Is Benzathine Penicillin the Treatment of Choice in Neurosyphilis?
We read the case report by Yousefian et al1 with great interest. Their case was a 20-year-old man who was diagnosed with granulomatous secondary syphilis. We think that there is a questionable point in this article. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - September 20, 2023 Category: General Medicine Authors: Hasan Tahsin Gozdas, Ahmet Dogan Tags: Letter Source Type: research
Idiopathic Giant Cell Myocarditis: A Subtype of Granulomatous Myocarditis?
In the differential diagnosis of granulomatous myocarditis and sarcoidosis (including cardiac sarcoidosis),1 the authors made no allusion to the controversy about presence vs absence of granulomas in idiopathic giant cell myocarditis (IGCM).2 (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - September 20, 2023 Category: General Medicine Authors: Oscar M.P. Jolobe Tags: Letter Source Type: research
The Reply
Sarcoidosis is a multisystemic disease of unknown cause. The diagnosis of sarcoidosis requires a compatible clinical picture accompanied by radiological and histopathological demonstration of the entity.1 Our patient did not present asthenia, usual symptoms, or extrapulmonary organ involvement.2 Laboratory tests did not identify hypercalcemia or angiotensin-converting enzyme elevation. On the other hand, the patient did not present typical radiological findings such as multiple micronodules with lymphatic distribution or lymphadenopathy; lung mass is a rare manifestation of the disease. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - September 20, 2023 Category: General Medicine Authors: Francisco Le ón-Román, Beatriz Pintado-Cort Tags: Letter Source Type: research
The Reply
We would like to thank Drs. Gozdas and Dogan for reading our previous article and for providing us feedback on the treatment of neurosyphilis.1 Syphilis re-emergence cases have been reported and increased globally within the past 2 decades. Neurosyphilis accounts for 1.8%-3.5% of the cases and causes serious consequences.2 Diagnosis of neurosyphilis is confirmed via lumbar puncture spinal fluid test analyses —venereal disease research laboratory test, fluorescent treponemal antibody absorption test, and polymerase chain reaction. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - September 20, 2023 Category: General Medicine Authors: Faraz Yousefian, Sujitha Yadlapati Tags: Letter Source Type: research
Table of Contents
(Source: The American Journal of Medicine)
Source: The American Journal of Medicine - September 20, 2023 Category: General Medicine Source Type: research
Do Current Hiring Processes for Residency Program Directors and Associate Program Directors Foster Diversity in Educational Leadership
Residency program and associate program directors (PDs and APDs) hold highly visible educational leadership roles with the power to influence residency training, hospital operations, and the future physician workforce.1,2 They are the leaders of the educational missions of medical schools and teaching hospitals.1 As health care strives to create a more diverse workforce, diversity in leadership positions is foundational to meeting this goal.3-5 Recent publications have described the lack of gender and racial diversity in academic medicine leadership roles. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - September 17, 2023 Category: General Medicine Authors: Kathleen M. Finn, Michael Kisielewski, Furman S. McDonald, Lisa Willett, Patricia F. Kao, Sanjay Desai, Aimee Zaas Tags: AAIM Perspectives Source Type: research
Do Current Hiring Processes for Residency and Associate Program Directors Foster Diversity in Educational Leadership?
Residency program and associate program directors (PDs and APDs) hold highly visible educational leadership roles with the power to influence residency training, hospital operations, and the future physician workforce.1,2 They are the leaders of the educational missions of medical schools and teaching hospitals.1 As health care strives to create a more diverse workforce, diversity in leadership positions is foundational to meeting this goal.3-5 Recent publications have described the lack of gender and racial diversity in academic medicine leadership roles. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - September 17, 2023 Category: General Medicine Authors: Kathleen M. Finn, Michael Kisielewski, Furman McDonald, Lisa Willett, Patricia Kao, Sanjay Desai, Aimee Zaas Tags: AAIM Perspectives Source Type: research
Long COVID: Clinical Findings, Pathology, and Endothelial Molecular Mechanisms
Persistence of COVID-19 symptoms may follow SARS-CoV-2 infection. The incidence of long COVID increases with the severity of acute disease, but even mild disease can be associated with sequelae. The symptoms vary widely with fatigue, shortness of breath, and cognitive dysfunction being the most common. Abnormalities of multiple organs have been documented and histopathology has revealed widespread microthrombi. Elevated levels of complement are present in acute COVID-19 patients and may persist at lower levels in long COVID. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - September 11, 2023 Category: General Medicine Authors: H. Bradford Hawley Tags: Review Source Type: research
Outcomes of Oral Anticoagulation in Atrial Fibrillation Patients with or without Comorbid Vascular Disease: Insights from the GARFIELD-AF Registry
Many patients with atrial fibrillation suffer from comorbid vascular disease. The comparative efficacy and safety of different types of oral anticoagulation (OAC) in this patient group have not been widely studied. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - September 11, 2023 Category: General Medicine Authors: Freek W.A. Verheugt, Keith A.A. Fox, Saverio Virdone, Giuseppe Ambrosio, Bernard J. Gersh, Sylvia Haas, Karen S. Pieper, Gloria Kayani, A. John Camm, Alexandr Parkhomenko, Frank Misselwitz, APHany Ragy, Hugo ten Cate, Matyas Keltai, Ajay K. Kakkar, GARFIE Tags: Clinical Research Study Source Type: research
Advancing the Quintuple Aim for Health Care Improvement Through the Integration of Genetic Counselors into Primary Care
There is an expectation that the promise of genomic medicine will be realized through its integration into primary care.1 However, primary care is in a state of crisis, where practitioners have additional demands with fewer resources, leading to tremendous strain on the system and stress on the workforce. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - September 10, 2023 Category: General Medicine Authors: Kennedy Borle, Nathan J. Michaels, Daniel R. Evans, Alison M. Elliott, Morgan Price, Jehannine Austin Tags: Commentary Source Type: research
Hospital-Acquired Anemia in Patients with Acute Coronary Syndrome: Epidemiology and Potential Impact on Long-Term Outcome
Anemia (either pre-existing or hospital-acquired) is considered an independent predictor of mortality in acute coronary syndromes. However, it is still not clear whether anemia should be considered as a marker of worse health status or a therapeutic target. We sought to investigate the relationship between hospital-acquired anemia and clinical and laboratory findings and to assess the association with mortality and major cardiovascular events at long-term follow-up. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - September 10, 2023 Category: General Medicine Authors: Claudia Colombo, Paola Rebora, Claudio Montalto, Silvia Cantoni, Alice Sacco, Marco Mauri, Anita Andreano, Antonio Giampiero Russo, Stefano De Servi, Stefano Savonitto, Nuccia Morici Tags: Clinical Research Study Source Type: research
Hospital-acquired anemia in patients with acute coronary syndromes: epidemiology and potential impact on long-term outcome
Anemia (either pre-existing or hospital-acquired) is considered an independent predictor of mortality in acute coronary syndromes. However, it is still not clear whether anemia should be considered as a marker of worse health status or a therapeutic target. We sought to investigate the relationship between hospital-acquired anemia and clinical and laboratory findings and to assess the association with mortality and major cardiovascular events (MACE) at long term follow-up. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - September 10, 2023 Category: General Medicine Authors: Claudia Colombo, Paola Rebora, Claudio Montalto, Silvia Cantoni, Alice Sacco, Marco Mauri, Anita Andreano, Antonio Giampiero Russo, Stefano De Servi, Stefano Savonitto, Nuccia Morici Tags: Clinical Research Study Source Type: research
Development of a Novel Clinical Risk Score for COVID-19 Infections
The SARS-CoV-2 pandemic has presented substantial challenges for healthcare systems, clinical care, and epidemiological models globally. The COVID-19 pandemic has not only led to severe clinical outcomes but has also imposed a burden on multiple aspects of society, including mental health,13 the education system,12 and societal burden associated with the long Covid syndrome. Precise prediction of severe outcomes is essential for efficient resource allocation and risk management. Multiple studies have been conducted to develop prognostic scores and identify patients at risk of severe COVID outcomes, such as hospitalizations...
Source: The American Journal of Medicine - September 10, 2023 Category: General Medicine Authors: James B Baker, Arnab Ghatak, Mark R Cullen, Ralph I Horwitz Tags: Clinical Research Study Source Type: research
Advancing the quintuple aim of healthcare through the integration of genetic counselors into primary care
There is an expectation that the promise of genomic medicine will be realized through its integration into primary care.1 However, primary care is in a state of crisis, where practitioners have additional demands with fewer resources, leading to tremendous strain on the system and stress on the workforce. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - September 10, 2023 Category: General Medicine Authors: Kennedy Borle, Nathan J. Michaels, Daniel R. Evans, Alison M. Elliott, Morgan Price, Jehannine Austin Tags: Commentary Source Type: research
A First Presentation of Autoimmune Primary Adrenal Insufficiency
Primary adrenal insufficiency is a rare disease with an estimated incidence in Western countries of 35-60 cases per million and is characterized by hypocortisolism and hypoaldosteronism.1 Autoimmune disease is the most common etiology of primary adrenal insufficiency and is responsible for 70-90% of cases.1 Patients with chronic autoimmune processes can present in adrenal crisis characterized by hypotension with other common features including weakness and fatigue, GI symptoms, hyperpigmentation, hyponatremia, and hyperkalemia. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - September 9, 2023 Category: General Medicine Authors: Case Brabham, Sarah Cohen, Evelyn Coves-Datson, Alexander R. Carbo Tags: Clinical Communication to the Editor Source Type: research
