Short-Term Changes in Serum Potassium and the Risk of Subsequent Vascular Events and Mortality: Results from a Randomized Controlled Trial of ACE Inhibitors
CONCLUSIONS: Continuation of angiotensin-converting enzyme inhibitor-based therapy consistently decreased the subsequent risk of clinical outcomes, including cardiovascular and kidney outcomes and death, regardless of short-term changes in serum potassium.CLINICAL TRIAL REGISTRY NAME AND REGISTRATION NUMBER: Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE), NCT00145925.PMID:35896277 | DOI:10.2215/CJN.00180122 (Source: Clinical Journal of the American Society of Nephrology : CJASN)
Source: Clinical Journal of the American Society of Nephrology : CJASN - July 27, 2022 Category: Urology & Nephrology Authors: Toshiaki Ohkuma Katie Harris Mark Cooper Diederick E Grobbee Pavel Hamet Stephen Harrap Giuseppe Mancia Michel Marre Anushka Patel Anthony Rodgers Bryan Williams Mark Woodward John Chalmers ADVANCE Collaborative Group Source Type: research
Management of Diabetes and Hypertension within the Gulf Region: Updates on Treatment Practices and Therapies
This article provides a summary of presentations made during the EVIDENT summit, a virtual symposium on Evidence in Diabetes and Hypertension, held in September 2021, including a review of the various guidelines for both T2D and hypertension, as well as recent findings relevant to the safety and efficacy for therapies relating to these conditions. Of relevance to the Gulf region, the risk of hypoglycaemia with sulfonylureas during Ramadan was reviewed. For the management of T2D, sulfonylureas have been a long-standing medication used to achieve glycaemic control; however, differences have emerged between early and later ge...
Source: Diabetes Therapy - June 9, 2022 Category: Endocrinology Source Type: research
Development of Simple Dissolution Methods for Felodipine and Combined Amlodipine Besylate -Indapamide Extended Release Tablets without Stationary (Felodipine) Basket
CONCLUSION: Test dissolution methods for Plendil® and Natrilam® tablets produced equivalent dissolution profiles compared to standard methods with stationary basket USP Apparatus II.PMID:35619254 | DOI:10.2174/1381612828666220526122615 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - May 27, 2022 Category: Drugs & Pharmacology Authors: Arslan Javed Ummarah Kanwal Syed Ahmad Nazir Gilani Farhan Akhtar Rahat Shamim Nasir Abbas Nadeem Irfan Bukhari Source Type: research
Development of Simple Dissolution Methods for Felodipine and Combined Amlodipine Besylate -Indapamide Extended Release Tablets without Stationary (Felodipine) Basket
CONCLUSION: Test dissolution methods for Plendil® and Natrilam® tablets produced equivalent dissolution profiles compared to standard methods with stationary basket USP Apparatus II.PMID:35619254 | DOI:10.2174/1381612828666220526122615 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - May 27, 2022 Category: Drugs & Pharmacology Authors: Arslan Javed Ummarah Kanwal Syed Ahmad Nazir Gilani Farhan Akhtar Rahat Shamim Nasir Abbas Nadeem Irfan Bukhari Source Type: research
Development of Simple Dissolution Methods for Felodipine and Combined Amlodipine Besylate -Indapamide Extended Release Tablets without Stationary (Felodipine) Basket
CONCLUSION: Test dissolution methods for Plendil® and Natrilam® tablets produced equivalent dissolution profiles compared to standard methods with stationary basket USP Apparatus II.PMID:35619254 | DOI:10.2174/1381612828666220526122615 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - May 27, 2022 Category: Drugs & Pharmacology Authors: Arslan Javed Ummarah Kanwal Syed Ahmad Nazir Gilani Farhan Akhtar Rahat Shamim Nasir Abbas Nadeem Irfan Bukhari Source Type: research
Development of Simple Dissolution Methods for Felodipine and Combined Amlodipine Besylate -Indapamide Extended Release Tablets without Stationary (Felodipine) Basket
CONCLUSION: Test dissolution methods for Plendil® and Natrilam® tablets produced equivalent dissolution profiles compared to standard methods with stationary basket USP Apparatus II.PMID:35619254 | DOI:10.2174/1381612828666220526122615 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - May 27, 2022 Category: Drugs & Pharmacology Authors: Arslan Javed Ummarah Kanwal Syed Ahmad Nazir Gilani Farhan Akhtar Rahat Shamim Nasir Abbas Nadeem Irfan Bukhari Source Type: research
Use of Perindopril Arginine/Indapamide/Amlodipine in the Management of Hypertension in Two Sub-Saharan African Island Countries of Madagascar and Mauritius
CONCLUSION: Triple fixed-dose therapy of perindopril arginine/indapamide/amlodipine continues to show additional blood pressure-lowering capacity even months after initiating the treatment in patients with hypertension in Madagascar and Mauritius. It is also well tolerated by patients with hypertension and assessed as safe to use by physicians.PMID:35438448 | DOI:10.1007/s12325-022-02134-0 (Source: Adv Data)
Source: Adv Data - April 19, 2022 Category: Epidemiology Authors: Armand Mbanya Azarkhan Ackbarkhan Mohammad Yaseen Mittoo Haja Andriamiadanarivo Ramamonjisoa Benja Ramilitiana Eliane Mikkelsen Ranivoharisoa Solohery Jean No ël Ratsimbazafy Jean Claude Mbanya Source Type: research
Use of Perindopril Arginine/Indapamide/Amlodipine in the Management of Hypertension in Two Sub-Saharan African Island Countries of Madagascar and Mauritius
ConclusionTriple fixed-dose therapy of perindopril arginine/indapamide/amlodipine continues to show additional blood pressure-lowering capacity even months after initiating the treatment in patients with hypertension in Madagascar and Mauritius. It is also well tolerated by patients with hypertension and assessed as safe to use by physicians. (Source: Advances in Therapy)
Source: Advances in Therapy - April 18, 2022 Category: Drugs & Pharmacology Source Type: research
Thiazide and the Thiazide-Like Diuretics: Review of Hydrochlorothiazide, Chlorthalidone, and Indapamide
Am J Hypertens. 2022 Apr 11:hpac048. doi: 10.1093/ajh/hpac048. Online ahead of print.ABSTRACTThe term thiazide is universally understood to refer to diuretics which exert their principal action in the distal tubule. The thiazide class is heterogenous, and can be further subdivided into compounds containing the benzothiadiazine ring structure - the thiazide-type (e.g. hydrochlorothiazide) - and those lacking the benzothiadiazine ring - the thiazide-like (e.g., chlorthalidone and indapamide) drugs. Thiazide-like agents are longer acting, and constitute the diuretics used in most of the cardiovascular outcome trials which est...
Source: American Journal of Hypertension - April 11, 2022 Category: Cardiology Authors: Michael E Ernst Michelle A Fravel Source Type: research
Correction to: Perindopril/Indapamide/Amlodipine in Hypertension: A Profile of Its Use
(Source: American Journal of Cardiovascular Drugs)
Source: American Journal of Cardiovascular Drugs - March 30, 2022 Category: Cardiology Source Type: research
Resolving alternative structure determinations of indapamide using 13C solid-state NMR
This article is licensed under aCreative Commons Attribution 3.0 Unported Licence.Caitlin L. Evans, Ivana Radosavlijevi ć Evans, Paul Hodgkinson The conflict between alternative crystal structures in the Cambridge Structural Database for the diuretic drug indapamide hemihydrate has been resolved with the aid of13C solid-state NMR. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chem. Commun. latest articles)
Source: RSC - Chem. Commun. latest articles - March 28, 2022 Category: Chemistry Authors: Caitlin L. Evans Source Type: research
Resolving alternative structure determinations of indapamide using < sup > 13 < /sup > C solid-state NMR
Chem Commun (Camb). 2022 Mar 28. doi: 10.1039/d1cc06256e. Online ahead of print.ABSTRACTThe conflict between alternative crystal structures in the Cambridge Structural Database for the diuretic drug indapamide hemihydrate (IND) has been resolved with the aid of 13C solid-state NMR. IND is seen to contain multiple distinct molecules in the asymmetric unit (Z' = 4) rather than exhibiting disorder in the orientation of sulfonamide groups. The NMR crystallographic approach is a more effective tool for distinguishing between alternative structures than naïve judgements of quality based on crystallographic refinement agreement ...
Source: Chemical Communications - March 28, 2022 Category: Chemistry Authors: Caitlin L Evans Ivana Radosavlijevi ć Evans Paul Hodgkinson Source Type: research
Resolving alternative structure determinations of indapamide using < sup > 13 < /sup > C solid-state NMR
Chem Commun (Camb). 2022 Mar 28. doi: 10.1039/d1cc06256e. Online ahead of print.ABSTRACTThe conflict between alternative crystal structures in the Cambridge Structural Database for the diuretic drug indapamide hemihydrate (IND) has been resolved with the aid of 13C solid-state NMR. IND is seen to contain multiple distinct molecules in the asymmetric unit (Z' = 4) rather than exhibiting disorder in the orientation of sulfonamide groups. The NMR crystallographic approach is a more effective tool for distinguishing between alternative structures than naïve judgements of quality based on crystallographic refinement agreement ...
Source: Chemical Communications - March 28, 2022 Category: Chemistry Authors: Caitlin L Evans Ivana Radosavlijevi ć Evans Paul Hodgkinson Source Type: research
Efficacy of Single-Pill, Triple Antihypertensive Therapy in Patients with Uncontrolled Hypertension: A Systematic Review and Meta-analysis
Conclusionperindopril/indapamide/amlodipine is effective in reducing systolic and diastolic blood pressures by 24 and 12 mmHg respectively. Over 24 h, the combination reduced systolic and diastolic blood pressures by 14 and 7 mmHg respectively. (Source: High Blood Pressure and Cardiovascular Prevention)
Source: High Blood Pressure and Cardiovascular Prevention - March 24, 2022 Category: Cardiology Source Type: research
