In vitro–in vivo correlations for three different commercial immediate-release indapamide tablets
Drug Development and Industrial Pharmacy, Volume 40, Issue 12, Page 1670-1676, December 2014. (Source: Drug Development and Industrial Pharmacy)
Source: Drug Development and Industrial Pharmacy - November 13, 2014 Category: Drugs & Pharmacology Tags: article Source Type: research

Cost-Utility Analysis Of Hypertensive Treatment With Indapamide And Amlodipine Single-Pill Combination In The Polish Setting
To assess cost-effectiveness of indapamide 1.5 mg +amlodipine 5/10 mg single-pill combination (SPC) compared with free combination (FC), in the Polish setting. (Source: Value in Health)
Source: Value in Health - November 1, 2014 Category: Global & Universal Authors: E. Stawowczyk, P. Holko, P. Kawalec, L. Borowiec, K.J. Filipiak Source Type: research

Budget Impact Analysis Of Hypertensive Treatment With Indapamide And Amlodipine Single-Pill Combination In The Polish Setting
The aim of this study was to calculate and compare public payer and patients’ costs of hypertensive treatment with indapamide 1.5 mg and amlodipine 5 mg or 10 mg single-pill combination (SPC) and free combination (FC), in the Polish setting. (Source: Value in Health)
Source: Value in Health - November 1, 2014 Category: Global & Universal Authors: P. Kawalec, E. Stawowczyk, P. Holko, L. Borowiec, K.J. Filipiak Source Type: research

Degree of blood pressure reduction and recurrent stroke: the PROGRESS trial
Objective There is ongoing controversy regarding a ‘J-curve’ phenomenon such that low and high blood pressure (BP) levels are associated with increased risks of recurrent stroke. We aimed to determine whether large treatment-related BP reductions are associated with increased risks of recurrent stroke. Design Data are from the PROGRESS trial, where 6105 patients with cerebrovascular disease were randomly assigned to either active treatment (perindopril±indapamide) or placebo(s). There were no BP criteria for entry. BP was measured at every visit, and participant groups defined by reduction in systolic B...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 17, 2014 Category: Neurosurgery Authors: Arima, H., Anderson, C., Omae, T., Woodward, M., MacMahon, S., Mancia, G., Bousser, M.-G., Tzourio, C., Harrap, S., Liu, L., Neal, B., Chalmers, J., for the PROGRESS Collaborative Group Tags: Stroke, Hypertension Cerebrovascular disease Source Type: research

Natriuresis and blood pressure reduction in hypertensive patients with diabetes mellitus: the NESTOR study
The antihypertensive effect of indapamide has never been clearly understood, particularly in hypertensive patients with diabetes mellitus. (Source: Journal of the American Society of Hypertension)
Source: Journal of the American Society of Hypertension - October 13, 2014 Category: Cardiology Authors: Yi Zhang, Davide Agnoletti, Ji-Guang Wang, Yawei Xu, Michel E. Safar Source Type: research

Triple Combination Therapy in Hypertension: The Antihypertensive Efficacy of Treatment with Perindopril, Amlodipine, and Indapamide SR
Abstract Background and Objective The blood pressure (BP) of most patients on antihypertensive monotherapy or bitherapy remains uncontrolled. Our study evaluated the efficacy of triple therapy with perindopril, amlodipine, and indapamide sustained release (SR) in patients with uncontrolled hypertension on previous antihypertensive therapy. Methods This 4-month, multicenter, prospective, observational, open-label study included patients switched from previous antihypertensive therapy to triple therapy with perindopril, amlodipine, and indapamide SR...
Source: Clinical Drug Investigation - September 25, 2014 Category: Drugs & Pharmacology Source Type: research

Acyclovir and Hyponatremia: A Case Report
A 61-year-old man attended the emergency department with decreased level of consciousness, repetitive language, and memory loss. Clinical history included type II diabetes and hypertension. Domiciliary treatment included oral metformin 850 mg every 24 hours and oral indapamide 2.5 mg every 24 hours. Laboratory tests disclosed high glycemia (198 mg/dL), increased C-reactive protein (7.4 mg/dL), and normal renal function. Intravenous acyclovir of 800 mg every 8 hours was started on admission due to suspicion of viral encephalitis. Blood analysis on 10th day displayed hyponatremia (123 mmol/L) that was at first explained by t...
Source: American Journal of Therapeutics - September 1, 2014 Category: Drugs & Pharmacology Tags: Case Report Source Type: research

Thiazide-Like/Calcium Channel Blocker Agents: A Major Combination for Hypertension Management
Abstract In recent years, treatment strategies for hypertension have often focused on combination therapies that include diuretics and renin angiotensin aldosterone system blockers such as angiotensin-converting enzyme inhibitors or angiotensin receptor blockers. However, in clinical practice, a significant number of patients do not respond completely to these combination treatments, and long-term reduction of cardiovascular risk remains insufficient. The particularly high residual cardiovascular risk of hypertensive patients, even when adequately treated with strategies based on renin angiotensin aldosterone syst...
Source: American Journal of Cardiovascular Drugs - August 28, 2014 Category: Cardiology Source Type: research

A systematic review and meta‐analysis of thiazide‐induced hyponatraemia: time to reconsider electrolyte monitoring regimens after thiazide initiation?
ConclusionsPatients with thiazide‐induced hyponatraemia were characterised by advanced age, female gender, inappropriate saliuresis and mild hypokalaemia. Low BMI was not found to be a significant risk factor, despite previous suggestions. The time from thiazide initiation to presentation with hyponatraemia suggests that the recommended practice of performing a single investigation of serum biochemistry 7–14 days after thiazide initiation may be insufficient or suboptimal. Further larger and more systematic studies of thiazide‐induced hyponatraemia are required. (Source: British Journal of Clinical Pharmacology)
Source: British Journal of Clinical Pharmacology - August 1, 2014 Category: Drugs & Pharmacology Authors: Jennifer Barber, Tricia M. McKeever, Sarah E. McDowell, Jennifer A. Clayton, Robin E. Ferner, Richard D. Gordon, Michael Stowasser, Kevin M. O'Shaughnessy, Ian P. Hall, Mark Glover Tags: Systematic Review Source Type: research

Which thiazide to choose as add-on therapy for hypertension?
Vivencio Barrios,1 Carlos Escobar2 1Department of Cardiology, Hospital Ramon y Cajal, 2Department of Cardiology, Hospital La Paz, Madrid, Spain Abstract: Combined therapy is required in the majority of patients with hypertension to achieve blood pressure (BP) targets. Although different antihypertensive drugs can be combined, not all combinations are equally effective and safe. In this context, the combination of a renin angiotensin system inhibitor with a diuretic, usually a thiazide, particularly hydrochlorothiazide (HCTZ) or thiazide-like diuretics, such as chlorthalidone or indapamide, is recommended. However, not all ...
Source: Integrated Blood Pressure Control - July 29, 2014 Category: Cardiology Tags: Integrated Blood Pressure Control Source Type: research

The effect of indapamide versus hydrochlorothiazide on ventricular and arterial function in patients with hypertension and diabetes: Results of a randomized trial
The objective of this study is to compare the effects of 2 types of diuretics, indapamide and hydrochlorothiazide, added to an angiotensin-converting enzyme inhibitor, on ventricular and arterial functions in patients with hypertension and diabetes.Methods: This is a prospective, randomized, active-controlled, PROBE design study in 56 patients (57 ± 9 years, 52% men) with mild-to-moderate hypertension and type 2 diabetes, with normal ejection fraction, randomized to either indapamide (1.5 mg Slow Release (SR)/day) or hydrochlorothiazide (25 mg/d), added to quinapril (10-40 mg/d). All patients had conventional, tissu...
Source: American Heart Journal - June 16, 2014 Category: Cardiology Authors: Dragos Vinereanu, Raluca Dulgheru, Stefania Magda, Ruxandra Dragoi Galrinho, Maria Florescu, Mircea Cinteza, Christopher Granger, Andrea O. Ciobanu Tags: Trial Designs Source Type: research

The effect of Indapamide versus Hydrochlorothiazide on ventricular and arterial function in patients with hypertension and diabetes: results of a randomized trial
(Source: American Heart Journal)
Source: American Heart Journal - June 13, 2014 Category: Cardiology Authors: Dragos Vinereanu, Raluca Dulgheru, Stefania Magda, Ruxandra Dragoi Galrinho, Maria Florescu, Mircea Cinteza, Christopher Granger, Andrea O. Ciobanu Source Type: research

The influence of selected antihypertensive drugs on zinc, copper, and iron status in spontaneously hypertensive rats.
Abstract Mineral homeostasis in hypertensive patients may be affected by hypotensive drugs. The aim of this study was to assess the influence of selected antihypertensive drugs on mineral homeostasis in a rat model of hypertension. Eight-week-old male spontaneously hypertensive rats (SHRs) were treated with perindopril, metoprolol, indapamide, amlodipine, or no drug for 45 days. In another experiment, the SHRs were treated with indapamide or amlodipine in the presence of zinc and copper gluconate supplement. Lipids, glucose, and insulin levels-along with superoxide dismutase and catalase activities-were assayed in...
Source: European Journal of Pharmacology - June 10, 2014 Category: Drugs & Pharmacology Authors: Suliburska J, Bogdanski P, Jakubowski H Tags: Eur J Pharmacol Source Type: research

Subgroup and per-protocol analyses from the Hypertension in the Very Elderly Trial
Background:The results of the Hypertension in the Very Elderly Trial showed positive benefits from blood pressure-lowering treatment in those aged 80 and over. Method:An analysis by the pre-specified subgroups [age, sex, history of cardiovascular disease (CVD) and initial SBP] was performed. The Hypertension in the Very Elderly Trial was a randomized, double-blind, placebo-controlled trial of 3845 participants aged 80 and over with SBPs of 160–199 mmHg and diastolic pressures below 110 mmHg recruited from Europe, China, Australasia and Tunisia. Active treatment was indapamide sustained-release 1.5 mg with the addit...
Source: Journal of Hypertension - June 6, 2014 Category: Cardiology Tags: ORIGINAL PAPERS: Elderly Source Type: research

Blood pressure-lowering efficacy of monotherapy with thiazide diuretics for primary hypertension.
CONCLUSIONS: This systematic review shows that hydrochlorothiazide has a dose-related blood pressure-lowering effect. The mean blood pressure-lowering effect over the dose range 6.25 mg, 12.5 mg, 25 mg and 50 mg/day is 4/2 mmHg, 6/3 mmHg, 8/3 mmHg and 11/5 mmHg, respectively. For other thiazide drugs, the lowest doses studied lowered blood pressure maximally and higher doses did not lower it more. Due to the greater effect on systolic than on diastolic blood pressure, thiazides lower pulse pressure by 4 mmHg to 6 mmHg. This exceeds the mean 3 mmHg pulse pressure reduction achieved by ACE inhibitors, ARBs and renin inhibito...
Source: Cochrane Database of Systematic Reviews - June 3, 2014 Category: Journals (General) Authors: Musini VM, Nazer M, Bassett K, Wright JM Tags: Cochrane Database Syst Rev Source Type: research

Effects of Combination Therapy With Olmesartan and Azelnidipine on Serum Osteoprotegerin in Patients With Hypertension
Background: Vascular calcification is a potent predictor of plaque instability and cardiac events. Osteoprotegerin (OPG), well-known vascular calcification mediator, is a signaling molecule involved in bone remodeling, which has been implicated in the regulation of vascular calcification and atherogenesis. The purpose of this study was to compare the combination treatments of olmesartan/azelnidipine and olmesartan/diuretics on serum bone-related markers in patients with essential hypertension. Methods and Results: A total of 48 patients with hypertension treated with 20 mg olmesartan were randomized to receive combination...
Source: Journal of Cardiovascular Pharmacology and Therapeutics - April 16, 2014 Category: Cardiology Authors: Uzui, H., Morishita, T., Nakano, A., Amaya, N., Fukuoka, Y., Ishida, K., Arakawa, K., Lee, J.-D., Tada, H. Tags: Clinical Studies Source Type: research

Treatment of calcium nephrolithiasis in the patient with hyperuricosuria.
Abstract Nearly one-third of patients with calcium stones have hyperuricosuria. In vitro studies and clinical trials have investigated the relationship between uric acid and calcium stones, but the association between hyperuricosuria and calcium stone formation in patients is still being debated. Uric acid appears to cause salting out of calcium oxalate in human urine. However, the importance of this in vitro phenomenon to the proposed association is not supported in cross-sectional observational studies. A small placebo-controlled randomized clinical trial showed that allopurinol decreased the rate of recurrent c...
Source: Journal of Nephrology - April 1, 2014 Category: Urology & Nephrology Authors: Arowojolu O, Goldfarb DS Tags: J Nephrol Source Type: research

Efficacy and Tolerability of Fixed-Dose Combination of Perindopril/Indapamide in Type 2 Diabetes Mellitus: PICASSO Trial.
Abstract BACKGROUND: Hypertension and type 2 diabetes mellitus (T2DM) synergistically deteriorate the vascular environment, making blood pressure reduction challenging, and substantially increasing cardiovascular risk. METHODS: In the real-life, open-label, observational, PICASSO study, 9,257 hypertensive patients unsuccessfully treated with antihypertensives were switched to fixed-dose combination of perindopril 10 mg/indapamide 2.5 mg. In this subgroup analysis, we analyzed changes in blood pressure and laboratory parameters of 2,762 hypertensive patients with T2DM or pre-diabetes. RESULTS: A...
Source: Advances in Therapy - February 20, 2014 Category: Drugs & Pharmacology Authors: Farsang C Tags: Adv Ther Source Type: research

Effects of Combination of Perindopril, Indapamide, and Calcium Channel Blockers in Patients With Type 2 Diabetes Mellitus: Results From the Action in Diabetes and Vascular Disease: Preterax and Diamicron Controlled Evaluation (ADVANCE) Trial [Clinical Trial: ADVANCE Trial]
The objective of the present analysis was to determine the effects of a fixed combination of perindopril and indapamide in combination with calcium channel blockers (CCBs) in patients with type 2 diabetes mellitus. The Action in Diabetes and Vascular Disease: Preterax and Diamicron Controlled Evaluation (ADVANCE) trial was a factorial randomized controlled trial. A total of 11 140 patients with type 2 diabetes mellitus were randomly assigned to fixed combination of perindopril–indapamide (4/1.25 mg) or placebo. Effects of randomized treatment on mortality and major cardiovascular outcomes were examined in subgroups d...
Source: Hypertension - January 8, 2014 Category: Cardiology Authors: Chalmers, J., Arima, H., Woodward, M., Mancia, G., Poulter, N., Hirakawa, Y., Zoungas, S., Patel, A., Williams, B., Harrap, S. Tags: Primary prevention, Other hypertension, Type 2 diabetes Clinical Trial: ADVANCE Trial Source Type: research

The role of flavonoids in false positive digoxin assays caused by the consumption of hibiscus flower and rose hip tea
The serum digoxin level of two of our chronic heart failure patients who were not taking digoxin was accidentally measured and was reported as 0.21 and 0.22ng/ml. These patients were not taking medications that may interfere with digoxin assays. (The medications of Patient 1 included metoprolol, perindopril and acenocoumarol while Patient 2 received bisoprolol, perindopril, indapamide, allopurinol, doxazosin, potassium chloride and acenocoumarol). Neither of these patients had signs or symptoms of cardiac decompensation and both were female. They reported to have consumed the same fruit tea on a daily basis (Pickwick Fruit...
Source: International Journal of Cardiology - December 23, 2013 Category: Cardiology Authors: Tamás Frész, Erzsébet Nagy, Ágnes Hilbert, János Tomcsányi Tags: Letters to the Editor Source Type: research

Diuretics: A Review and Update
In conclusion, diuretics are a diverse class of drugs that remain extremely important in the management of hypertension and hypervolemic states. (Source: Journal of Cardiovascular Pharmacology and Therapeutics)
Source: Journal of Cardiovascular Pharmacology and Therapeutics - December 17, 2013 Category: Cardiology Authors: Roush, G. C., Kaur, R., Ernst, M. E. Tags: Cardiovascular Pharmacology Core Reviews Source Type: research

Indapamide-induced transient myopia with supraciliary effusion: case report
Conclusions: Our case report is the third one in the literature to present indapamide-induced transient myopia, and the first to employ UBM for describing the characteristics of this rare condition. According to the findings, authors suggest that both ciliary muscle contraction and ciliary body edema may play role in the pathomechanism. UBM seems to be a useful tool in the differential diagnosis of acute myopia. Further, authors wish to draw attention to one of the potential adverse effects of this drug which was not listed by its package insert. (Source: BMC Ophthalmology - Latest articles)
Source: BMC Ophthalmology - Latest articles - October 19, 2013 Category: Opthalmology Authors: Mihály VéghAndrás Hári-KovácsKata RézBeáta TapasztóÁgnes SzabóAndrea Facskó Source Type: research

Electrolyte imbalance triggering relapse of inflammatory neuropathy
We describe a case of a 71 year old female with a fourteen year history of chronic inflammatory demyelinating polyneuropathy (CIDP) and stable monoclonal gammopathy, normally maintained on three–weekly intravenous immunoglobulin (IVIG) therapy. At her best baseline, she has a normal motor examination and reduced vibration sense only to the ankles. She presented with a four week history of progressive numbness and paresthesiae in all four limbs, reduced balance, a decline in mobility with frequent falls and reduced hand function. The deterioration developed after a week of non–bloody diarrhoea with night sweats ...
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Keshavan, A., Gandhi, S., Lunn, M., Reilly, M. Tags: Neurogastroenterology, Immunology (including allergy), Drugs: CNS (not psychiatric), Multiple sclerosis, Neuromuscular disease, Peripheral nerve disease, Stroke, Hypertension Association of British Neurologists (ABN) joint meeting with the Royal College Source Type: research

Molecular Dynamics, Physical Stability and Solubility Advantage from Amorphous Indapamide Drug
Molecular PharmaceuticsDOI: 10.1021/mp400116q (Source: Molecular Pharmaceutics)
Source: Molecular Pharmaceutics - September 26, 2013 Category: Drugs & Pharmacology Authors: Z. Wojnarowska, K. Grzybowska, L. Hawelek, M. Dulski, R. Wrzalik, I. Gruszka, M. Paluch, K. Pienkowska, W. Sawicki, P. Bujak, K. J. Paluch, L. Tajber and J. Markowski Source Type: research

Indapamide SR effects on ambulatory brachial and aortic pressure in hypertensive patients
Aim: Ambulatory monitoring of central blood pressure (BP) is a new technique for evaluation of antihypertensive drugs efficacy. The aim of the study was to assess changes in ambulatory brachial and central BP after indapamide SR adjunction to treatment regimen in hypertensive patients. (Source: Artery Research)
Source: Artery Research - September 1, 2013 Category: Cardiology Authors: Y. Kotovskaya, O. Kravtsova, Z. Kobalava Tags: Abstracts from Artery 13, Mermaid Conference and Events Centre, London, UK, 17–19 October 2013 Source Type: research

Increased pulse pressure linked to dementia: further results from the Hypertension in the Very Elderly Trial - HYVET
Conclusion:Wider PP may possibly indicate an increased risk for dementia. Active treatment may act to change the shape of the relationship between DBP and dementia. Future studies need to focus on exploring the ideal goal pressure for this age group. (Source: Journal of Hypertension)
Source: Journal of Hypertension - August 17, 2013 Category: Cardiology Tags: ORIGINAL PAPERS: Brain Source Type: research

Increased pulse pressure linked to dementia: further results from the Hypertension in the Very Elderly Trial – HYVET
Conclusion: Wider PP may possibly indicate an increased risk for dementia. Active treatment may act to change the shape of the relationship between DBP and dementia. Future studies need to focus on exploring the ideal goal pressure for this age group. (Source: Journal of Hypertension)
Source: Journal of Hypertension - August 16, 2013 Category: Cardiology Tags: ORIGINAL PAPERS: Brain Source Type: research

Effects of Antihypertensive Drugs on Central Blood Pressure in Humans: A Preliminary Observation.
Abstract BACKGROUND: Central blood pressure (BP) is considered a better predictor of cardiovascular events than brachial BP. Modifications of central, beyond brachial BP, can be assessed by pressure amplification, a potential new cardiovascular risk factor. Comparison between drugs' effect on central hemodynamics has been poorly studied. Our aim was to assess the hemodynamic effect of a 12-week treatment with amlodipine 5mg, or candesartan 8mg, or indapamide sustained-release 1.5mg, in comparison with placebo. METHODS: We analyzed 145 out-patients with essential hypertension in primary prevention enrolled in the N...
Source: American Journal of Hypertension - June 4, 2013 Category: Cardiology Authors: Agnoletti D, Zhang Y, Borghi C, Blacher J, Safar ME Tags: Am J Hypertens Source Type: research

Prevalence of hyponatremia among patients who used indapamide and hydrochlorothiazide: a single center retrospective study.
Abstract Hyponatremia is the most frequently encountered electrolyte abnormality among hospitalized patients and thiazide users. In this large single-center retrospective study, we aim to determine the prevalence and risk factors of hyponatremia among patients at the King Abdulaziz Medical City (KAMC), Riyadh, Saudi Arabia.To the best of our knowledge, this is the first such study in Saudi Arabia. A chart review was done for the years 2011-2012 of all admitted Saudi patients at KAMC who were treated with indapamide and hydrochlorothiazide. A total of 2000 patients were included [1237 females (629 indapamide and 60...
Source: Saudi Journal of Kidney Diseases and Transplantation - March 1, 2013 Category: Urology & Nephrology Authors: Al Qahtani M, Alshahrani A, Alskaini A, Abukhalid N, Al Johani N, Al Ammari M, Al Swaidan L, Binsalih S, Al Sayyari A, Theaby A Tags: Saudi J Kidney Dis Transpl Source Type: research

Patient-centered Medical Therapy for Nephrolithiasis
Objective: To elucidate the effect of a patient-centered combined nutritional and medical therapy approach on stone disease management, guided by 24-hour urinary stone risk.Materials and Methods: We retrospectively analyzed the records of patients treated at our multidisciplinary stone clinic from July 2007 to February 2009. Included were adult stone formers who presented with severe urinary abnormalities or whose urinary parameters failed to improve with dietary changes. Urinary risk factors for stone disease were evaluated before and after intervention with 24-hour urine collections. Hypercalciuria was treated with hydro...
Source: Urology - February 25, 2013 Category: Urology & Nephrology Authors: Giovanni Scala Marchini, Omar Ortiz-Alvarado, Ricardo Miyaoka, Carly Kriedberg, Angela Moeding, Michelle Stessman, Manoj Monga Tags: Endourology and Stones Source Type: research

Kidney function in the very elderly with hypertension: data from the hypertension in the very elderly (HYVET) trial
Background: numerous reports have linked impaired kidney function to a higher risk of cardiovascular events and mortality. There are relatively few data relating to kidney function in the very elderly. Methods: the Hypertension in the Very Elderly Trial (HYVET) was a randomised placebo-controlled trial of indapamide slow release 1.5mg ± perindopril 2–4 mg in those aged ≥80 years with sitting systolic blood pressures of ≥160 mmHg and diastolic pressures of
Source: Age and Ageing - February 18, 2013 Category: Geriatrics Authors: Peters, R., Beckett, N., Poulter, R., Burch, L., Narkiewicz, K., Fagard, R., Nitsch, D., Wang, N., Li, M., Fletcher, A., Bulpitt, C. Tags: Short Reports Source Type: research

Ion-pairing reverse-phase high performance liquid chromatography method for simultaneous estimation of atenolol and indapamide in bulk and combined dosage form
KG Baheti, N Shah, S ShaikhIndian Journal of Pharmaceutical Sciences 2012 74(3):271-274A sensitive, accurate, precise and validated ion-pairing reverse-phase liquid chromatographic method for the quantitative determination of atenolol and indapamide in bulk and tablet dosage form was developed. The proposed ion-pairing reverse-phase high performance liquid chromatography method utilises C 18 column with 5 μm, 150×4.6 mm i.d. column and mobile phase consisting of 0.1% w/v solution of octane sulphonic acid, sodium salt and methanol (55:45 v/v), (pH 2.8) and ultraviolet detection at 235 nm. A linearity range of 1-25...
Source: Indian Journal of Pharmaceutical Sciences - January 14, 2013 Category: Drugs & Pharmacology Authors: KG BahetiN ShahS Shaikh Source Type: research