Improving Diabetic Retinopathy Outcomes: FIELD Fenofibrate.
Authors: Kalra S, Sahay R
Abstract
This brief communication describes evidence which proves the beneficial effects of fenofibrate on the retinal vasculature in type 2 diabetes, acting via both lipid lowering and non-lipid lowering mechanisms. It discusses data from FIELD and other trials to support the use of fenofibrate as a secondary preventive therapy for diabetic retinopathy. These data contrast with the lack of retinal benefit shown in major cardiovascular outcome trials of other blood pressure lowering and glucose lowering agents such as empagliflozin, liraglutide, perindopril + indapamide, and ramip...
Source: Journal of the Association of Physicians of India - July 18, 2019 Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Resistant Hypertension Management: Comparison of the 2017 American and 2018 European High Blood Pressure Guidelines
AbstractPurpose of ReviewTo compare European and American guidelines for the diagnosis, evaluation, and management of resistant hypertension.Recent FindingsResistant hypertension is defined as high blood pressure that remains above goal with the use of 3 or more antihypertensive agents, commonly a renin-angiotensin blocker (either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker), a long-acting calcium channel blocker, and thiazide or thiazide-like diuretic. Resistant hypertension is common, with a recent analysis indicating that it affects approximately 17 –19% of adult Americans with hypert...
Source: Current Hypertension Reports - July 17, 2019 Category: Primary Care Source Type: research
Redefining diuretics use in hypertension: why select a thiazide-like diuretic?
Diuretics are listed in hypertension guidelines as one of three equally weighted first-line treatment options. In order to differentiate between antihypertensives, a lot of discussion has been directed at side effect profiles and as a result, has created a perhaps disproportionate fear of the metabolic effects that can be associated with diuretics. Data, however, show that the risk of a clinically meaningful change in laboratory parameters is very low, whereas the benefits of volume control and natriuresis are high and the reductions in morbidity and mortality are clinically significant. Moreover, as clinically significant...
Source: Journal of Hypertension - June 27, 2019 Category: Cardiology Tags: REVIEWS AND META-ANALYSES Source Type: research
HPLC-PDA analysis of ACE-inhibitors, hydrochlorothiazide and indapamide utilizing design of experiments
Publication date: July 2019Source: Arabian Journal of Chemistry, Volume 12, Issue 5Author(s): Eyad Rashed Dawud, Ashok K. ShakyaAbstractA simple, rapid, precise, accurate and sensitive high performance liquid chromatographic method has been developed for simultaneous determination of ACE inhibitors with hydrochlorothiazide and indapamide in pharmaceutical formulations. ‘Design of Experiments’ (DoE) using ‘central composite design’ (CCD) was applied to facilitate method development and optimization. Mobile phase was optimized utilizing response surface methodology using Design Expert software. Chromatographic separa...
Source: Arabian Journal of Chemistry - June 22, 2019 Category: Chemistry Source Type: research
Development of High-Strength Extended-Release Multiparticulate System by Crystallo-co-agglomeration Technique with Integration of Central Composite Design.
Abstract
The number of unit operations to be followed in the preparation of tablets was cumbersome and may introduce material as well as process-related critical parameters which may negatively affect the quality of final formulation. The hypothesis of the present research was to develop directly compressible, high-strength extended-release spherical agglomerates of talc containing indapamide by crystallo-co-agglomeration technique. Hydroxypropyl methylcellulose 15 cps and polyethylene glycol 6000 were used to impart the desired sphericity, strength, and deformability to agglomerates, respectively. Ethyl ...
Source: AAPS PharmSciTech - May 20, 2019 Category: Drugs & Pharmacology Authors: Gaikwad VL, Jadhav NR, Pawar AP, Mahadik KR Tags: AAPS PharmSciTech Source Type: research
Molecules, Vol. 24, Pages 1764: A Deeper Investigation of Drug Degradation Mixtures Using a Combination of MS and NMR Data: Application to Indapamide
t
Serge Pilard
A global approach that is based on a combination of mass spectrometry (MS) and nuclear magnetic resonance (NMR) data has been developed for a complete and rapid understanding of drug degradation mixtures. We proposed a workflow based on a sample preparation protocol that is compatible to MS and NMR, the selection of the most appropriate experiments for each technique, and the implementation of prediction software and multivariable analysis method for a better interpretation and correlation of MS and NMR spectra. We have demonstrated the efficient quantification of the remaining active pharmaceutical in...
Source: Molecules - May 6, 2019 Category: Chemistry Authors: C écile Palaric Roland Molini é Dominique Cailleu Jean-Xavier Fontaine David Mathiron Fran çois Mesnard Yoann Gut Tristan Renaud Alain Petit Serge Pilard Tags: Article Source Type: research
Role of hydrogen bonding in cocrystals and coamorphous solids: indapamide as a case study
CrystEngComm, 2019,21,2043-2048 DOI: 10.1039/C8CE01075G, CommunicationSuryanarayana Allu, Kuthuru Suresh, Geetha Bolla, M. K. Chaitanya Mannava, Ashwini Nangia Crystalline and amorphous stable binary compounds of indapamide for high solubility and permeability. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - CrystEngComm latest articles)
Source: RSC - CrystEngComm latest articles - March 25, 2019 Category: Chemistry Authors: Suryanarayana Allu Source Type: research
Investigation of the formation of drug-drug cocrystals and coamorphous systems of the antidiabetic drug gliclazide
Publication date: Available online 23 February 2019Source: International Journal of PharmaceuticsAuthor(s): Marwah Aljohani, Pól MacFhionnghaile, Patrick McArdle, Andrea ErxlebenAbstractThe antidiabetic drug gliclazide (GLZ) has a slow absorption rate and a low bioavailability due to its poor solubility. GLZ is often prescribed along with an antihypertensive, as many diabetic patients have coexistent hypertension. Cocrystallization and coamorphization are attractive strategies to enhance dissolution rates and to reduce the number of medications a patient has to take. In this work the formation of cocrystals and coamorphou...
Source: International Journal of Pharmaceutics - February 23, 2019 Category: Drugs & Pharmacology Source Type: research
Effectiveness and Adherence to Treatment with Perindopril/Indapamide/Amlodipine Single-Pill Combination in a Greek Population with Hypertension
ConclusionsPerindopril/indapamide/amlodipine SPC decreased BP levels rapidly and significantly. The degree of BP reduction was associated with the severity of hypertension and/or with total cardiovascular risk at baseline. Simplifying the drug regimen by using this SPC improved adherence and showed excellent tolerability. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - February 21, 2019 Category: Drugs & Pharmacology Source Type: research
Heat capacity and enthalpy of indapamide
Publication date: Available online 30 January 2019Source: Thermochimica ActaAuthor(s): M. Skotnicki, A. Drogoń, J.J Calvin, P.F Rosen, B.F Woodfield, M PydaAbstractThe heat capacities and total enthalpy of anhydrous indapamide (IND, CAS no.: 26807-65-8) are reported from temperature 1.84 to 523.15 K measured by a Quantum Design Physical Property Measurement System® (PPMS) and differential scanning calorimetry (DSC). The low-temperature experimental heat capacities of crystalline IND from 1.84 to 302.65 K were measured by PPMS and fit to a theoretical model in the low temperature range (T < 7.68 K), orthogon...
Source: Thermochimica Acta - January 30, 2019 Category: Chemistry Source Type: research
'Temporary Plasticiser': A Novel Solution to Fabricate 3D Printed Patient-Centred Cardiovascular 'Polypill' Architectures.
Abstract
Hypertension and dyslipidaemia are modifiable risk factors associated with cardiovascular diseases (CVDs) and often require a complex therapeutic regimen. The administration of several medicines is commonly associated with poor levels of adherence among patients, to which World Health Organisation (WHO) proposed a fixed-dose combination unit (polypill) as a strategy to improve adherence. In this work, we demonstrate the fabrication of patient-specific polypills for the treatment of CVDs by fused deposition modelling (FDM) 3D printing and introduce a novel solution to meet critical quality attribut...
Source: European Journal of Pharmaceutics and Biopharmaceutics - December 20, 2018 Category: Drugs & Pharmacology Authors: Pereira BC, Isreb A, Forbes RT, Dores F, Habashy R, Petit JB, Alhnan MA, Oga E Tags: Eur J Pharm Biopharm Source Type: research
Management of vulval melanoma in situ with imiquimod.
This article is protected by copyright. All rights reserved.
PMID: 30430545 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 15, 2018 Category: Dermatology Authors: Veraitch O, Lewis F, Craythorne E, Calonje E, Nath R Tags: Br J Dermatol Source Type: research
Management of vulval melanoma in situ with imiquimod
This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - November 15, 2018 Category: Dermatology Authors: O. Veraitch,
F. Lewis,
E. Craythorne,
E. Calonje,
R. Nath Tags: Research Letter Source Type: research
Perindopril/indapamide
(Source: Reactions Weekly)
Source: Reactions Weekly - November 1, 2018 Category: Drugs & Pharmacology Source Type: research
The effect of indapamide versus bendroflumethiazide for primary hypertension: a systematic review
British Journal of Clinical Pharmacology,Volume 0, Issue ja, -Not available-. (Source: British Journal of Clinical Pharmacology)
Source: British Journal of Clinical Pharmacology - October 12, 2018 Category: Drugs & Pharmacology Authors: Tatiana V. Macfarlane,
Filippo Pigazzani,
Robert W.V. Flynn,
Tom M. Macdonald Source Type: research
