The Conflict of Public Health Law and Civil Liberties Part II: The Vaccine Mandates and What the Supreme Court Decided
We are now beginning to understand both the science of the COVID-19 virus and its mutations, and the social and legal impact of the pandemic upon all our lives. Two years of quarantine, masking, limits on public school attendance, vaccination mandates and cancelled public meetings have caused serious social change and continuing challenges to our laws, as well as to our public trust in governance. The cost of COVID-19 across the world has been both economic and non-economic, social and spiritual, as well discussed by John Tierney in an excellent review “The Panic Pandemic”. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - March 16, 2022 Category: General Medicine Authors: Curtis E. Harris Tags: Commentary Source Type: research

Corrigendum to ‘Effect of Inpatient Medication-Assisted Therapy on Against-Medical-Advice Discharge and Readmission Rates’ The American Journal of Medicine (2020) 1343-1349
The authors regret that Figure 3 was replicated as Figure 4. The authors would like to apologize for any inconvenience caused. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - March 16, 2022 Category: General Medicine Authors: Sijie Jason Wang, Elizabeth Wade, Jennifer Towle, Tabitha Hachey, Jennifer Rioux, Omrie Samuels, Casey Bonner, Christina Kirkpatrick, Sandra O'Loughlin, Keith Foster Tags: Corrigendum Source Type: research

Ischemic stroke due to metastatic cervical bone tumor: the importance of ‘peripheral vision’
To the Editor: (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - March 16, 2022 Category: General Medicine Authors: Akiyuki Hiraga, Satoshi Kuwabara Source Type: research

Teaching Leadership …More than Just White Men
“I'm all ears for your recommendations on good leadership books! If there are some that come to mind written by women in particular that would also be helpful.” Past Medicine Resident (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - March 16, 2022 Category: General Medicine Authors: Joshua D. Hartzell, Jessica T. Servey, Guen Hunt, Melanie Wiseman, Kim Gibson Tags: Commentary Source Type: research

Peripherally Inserted Central Catheter Line Misuse Among People Who Inject Drugs While on Therapy for Infective Endocarditis
People who inject drugs and have infective endocarditis have a high risk of recurrent infective endocarditis and death. We aimed to characterize clinical factors associated with mortality and assess the probability of infective endocarditis recurrence in the presence of death as a competing risk. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - March 15, 2022 Category: General Medicine Authors: Janica Adams, Tara Elton-Marshall, Esfandiar Shojaei, Michael Silverman Tags: Clinical Research Study Source Type: research

Peripherally Inserted Central Catheter Line Misuse Among Persons Who Inject Drugs while on Therapy for Infective Endocarditis is Associated with Infective Endocarditis Recurrence and Death
Persons who inject drugs with infective endocarditis have a high risk of recurrent infective endocarditis and death. We aimed to characterize clinical factors associated with mortality and assess the probability of infective endocarditis recurrence in the presence of death as a competing risk. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - March 15, 2022 Category: General Medicine Authors: Janica Adams, Tara Elton-Marshall, Esfandiar Shojaei, Michael Silverman Tags: Clinical Research Study Source Type: research

Madelung Disease
A 42-year-old Japanese man had a neck mass for 6 months that gradually grew in size. Similar masses appeared in the posterior part of bilateral auricles and upper arms. His medical history was only remarkable for alcoholic liver disease. He had been drinking 2 liters of beer per day for 20 years and smoking 20 cigarettes per day for 20 years. His medication and family history were unremarkable. Physical examination revealed symmetrical, soft, mobile masses on the neck and bilateral upper arms (Figure 1). (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - March 13, 2022 Category: General Medicine Authors: Junsuke Tawara, Kosuke Ishizuka, Kei Enomoto, Masafumi Kamata, Kohta Katayama, Yuki Kaji, Yoshiyuki Ohira Tags: Clinical Communication to the Editor Source Type: research

Outcomes of Transcatheter Aortic Valve Implantation in Nonagenarians Compared to Younger than 90 Year Old Patients
Given that life expectancy has improved, nonagenarians have become a significant proportion of world population. As aortic stenosis is primarily a disease of the elderly, the need for invasive cardiac approaches is expected to increase in people of extreme age. Herein, we compare the in-hospital adverse clinical outcomes and mortality after transcatheter aortic valve implantation (TAVI) procedures in nonagenarians to younger than 90 year old patients. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - March 13, 2022 Category: General Medicine Authors: Anthony Matta, Thibault Lhermusier, Fr éderic Bouisset, Francisco-Campelo Parada, Meyer ELBaz, Vanessa Nader, Stephanie Blanco, Jerome Roncalli, Didier Carrié Tags: Clinical Research Study Source Type: research

Statin use in hospitalized patients with COVID-19: A comprehensive analysis of the New York City Public Hospital System
Statins have been commonly used for primary and secondary cardiovascular prevention. We hypothesized that statins may improve in-hospital outcomes for hospitalized patients with COVID-19 due to its known anti-inflammatory effects. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - March 13, 2022 Category: General Medicine Authors: Weijia Li, Saul Rios, Sanjana Nagraj, Adrija Hajra, Tinatin Saralidze, Dimitrios Varrias, Sheetal Vasundara Mathai, Marko Novakovic, Kenneth H. Hupart, Jeremy A. Miles, Adarsh Katamreddy, Leonidas Palaiodimos, Robert T. Faillace Source Type: research

Effect of Alirocumab on Incidence of Atrial Fibrillation After Acute Coronary Syndromes: Insights from the ODYSSEY OUTCOMES Randomized Trial
Proprotein convertase subtilisin –kexin type 9 (PCSK9) inhibitors promote substantial and sustained low-density lipoprotein cholesterol lowering and reduce cardiovascular events in high-risk patients treated with statins.1,2 The ODYSSEY OUTCOMES trial (NCT01663402) compared treatment with the PCSK9 inhibitor, alirocumab, with pla cebo in 18,924 patients with recent acute coronary syndromes and residual dyslipidemia despite high-intensity or maximum-tolerated statin therapy.1 (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - March 13, 2022 Category: General Medicine Authors: Renato D. Lopes, Patr ícia O. Guimarães, Gregory G. Schwartz, Deepak L. Bhatt, Vera A. Bittner, Andrzej Budaj, Anthony J. Dalby, Rafael Diaz, Shaun G. Goodman, Robert A. Harrington, J. Wouter Jukema, Robert Gabor Kiss, Megan Loy, Robert Pordy, Yann Poul Tags: Brief Observation Source Type: research

Understanding Antiarrhythmic Drug Efficacy for the Clinical Practitioner: There is More than Meets the Eye
In theory, determining if a medication is effective should be easy. However, it is often complex. Nowhere is this truer than when using antiarrhythmic drugs (AAD) for the therapy of atrial fibrillation, whose incidence and prevalence are increasing progressively.1-3 (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - March 13, 2022 Category: General Medicine Authors: James A. Reiffel, Gerald V. Naccarelli Source Type: research

Outcomes of Transcatheter Aortic Valve Implantation in Nonagenarians Compared to < 90 Years Patients
: Given that life expectancy has been improved, nonagenarians become a significant proportion of world population. As aortic stenosis is primarily a disease of the elderly, the need for invasive cardiac approaches is expected to increase in people of extreme age. Herein, we compare the in-hospital adverse clinical outcomes and mortality after Trans-catheter aortic valve implantation (TAVI) procedures in nonagenarians to (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - March 13, 2022 Category: General Medicine Authors: Anthony Matta, Thibault Lhermusier, Fr éderic Bouisset, Francisco-Campelo Parada, Meyer ELBaz, Vanessa Nader, Stephanie Blanco, Jerome Roncalli, Didier Carrié Tags: Clinical Research Study Source Type: research

Oral histoplasmosis presenting as a solitary ulcer on tongue in an immunocompetent adult
Histoplasmosis or Darling's disease is caused by the opportunistic dimorphic fungi Histoplasma capsulatum, ubiquitous in soil contaminated by bird or bat excreta. Humans get infected by inhaling spores of the organism. The organism mainly affects the aerodigestive tracts of susceptible individuals but it can also involve other organs and occur in disseminated and localised forms. Most cases have been associated with immunosuppression particularly in HIV infected individuals in whom disseminated disease is more common, but immunocompetent patients with underlying risk factors may develop histoplasmosis very rarely. (Source:...
Source: The American Journal of Medicine - March 13, 2022 Category: General Medicine Authors: Kaushiki Hajra, Uddalak Chakraborty, Kingshuk Chatterjee, Srinjani Mukherjee, Saswati Halder Tags: Clinical communication to the Editor Source Type: research

Madelung's disease
To the Editor: (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - March 13, 2022 Category: General Medicine Authors: Junsuke Tawara, Kosuke Ishizuka, Kei Enomoto, Masafumi Kamata, Kohta Katayama, Yuki Kaji, Yoshiyuki Ohira Tags: Clinical Communication to the Editor Source Type: research

Aquagenic wrinkling of the palms
A 47 ‐year‐old Japanese woman presented with blanching and whitening of both palms after bathing and washing dishes for the past 20 years. It is induced by immersion of hands in water for about 5 minutes. She did not report any pain or itching. Her medical history and medications were unremarkable. Physical examination revealed a temperature of 36.5°C, pulse rate of 74 beats/minute, blood pressure of 111/67 mmHg, and respiratory rate of 12 breaths/minute. A five-minute water immersion test induced wrinkling of the palms (Figure 1 and 2), which led to the diagnosis of aquagenic wrinkling of t he palms (AWP). (Source:...
Source: The American Journal of Medicine - March 13, 2022 Category: General Medicine Authors: Mutsuka Kurihara, Kosuke Ishizuka, Masatomi Ikusaka Tags: Clinical Communication to the Editor Source Type: research