Characteristics and diagnostic challenge of antineutrophil cytoplasmic antibody positive infective endocarditis
ANCA are well-known diagnostic markers for ANCA-associated vasculitis and is proved to be pathogenic in the disease1. However, it is suggested that ANCA may have clinical and pathogenic relevance in other diseases such as various autoimmune, infectious and neoplastic diseases2. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - July 8, 2022 Category: General Medicine Authors: SanXi Ai, XinPei Liu, Gang Chen, YueLun Zhang, Xue Bai, Yan Qin, Qi Miao, XueMei Li Tags: Clinical Research Study Source Type: research

COPD Readmission: The Missing Link
Chronic Obstructive Pulmonary Disease (COPD) is a devastating disease with significant morbidity, mortality, and healthcare cost. COPD is the fourth leading cause of death in the United States, accounting for one-third of all deaths, and the mortality from COPD continues to rise.1,2 The response to this health crisis has been to improve hospital and healthcare efficiencies with the development of certified COPD management programs, including the one introduced in 2007 by the Joint Commission.3 The focus was directed towards six attributes, including staff education, use of spirometry, smoking cessation, risk factor reducti...
Source: The American Journal of Medicine - July 8, 2022 Category: General Medicine Authors: Smita Pakhale, Nina Huynh, Saania Tariq Tags: Commentary Source Type: research

National Adherence To Medical Management of Aortic Aneurysms
Cardiovascular disease accounts for approximately 800,000 deaths in the United States each year (1 in 3) and is projected to incur an annual cost of $800 billion dollars by 2030.1,2 Risk modification for patients with coronary artery disease has been a high priority for preventative cardiology for decades. Aortic disease has received less attention, though has a prevalence of approximately 5-7% and causes around 5 in 100,000 deaths.3 –6 (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - July 8, 2022 Category: General Medicine Authors: William L. Patrick, Fabliha Khurshan, Joseph E. Bavaria, Yu Zhao, Peter W. Groeneveld, Siddharth Yarlagadda, Jake L. Rosen, Joshua C. Grimm, Wilson Y. Szeto, Nimesh D. Desai Tags: Clinical Research Study Source Type: research

Mapping One Million COVID-19 Deaths and Unhealthy Lifestyle Behaviors in the United States: Recognizing the Syndemic Pattern and Taking Action
Tragically, the Unites States (US) surpassed one million documented deaths due to the coronavirus disease 2019 (COVID-19) pandemic. A convincing association between unhealthy lifestyle behaviors and poorer outcomes associated with COVID-19 infection has already been demonstrated and communicated by the Centers for Disease Control and Prevention in public health messaging. The US is experiencing not a pandemic, but a syndemic, specifically an unhealthy lifestyle behaviors - chronic diseases - COVID-19 syndemic. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - July 8, 2022 Category: General Medicine Authors: Ross Arena, Nicolaas P Pronk, Deepika Laddu, Laurie P. Whitsel, James F. Sallis, Carl J Lavie, HL-PIVOT Network Tags: Review Source Type: research

Practice Changing Updates in Perioperative Medicine Literature 2020- 2021. A Systematic Review
Recent literature published in a variety of multidisciplinary journals has significantly influenced perioperative patient care. Distilling and synthetizing the clinically important literature can be challenging. This review summarizes practice changing articles in perioperative medicine from the years 2020 and 2021. Embase, Ovid, and EBM reviews databases were queried from January 2020 to December 2021. Inclusion criteria were original research, systematic review, metaanalysis, and important guidelines. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - July 8, 2022 Category: General Medicine Authors: Maleka Khambaty, Richard E. Silbert, Aditya P. Devalapalli, Deanne T. Kashiwagi, Dennis W. Regan, Karna K. Sundsted, Karen F. Mauck Tags: Review Source Type: research

Nocebo Versus Placebo Effects: Their Clinical Relevance
The placebo effect can be defined as any improvement of illnesses or reduction of subjective symptoms that result from interventions possessing no known physical effects. By contrast, the nocebo effect refers to undesirable symptoms or illnesses that follow interventions also lacking known physical effects. It may also play a role in chronic illnesses that lack objective confirmation. Both placebo and nocebo effects can be potent and must be understood by both practitioners and researchers for proper application in clinical medicine. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - July 8, 2022 Category: General Medicine Authors: Morton E Tavel Tags: Review Source Type: research

High fitness levels offset the increased risk of chronic kidney disease due to low socioeconomic status: a prospective study
: Socioeconomic status (SES) and cardiorespiratory fitness (CRF) are each independently associated with chronic kidney disease. The interplay between SES, CRF, and chronic kidney disease is not well understood. We aimed to evaluate the separate and joint associations of SES and CRF with chronic kidney disease risk in a cohort of Caucasian men. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - July 8, 2022 Category: General Medicine Authors: Setor K. Kunutsor, Sae Young Jae, Jussi Kauhanen, Jari A. Laukkanen Tags: CLINICAL RESEARCH STUDY Source Type: research

Emerging from the Pandemic: AAIM Recommendations for Internal Medicine Residency and Fellowship Interview Standards
Traditionally, graduate medical education (GME) programs have conducted applicant interviews via in-person format. The COVID-19 pandemic transformed the process for interviewing residency and fellowship applicants during the 2020-2021 and 2021-2022 recruitment seasons. Applicants and programs developed new approaches for the application and recruitment process; interviews were conducted almost exclusively via a virtual/online format.1-3 Early data from all-virtual GME interview experiences suggest that virtual interviews are widely acceptable to applicants as well as to program directors and allow both groups to adequately...
Source: The American Journal of Medicine - July 8, 2022 Category: General Medicine Authors: Vera P. Luther, David A Wininger, Cindy J. Lai, Anthony Dao, Maria M. Garcia, Whitney Harper, Timothy M. Chow, Ricardo Correa, Lindsey J. Gay, Lyle Fettig, Bhavin Dalal, Patricia Vassallo, Steven Barczi, Michelle Sweet Source Type: research

A More Fitting Approach to Mask Policy
Over the course of the COVID-19 pandemic, one of the central public policy debates revolved around masking requirements as a mitigation technique to impede the spread of transmission. Controversy arose over masking mandates that were implemented across American society at various levels, some at the behest of individual businesses and others via the edict of municipal or state governments. At the federal level, Executive Orders issued during the first week of the Biden administration made masking a requirement on federal property – including National Parks – as well as on commercial transportation such as trains, ferri...
Source: The American Journal of Medicine - July 8, 2022 Category: General Medicine Authors: Marc Levine Tags: Commentary Source Type: research

Hidden in plain sight: Eosinophilic Fasciitis
A 66-year-old woman complained of gradual swelling and hardening of the skin of all limbs over 2 months, which started distally in the legs and progressed upwards, symmetrically, associated with difficulties in function and a weight gain of 10%. Examination was notable for diffuse marked limb edema (mostly non-pitting) and hardening of the skin with prominent peau d'orange appearance of the cubital fossa (Fig. 1A, B). The examination was otherwise normal. Her past history included obesity and diabetes and dyslipidemia treated with empagliflozin and atorvastatin. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - July 8, 2022 Category: General Medicine Authors: Ami Schattner, Yair Glick Source Type: research

mRNA COVID-19 Vaccination in Active COVID-19 –Infected Acute Myeloid Leukemia Patient
We present a case of a 64-year-old Chinese female with intermediate risk acute myeloid leukemia (with t(9;11)(p21.3;q23.3); KMT2A –MLLT3, who had undergone induction chemotherapy with a continuous infusion of standard-dose cytarabine 100 mg/m2 for 7 days with daunorubicin 60 mg/m2 for 3 days (DA60 3+7). Following her induction, she achieved morphological remission with evidence of minimal residual disease on flow cytometry. As she declined allogenic stem cell transplant postinduction therapy, she continued with 1 cycle of continuous infusion standard-dose cytarabine 100 mg/m2 for 7 days with daunorubicin 45 mg/m2 for 3 d...
Source: The American Journal of Medicine - July 7, 2022 Category: General Medicine Authors: Samuel S.Y. Wang, Monica Chan, Ling Cao Tags: Clinical Communication to the Editor Source Type: research

In Plain Sight: An Inconspicuous Case of a Giant Cell Tumor
A 37-year-old Jamaican male presented to the emergency department for two months of increasing fatigue, left thigh pain, and difficulty ambulating. He has been living in the United States for the past two years. His medical history includes iron deficiency anemia diagnosed in 2008 during a work health exam. He was placed on ferrous sulfate tablets without any additional workup performed. At that time, he had been living in Jamaica and worked as a cruise ship chef. A year prior to presentation, he had undergone a single blood transfusion which he attributed to his iron deficiency anemia. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - July 7, 2022 Category: General Medicine Authors: Melissa Oye, Nicholas Schuck, Fadi Kandah, Pramod Reddy Tags: Images in Radiology Source Type: research

mRNA Covid-19 vaccination in active Covid-19 infected acute myeloid leukaemia patient
Dear Editor, (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - July 7, 2022 Category: General Medicine Authors: Samuel S.Y. Wang, Monica Chan, Cao Ling Tags: Clinical Communication to the Editor Source Type: research

IgG4-Related Disease of the Pharynx with Spontaneous Regression
To the Editor, (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - July 7, 2022 Category: General Medicine Authors: Shen-Han Lee, Rohaizam Jaafar, Nurul Akmar Misron, Zulkifli Yusof Tags: Clinical Communication to the Editor Source Type: research

Comments on ‘The Language Game’
I enjoyed reading the commentary by Drs. Mangione, Mandell, and Post1 regarding the use of the word “provider,” and its contribution to the degradation of physician professionalism, with resultant burnout. I'm writing to contribute a couple of historical perspectives. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - June 17, 2022 Category: General Medicine Authors: Daniel Reinharth Tags: Letter Source Type: research