Comments on Whether Physicians and Nurses Should Sit on the Patient's Bed
I read with great interest the recent perspective by Dr Alpert on the bedside sitting by doctors.1 I wholeheartedly praise Dr Alpert for discussing such a tender issue. I would like to further address this topic using anecdotes from my professional journey. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - April 1, 2024 Category: General Medicine Authors: Ankur Jain Tags: Letter Source Type: research

Table of Contents
(Source: The American Journal of Medicine)
Source: The American Journal of Medicine - April 1, 2024 Category: General Medicine Source Type: research

Calculated Medicine: Seven Decades of Accelerating Growth
This article reviews the history and varied methodologies of Calculated Medicine starting with the 1953 Apgar Score and concluding with a look into modern computational tools of the field: machine learning, natural language processing, artificial intelligence, and in silico research techniques. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - March 29, 2024 Category: General Medicine Authors: Louis E. Leff, Mara L. Koperwas Tags: Review Source Type: research

Primary Care —Its Pokemon Moment.
Primary care in the United States is undergoing bursts of evolution in response to health system stresses, changing demographics, and expansion of risk and value-based reimbursement structures.The impact of primary care remains substantive and associated with improved population health. However, the spectrum of services, the nature of the physicians involved and new ways of including the patient in her, or his own care suggests that a new definition of primary care be considered, and patient expectations be heeded and understood. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - March 29, 2024 Category: General Medicine Authors: Bryan Becker Tags: Review Source Type: research

A Pragmatic Study of Cardiovascular Disease During Long-Term COVID-19
This study assessed whether symptoms associated with long COVID among patients referred for cardiovascular evaluation are associated with objective abnormalities on cardiac testing to explain their clinical presentation. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - March 26, 2024 Category: General Medicine Authors: James F. Howick V, Petar Saric, Mohamed Elwazir, Darrell B. Newman, Patricia A. Pellikka, Annelise S. Howick, John C. O'Horo, Leslie T. Cooper, Abhishek J. Deshmukh, Ravindra Ganesh, Ryan Hurt, Bernard Gersh, John P. Bois Tags: Clinical Research Study Source Type: research

EXPRESSION OFCONCERN: WIMALAWANSA 1 A Four-Year Randomized Controlled Trial of Hormone Replacement and Bisphosphonate, Alone or in Combination, in Women with Postmenopausal Osteoporosis - ScienceDirect
This temporary Expression of Concern relates to the above article. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - March 22, 2024 Category: General Medicine Source Type: research

EXPRESSION OF CONCERN: WIMALAWANSA 2 Combined therapy with estrogen and etidronate has an additive effect on bone mineral density in the hip and vertebrae: Four-year randomized study - ScienceDirect
This temporary Expression of Concern relates to the above article. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - March 22, 2024 Category: General Medicine Source Type: research

The Irony of Having All the Information You Need at Your Fingertips, and Not Accessing It
I was recently making rounds with the house staff team on our Cardiology telemetry service at our tertiary care hospital. As the chair of our Cardiology department, I find that sometimes residents, students, and even Cardiology fellows become a little nervous when presenting patients they have admitted overnight to me on morning rounds. That being said, however, I always put the house staff team at ease by reminding them that we (including myself) are all here to work together and that medicine is a lifelong learning process. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - March 22, 2024 Category: General Medicine Authors: Amgad N. Makaryus Tags: Commentary Source Type: research

Is Low Cortisol a Marker of Long COVID?
Cortisol is the primary glucocorticoid hormone produced by the adrenal glands, playing a critical role in multiple physiological processes, including metabolism, immune response regulation, cardiovascular regulation, and the body's stress response1. The secretion of cortisol is closely regulated by the hypothalamus-pituitary-adrenal (HPA) axis. The process is initiated by the release of corticotropin-releasing hormone (CRH) from the hypothalamus, which stimulates the production of adrenocorticotropic hormone (ACTH) by the pituitary gland. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - March 21, 2024 Category: General Medicine Authors: Armin Alaedini, Stafford Lightman, Gary P. Wormser Tags: Commentary Source Type: research

Frailty: The Sixth and Seventh Ages of Man: Disability and Dementia
“…The sixth age shifts Into the lean and slippered pantaloon, With spectacles on nose and pouch on side; His youthful hose, well saved, a world too wide For his shrunk shank; and his big manly voice, Turning again toward childish treble, pipes And whistles in his sound. Last scene of all, That e nds this strange eventful history, Is second childishness and mere oblivion, Sans teeth, sans eyes, sans taste, sans everything.”The seven ages of man, Jacques, in William Shakespeare, As You Like It, Act II, Scene vii (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - March 21, 2024 Category: General Medicine Authors: Joseph S. Alpert, Mindy Fain Tags: Commentary Source Type: research

Management of Clostridioides difficile infection: Diagnosis, Treatment, and Future Perspectives
Clostridioides difficile infection is the most common healthcare-associated infection in the United States, with potential life-threatening complications and significant impact in the costs of care. Antibiotic stewardship as well as discontinuation of chronic acid suppressive therapy are key for its prevention and treatment. Effective infection management requires appropriate interpretation of diagnostic tests, as well as the use of vancomycin and fidaxomicin as first-line treatment. Novel treatments as Bezlotoxumab, fecal microbiota transplant and live biotherapeutic products are proven effective in recurrent C. (Source: ...
Source: The American Journal of Medicine - March 18, 2024 Category: General Medicine Authors: Michael Cymbal, Arjun Chatterjee, Brian Baggott, Moises Auron Tags: Review Source Type: research

An Urticarial Rash, Fevers, and Arthralgias
A 34-year-old female presented to dermatology clinic with a waxing and waning rash that started 3 months prior. Symptoms included pruritus and burning, as well as recurrent daily fevers up to 39.5 °C, sore throat, and severe arthralgias limiting her ability to ambulate. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - March 18, 2024 Category: General Medicine Authors: Colton H Funkhouser, Oluwakemi Onajin, Arlene M Ruiz de Luzuriaga, Amy Z Xu Tags: Clinical Communication to the Editor Source Type: research

Primary Care in the United States: Past, Present and Future
Even though a well-functioning primary care system is widely acknowledged as critical to population health, the number of primary care physicians practicing in the United States has steadily declined, and primary care physicians are in short supply. The reasons are multiple and include inadequate income relative to other specialties, excessive administrative demands on PCPs and the lack of respect given to primary care specialties during medical school and residency. Advanced practice nurses can augment the services of primary care physicians but cannot substitute for them. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - March 16, 2024 Category: General Medicine Authors: Edward P Hoffer Tags: Review Source Type: research

Enhancing Attentional Performance in Parkinson's Disease: The Impact of Combined Deep Brain Stimulation of the Substantia Nigra Pars Reticulata and the Subthalamic Nucleus
: The concomitant stimulation of the subthalamic nucleus and the substantia nigra pars reticulata is a promising approach to improve treatment of refractory axial symptoms in Parkinson`s disease. While dual stimulation of the subthalamic nucleus and the substantia nigra pars reticulata has previously shown beneficial effects on gait, the role of the substantia nigra, a crucial component of the basal ganglia circuitry, in cognitive functions such as attention an executive control remains underexplored. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - March 16, 2024 Category: General Medicine Authors: Julia Thein, Stefanie Linnhoff, J ürgen Voges, Imke Galazky, Tino Zaehle Tags: Brief Observation Source Type: research

Gastrointestinal Bleeding Related to Visceral Kaposi Sarcoma
We describe a case of catastrophic gastrointestinal bleeding from AIDS-related Kaposi sarcoma and highlight the challenges associated with this underrecognized condition in a subset of high-risk patients. (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - March 16, 2024 Category: General Medicine Authors: Kabeer Ali, Layton Wiemer, Aleem Azal Ali, Austin Quan, Bruno De Souza Ribeiro, Jr Walter Quan Tags: Clinical Communication to the Editor Source Type: research