Validated liquid chromatography–tandem mass spectrometry method for simultaneous determination of clopamide, reserpine and dihydroergotoxine: Application to pharmacokinetics in human plasma
Publication date: 5 June 2016 Source:Journal of Pharmaceutical and Biomedical Analysis, Volume 125 Author(s): Mohie M.K. Sharaf El-Din, Mohamed W.I. Nassar, Khalid A.M. Attia, Maha A.El Demellawy, Mohamed M.Y. Kaddah A simple, sensitive and rapid high performance liquid chromatography–tandem mass spectrometry (HPLC–MS/MS) method was developed and validated for the simultaneous quantitation of clopamide, reserpine and dihydroergotoxine (ergoloid mesylates) in human plasma. Under basic conditions, liquid–liquid extraction using ethyl acetate was efficiently used for extraction of the analytes from plasma ...
Source: Journal of Pharmaceutical and Biomedical Analysis - March 30, 2016 Category: Drugs & Pharmacology Source Type: research
Quantifying intermolecular interactions in solid state indapamide and other popular diuretic drugs: Insights from Hirshfeld surface study
Publication date: 15 July 2016 Source:Journal of Molecular Structure, Volume 1116 Author(s): Joanna Bojarska, Andrzej Fruziński, Waldemar Maniukiewicz Hirshfeld surfaces (HS) and two-dimensional fingerprint plots are used to analyze the intermolecular interactions in indapamide and other popular thiazide diuretic derivatives. The crystal structure of indapamide (INDP) at 100 K determined by single-crystal X-ray analysis, is also reported. The title compound crystallizes in the centrosymmetric I2/a space group with one indapamide and half water molecule (lying on the glide plane) in the asymmetric unit. An inter...
Source: Journal of Molecular Structure - March 15, 2016 Category: Molecular Biology Source Type: research
Evaluation of drug-carrier interactions in quaternary powder mixtures containing perindopril tert-butylamine and indapamide
Publication date: 30 April 2016 Source:International Journal of Pharmaceutics, Volume 503, Issues 1–2 Author(s): Adam Voelkel, Kasylda Milczewska, Michał Teżyk, Bartłomiej Milanowski, Janina Lulek Interactions occurring between components in the quaternary powder mixtures consisting of perindopril tert-butylamine, indapamide (active pharmaceutical ingredients), carrier substance and hydrophobic colloidal silica were examined. Two grades of lactose monohydrate: Spherolac® 100 and Granulac® 200 and two types of microcrystalline cellulose: M101D+ and Vivapur® 102 were used as carriers. We determined the ...
Source: International Journal of Pharmaceutics - March 5, 2016 Category: Drugs & Pharmacology Source Type: research
Risks associated with permanent discontinuation of blood pressure-lowering medications in patients with type 2 diabetes
Conclusion: Discontinuation of study medication is a potent risk marker for identifying high-risk patients. Thus it is important that clinicians seek to identify such patients early after discontinuation of treatment. Although some short-term residual effects of previous active treatment can be expected, patients who discontinue require further urgent investigation and management. (Source: Journal of Hypertension)
Source: Journal of Hypertension - March 4, 2016 Category: Cardiology Tags: ORIGINAL PAPERS: Therapeutic aspects Source Type: research
Simultaneous high-throughput determination of interaction kinetics for drugs and cyclodextrins by high performance affinity chromatography with mass spectrometry detection.
In this study, a HPAC with mass spectrometry detection (HPAC-MS/MS) was employed to determine the drug-cyclodextrin (CD) interaction kinetics with low sample loading quantity (<10 ng per injection for single compound) and high-throughput yield as twenty drugs determined in one injection. The kd,app measured by HPAC-MS/MS approach were 0.89 ± 0.07, 4.34 ± 0.01, 1.48 ± 0.01 and 7.77 ± 0.04 s(-1) for ketoprofen, trimethoprim, indapamide and acetaminophen, with kd,app for acetaminophen consistent with that from the HPAC method with UV detector in our previous studies. For twenty drugs with diverse structures an...
Source: Analytica Chimica Acta - February 8, 2016 Category: Chemistry Authors: Wang C, Wang X, Xu X, Liu B, Xu X, Sun L, Li H, Zhang J Tags: Anal Chim Acta Source Type: research
13C solid-state NMR analysis of the most common pharmaceutical excipients used in solid drug formulations Part II: CP kinetics and relaxation analysis
Publication date: 15 April 2016 Source:Journal of Pharmaceutical and Biomedical Analysis, Volume 122 Author(s): Dariusz Maciej Pisklak, Monika Zielińska-Pisklak, Łukasz Szeleszczuk, Iwona Wawer Excipients used in the solid drug formulations differ in their NMR relaxation and 13C cross-polarization (CP) kinetics parameters. Therefore, experimental parameters like contact time of cross-polarization and repetition time have a major impact on the registered solid state NMR spectra and in consequence on the results of the NMR analysis. In this work the CP kinetics and relaxation of the most common pharmaceutical e...
Source: Journal of Pharmaceutical and Biomedical Analysis - February 3, 2016 Category: Drugs & Pharmacology Source Type: research
Addition of indapamide to frusemide increases natriuresis and creatinine clearance, but not diuresis, in fluid overloaded ICU patients
The objective of this study was to examine the effect of adding indapamide to frusemide on diuresis, natriuresis, creatinine clearance and serum electrolytes. (Source: Journal of Critical Care)
Source: Journal of Critical Care - January 27, 2016 Category: Intensive Care Authors: Shailesh Bihari, Andrew W. Holt, Shivesh Prakash, Andrew D. Bersten Source Type: research
Correction of endothelial dysfunction in patients with COPD and concomitant arterial hypertension
Conclusions: Endothelial dysfunction were observed in studied patients with COPD and concomitant hypertension. Indapamide SR treatment in complex therapy of COPD and concomitant hypertension leads to a significant reduction of endothelial dysfunction markers (endothelin-1, sP-selectin, ICAM-1), which indicates the presence of pleiotropic effects of indapamide. (Source: European Respiratory Journal)
Source: European Respiratory Journal - October 30, 2015 Category: Respiratory Medicine Authors: Nersesyan, Z., Ovcharenko, S., Morozova, T. Tags: 1.12 Clinical Problems - COPD Source Type: research
Red cell distribution width in type 2 diabetic patients
Conclusion: RDW, which is recently considered as an inflammatory marker with a significant predictive value of mortality in diseased and healthy populations, is significantly higher in diabetic patients than healthy subjects and is particularly higher in uncontrolled glycemia. None of the studied hypoglycemic agents showed a significant effect on RDW. Diabetic hypertensive patients receiving antihypertensive therapy in the form of indapamide or the combined therapy of thiazides and angiotensin receptor blockers have RDW values comparable to those of the healthy population. Keywords: red cell distribution, platelet, diabet...
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - October 29, 2015 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
Antihypertensive therapy increases natural immunity response in hypertensive patients
Publication date: Available online 26 October 2015 Source:Life Sciences Author(s): Henrique Andrade R. Fonseca, Francisco A. Fonseca, Lívia C. Lins, Andrea M. Monteiro, Henrique T. Bianco, Sergio A. Brandão, Rui M. Povoa, Luiz Juliano, Antônio M. Figueiredo-Neto, Paulo Boschcov, Magnus Gidlund, Maria C. Izar Aims The aim of this work was to evaluate the effects of treatment of hypertension on the autoantibodies to apolipoprotein B-derived peptides (anti-ApoB-D peptide Abs) response, inflammation markers and vascular function. Main methods Eighty-eight patients with hypertension (stage 1 or ...
Source: Life Sciences - October 26, 2015 Category: Biology Source Type: research
Budget Impact Analysis Of Tripliam For The Treatment Of Hypertension In Italy
The objective of this study was to perform a Budget Impact Analysis (BIA) assessing the introduction of Tripliam for the treatment of hypertension into the Italian market. Tripliam is the first and only available single-tablet triple combination antihypertensive therapy containing perindopril, amlodipine and indapamide, in line with current evidence-based recommendations for the treatment and management of hypertension. (Source: Value in Health)
Source: Value in Health - October 23, 2015 Category: Global & Universal Authors: EP Lanati, VL Orlando Source Type: research
Molecular Dynamics and Physical Stability of Coamorphous
Ezetimib and Indapamide Mixtures
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.5b00334 (Source: Molecular Pharmaceutics)
Source: Molecular Pharmaceutics - September 1, 2015 Category: Drugs & Pharmacology Authors: J. Knapik, Z. Wojnarowska, K. Grzybowska, K. Jurkiewicz, L. Tajber and M. Paluch Source Type: research
Dissolution profiles of perindopril and indapamide in their fixed-dose formulations by a new HPLC method and different mathematical approaches.
Abstract
A new HPLC method was introduced and validated for simultaneous determination of perindopril and indapamide. Validation procedure included specificity, sensitivity, robustness, stability, linearity, precision and accuracy. The method was used for the dissolution test of perindopril and indapamide in three fixed-dose formulations. The dissolution procedure was optimized using different media, different pH of the buffer, surfactants, paddle speed and temperature. Similarity of dissolution profiles was estimated using different model-independent and model-dependent methods and, additionally, by princ...
Source: Acta Pharmaceutica - September 1, 2015 Category: Drugs & Pharmacology Authors: Gumieniczek A, Mączka P, Komsta Ł, Pietraś R Tags: Acta Pharm Source Type: research
Hydrochlorothiazide is not the most useful nor versatile thiazide diuretic
Purpose of review: To determine usefulness and versatility of hydrochlorothiazide (HCTZ) relative to other thiazide diuretics in the treatment of hypertension.
Recent findings: HCTZ was found to be less potent in lowering blood pressure (BP) than other thiazide diuretics, including chlorthalidone (CTD) and bendroflumethiazide. A recent meta-analysis also suggested HCTZ (12.5–25 mg daily) to be less potent than antihypertensive agents from several other classes, including angiotensin-converting enzyme inhibitors, angiotensin-receptor blockers, and calcium antagonists. The risk of hyponatremia, hypokalemia, and hyperuric...
Source: Current Opinion in Cardiology - June 8, 2015 Category: Cardiology Tags: HYPERTENSION: Edited by Franz H. Messerli and Stefano F. Rimoldi Source Type: research
Effects of a selective aldosterone blocker and thiazide-type diuretic on blood pressure and organ damage in hypertensive patients.
In conclusion, eplerenone and indapamide were similarly effective in lowering office and home BPs in hypertensive patients treated with CCBs and ARBs. Eplerenone may exert more favorable effects on arterial stiffness and oxidative stress.
PMID: 25992488 [PubMed - as supplied by publisher] (Source: Clinical and Experimental Hypertension)
Source: Clinical and Experimental Hypertension - May 20, 2015 Category: Cardiology Authors: Ohta Y, Ishizuka A, Hayashi S, Iwashima Y, Kishida M, Yoshihara F, Nakamura S, Kawano Y Tags: Clin Exp Hypertens Source Type: research
