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The Forgotten Antiproteinuric Properties of Diuretics
Am J Nephrol. 2021 Jul 7:1-15. doi: 10.1159/000517020. Online ahead of print.ABSTRACTBACKGROUND: Although diuretics are one of the most widely used drugs by nephrologists, their antiproteinuric properties are not generally taken into consideration.SUMMARY: Thiazide diuretics have been shown to reduce proteinuria by >35% in several prospective controlled studies, and these values are markedly increased when combined with a low-salt diet. Thiazide-like diuretics (indapamide and chlorthalidone) have shown similar effectiveness. The antiproteinuric effect of mineralocorticoid receptor antagonists (spironolactone, eplerenone...
Source: American Journal of Nephrology - July 7, 2021 Category: Urology & Nephrology Authors: Hernando Trujillo Fernando Caravaca-Font án Jara Caro Enrique Morales Manuel Praga Source Type: research

Risk of electrolyte disorders, syncope and falls in patients taking thiazide diuretics: results of a cross-sectional study
Thiazide diuretics are commonly prescribed drugs and are considered a mainstay in the treatment of arterial hypertension 1,2. Thiazides or thiazide-like diuretics such as hydrochlorothiazide, indapamide, chlorthalidone and metolazone were found to be associated with hyponatremia and hypokalemia 1,3. Moreover, thiazides were described to be independently associated with hypomagnesemia 4. However, especially the occurrence of thiazide-associated hyponatremia has been in the focus of research during the last years 1,5,6. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - May 8, 2021 Category: General Medicine Authors: Svenja Ravioli, Shawki Bahmad, Georg-Christian Funk, Christoph Schwarz, Aristomenis Exadaktylos, Gregor Lindner Tags: Clinical research study Source Type: research

Comparison of diuretic strategies in diuretic-resistant acute heart failure: a systematic review and network meta-analysis
CONCLUSIONS: None of the diuretics considered in RCTs performed to date (tolvaptan, metolazone, hydrochlorothiazide, indapamide) appear to be more effective than furosemide therapy alone for the treatment of patients with diuretic-resistant AHF.PMID:33877660 | DOI:10.26355/eurrev_202104_25550 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - April 20, 2021 Category: Drugs & Pharmacology Authors: D Orso G Tavazzi F Corradi F Mearelli N Federici D Peric N D'Andrea G Santori F Mojoli F Forfori L Vetrugno T Bove Source Type: research

Comparison of diuretic strategies in diuretic-resistant acute heart failure: a systematic review and network meta-analysis
CONCLUSIONS: None of the diuretics considered in RCTs performed to date (tolvaptan, metolazone, hydrochlorothiazide, indapamide) appear to be more effective than furosemide therapy alone for the treatment of patients with diuretic-resistant AHF.PMID:33877660 | DOI:10.26355/eurrev_202104_25550 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - April 20, 2021 Category: Drugs & Pharmacology Authors: D Orso G Tavazzi F Corradi F Mearelli N Federici D Peric N D'Andrea G Santori F Mojoli F Forfori L Vetrugno T Bove Source Type: research