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Insulin ‐like growth factor‐2 mRNA‐binding protein 3 as a novel prognostic biomarker for acral lentiginous melanoma
(Source: British Journal of Dermatology)
Source: British Journal of Dermatology - February 22, 2018 Category: Dermatology Authors: J.W. Seo, S.M. Ha, K.H. Song Tags: Research Letter Source Type: research

The Validity of the Diagnostic Code for Pyoderma Gangrenosum in an Electronic Database
This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - February 16, 2018 Category: Dermatology Authors: S.J. Lockwood, D.G. Li, D. Butler, W. Tsiaras, C. Joyce, A. Mostaghimi Tags: Research Letter Source Type: research

“It's a traumatic illness, traumatic to witness.” A qualitative study of the experiences of bereaved family caregivers of patients with cutaneous T‐cell lymphoma
ConclusionsFamily caregivers should be considered part of the wider healthcare team, acknowledging their multiple roles and the challenges they encounter in looking after their relative with CTCL as the disease progresses. Their experiences highlight the importance of organisational flexibility and of good communication between health care providers in advanced CTCL.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - February 16, 2018 Category: Dermatology Authors: D. Orlowska, L. E. Selman, T. Beynon, E. Radcliffe, S. Whittaker, F. Child, R. Harding Tags: Original Article Source Type: research

Aquagenic Wrinkling of the Palms in Patients with Cystic Fibrosis
This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - February 16, 2018 Category: Dermatology Authors: H. Kaiser, N. Brustad, T. Pressler, A. Bygum Tags: Research Letter Source Type: research

Children with Facial Morphea Managing Everyday Life: A Qualitative Study
ConclusionUnderstanding what it is like to live with facial morphea from the perspectives of children and parents is important for devising ways to support children with facial morphea to achieve a better quality of life. Health care providers can help families access resources to manage anxiety, deal with bullying and construct adequate explanations of facial morphea, as well as providing opportunities for peer support.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - February 16, 2018 Category: Dermatology Authors: E. Stasiulis, B. Gladstone, K. Boydell, C. O'Brien, E. Pope, R. Laxer Tags: Original Article Source Type: research

Acute psychosocial stress downregulates N ‐Methyl‐d‐aspartate receptors (NMDAR) in healthy human skin
This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - February 16, 2018 Category: Dermatology Authors: H. J. A. Hunter, E. Morsman, K. T. Mellody, S. K. Ogden, L. A. H. Zeef, A. Hayes, C. E. M. Griffiths, C. E. Kleyn Tags: Research Letter Source Type: research

Optimizing case reports and case series: guidance on how to improve quality
This article reviews their characteristics, aims and limitations. It provides information on how to increase the validity of the bedside decision‐making process that these studies report, using tools such as validated outcomes and split body or n‐of‐1 trials. A section describing tools to improve writing of case reports and case series provides suggestions for detailed reporting and good evaluation of novelty, validity and relevance. It includes general and British Journal of Dermatology specific guidance. This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - February 16, 2018 Category: Dermatology Authors: I. Garcia ‐Doval, J. Albrecht, C. Flohr, J Batchelor, J. R. Ingram, Tags: Review Article Source Type: research

Successful therapy of Pyoderma gangrenosum with a JAK2 inhibitor
This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - February 16, 2018 Category: Dermatology Authors: S. Nasifoglu, B. Heinrich, J. Welzel Tags: Research Letter Source Type: research

Minimally invasive and targeted therapeutic cell delivery to the skin using microneedle devices
ConclusionsHollow microneedles provide an innovative and minimally invasive method for delivering functional cells into the skin. Microneedle cell delivery represents a potential new treatment option for cell therapy approaches including skin repigmentation, wound repair, scar and burn remodelling, immune therapies and cancer vaccines. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - February 15, 2018 Category: Dermatology Authors: B. Gualeni, S.A. Coulman, D. Shah, P.F. Eng, H. Ashraf, P. Vescovo, G.J. Blayney, L. ‐D. Piveteau, O.J. Guy, J.C. Birchall Tags: Translational Research Source Type: research

Bioinformatics for dermatology: why we should learn about code
(Source: British Journal of Dermatology)
Source: British Journal of Dermatology - February 15, 2018 Category: Dermatology Authors: A.C. Foulkes, D.S. Watson, M.R. Barnes Tags: Letter to the Editor Source Type: research

Novel POFUT1 mutation associated with hidradenitis suppurativa –Dowling–Degos disease firm up a role for Notch signalling in the pathogenesis of this disorder
(Source: British Journal of Dermatology)
Source: British Journal of Dermatology - February 15, 2018 Category: Dermatology Authors: I. Gonz ález‐Villanueva, M. Gutiérrez, P. Hispán, I. Betlloch, J.C. Pascual Tags: Letter to the Editor Source Type: research

先天性黑色素细胞痣的激光疗法:系统性评述
Summary 大多数人的皮肤上都有几个褐斑,我们称之为黑色素细胞痣或痣。痣对人体无害,但偶尔可能转化为潜在致死性肿瘤,也就是恶性黑色素瘤。先天性黑色素细胞痣(CMN)在婴儿出生时就存在,或者在出生后第一周逐渐形成。先天性痣,尤其是尺寸较大并长于明显部位的痣对于那些对自己的容貌不满意的人来说是个巨大的负担。此外,拥有CMN(尤其是较大的CMN)的患者患上恶性黑色素瘤的风险也会增加。拥有CMN的患者罹患恶性黑色素瘤的风险被认为在0.7%至2.9%之间。通过手术摘除CMN以...
Source: British Journal of Dermatology - February 14, 2018 Category: Dermatology Authors: C.A.M. Eggen, J.E. Lommerts, E.J. Zuuren, J. Limpens, S.G.M.A. Pasmans, A. Wolkerstorfer Tags: Plain Language Summary Source Type: research

针对外周血管畸形的国际核心指标集的开发(ovama项目)
Summary 外周血管畸形(VM)是指由在胚胎中形成的血管发育缺陷而导致的胎记或肿胀。不同的类型可根据其主要组成部分来分类:分为淋巴管(LM)、血管(VM)或结合动脉和血管(AVM)。目前难以评估现有的各种医疗和外科手术治疗方法,因为医学界尚没有衡量结果指标的统一方法。该国际组织针对医务人员和患者开展了一项在线调查,以决定未来的临床试验中需要重点记录的因素。他们首先列出了病情及其疗法的各种方面,涉及36个领域共97个具体项目。随后,他们邀请了167名医生和134名患...
Source: British Journal of Dermatology - February 14, 2018 Category: Dermatology Authors: S.E.R. Horbach, C.M.A.M. Horst, F. Blei, C.J.M. Vleuten, I. J. Frieden, G.T. Richter, S.T. Tan, T. Muir, A.J. Penington, L.M. Boon, P.I. Spuls, Tags: Plain Language Summary Source Type: research

局部JTE‐052(一种Janus激酶抑制剂) 对患有中度至重度异位性皮炎的日本成人患者的功效和安全性:一项2期、多中心随机、赋形剂对照临床研究
Summary 异位性皮炎(湿疹)是一种慢性且有时为耗弱性的炎症性皮肤病,会引起瘙痒和皮肤屏障功能损坏。目前的疗法包括局部(在皮肤上涂敷)皮质类固醇和钙调神经磷酸酶抑制剂(例如他克莫司);但长期使用局部皮质类固醇可能会导致皮肤变薄,而他克莫司则是刺激性药物。激酶是一种对体内细胞的许多功能都非常重要的一种酶,而Janus激酶(JAK)途径则对炎症有作用。近年来,科学家们开发出了多种可抑制此途径的药物,对炎性皮肤(例如湿疹或银屑病)有潜在效果。来自日本东京和北海...
Source: British Journal of Dermatology - February 14, 2018 Category: Dermatology Authors: H. Nakagawa, O. Nemoto, A. Igarashi, T. Nagata Tags: Plain Language Summary Source Type: research

杜匹鲁单抗治疗提升了患有中度至重度异位性皮炎的成人患者的生活质量:来自随机、安慰剂对照临床试验
Summary 异位性皮炎是一种皮肤病,也称为异位性湿疹。10位成人里就有1位患有异位性皮炎。异位性皮炎常常会引起严重瘙痒,使患者在夜里难以入睡、情绪低沉。这种浑身不舒服的状态称为生活质量降低。杜匹鲁单抗是一种已获美国批准的新型药物,可用于治疗患有中度至重度异位性皮炎的成人患者。该药物能够抑制这种皮炎的某些机制。在欧洲开展的一项临床试验中,研究人员观察了109位患有中度至重度异位性皮炎的患者。这些患者服用杜匹鲁单抗超过了12周。他们发现这种药...
Source: British Journal of Dermatology - February 14, 2018 Category: Dermatology Authors: A. Tsianakas, T.A. Luger, A. Radin Tags: Plain Language Summary Source Type: research

秋水仙碱:一种拥有新型应用的古老药物
Summary 秋水仙碱是迄今仍在使用的最古老的药物之一。它来源于秋水仙植物的球状茎,也称为番红花。它用作治疗关节痛的草本药物的历史可以追溯到至少一千年前,并且它还可以用于治疗痛风和家族性地中海热等疾病。除此之外,医学界仍在探索秋水仙碱是如何发挥功效的。近期,有报告指出秋水仙碱可有效治疗一些皮肤病,包括贝赛特氏症、获得性大疱性表皮松解症、白细胞破坏性脉管炎、斯维特综合征和复发性阿弗它口炎。但现有的研究所基于的患者人数通常较少。这项由...
Source: British Journal of Dermatology - February 14, 2018 Category: Dermatology Authors: B. Dasgeb, D. Kornreich, K. McGuinn, L. Okon, I. Brownell, D.L. Sackett Tags: Plain Language Summary Source Type: research

因“无效”而从依那西普临床试验中“退出”的银屑病患者的时间、pasi和dlqi——十项临床试验的汇总分析
Summary 银屑病是一种常见的皮肤病,而临床试验则用于衡量不同的治疗对银屑病的具体功效如何。在此类试验中,研究人员一般会利用特定的方法来衡量患者症状的改善和生活质量的提升情况,其中包括银屑病面积和严重程度指数(PASI,分数越低,病情就越严重)、医生全面评估指标(PGA)和皮肤病生活质量指数(DLQI)。如果一项治疗到特定的时间点上还未有效,则可能会增加患者不满并退出临床研究的可能性。在此项研究中,研究人员查看了涉及一种名为依那西普的银屑病药物的临床试验,...
Source: British Journal of Dermatology - February 14, 2018 Category: Dermatology Authors: A. Nast, M. Dilleen, W. Liyanage, L. Aikman, P. Szczypa, C. Dressler Tags: Plain Language Summary Source Type: research

设立针对脱发(斑秃除外)预防、诊断和治疗的研究问题并安排优先顺序:脱发优先设定合作伙伴关系
Summary 头发和头皮问题相当常见。有多种情况可能导致脱发,可能表现为头发脱落、稀疏或斑驳,进而形成脱发。有些情况下头发会重新生长,而其他情况的秃头症(脱发)则是永久性的。经常性疏于打理是人们脱发的心理影响因素。脱发的表现以及对进一步发展的恐惧可能会导致患者自尊心下降、焦躁和沮丧。遗憾的是,治疗脱发的最有效疗法尚有许多不确定因素。这项由英国脱发慈善组织资助的研究旨在识别脱发管理、预防、诊断和治疗中的不确定因素,这对有脱发烦恼的人们和...
Source: British Journal of Dermatology - February 14, 2018 Category: Dermatology Authors: A. Macbeth, J. Tomlinson, A. Messenger, K. Moore ‐Millar, C. Michaelides, A. Shipman, J. Kassim, J. Brockley, W. Szczecinska, P. Farrant, R. Robinson, J. Rodgers, J. Chambers, S. Upadhyaya, M. Harries Tags: Plain Language Summary Source Type: research

静脉注射免疫球蛋白用作顽固性坏疽性脓皮病的辅助疗法:病例和病例系列的系统性评述
Summary 坏疽性脓皮病是一种罕见的皮肤问题,患者的白血球和中性粒细胞渗透皮肤,从而导致坏死和溃疡。由于早期治疗主要采用用于降低此种损害的逻辑方法,因此医生们尝试了各种不同的治疗方法,包括通过静脉注射使用免疫球蛋白(IVIG),一种从含有抗体的血浆中提取的蛋白质。此项研究利用此技术检查了此前发布的研究。研究的作者来自哈佛大学和美国波士顿的医院,他们寻找了49名在其他疗法(例如口服皮质类固醇和环孢霉素)无效后接受了这种治疗以改变疾病状况的患者。大...
Source: British Journal of Dermatology - February 14, 2018 Category: Dermatology Authors: H. Song, N. Lahood, A. Mostaghimi Tags: Plain Language Summary Source Type: research

生物制剂和生物仿制药对中度至重度斑块状银屑病患者的安全性、疗效和药物存活率
Summary 银屑病是一种影响全球2~3%人口的常见疾病,中度至重度病例需要使用生物药物(生物制剂)进行系统的治疗。治疗通常是永久性的,但这些药物久而久之可能会失去功效。当原药(原研药)的专利到期之后,其他公司就可以生产生物仿制药,即与原研药非常相似的药物(但并非完全一致,因为生物制剂来源于活跃的人类基因)。这项在丹麦开展的研究比较了五种生物制剂的安全性、功效和药物存活率(即患者持续治疗的时长):阿达木单抗、依那西普、英夫利昔、苏金单抗和优特克单抗...
Source: British Journal of Dermatology - February 14, 2018 Category: Dermatology Authors: A. Egeberg, M.B. Ottosen, R. Gniadecki, S. Broesby ‐Olsen, T.N. Dam, L.E. Bryld, M.K. Rasmussen, L. Skov Tags: Plain Language Summary Source Type: research

Iv 阶段一对一随机对照试验就治疗面部或头皮光化性角化病比较了巨大戟醇甲基丁烯酸酯0.015%凝胶与双氯芬酸钠3%凝胶
Summary 这项在德国、西班牙和英国开展的研究比较了两种凝胶疗法对治疗面部或头皮光化性角化病(AK)的有效性。AK是指皮肤表面出现小型、穗状、有鳞片或类似砂纸状的晒伤区域。有很小的比例会发展成皮肤鳞状细胞癌。当整个头皮等大面积区域受到多处AK影响时,建议在皮肤表面擦拭膏药或凝胶。研究人员在502名患者中比较了巨大戟醇甲基丁烯酸酯0.015%凝胶(IngMeb)和双氯芬酸钠3%凝胶(DS),这些患者大部分是男性且几乎都是白皮肤。IngMeb每天擦一次,连续擦三天,而DS则每天擦两次...
Source: British Journal of Dermatology - February 14, 2018 Category: Dermatology Authors: E. Stockfleth, C.A. Harwood, C. Serra ‐Guillén, T. Larsson, M.L. Østerdal, T. Skov Tags: Plain Language Summary Source Type: research

在工作中遭受的紫外线照射是否是皮肤鳞状细胞癌最重要的风险因素?基于人群的病例对照研究fb‐181的结果
Summary 鳞状细胞癌(SCC)是一种特定形式的皮肤癌,也是欧洲最常见的癌症之一。因此,SCC对患者本身以及在社会代价方面都造成了极大的负担。SCC的一个主要原因是暴露在自然阳光下,因此可以通过避免过度曝晒来预防SCC。外出时,人们可以利用衣物(例如长袖、帽子)和防晒霜来保护皮肤。到目前为止,SCC和其他皮肤癌的预防计划主要是尝试减少在休闲时间中的过度曝晒。然而,有许多人是在室外工作的,例如农民、建筑工人和屋顶工。职业(与工作相关)和休闲时间的阳光曝晒在导致SCC...
Source: British Journal of Dermatology - February 14, 2018 Category: Dermatology Authors: J. Schmitt, E. Haufe, F. Trautmann, H. ‐J. Schulze, P. Elsner, H. Drexler, A. Bauer, S. Letzel, S.M. John, M. Fartasch, T. Brüning, A. Seidler, S. Dugas‐Breit, M. Gina, W. Weistenhöfer, K. Bachmann, I. Bruhn, B.M. Lang, S. Bonness, J.P. Allam, W. Gr Tags: Plain Language Summary Source Type: research

由PSENEN始祖突变引起的结合了化脓性汗腺炎与道林‐德戈斯(Dowling–Degos)病的表现型
Summary 道林‐德戈斯病是一种罕见的遗传病,在青春期就会开始出现症状,表现为皮肤色素异常(色素沉着),常见于皮肤褶皱处,称为肢端曲侧。家族性化脓性汗腺炎也是一种罕见的遗传病,表现为肢端曲侧出现再生疖。通常在青春期就会开始出现症状。有时,患者身上会同时存在这两种疾病。最近,同时患有化脓性汗腺炎和道林‐德戈斯病的患者被发现名为PSENEN的同一基因存在缺陷。PSENEN的产物是一种蛋白质,它是名为NOTCH的合成物的一部分,后者在皮肤和其他器官发育的过程中起着重...
Source: British Journal of Dermatology - February 14, 2018 Category: Dermatology Authors: M. Pavlovsky, O. Sarig, M. Eskin ‐Schwartz, N. Malchin, R. Bochner, J. Mohamad, A. Gat, A. Peled, A. Hafner, E. Sprecher Tags: Plain Language Summary Source Type: research

抗生素是否有助于降低治疗皮肤癌的皮肤外科手术后的创面感染风险?
Summary 皮肤癌是英国最常见的癌症之一,并且全球范围内的发病人数还在不断增加。大部分皮肤癌都会通过外科手术去除皮肤中的癌细胞。而皮肤外科手术后发生创面感染的风险低于5%。目前的证据显示,如果皮肤癌病灶表面出现裂口(称为溃疡),则发生创面感染的风险就会增加。目前,英国尚未制定在皮肤外科手术后使用抗生素以潜在降低感染风险的指导。此报告旨在审查所有可用的研究证据,以帮助医生决定是否要为接受皮肤癌外科手术的患者开具抗生素处方,以减少术后发生创...
Source: British Journal of Dermatology - February 14, 2018 Category: Dermatology Authors: S.A. Chan, A.G.H. Wernham, N. Stembridge, N. Harper, S. Verykiou, G.A. Fremlin, R.A. Abbott, R.N. Matin Tags: Plain Language Summary Source Type: research

在潮湿环境下工作的医护人员的手部湿疹问题:一项横断面研究
Summary 手部湿疹是医护人员的常见问题。一个原因是,他们需要经常接触肥皂和水。在过去的十年中,为了防止传染病的蔓延,医疗机构中实施了更加严格的卫生措施。此项研究的目的在于证明一次性手套、酒精手消毒剂和肥皂的使用与手部湿疹的关系。研究人员向瑞典南部所有医院职工发送了电子版问卷调查。该项分析中仅包含了职务为护士、助理护士和医生的调查对象。在此群体中,有21%的人表示在过去的12个月中曾经有过手部湿疹,这一比例要高于一般人群。30%的人每天在工...
Source: British Journal of Dermatology - February 14, 2018 Category: Dermatology Authors: N. Hamnerius, C. Svedman, O. Bergendorff, J. Bj örk, M. Bruze, A. Pontén Tags: Plain Language Summary Source Type: research

在模拟初级护理实践中用于区分良性和恶性色素病灶的光学传递诊断
Summary 一种称为黑色素瘤的皮肤癌的发病率正不断增加。黑色素瘤的检测相当困难,尤其对于只经过有限培训(与专门研究皮肤的皮肤科医生相比)的临床医生而言,他们通常难以区分正常的痣与黑色素瘤。无创光学传递诊断(OTD)法旨在帮助筛查可能是黑色素瘤的病灶(例如痣)。这项在美国、英国和挪威开展的研究中,作者利用OTD拍摄了图像并分析了712种色素病灶(可能是痣或黑色素瘤)。专家采用名为皮肤镜的放大镜检查后发现,这其中有415种病灶是无害(即良性)的,其余297种则为疑似...
Source: British Journal of Dermatology - February 14, 2018 Category: Dermatology Authors: D.L. Swanson, R.V. Venneugues, S.Q. Vicencio, J. Garioch, M. Biryulina, G. Ryzhikov, B. Hamre, L. Zhao, F.S. Castellana, K. Stamnes, J.J. Stamnes Tags: Plain Language Summary Source Type: research

开发和验证皮肤疣(cwarts)诊断工具:一种新型皮肤疣临床评估和分类系统
Summary 并非所有皮肤疣的症状都相同。这项在荷兰开展的研究旨在开发并测试精确的诊断工具,以帮助临床医生诊断疣。该项研究的作者根据各种文献和专家访谈定义了九大外观特征,进而开发出了皮肤疣诊断工具(CWARTS诊断工具)。该项研究包括两个部分。在第一个部分(部分A)中,28名研究人员(“观察员”)评估了10种疣的照片,然后该团队调查了这些研究人员之间的共识程度。在第二个部分(部分B)中,6名研究人员再次评估了299种疣的照片,这次该团队测试了这6名观察员的第一...
Source: British Journal of Dermatology - February 14, 2018 Category: Dermatology Authors: G.K. Hogendoorn, S.C. Bruggink, K.E. Hermans, S.T.P. Kouwenhoven, K.D. Quint, R. Wolterbeek, J.A.H. Eekhof, M.N.C. de Koning, R. Rissmann, J. Burggraaf, J.N. Bouwes Bavinck Tags: Plain Language Summary Source Type: research

原发性免疫缺陷的皮肤症状——如何找到要检查的基因
Summary 原发性免疫缺陷是一种罕见的慢性疾病,患者的一部分免疫系统可能会存在缺失或功能紊乱的现象,因而导致免疫系统减弱,患者更易感染会引起传染病的细菌。患者会出现各种症状,但共同点是都会存在反复、持久且/或严重的感染,有时是因罕见细菌引起的。近半数患者会出现皮肤症状,这有助于医生辨别潜在的免疫紊乱问题。因此,本研究的作者制作了一张表格,便于医生在疑似免疫缺陷的情况中根据皮肤症状来诊断免疫紊乱的问题。他们列出了典型的皮肤表现以及需要检...
Source: British Journal of Dermatology - February 14, 2018 Category: Dermatology Authors: M. Ettinger, J. Schreml, K. Wirsching, M. Berneburg, S. Schreml Tags: Plain Language Summary Source Type: research

Laser treatment of congenital melanocytic naevi: a systematic review
The objective of this study from the Netherlands was to review the efficacy and safety of different laser types used for CMN. The researchers found that a great variety of laser devices and combinations of lasers have been used for treatment of congenital nevi. There is very low quality evidence that laser therapy in CMN is effective and safe in the short term, however there were high incidences of scarring, repigmentation (colour coming back) and complications. More high quality studies are required in order to really answer the question regarding efficacy and safety of laser treatment in CMN. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - February 14, 2018 Category: Dermatology Authors: C.A.M. Eggen, J.E. Lommerts, E.J. Zuuren, J. Limpens, S.G.M.A. Pasmans, A. Wolkerstorfer Tags: Plain Language Summary Source Type: research

Development of an international core outcome set for peripheral vascular malformations: the OVAMA project
Summary Peripheral vascular malformations (VMs) are birthmarks or swellings caused by the faulty development of blood vessels in the embryo. Different types are classified according to whether the components are mainly lymph vessels (LMs), veins (VMs) or combined arteries and veins (AVMs). It is hard to assess the various medical and surgical treatments available because there are no agreed methods for measuring the outcome. This international group carried out an on‐line survey of health professionals and patients to decide which factors would be important to record in future clinical trials. First they listed aspects o...
Source: British Journal of Dermatology - February 14, 2018 Category: Dermatology Authors: S.E.R. Horbach, C.M.A.M. Horst, F. Blei, C.J.M. Vleuten, I. J. Frieden, G.T. Richter, S.T. Tan, T. Muir, A.J. Penington, L.M. Boon, P.I. Spuls, Tags: Plain Language Summary Source Type: research

Efficacy and safety of topical JTE ‐052, a Janus kinase inhibitor, in Japanese adult patients with moderate‐to‐severe atopic dermatitis: a phase II, multicentre randomized, vehicle‐controlled clinical study
Summary Atopic dermatitis (eczema) is a chronic, and sometimes debilitating, inflammatory skin disease which causes itching and damaged skin barrier function. Current treatments include topical (applied to the skin) corticosteroids and calcineurin inhibitors such as tacrolimus; unfortunately long‐term use of topical corticosteroids may cause thinning of the skin and tacrolimus can be irritant. Kinases are enzymes that are important to many roles of cells within the body, and the Janus Kinase (JAK) pathway plays a role in inflammation. In recent years, medicines that inhibit this pathway have been developed, with potentia...
Source: British Journal of Dermatology - February 14, 2018 Category: Dermatology Authors: H. Nakagawa, O. Nemoto, A. Igarashi, T. Nagata Tags: Plain Language Summary Source Type: research

Dupilumab treatment improves quality of life in adult patients with moderate ‐to‐severe atopic dermatitis: results from a randomized, placebo‐controlled clinical trial
Summary Atopic dermatitis is a skin disease, commonly known as eczema. It affects up to 1 in 10 adults. Atopic dermatitis is usually very itchy, causing people to wake up at night, and feel “low”. This state of general discomfort is known as reduced quality of life. Dupilumab is a new treatment approved in the U.S.A. for adults with moderate‐to‐severe atopic dermatitis. The treatment blocks some of the mechanisms involved in the disease. In a clinical trial conducted in Europe, researchers observed 109 patients with moderate‐to‐severe atopic dermatitis. The patients received dupilumab over 12 weeks...
Source: British Journal of Dermatology - February 14, 2018 Category: Dermatology Authors: A. Tsianakas, T.A. Luger, A. Radin Tags: Plain Language Summary Source Type: research

Colchicine: an ancient drug with novel applications
Summary Colchicine is one of the oldest remedies still in use today. It is derived from the bulb‐like corms of the Colchicum autumnale plant, also known as autumn crocus. Its history as an herbal remedy for joint pain goes back at least a thousand years, and it is used to treat disorders including gout and Familial Mediterranean Fever. Despite this, exactly how colchicine works is still being explored. More recently, colchicine has been reported to be an effective treatment for several skin diseases, including Behçet's disease, epidermolysis bullosa acquisita, leukocytocastic vasculitis, Sweet's syndrome and recur...
Source: British Journal of Dermatology - February 14, 2018 Category: Dermatology Authors: B. Dasgeb, D. Kornreich, K. McGuinn, L. Okon, I. Brownell, D.L. Sackett Tags: Plain Language Summary Source Type: research

Time, Psoriasis Area and Severity Index and Dermatology Life Quality Index of patients with psoriasis who drop out of clinical trials on etanercept because of lack of efficacy: a pooled analysis from 10 clinical trials
In this study, the researchers looked at clinical trials involving a drug for psoriasis called etanercept, to learn more about the number of patients who drop out due to ‘lack of efficacy’, when they most commonly do so, and how this relates to their PASI and DLQI. Of 6119 patients taking part in the studies looked at, 128 dropped out due to ‘lack of efficacy’. The highest increase of patients dropping out happened between Day 75 and 85. The lowest PASI score of patients dropping out was 6.3 within 120 days. Dropouts who achieved ≥ PASI 75 were rare. The authors conclude that around Day 80 i...
Source: British Journal of Dermatology - February 14, 2018 Category: Dermatology Authors: A. Nast, M. Dilleen, W. Liyanage, L. Aikman, P. Szczypa, C. Dressler Tags: Plain Language Summary Source Type: research

Establishing and prioritizing research questions for the prevention, diagnosis and treatment of hair loss (excluding alopecia areata): the Hair Loss Priority Setting Partnership
This study, funded by the charity Alopecia UK, aimed to identify uncertainties in hair loss management, prevention, diagnosis and treatment that are important both to people with hair loss and to healthcare professionals. This was done by creating a hair loss ‘priority setting partnership’ (PSP) between patients, their carers and relatives, and healthcare professionals, to identify the most important uncertainties in hair loss. This study presents the top 10 research priorities for hair loss (excluding alopecia areata) to guide researchers and funding bodies to support studies important both to patients and cli...
Source: British Journal of Dermatology - February 14, 2018 Category: Dermatology Authors: A. Macbeth, J. Tomlinson, A. Messenger, K. Moore ‐Millar, C. Michaelides, A. Shipman, J. Kassim, J. Brockley, W. Szczecinska, P. Farrant, R. Robinson, J. Rodgers, J. Chambers, S. Upadhyaya, M. Harries Tags: Plain Language Summary Source Type: research

Intravenous immunoglobulin as adjunct therapy for refractory pyoderma gangrenosum: systematic review of cases and case series
This study is a review of previously published studies using this technique. The authors from Harvard and hospitals in Boston, U.S.A., identified 49 patients who had received this treatment after the failure of other therapies, such as oral corticosteroids and cyclosporine, to improve the condition. Most had at least one underlying disease including cancer or inflammatory bowel disease such as ulcerative colitis. The skin damage affected different body sites such as the lower limbs or trunk. In most cases the patients were also receiving oral corticosteroids at the time of the IVIG treatment. Over half the patients respond...
Source: British Journal of Dermatology - February 14, 2018 Category: Dermatology Authors: H. Song, N. Lahood, A. Mostaghimi Tags: Plain Language Summary Source Type: research

Safety, efficacy, and drug survival of biologics and biosimilars for moderate ‐to‐severe plaque psoriasis
Summary Psoriasis, a common disease affecting 2‐3% of the world's population, may in moderate‐to‐severe cases require systemic treatment with biological drugs (biologics). Treatment is usually permanent, but these drugs may loose their effect over time. When the patent for the original (originator) drug expires, other companies can produce a biosimilar, i.e. a drug that is very similar (but not completely identical, since biologics are derived from living human genes) to the originator. This Danish study compared safety, efficacy, and drug survival (i.e. how long patients stay on therapy) for five biologics: adalimum...
Source: British Journal of Dermatology - February 14, 2018 Category: Dermatology Authors: A. Egeberg, M.B. Ottosen, R. Gniadecki, S. Broesby ‐Olsen, T.N. Dam, L.E. Bryld, M.K. Rasmussen, L. Skov Tags: Plain Language Summary Source Type: research

Phase IV head ‐to‐head randomized controlled trial comparing ingenol mebutate 0·015% gel with diclofenac sodium 3% gel for the treatment of actinic keratosis on the face or scalp
This study from Germany, Spain and the U.K. compared the effectiveness of two gel treatments for actinic keratosis (AK) on the face or scalp. An AK is a small, spiky, scaly or sandpaper‐like area of sun damage on the skin surface. A very small proportion progress to squamous cell skin cancer. Creams or gels rubbed into the skin are recommended when a large area such as the entire scalp is affected by multiple AKs. Ingenol mebutate 0·015% gel (IngMeb) and diclofenac sodium 3% gel (DS) were compared in 502 patients, mostly male and almost all white‐skinned. IngMeb was applied once daily for three consecutive days ...
Source: British Journal of Dermatology - February 14, 2018 Category: Dermatology Authors: E. Stockfleth, C.A. Harwood, C. Serra ‐Guillén, T. Larsson, M.L. Østerdal, T. Skov Tags: Plain Language Summary Source Type: research

Is ultraviolet exposure acquired at work the most important risk factor for cutaneous squamous cell carcinoma? Results of the population ‐based case–control study FB‐181
Summary Squamous cell carcinoma (SCC) is a specific type of skin cancer. It is one of the most common cancers in Europe. SCC therefore causes a significant burden, both for the people affected and also in terms of costs to society. One main cause of SCC is exposure to natural sunlight. SCC can be prevented by avoiding sun exposure. When people go outside, they can protect themselves through clothes (e.g. long sleeves, hat) and using sunscreens. Until now, prevention programs for SCC and other skin cancers have mainly tried to reduce sun exposure during leisure time. However, there are many people working outdoors, e.g. far...
Source: British Journal of Dermatology - February 14, 2018 Category: Dermatology Authors: J. Schmitt, E. Haufe, F. Trautmann, H. ‐J. Schulze, P. Elsner, H. Drexler, A. Bauer, S. Letzel, S.M. John, M. Fartasch, T. Brüning, A. Seidler, S. Dugas‐Breit, M. Gina, W. Weistenhöfer, K. Bachmann, I. Bruhn, B.M. Lang, S. Bonness, J.P. Allam, W. Gr Tags: Plain Language Summary Source Type: research

A phenotype combining hidradenitis suppurativa with Dowling –Degos disease caused by a founder mutation in PSENEN
In conclusion, in this present study we showed a new genetic defect in PSENEN that can cause two diseases at once: Dowling‐Degos disease and hidradenitis suppurativa. We also show that NOTCH is important in both of these diseases. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - February 14, 2018 Category: Dermatology Authors: M. Pavlovsky, O. Sarig, M. Eskin ‐Schwartz, N. Malchin, R. Bochner, J. Mohamad, A. Gat, A. Peled, A. Hafner, E. Sprecher Tags: Plain Language Summary Source Type: research

Do perioperative antibiotics reduce the risk of surgical ‐site infections following excision of ulcerated skin cancers? A Critically Appraised Topic
This report aimed to review all the research evidence available to help doctors decide if prescribing antibiotics to patients having skin cancers removed by surgery, reduces the chances of wound infection after their skin surgery. A total of 1018 scientific articles were identified in the English Language. The team identified 13 trials as high quality (called randomised controlled trials) where different types of antibiotics were used to see if they reduced infection rates after skin surgery. These included antibiotics applied on the wound surface, antibiotics ingested by mouth, antibiotics given by injection into the musc...
Source: British Journal of Dermatology - February 14, 2018 Category: Dermatology Authors: S.A. Chan, A.G.H. Wernham, N. Stembridge, N. Harper, S. Verykiou, G.A. Fremlin, R.A. Abbott, R.N. Matin Tags: Plain Language Summary Source Type: research

Wet work exposure and hand eczema among healthcare workers: a cross ‐sectional study
This study shows that hand eczema still is common in healthcare workers. Educational programmes directed at prevention of hand eczema are needed. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - February 14, 2018 Category: Dermatology Authors: N. Hamnerius, C. Svedman, O. Bergendorff, J. Bj örk, M. Bruze, A. Pontén Tags: Plain Language Summary Source Type: research

Optical transfer diagnosis differentiating benign and malignant pigmented lesions in a simulated primary care practice
In this study, from the U.S.A., U.K. and Norway, the authors took images using OTD and then analysed 712 pigmented lesions (which could be moles or melanomas). Of them, 415 were harmless, or ‘benign’, and 297 were suspicious when examined by specialists using a magnifier called a dermatoscope. After image capture, all of the suspicious moles were biopsied and the tissue samples were examined under the miscroscope. Of the suspicious lesions, 80 proved to be cancer on biopsy (64 melanomas, and 16 other types of skin cancer). OTD misdiagnosed 1 of the 80 cancerous lesions as benign. If verified in further studies,...
Source: British Journal of Dermatology - February 14, 2018 Category: Dermatology Authors: D.L. Swanson, R.V. Venneugues, S.Q. Vicencio, J. Garioch, M. Biryulina, G. Ryzhikov, B. Hamre, L. Zhao, F.S. Castellana, K. Stamnes, J.J. Stamnes Tags: Plain Language Summary Source Type: research

Developing and validating the Cutaneous WARTS (CWARTS) diagnostic tool: a novel clinical assessment and classification system for cutaneous warts
This study from the Netherlands aimed to develop and test an accurate diagnostic tool to help clinicians diagnose warts. The authors defined nine characteristics of appearance using literature and interviews with experts. This led to the development of the Cutaneous WART Diagnostic tool (the CWARTS diagnostic tool). The study consisted of two parts. In the first part, part A, 28 researchers (‘observers’) assessed photographs of 10 warts and the team investigated how well the researchers agreed with each other. In the second part, part B, this was repeated with 6 researchers and 299 warts and the team ...
Source: British Journal of Dermatology - February 14, 2018 Category: Dermatology Authors: G.K. Hogendoorn, S.C. Bruggink, K.E. Hermans, S.T.P. Kouwenhoven, K.D. Quint, R. Wolterbeek, J.A.H. Eekhof, M.N.C. de Koning, R. Rissmann, J. Burggraaf, J.N. Bouwes Bavinck Tags: Plain Language Summary Source Type: research

Skin signs of primary immunodeficiencies: how to find the genes to check
Summary Primary immunodeficiencies are rare chronic disorders, in which parts of the immune system either lack or function improperly. Thus, the immune system is weakened, and patients are more susceptible to germs that can cause infections. Patients can have various symptoms, but all have repeated prolonged and/or serious infections, sometimes from uncommon germs. Half of the patients have symptoms on their skin, which can help a doctor to recognize the underlying immune disorder. Therefore, the authors of this study provide a table to make it easier for the physician to diagnose an immune disorder according to the skin s...
Source: British Journal of Dermatology - February 14, 2018 Category: Dermatology Authors: M. Ettinger, J. Schreml, K. Wirsching, M. Berneburg, S. Schreml Tags: Plain Language Summary Source Type: research

British Society for Paediatric Dermatology 32nd Annual Meeting, Aston Conference Centre, Birmingham, 10 –11 November 2017
(Source: British Journal of Dermatology)
Source: British Journal of Dermatology - February 14, 2018 Category: Dermatology Tags: Abstracts Source Type: research

Image Gallery: Paraneoplastic pemphigus and follicular dendritic cell sarcoma
(Source: British Journal of Dermatology)
Source: British Journal of Dermatology - February 14, 2018 Category: Dermatology Authors: M.F. Jonkman, H.H. Pas Tags: Image Correspondence Source Type: research

Image Gallery: Periumbilical purpura: a  dermatological clue for disseminated strongyloidiasis
(Source: British Journal of Dermatology)
Source: British Journal of Dermatology - February 14, 2018 Category: Dermatology Authors: C.P.H. Reinehr, C.R. Barone, A.P. Naspolini, A. Cartell, R.M. Bakos Tags: Image Correspondence Source Type: research

Image Gallery: Acquired zinc deficiency of prematurity
(Source: British Journal of Dermatology)
Source: British Journal of Dermatology - February 14, 2018 Category: Dermatology Authors: Z.R. Csoma, L. Kem ény Tags: Image Correspondence Source Type: research

Image Gallery: Pigmented mammary Paget disease: a rare clinicopathological variant mimicking melanoma
(Source: British Journal of Dermatology)
Source: British Journal of Dermatology - February 14, 2018 Category: Dermatology Authors: E.E. Dando, G.F.S. Lim, J. Ho, A. James Tags: Image Correspondence Source Type: research