An Inevitable Challenge in Primary Prevention of Upper Gastrointestinal Bleeding Among Aspirin Users: Appropriate Use of Proton Pump Inhibitors
Li et al1 conducted a retrospective observational study using the Nationwide Emergency Department Sample, demonstrating an increased incidence of upper gastrointestinal bleeding among patients on long-term aspirin therapy without cardiovascular disease. Considering the rising incidence, severity, and costs associated with upper gastrointestinal bleeding among patients using aspirin for primary cardiovascular prevention, the authors conclude that there is a need for cautious discussion beyond current guidelines regarding the indications for aspirin use. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - April 27, 2024 Category: General Medicine Authors: Hiroshi Ito Tags: Letter Source Type: research
Depression, Cardiovascular Disease, and Mortality
I read the paper by Krittanawong et al1 with great interest. The authors conducted a meta-analysis on the relationship between depression and the incidence of cardiovascular disease and cardiovascular disease outcomes. Pooled hazard ratios (HR) (95% confidence interval [CI]) of depression for incident stroke, myocardial infarction, congestive heart failure, and any cardiovascular diseases were 1.13 (1.00-1.28), 1.28 (1.14-1.45), 1.04 (1.00-1.09), and 1.16 (1.04-1.30), respectively. Regarding mortality risk, pooled HRs (95% CI) of depression for all-cause, cardiovascular disease, and congestive heart failure causes were 1.4...
Source: The American Journal of Medicine - April 27, 2024 Category: General Medicine Authors: Tomoyuki Kawada Tags: Letter Source Type: research
The Reply
We thank Dr. Kawada for his interest in our meta-analysis.1 Dr. Kawada suggests that optimism is associated with a reduced risk of all-cause mortality and of cardiovascular disease.2 Indeed, we totally agree that there is a possibility of risk reduction in cardiovascular disease and mortality by maintaining favorable psychological health. Although there has been no randomized clinical trial and there are potential confounders for these studies, maintaining good psychological health would likely be beneficial to overall cardiovascular health. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - April 27, 2024 Category: General Medicine Authors: Chayakrit Krittanawong, Neil Sagar Maitra, Yusuf Kamran Qadeer, Zhen Wang, Sonya Fogg, Eric A. Storch, Christopher M. Celano, Jeff C. Huffman, Manish Jha, Dennis S. Charney, Carl J. Lavie Tags: LETTER Source Type: research
The Reply
We thank Dr. Ito for his commentary on our manuscript1 and we appreciate the opportunity to respond. We agree with Dr. Ito that the appropriate prescription of proton pump inhibitors (PPIs) is an important issue facing the medical community and that inappropriate use of PPI is widespread. We also agree that given observational data from real-world population,2 it is likely that a proportion of patients in our cohort were taking PPIs without a clear indication. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - April 27, 2024 Category: General Medicine Authors: Darrick K. Li, Dennis L. Shung Tags: Letter Source Type: research
Table of Contents
(Source: The American Journal of Medicine)
Source: The American Journal of Medicine - April 27, 2024 Category: General Medicine Source Type: research
Social Networks as a Key Health Determinant in Acute Illness Recovery: A Lesson from the COVID-19 Pandemic
This study aimed to investigate the relationship between social networks and self-rated health change, as well as physical function, in patients recovering from COVID-19 pneumonia. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - April 25, 2024 Category: General Medicine Authors: Di Pan DO, Jihui L. Diaz, Karissa Weidman, Julia Graham, Parag Goyal, Mangala Rajan, Jennifer Lau, Laura Pinheiro, Leena Rachid, Will Simmons, Edward J. Schenck, Monika M. Safford, Lindsay Lief Tags: Clinical Research Study Source Type: research
Risk of major adverse cardiovascular events after SARS-CoV-2 infection in British Columbia: a population-based study
COVID-19 is associated with increased risk of post-acute cardiovascular outcomes. Population-based evidence for long periods of observation is still limited. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - April 24, 2024 Category: General Medicine Authors: H éctor Alexander Velásquez García, Stanley Wong, Dahn Jeong, Mawuena Binka, Zaeema Naveed, James Wilton, Nathaniel Mark Hawkins, Naveed Zafar Janjua Source Type: research
Impact of quantitative ST-T analysis in patients with suspected myocardial infarction presenting with right bundle branch block
While left bundle branch block (LBBB) is a well-known risk feature in patients with acute myocardial infarction and a rapid invasive management is recommended, data supporting this strategy for patients with right bundle branch block (RBBB) is less robust. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - April 24, 2024 Category: General Medicine Authors: Nils A. S örensen, Yama Fakhri, Alina Goßling, Johannes T. Neumann, Paul M. Haller, Betül Toprak, Juliana Senftinger, Jonas Lehmacher, Lea Scharlemann, Alina Schock, Raphael Twerenbold, Dirk Westermann, Hedvig Andersson, Lisette O. Jensen, Lene Holmvan Tags: Clinical Research Study Source Type: research
The Conflict of Public Health Law and Civil Liberties Part IV: Anger, Frustration, and the Loss of Trust
Political power and public trust are fragile things. Short of criminal law enforcement, voluntary agreement with any significant restriction of ordinary freedom of speech or behavior depends on convincing large numbers of citizens that temporary suspension of a particular liberty is in their best interest. Threats to health or property are convincing reasons to change behavior, to give someone else control over our daily lives. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - April 23, 2024 Category: General Medicine Authors: Curtis E. Harris Tags: Commentary Source Type: research
The importance of history (her story)
A 75-year-old woman was admitted with recurrent urinary tract infection (UTI). (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - April 23, 2024 Category: General Medicine Authors: Ami Schattner, Ina Dubin, Yair Glick Tags: Clinical Communication to the Editor Source Type: research
Long COVID Characteristics and Experience: A Descriptive Study from the Yale LISTEN Research Cohort
To describe the experience of people with long COVID symptomatology and characterize the psychological, social, and financial challenges they experience. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - April 23, 2024 Category: General Medicine Authors: Mitsuaki Sawano, Yilun Wu, Rishi M. Shah, Tianna Zhou, Adith S. Arun, Pavan Khosla, Shayaan Kaleem, Anushree Vashist, Bornali Bhattacharjee, Qinglan Ding, Yuan Lu, C ésar Caraballo, Frederick Warner, Chenxi Huang, Jeph Herrin, David Putrino, Teresa Miche Source Type: research
Categorization of Patients with Pulmonary Embolism by Charlson Comorbidity Index
Pulmonary embolism is a cardiovascular life-threatening acute event afflicted by high morbidity and mortality.1-6 While the annual incidence of pulmonary embolism has increased in the past decades, the case fatality of this emergency event decreased in the same time.3,7-9 Mortality caused by pulmonary embolism is strongly and closely related to the patients ’ hemodynamic status and cardiac involvement, including right ventricular dysfunction and/or myocardial injury, as well as the patients’ comorbidity profile. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - April 23, 2024 Category: General Medicine Authors: Karsten Keller, Volker H. Schmitt, Omar Hahad, Christine Espinola-Klein, Thomas M ünzel, Philipp Lurz, Stavros Konstantinides, Lukas Hobohm Tags: Clinical Research Study Source Type: research
Looking Beyond LinkedIn: The Case for Excellence and Academic Rigor in Quality and Safety Programs
"...in life, you gotta keep showing up …until they give you those accolades you feel you deserve, until they call you chairman, until they call you a genius, until they call you the greatest of all time. You feel me? Thank you."-Jay Z, Grammy Awards, 2024 (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - April 23, 2024 Category: General Medicine Authors: Gonzalo Bearman, Priya Nori Tags: Commentary Source Type: research
Sociologic and Psychiatric Aspects of U.S. Gun Violence: A Cure For This Endemic
There are at least fifty million more guns in than people in America. The U.S. also suffers more shootings and ten times more gun deaths per-capita than any other developed country in the world1. Clearly the underlying problem is the widespread availability of weapons exclusively and efficiently designed to kill humans. These are the semi-automatic, double action handguns (E.G. Glock, Sig-Sauer, Beretta, etc.) used in homicides and suicides and the assault rifles used in mass shootings. However, upon forensic analysis virtually every event of gun violence (GV) routinely embodies societal and individual factors that made it...
Source: The American Journal of Medicine - April 23, 2024 Category: General Medicine Authors: James Webster Tags: Commentary Source Type: research
Overall medication adherence as an indicator for health outcomes among elderly patients with hypertension and diabetes
Various studies have demonstrated that medication adherence is a key factor in medical treatment. Stuart and colleagues found that good adherence to medication among diabetic patients was associated with lower medical costs1. In another study, Franchi and colleagues found that better adherence to treatment was associated with better health results2. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - April 23, 2024 Category: General Medicine Authors: Michal Shani, Alex Lustman, Doron Comaneshter, Yochai Schonmann Tags: Clinical Research Study Source Type: research
