW, Gulam SM, Thomas D, Gebreigziabher FB, Al-Salloum J, Assadi RA, Sam KG Tags: Curr Drug Saf Source Type: research

Increased risk of falls, fall-related injuries and fractures in people with type 1 and type 2 diabetes - a nationwide cohort study.
Conclusion: People with diabetes have an increased risk of first fall and a higher incidence of fall-related injuries including fractures. Advanced aging and sex are non-modifiable risk factors, whereas diabetes, the use of SSRIs and opioids and alcohol abuse could be potentially modifiable risk factors for falls. Gaining information on risk factors for falls could guide the management of diabetes treatment i.e. choice of drugs, which enables us to improve treatment particularly in people with a high risk of falls and fractures associated with high mortality. PMID: 32900349 [PubMed - as supplied by publisher] (Source:...
Source: Current Drug Safety - September 7, 2020 Category: Drugs & Pharmacology Authors: Rasmussen NH, Dal J, den Bergh JV, de Vries F, Jensen MH, Vestergaard P Tags: Curr Drug Saf Source Type: research

Self-Treatment with Antibiotics: Knowledge level, Prevalence and Indications for Practicing among University Students in Jordan.
CONCLUSION: Self-treatment with antibiotics is affected by several social and demographic variables, and the role of media, public policies, university curricula as well as physicians and pharmacists should be enforced and activated to eliminate inappropriate uses of antibiotics and to correct misconceptions that encourage self-treatment with antibiotics. PMID: 32881672 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - September 1, 2020 Category: Drugs & Pharmacology Authors: Najjar Y, Hassan Z Tags: Curr Drug Saf Source Type: research

Biologic Therapy and Treatment Options in Diabetic Retinopathy with Diabetic Macular Edema.
Abstract Proliferative diabetic retinopathy and diabetic macular edema can be a potentially sight-threatening disease if not treated correctly. It is directly correlated to the duration of diabetes, and how well managed the patients diabetes is. In the last 15 years, the treatment of diabetic eye disease has taken a quantum leap in methodology due to the group of biological agents named anti-vascular endothelial growth factor (anti-VEGF). The introduction of the first biological agent has revolutionized the treatment, not only in diabetic eye disease but also across most inflammatory eye diseases causing leakage o...
Source: Current Drug Safety - September 1, 2020 Category: Drugs & Pharmacology Authors: Nissen TPH, Vorum H, Aasbjerg K Tags: Curr Drug Saf Source Type: research

Cardiovascular Effects of Hypoglycemic Agents in Diabetes Mellitus.
CONCLUSION: Both play a role in secondary prevention of atherosclerotic cardiovascular disease. Additionally, sodiumglucose transporter 2 inhibitors play a role in both primary and secondary prevention of heart failure, yet at a price of the rare, but potentially dangerous, euglyceamic diabetic ketoacidosis. PMID: 32881674 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - September 1, 2020 Category: Drugs & Pharmacology Authors: Pietraszek A Tags: Curr Drug Saf Source Type: research

Adrenocortical Crisis Triggered by Levothyroxine in an Unrecognized Autoimmune Polyglandular Syndrome Type-2: A Case Report with Review of the Literature.
CONCLUSION: The patients of one major component of APS-2 should be screened for other components of the disease to pick up latent cases. Addison's disease should be ruled out in patients of hypothyroidism who are intolerant to levothyroxine. PMID: 32851966 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - August 24, 2020 Category: Drugs & Pharmacology Authors: Patel DM, Gurumikhani JK, Patel MK, Patel MM, Patel SY, Patel PN Tags: Curr Drug Saf Source Type: research

Impact of Climatic Variations on Drug-induced skin Reactions in two Different Regions of India.
Discussion: Overall, 99 and 81 dermatological adverse drug reactions were reported in tertiary care hospitals in the Northern and Eastern regions, respectively. During the summer season, the humidity level was found to be low in the Northern region as compared to the Eastern region. During this period, drug-induced skin reactions were reported significantly (p
Source: Current Drug Safety - August 23, 2020 Category: Drugs & Pharmacology Authors: Deb T, Ghosh A, Dalai CK, Rani N Tags: Curr Drug Saf Source Type: research

Sodium glucose cotransporter-2 inhibitor treatment and the risk of diabetic ketoacidosis in Denmark: A retrospective cohort study of five years of use.
CONCLUSION: We observed no significant increase in risk of DKA for SGLT2i users compared to GLP1-RA. However, a significantly higher IR of DKA was observed with concomitant insulin use, and the risk of DKA was considerably higher for the SGLT2 group using insulin. PMID: 32814538 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - August 18, 2020 Category: Drugs & Pharmacology Authors: Laursen HVB, Røikjer JB, Dal J, Jensen MH Tags: Curr Drug Saf Source Type: research

Efficacy and Cardiovascular Safety of DPP-4 Inhibitors.
Abstract Dipeptidyl peptidase-4 (DPP-4) inhibitors or gliptins belong to the class of incretin mimetics, one important group of antidiabetic medications. These drugs were available in the market for management of type 2 diabetes mellitus (T2DM) over a decade. Sitagliptin, linagliptin, vildagliptin, saxagliptin and alogliptin are the common drugs from gliptin family widely available globally, whilst anagliptin, gemigliptin and teneliptin are used mainly in the Asian countries. The glycemic control conferred by gliptins varies among individual molecules with an average reduction of glycated hemoglobin (HbA1c) rangin...
Source: Current Drug Safety - August 18, 2020 Category: Drugs & Pharmacology Authors: Subrahmanyan NA, Koshy RM, Jacob K, Pappachan JM Tags: Curr Drug Saf Source Type: research

Tofacitinib-induced Ramsay- Hunt Syndrome in a Patient with Rheumatoid Arthritis.
CONCLUSION: Herein we reported the fırst case of tofacitinib-induced RHS in a patient with RA. This is may be the another side effect of biologic treatment. New studies are needed in this subject. PMID: 32819263 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - August 18, 2020 Category: Drugs & Pharmacology Authors: Kobak S Tags: Curr Drug Saf Source Type: research

Use of Sodium-Glucose Co-Transporter-2-Inhibitors (SGLT2-Is) and Risk of Lower Limb Amputation.
CONCLUSION: Use of SGLT2-Is, with or without signs of hypovolemia, was not associated with an increased risk of LLA or DFU versus current SU use. Future studies powered to detect potential differences between individual SGLT2-Is are required to rule out a canagliflozin-specific effect. PMID: 32767909 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - August 3, 2020 Category: Drugs & Pharmacology Authors: Werkman NCC, Nielen JTH, van den Bergh JPW, Ejskjaer N, Røikjer J, Schaper NC, Rossi B, Klungel O, Vestergaard P, de Vries F, Driessen JHM Tags: Curr Drug Saf Source Type: research

Spontaneous adverse drug reaction monitoring in a tertiary care centre.
CONCLUSION: Spontaneous reporting among indoor patients shows highest number of ADRs with use of antibiotics and almost all of the ADRs were non-serious in nature. Almost half of the total ADRs were skin and subcutaneous tissue related. Continuous efforts are required for further strengthening of the pharmacovigilance program of India. PMID: 32735525 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - July 30, 2020 Category: Drugs & Pharmacology Authors: Kaur K, Kanwal P, Goyal P, Singh P, Yakhmi S, Jain S, Kaushal S Tags: Curr Drug Saf Source Type: research

Diabetic Peripheral Neuropathy: Diagnosis and Treatment.
CONCLUSION: NCS remain the method of choice for detecting LFN in people with diabetes, while a gold standard for the detection of SFN is yet to be internationally accepted. In the recent years, several methods with huge potential for detecting and grading this condition has become available including skin biopsies and corneal confocal microscopy, which in the future could represent reliable endpoints for clinical studies. While several newer methods for detecting SFN have been developed, no new drugs have been accepted for treating neuropathic pain in people with diabetes. Tricyclic antidepressants, serotonin-norepinephrin...
Source: Current Drug Safety - July 30, 2020 Category: Drugs & Pharmacology Authors: Røikjer J, Mørch CD, Ejskjaer N Tags: Curr Drug Saf Source Type: research

A case of acute Generalized Exanthematous Pustulosis by Cefixime with oral Mucosal Involvement.
Abstract Acute generalized exanthematous pustulosis (AGEP) is a rare severe cutaneous adverse reaction characterized by the development of numerous sterile and non-follicular pustules on an erythematous base with no or minimal mucous membrane involvement associated with fever and leucocytosis. Cefixime is a cephalosporin-type beta-lactam antibiotic commonly used for the management of several infections. The Cefixime-induced AGEP cases are known to be rare. Here we present the case report of a 26-year old female developed Cefixime-induced AGEP with mucosal membrane involvement. To the best of our knowledge, this is...
Source: Current Drug Safety - July 28, 2020 Category: Drugs & Pharmacology Authors: Namoju R, Ismail M, Golla VK, Bamini T, Akarapu TL, Baloju D Tags: Curr Drug Saf Source Type: research

Transient Hepatotoxicity Induced by Vinblastine in a Young Girl with Chiasmatic low Grade Glioma.
Abstract BACKGROUND: Vinblastine (VBL) is a cytostatic drug frequently applied in children with lymphoma and progressive low-grade glioma (LGG) in children, with hematotoxicity as main side effect. CASE REPORT: Here we present a 7-month-old girl with tumor progression of a LGG during standard chemotherapy with carboplatin and vincristine. Switch to VBL led to a 20-30-fold increase of transaminases (grade IV CTCAE 5.0) spontaneously resolving after end of treatment. The toxicity is possibly age related since it did not re-occur at restart of VBL at 4 years old. This finding might have consequences for toxicity...
Source: Current Drug Safety - July 17, 2020 Category: Drugs & Pharmacology Authors: Franke NE, Blok GJ, Voll ML, Schouten-van Meeteren AY Tags: Curr Drug Saf Source Type: research

Prenatal Pregabalin Exposure Alters Postnatal Pain Sensitivity and Some Behavioral Responses in adult Offspring Rats.
CONCLUSION: These findings suggest that prenatal PGB exposure could be associated with significant changes in pain response, anxiety, locomotor activity and coordination in adult offspring rats. PMID: 32598270 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - June 27, 2020 Category: Drugs & Pharmacology Authors: Meymandi MS, Sepehri G, Moslemizadeh A, Shahrbabaki SSV Tags: Curr Drug Saf Source Type: research

Poor And Unsatisfactory Disposal Of Expired And Unused Pharmaceuticals: A Global Issue.
Abstract Pharmaceuticals are beneficial to humankind and emerged as crucial arms to treat/manage multiple disease pathogenesis in the present era. In analogous, these medicines/ medical devices should be used cautiously as they possess a potential threat to induce multiple undesired effects that may be related to human health or the environment. Daunting may arise due to the improper disposal of unused/expired medicines. Hence, to minimize such harm, there should be adequate knowledge and practice among the population regarding the safe disposal of unused/expired medicines or related pharmaceutical devices. The la...
Source: Current Drug Safety - June 25, 2020 Category: Drugs & Pharmacology Authors: Nepal S, Giri A, Bhandari R, Chand S, Nepal S, Aryal S, Khanal P, Moktan JB, Shastry CS Tags: Curr Drug Saf Source Type: research

Evaluation of risk factors for development of anti-tubercular therapy induced hepatotoxicity - A prospective study.
CONCLUSION: Intensive liver function monitoring needs to be done in patients with these risk factors, female gender, alcoholism, HIV co-infection, extra-pulmonary tuberculosis and age>35 yrs. PMID: 32589563 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - June 25, 2020 Category: Drugs & Pharmacology Authors: Radhika S, Subbalaxmi Mvs, Lakshmi A V Tags: Curr Drug Saf Source Type: research

A Case of Liver Failure Due to Dabigatran Treated with Venovenous He-modiafiltration and Idarucizumab.
We present a case of an older adult who suffered a severe accidental dabigatran intoxication with acute liver toxicity recovered after dialytic treatment and Idarucizumab. PMID: 32576132 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - June 22, 2020 Category: Drugs & Pharmacology Authors: Guglielmo N, Orso D, Mestroni R, Montanari G Tags: Curr Drug Saf Source Type: research

A prospective analysis of potential and observed Drug-Drug Interactions, Adverse Events and its associated factors in hospitalized Cardiology Patients in Benin.
CONCLUSION: This study highlights the need to optimize treatments by strictly regulating blood pressure, serum sodium and potassium levels, coagulation parameters and looking for clinical signs of hemorrhage. Physician should be aware of certain drug associations that may carry a risk of severe adverse events. PMID: 32564759 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - June 20, 2020 Category: Drugs & Pharmacology Authors: Allabi AC, Chabi Y, Hounkponou M, Quenum R, Vehounkpe-Sacca J Tags: Curr Drug Saf Source Type: research

Risk Minimization Measures in Off-Label Drug Use: A Survey of Community Pharmacists in Malaysia.
CONCLUSION: The community pharmacists have positive beliefs towards most of the risk minimization measures. However, beliefs towards written informed consent requirement are not encouraging. Enhancing risk perception may help influence positive beliefs towards risk minimization measures. PMID: 32538733 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - June 14, 2020 Category: Drugs & Pharmacology Authors: Fatokuna O Tags: Curr Drug Saf Source Type: research

Pharmacovigilance Assessment of Cardiac Implications of Nicotine Replacement Therapy Among Smokers.
CONCLUSION: Our study findings showed lower cardiac disorder risk with NRT group compared to non-NRT (varenicline and bupropion) group. While the study was not aimed to undermine either using NRT or non-NRT for smoking cessation therapy to prevent smoking illness, the study results offer informed findings that could potentially improve current smoking cessation management using NRT intervention among smokers and enhance smokers' health outcome. Despite the negative signal detection of cardiac disorder risk with NRT as compared to non-NRT in final findings, we still recommend further research on causal relationship between ...
Source: Current Drug Safety - June 10, 2020 Category: Drugs & Pharmacology Authors: Olawuyi O, Mathieson K Tags: Curr Drug Saf Source Type: research

Linezolid Induced Skin Reactions In A Multi Drug Resistant Infective Endocarditis Patient: A Rare Case.
CONCLUSION: Healthcare Professionals should be vigilant for the rare CADRs, while monitoring the patients on LNZ therapy especially on MDR patients as they are exposed to multiple drugs. Moreover, a strengthened spontaneous reporting is required for a better quantification. PMID: 32416699 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - May 15, 2020 Category: Drugs & Pharmacology Authors: Rajan AK, Kashyap A, Chhabra M, Rashid M Tags: Curr Drug Saf Source Type: research

Adverse drug reaction monitoring and reporting among physicians and pharmacists in Pakistan: A cross-sectional study.
This study was carried out to determine knowledge, attitude and practices of ADR among physicians and pharmacists working in Pakistan and the factors which encourage and discourage effective reporting. METHODS: A cross-sectional study was conducted using a pretested questionnaire. Questionnaires were distributed among 333 physicians and 34 pharmacists with a 95.5% response rate. The Statistical Package for Social Science (SPSS) was used for data analysis. RESULTS: Pharmacists have more knowledge regarding ADR compared to physicians (47.1% vs 13.8%, p
Source: Current Drug Safety - April 26, 2020 Category: Drugs & Pharmacology Authors: Zaka Un Nisa, Zafar A, Zafar F, Pezaro S, Sher F Tags: Curr Drug Saf Source Type: research

Disposal practices of unused medications among patients in public health centers of Dessie town, Northeast Ethiopia: A cross sectional study.
CONCLUSION: In present study, there was high practice of keeping medications at home and most of the disposal practices were not recommended methods. In addition, most of the respondents did not get an advice from pharmacists and other health care professionals how to dispose unused medications. Hence, there is a need for proper education and guidance of patients about disposal practices of unused medications. PMID: 32228428 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - March 30, 2020 Category: Drugs & Pharmacology Authors: Kassahun H, Tesfaye D Tags: Curr Drug Saf Source Type: research

Central Nervous System Depressants and Risk of Hospitalization due to Community Acquired Pneumonia in the Very Old.
CONCLUSION: The use of antipsychotics in the very old adults was associated with an increased risk of hospital admission due to CAP. This suggests that use of these medications in this population should be done with caution. No association was observed with opioids, benzodiazepines and zolpidem with the latter outcome. PMID: 32189596 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - March 18, 2020 Category: Drugs & Pharmacology Authors: Espinosa J, Alvarez P, Castro V, Caceres M, Soler-Riera M, Bril F Tags: Curr Drug Saf Source Type: research

Ustekinumab-induced sarcoidosis in a patient with psoriatic arthritis.
Abstract Psoriatic arthritis(PsA) is a chronic inflammatory disease which may affect many different joints. Sarcoidosis is a Th-1 cell related chronic granulomatous disease characterized by non-caseating granuloma formation. The coexistence of both diseases is a rare entity. In addition to conventional DMARDs, biological agents are also used in the treatment of PsA. One of these drugs is ustekinumab, an IL12 / 23 inhibitor that control both skin lesions and locomotor system findings. In this paper, we report the development of sarcoidosis in a 52 years old female patient treated with ustekinumab for PsA. PMID...
Source: Current Drug Safety - March 15, 2020 Category: Drugs & Pharmacology Authors: Kobak S, Semiz H Tags: Curr Drug Saf Source Type: research

Inappropriate Medication Use and cost comparison analysis of Proton pump inhibitors: Evidence from an Indian tertiary care facility.
CONCLUSION: The study inferred that irrational drug use of PPI still prevalent, that too without considering the economic impact of it on general populations. Healthcare practitioners should be aware and cautious while prescribing the PPI to identify the actual need and to choose with the most cost-effective alternative. PMID: 32160850 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - March 10, 2020 Category: Drugs & Pharmacology Authors: Venkataraman R, Rashid M, Shrestha H Tags: Curr Drug Saf Source Type: research

Impact of clinical audit on adherence to the guidelines directed medical therapy in patients admitted with heart failure.
CONCLUSION: This study reveals that periodic clinical audit improves adherence to GDMT in patients admitted with heart failure with reduced ejection fraction. PMID: 32156240 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - March 9, 2020 Category: Drugs & Pharmacology Authors: Ahamed A, George N, Radhakrishnan S, Velusamy S, Kaliappan T, Gopalan R, Anandan P, Palanimuthu R, Balasubramanian VR Tags: Curr Drug Saf Source Type: research

Delirium Secondary to Lamotrigine Toxicity.
CONCLUSION: Clinicians should use caution interpreting lamotrigine levels when working up delirium, as normal levels may not rule out the development of lamotrigine toxicity. PMID: 32096747 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - February 23, 2020 Category: Drugs & Pharmacology Authors: Sanchez DL, Fusick AJ, Gunther SR, Hernandez MJ, Sullivan GA, Catalano MC, Catalano G Tags: Curr Drug Saf Source Type: research

Integrating Regulatory Drug Label Information to Facilitate Evaluation of Adverse Events in Pharmacovigilance.
CONCLUSION: In addition to providing standalone KIM table as reference, adoption of this concept and automation may also be fully integrated into commercial signal detection and management software packages for easy use and accessibility and may even lead to reduced False Positive rate in signal detection within the PV space. PMID: 32091345 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - February 22, 2020 Category: Drugs & Pharmacology Authors: Hui TZ Tags: Curr Drug Saf Source Type: research

Analysis of QTc Interval during Levofloxacin Prescription in Cardiac Patients with Pneumonia: A Comparative Study.
Abstract BACKGROUND: Medications induced QT prolongation could cause ventricular arrhythmia, torsade de pointes, and death. OBJECTIVE: The purpose of this study was to evaluate the magnitude of QTc interval prolongation as a result of levofloxacin treatment in patients admitted to cardiology wards. METHODS: This was a cross-sectional study conducted in the coronary care units and general wards of the Imam Ali Heart Hospital in Kermanshah, Iran. The QTc interval was determined at baseline and after 72 hours of levofloxacin administration. Changes in the QTc interval before and after the levofloxacin presc...
Source: Current Drug Safety - February 11, 2020 Category: Drugs & Pharmacology Authors: Shojaei L, Ruzbahani M, Khajavian S, Shahsavari S, Tamasoki N, Rajabian M, Moradi F, Shahbazi F Tags: Curr Drug Saf Source Type: research

A Rare Case Report Of Dabigatran Induced Oral Ulcers.
CONCLUSION: Patient education and counselling should be done regarding this side effect of dabigatran and proper intake of this medicine. PMID: 32048978 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - February 10, 2020 Category: Drugs & Pharmacology Authors: Singh A, Prabha N, Yadav H Tags: Curr Drug Saf Source Type: research

Treatment of psoriasis: A comprehensive review of entire therapies.
CONCLUSION: A rationalized cost effective patient compliant therapy is required for effective management and complete cure of psoriasis. PMID: 31994468 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - January 26, 2020 Category: Drugs & Pharmacology Authors: Bakshi H, Nagpal M, Singh M, Dhingra GA, Aggarwal G Tags: Curr Drug Saf Source Type: research

Self-Medication Pattern and Prevalence among Iranian Medical Sciences Students.
CONCLUSIONS: Although medical sciences students have information about treatment of illnesses but they should be more informed about negative results and side-effects of self-medication. They should also transfer their knowledge to the society to decrease self-medication behavior. PMID: 31642791 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - October 20, 2019 Category: Drugs & Pharmacology Authors: Niroomand N, Bayati M, Seif M, Delavari S, Delavari S Tags: Curr Drug Saf Source Type: research

Disposal Practices of Unused and Expired Medicines among General Public in Delhi & National Capital Region, India.
CONCLUSION: The knowledge and practices of consumers towards disposal of unused and expired medicines needs to be improved. Health care professionals, government and policy makers should offer training to educate and guide the general public on safe and proper disposal practices of expired or unused medicines. PMID: 31593533 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - October 6, 2019 Category: Drugs & Pharmacology Authors: Manocha S, Suranagi UD, Sah RK, Chandane RD, Kulhare S, Goyal N, Tanwar K Tags: Curr Drug Saf Source Type: research

Drug withdrawal due to safety reasons: A review of the data supporting the withdrawal decision.
CONCLUSION: According to available and published evidence, there is no gold standard to identify risks associated with drug exposure. These findings strengthen the role of different information sources within the drug safety review process. PMID: 31584381 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - October 2, 2019 Category: Drugs & Pharmacology Authors: Craveiro NS, Lopes BS, Tomás L, Almeida SF Tags: Curr Drug Saf Source Type: research

Analysis of ADRs from oral anticoagulants: Clinical pictures, preventability and need for clinical and laboratory monitoring. A pilot study in an Internal Medicine Department.
CONCLUSIONS: This study highlights the large percentage of adverse reactions from oral anticoagulants that can be avoided with more careful patient management. A clinical picture of cardiac failure often leads to a diagnosis of hemorrhage/anemia; Periodic check up of cardiac and renal function and of blood count may be very useful, especially in older patients and in those in therapy with DOACs. A larger study, including patients from different hospitals, could yeld a higher general value. PMID: 31580253 [PubMed - as supplied by publisher] (Source: Current Drug Safety)
Source: Current Drug Safety - October 2, 2019 Category: Drugs & Pharmacology Authors: Spada G, Vighi GVGV, Pagani S, Vighi GD, Venegoni M, Ruocco M Tags: Curr Drug Saf Source Type: research