The Reply
We thank Angel Sebastian Trevi ño-Juarez for his comments on our paper.1 (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - February 28, 2024 Category: General Medicine Authors: Ying Gue, Gregory Y.H. Lip Tags: Letter Source Type: research

Table of Contents
(Source: The American Journal of Medicine)
Source: The American Journal of Medicine - February 28, 2024 Category: General Medicine Source Type: research

Free Speech in Articles and Letters to the Editor in The American Journal of Medicine
“… it is well understood that the right of free speech is not absolute at all times and under all circumstances. There are certain well-defined and narrowly limited classes of speech, the prevention and punishment of which have never been thought to raise any Constitutional problem. These includ e the lewd and obscene, the profane, the libelous, and the insulting or ‘fighting’ words—those which by their very utterance inflict injury or tend to incite an immediate breach of the peace. It has been well observed that such utterances are no essential part of any exposition of ideas and ar e of such slight social valu...
Source: The American Journal of Medicine - February 28, 2024 Category: General Medicine Authors: Joseph S. Alpert, Stuart Chipkin Tags: Commentary Source Type: research

The Importance of apo B and Lipoprotein Little a [Lp(a)]
The lipid profile measured in the clinic usually involves 5 items. Three are measured (cholesterol, triglycerides, and HDL-C) and two are derived (low density lipoprotein cholesterol (LDL-C) and non-HDL-cholesterol (non-HDL-C). Various ratios are possible, but two measurements, apo B and Lipoprotein (a) add special value. Apo B provides a measure of the atherogenic particles in the blood that carry apo B. These include LDL, very low –density lipoprotein, intermediate-density lipoprotein and lipoprotein(a). (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - February 25, 2024 Category: General Medicine Authors: Joseph S. Alpert, Neil J. Stone Tags: Commentary Source Type: research

Orbital Emphysema
To the Editor, (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - February 24, 2024 Category: General Medicine Authors: Etaro Hashimoto, Kazuya Nagasaki Tags: Clinical Communication to the Editor Source Type: research

Census Management
Hospital overcrowding was a pre-existing condition, prior to the COVID-19 pandemic. This chronic census malady was acutely worsened by the pandemic-driven demand for beds, combined with the comorbidities of nursing and other staff shortages, and supply chain disruptions. At the same time length of stay increased worsening the ailment. An absence of post-acute care options, which might reduce the afterload of hospital congestion, was similarly impacted by high volumes, long stays, closures due to outbreaks and under staffing. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - February 24, 2024 Category: General Medicine Authors: Jamie Newman Tags: Commentary Source Type: research

Update in Outpatient General Internal Medicine: Practice-Changing Evidence Published in 2023
The expansive scope of internal medicine can make it challenging for clinicians to stay informed about new literature that changes practice. Guideline updates and synthesis of relevant evidence can facilitate incorporation of advancements into clinical practice. The titles and abstracts from the seven general medicine journals with highest impact factors and relevance to outpatient internal medicine were reviewed by six internal medicine physicians. Coronavirus disease 19 research was excluded. The New England Journal of Medicine (NEJM), The Lancet, Journal of the American Medical Association (JAMA), The British Medical Jo...
Source: The American Journal of Medicine - February 23, 2024 Category: General Medicine Authors: Majken T. Wingo, Carl A. Andersen, Shari L. Bornstein, Jill M. Huber, Jason H. Szostek, Mark L. Wieland Tags: Review Source Type: research

People with Long Covid and ME/CFS Exhibit Similarly Impaired Dexterity and Bimanual Coordination: A Case-Case-Control Study
Dexterity and bimanual coordination had not previously been compared between people with long COVID and people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Therefore, this study determined dexterity and bimanual coordination in people with long COVID ( ∼16 month illness duration; n=21) and ME/CFS (∼16 year illness duration; n=20), versus age-matched healthy controls (n=20). (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - February 23, 2024 Category: General Medicine Authors: Nilihan E.M. Sanal-Hayes, Lawrence D. Hayes, Marie Mclaughlin, Ethan C.J. Berry, Nicholas F. Sculthorpe Source Type: research

The Ultrasound Hepato-Jugular Reflux: Measuring the Hepato-Jugular Reflux with Ultrasound with Comparison to Invasive Right Heart Catheterization.
Ultrasound can overcome barriers to visualizing the internal jugular vein, allowing jugular venous pressure and hepato-jugular reflux measurement. We aimed to determine operating characteristics of the ultrasound hepato-jugular reflux and ultrasound jugular venous pressure predicting right atrial and pulmonary capillary occlusion pressures. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - February 22, 2024 Category: General Medicine Authors: Ernest A. Fischer, Rolando Barajas, Kazi A. Kalam, Shiavax J. Rao, Jiling Chou, Luis M. Calderon, David S. Weisman Tags: Clinical Research Study Source Type: research

Monoclonal Gammopathy of Anemic Significance? Resolution of Pure Red Cell Aplasia with Daratumumab-based Therapy
A 65-year-old male with a history of giant cell arteritis developed progressive anemia with hemoglobin declining from a baseline of 14-16 g/dL to 12-13 g/dL over a year. He presented to clinic with fatigue and dyspnea on exertion. Laboratory investigation was notable for a normocytic, normochromic, hypoproliferative anemia (hemoglobin of 8.9 g/dL, mean corpuscular volume 92.1 fL, mean corpuscular hemoglobin concentration 33.3 g/dL, reticulocyte count 20,300 cells/uL), mildly increased platelets to 465  × 103/uL, and normal neutrophils. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - February 22, 2024 Category: General Medicine Authors: Omar Khan MD, Sonam Prakash, Alfred Chung, Sandy W. Wong, Vanessa E. Kennedy Source Type: research

An Age-Period-Cohort Analysis of Cardiovascular Disease Mortality in the United States from 1999 to 2018
Although cardiovascular disease mortality rates in the US declined from the 1970s to 2010s, they have now plateaued. The independent effects of age, period, and birth year (cohort) on cardiovascular disease mortality have not previously been defined. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - February 22, 2024 Category: General Medicine Authors: Michael M. Hammond, Natalie A. Cameron, Nilay S. Shah, Sadiya S. Khan Tags: Clinical Research Study Source Type: research

Association of Obstructive Sleep Apnea with Post-Acute Sequelae of SARS-CoV-2 infection
Obstructive sleep apnea is associated with COVID-19 infection. Less clear is whether obstructive sleep apnea is a risk factor for the development of Post-Acute Sequelae of SARS-CoV-2 infection (PASC). (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - February 22, 2024 Category: General Medicine Authors: Stuart F. Quan, Matthew D. Weaver, Mark É. Czeisler, Laura K. Barger, Lauren A. Booker, Mark E. Howard, Melinda L. Jackson, Rashon I. Lane, Christine F. McDonald, Anna Ridgers, Rebecca Robbins, Prerna Varma, Joshua F. Wiley, Shantha M.W. Rajaratnam, Char Tags: Clinical Research Study Source Type: research

Pulmonary Coccidioidomycosis Presenting as Recurrent Diabetic Ketoacidosis
Coccidioides is a genus of dimorphic fungi mostly present in Arizona and California, but also found in Southern New Mexico, Texas, and Northern Mexico1. Coccidioidomycosis is the infection caused by these fungi and while it commonly has as an asymptomatic course when illness occurs it is a primarily pulmonary disease2. Diabetes mellitus has been recognized in the past as an important risk factor for the development of Coccidioides spp infection. Here, we report a case of a patient who experienced two episodes of diabetic ketoacidosis in association with pulmonary coccidioidomycosis. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - February 21, 2024 Category: General Medicine Authors: Jorge A. Zu ñiga-Hernandez, Alan Gamboa-Meza, Hector A. Medina-Ramirez, Homero Nañez-Terreros Tags: Clinical Communication to the Editor Source Type: research

Predatory Journals: What the researchers and authors should know
In the ever-expanding landscape of academic publishing, the emergence of predatory journals poses a significant challenge to the integrity and credibility of scholarly research. These deceptive publications exploit the academic pursuit of disseminating knowledge by offering an illusion of legitimacy while lacking the critical elements of rigorous peer review and editorial oversight.1 Publishing in a reputable peer-reviewed journal signify credibility, trustworthiness and adherence to scholarly standards, enhancing the visibility and impact of research within the academic community. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - February 21, 2024 Category: General Medicine Authors: Atanu Chandra, Sugata Dasgupta Tags: Commentary Source Type: research

Reconsidering the Benefits of Osteoporosis Treatment: The Case of Bisphosphonates
Osteoporosis is a significant public health issue associated with morbidity and mortality risk due to fractures and functional decline. Clinical guidelines generally agree that when osteoporosis is identified, pharmacologic treatment should be initiated to lower fracture risk. Despite the consensus, evidence shows that many patients with osteoporosis are not treated, leading some clinicians and professional organizations to call for action to increase use of osteoporosis medications. Guidelines and reports of inadequate treatment may give clinicians and patients the impression that the benefits of medications for osteoporo...
Source: The American Journal of Medicine - February 21, 2024 Category: General Medicine Authors: Christopher W. Goodman Tags: Commentary Source Type: research