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Aprepitant improves refractory pruritus in primary cutaneous T ‐cell lymphomas: experience of the Spanish Working Group on Cutaneous Lymphomas
This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - November 18, 2017 Category: Dermatology Authors: L. Maro ñas‐Jiménez, T. Estrach, F. Gallardo, A. Pérez, H. Andrés Borja, O. Servitje, S. Pérez Gala, M. Linares Barrio, D. Jiménez Gallo, D J. Sanz‐Bueno, D. Lora, V. Monsálvez, P. L. Ortiz‐Romero Tags: Research Letter Source Type: research

Chronic sun exposure is associated with distinct histone acetylation changes in human skin
ConclusionsChronic sun exposure induced histone H3 hyperacetylation may play a critical role in the pathogenesis of skin photoaging.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - November 18, 2017 Category: Dermatology Authors: S. Ding, J. Chen, Q. Zeng, J. Lu, L. Tan, A. Guo, J. Kang, S. Yang, Y. Xiang, C. Zuo, J. Huang Tags: Original Article Source Type: research

Response to “IL‐36 in hidradenitis suppurativa: Evidence for a distinctive pro‐inflammatory role and a key factor in the development of an inflammatory loop”
This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - November 18, 2017 Category: Dermatology Authors: A. Balato, G. Caiazzo, R. Di Caprio, S. Lembo, A. Raimondo, G. Monfrecola, G. Fabbrocini Tags: Letter to the Editor Source Type: research

Response to ‘Clinical presentation of terbinafine‐induced severe liver injury and the value of laboratory monitoring: a critically appraised topic’
This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - November 18, 2017 Category: Dermatology Authors: A. Khurana, K. Sardana, V. Bhardwaj Tags: Letter to the Editor Source Type: research

The expanding spectrum of clinical phenotypes associated with PSTPIP1 mutations: from PAPA to PAMI syndrome and beyond
This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - November 18, 2017 Category: Dermatology Authors: H. ‐W. Klötgen, H. Beltraminelli, N. Yawalkar, M.E. van Gijn, D. Holzinger, L. Borradori Tags: Research Letter Source Type: research

How well are reporting guidelines and trial registration used by dermatology journals to limit bias? A meta ‐epidemiological study
This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - November 18, 2017 Category: Dermatology Authors: C. Cook, J. X. Checketts, P. Atakpo, N. Nelson, M. Vassar Tags: Research Letter Source Type: research

Q ‐switched 532nm laser energy causes significant vascular damage in the capillary plexus – how does this affect laser tattoo removal?
This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - November 18, 2017 Category: Dermatology Authors: M. Murphy Tags: Research Letter Source Type: research

A Phase I Randomised Controlled Trial to Evaluate Safety and Clinical Effect of Topically Applied GSK2981278 Ointment in a Psoriasis Plaque Test
This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - November 18, 2017 Category: Dermatology Authors: E. G. Kang, S. Wu, A. Gupta, Y ‐L. von Mackensen, H. Siemetzki, J. M. Freudenberg, W. Wigger‐Alberti, Y. Yamaguchi Tags: Research Letter Source Type: research

Serum thymus and activation ‐regulated chemokine (TARC) is associated with the severity of drug reaction with eosinophilia and systemic symptoms/drug‐induced hypersensitivity syndrome (DRESS/DIHS)
This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - November 18, 2017 Category: Dermatology Authors: Y. Nakamura ‐Nishimura, F. Miyagawa, K. Miyashita, R. Ommori, H. Azukizawa, H. Asada Tags: Research Letter Source Type: research

Coexistence of Eph receptor B1 and ephrin B2 in port ‐wine stain endothelial progenitor cells contributes to clinicopathological vasculature dilatation
ConclusionsPWS ECs are differentiation‐impaired, late‐stage endothelial progenitor cells with a specific phenotype of CD133+/CD166+/EphB1+/EfnB2+, which form immature venule‐like pathoanatomical vasculatures. The disruption of normal EC–EC interactions by coexistence of EphB1 and EfnB2 contributes to progressive dilatation of PWS vasculatures. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - November 16, 2017 Category: Dermatology Authors: W. Tan, J. Wang, F. Zhou, L. Gao, R. Yin, H. Liu, A. Sukanthanag, G. Wang, M.C. Mihm, D. ‐B. Chen, J.S. Nelson Tags: Translational Research Source Type: research

Analysis of anti ‐TNF‐induced skin lesions reveals strong Th1 activation with some distinct immunological characteristics
ConclusionsNew‐onset anti‐TNF‐α‐induced eruptions previously classified as psoriasis or spongiotic dermatitis (eczema) exhibit a molecular profile that is different from either of these disorders.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - November 16, 2017 Category: Dermatology Authors: E. Stoffel, H. Maier, E. Riedl, M. ‐C. Brüggen, B. Reininger, M. Schaschinger, C. Bangert, E. Guenova, G. Stingl, P.M. Brunner Tags: Original Article Source Type: research

Underreported use of palliative care and patient ‐reported outcome measures to address reduced quality of life in patients with calciphylaxis: a systematic review
Summary Calciphylaxis is associated with significant morbidity and mortality. Palliative care (PC) is a subspecialty that treats the pain and stress of serious illness. To assess whether the role of quality of life (QoL) indices, patient‐reported outcome measures and PC have been studied in patients with calciphylaxis, we performed a systematic literature review. Several databases were searched from inception to October 2016 according to modified Preferred Reporting Items for Systematic Reviews and Meta‐Analyses criteria. We searched for papers on calciphylaxis that mentioned the symptoms and supportive needs of patien...
Source: British Journal of Dermatology - November 16, 2017 Category: Dermatology Authors: C.A. Riemer, R.A. el ‐Azhary, K.L. Wu, J.J. Strand, J.S. Lehman Tags: Systematic Review Source Type: research

Heterogeneity of trichoscopy findings in dissecting cellulitis of the scalp: correlation with disease activity and duration
(Source: British Journal of Dermatology)
Source: British Journal of Dermatology - November 16, 2017 Category: Dermatology Authors: A.E. Verz ì, F. Lacarrubba, G. Micali Tags: Research Letter Source Type: research

Recommendation to test limonene hydroperoxides 0 ·3% and linalool hydroperoxides 1·0% in the British baseline patch test series
ConclusionsWe recommend that limonene hydroperoxides be tested at 0·3% and linalool hydroperoxides at 1·0% in the British baseline patch test series. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - November 16, 2017 Category: Dermatology Authors: C. Wlodek, C.M. Penfold, J.F. Bourke, M.M.U. Chowdhury, S.M. Cooper, S. Ghaffar, C. Green, C.R. Holden, G.A. Johnston, A.A. Mughal, C. Reckling, R.A. Sabroe, N.M. Stone, D. Thompson, S.M. Wilkinson, D.A. Buckley Tags: General Dermatology Source Type: research

Infections from seven clinical trials of ixekizumab, an anti ‐interleukin‐17A monoclonal antibody, in patients with moderate‐to‐severe psoriasis
Summary BackgroundInfections are associated with biological therapies in psoriasis. ObjectivesTo summarize the incidence of infections in patients with moderate‐to‐severe psoriasis treated with ixekizumab, an anti‐interleukin‐17A monoclonal antibody. MethodsInfections are summarized from an integrated database of seven controlled and uncontrolled ixekizumab psoriasis trials. Data are presented from placebo‐controlled induction (weeks 0–12; UNCOVER‐1, UNCOVER‐2 and UNCOVER‐3) and maintenance periods (weeks 12–60; UNCOVER‐1 and UNCOVER‐2), and all patients exposed to ixekizumab pooled from all...
Source: British Journal of Dermatology - November 16, 2017 Category: Dermatology Authors: K.A. Papp, H. Bachelez, A. Blauvelt, K.L. Winthrop, R. Romiti, M. Ohtsuki, N. Acharya, D.K. Braun, L. Mallbris, F. Zhao, W. Xu, C.D. Walls, B. Strober Tags: Clinical Trial Source Type: research

Prognostic role of histological regression in primary cutaneous melanoma: a systematic review and meta ‐analysis
Summary The prognostic significance of histological regression in primary melanoma has been debated for many years. We aim to review the evidence to see how histological regression may affect prognosis. A systematic review was performed by searching in MEDLINE, Scopus and the Cochrane Library from 1 January 1966 to 1 August 2015. All studies reporting hazard ratios or data on survival and histological regression were included. Primary random‐effects meta‐analyses were used to summarize outcome measures. Heterogeneity was assessed using the χ2‐test and I2‐statistic. To assess the potential bias of small studies ...
Source: British Journal of Dermatology - November 15, 2017 Category: Dermatology Authors: M.R. Gualano, S. Osella ‐Abate, G. Scaioli, E. Marra, F. Bert, E. Faure, E.S. Baduel, E. Balagna, P. Quaglino, M.T. Fierro, R. Siliquini, S. Ribero Tags: Systematic Review Source Type: research

Quality of life in patients with vitiligo using the Short Form ‐36
(Source: British Journal of Dermatology)
Source: British Journal of Dermatology - November 15, 2017 Category: Dermatology Authors: Y. Yang, L. Zapata, C. Rodgers, K. Hernandez, M. Iyer, G. Jia, L. S. Hynan, A.G. Pandya Tags: Letter to the Editor Source Type: research

Effect of long ‐term treatment with tumour necrosis factor‐α inhibitors on single‐dose ultraviolet‐induced changes in human skin
(Source: British Journal of Dermatology)
Source: British Journal of Dermatology - November 15, 2017 Category: Dermatology Authors: H.J. Kim, J.L. Langenhan, E.S. Robinson, E. Privette, J.C. Achtman, R.A. Mitrani, M. Zeidi, M.R. Sharma, R. Feng, J.L. Nevas, C. Calianno, J. Okawa, L. Taylor, L. Pappas ‐Taffer, V.P. Werth Tags: Letter to the Editor Source Type: research

A comparison of programmable and nonprogrammable compression devices for treatment of lymphoedema using an administrative health outcomes dataset
Summary BackgroundPatients with lymphoedema experience lifelong swelling and recurrent cellulitis despite use of complete decongestive therapy. Pneumatic compression devices (PCDs), including nonprogrammable and programmable devices that meet individual patient needs, support long‐term self‐care in the home. ObjectivesPatients with either a nonprogrammable device (NP‐PCD) or a dynamic pressure programmable device [P‐PCD; Flexitouch® (Tactile Medical, Minneapolis, MN, U.S.A.)] were evaluated to compare associated clinical and health utilization outcomes pre‐/postdevice acquisition. MethodsRetrospective analysi...
Source: British Journal of Dermatology - November 14, 2017 Category: Dermatology Authors: P. Karaca ‐Mandic, A.T. Hirsch, S.G. Rockson, S.H. Ridner Tags: General Dermatology Source Type: research

Prognostic importance of a second invasive primary melanoma according to tumour stage
Respond to this article (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - November 14, 2017 Category: Dermatology Authors: D.R. Youlden, P.D. Baade, J.F. Aitken, A.C. Green, K. Khosrotehrani Tags: Research Letter Source Type: research

Inhibition of p38MAPK signalling prevents epidermal blistering and alterations of desmosome structure induced by pemphigus autoantibodies in human epidermis
ConclusionsOur data demonstrate that blistering can be prevented by inhibition of p38MAPK in the human epidermis. Moreover, typical morphological alterations induced by mcPV‐IgG such as interdesmosomal widening and the reduction of desmosome size at least in part require p38MAPK signalling. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - November 14, 2017 Category: Dermatology Authors: D.T. Egu, E. Walter, V. Spindler, J. Waschke Tags: Translational Research Source Type: research

Generating new evidence, improving clinical practice and developing research capacity: the benefits of recruiting to the U.K. Dermatology Clinical Trials Network's STOP GAP and BLISTER trials
Summary Clinical trials may benefit clinical practice in three ways: firstly, clinicians may change their practice according to the new trial evidence; secondly, clinical processes can improve when working on a trial; and thirdly, research capacity is increased. We held a meeting to present and discuss the results of two large multicentre randomized controlled trials delivered through the U.K. Dermatology Clinical Trials Network. Investigators gave reflections on how the trials had changed their clinical practice. The STOP GAP trial showed that prednisolone and ciclosporin are equally effective as first‐line systemic tre...
Source: British Journal of Dermatology - November 10, 2017 Category: Dermatology Authors: J.M. Batchelor, A. Chapman, F.E. Craig, K.E. Harman, G. Kirtschig, A. Martin ‐Clavijo, A.D. Ormerod, S. Walton, H.C. Williams Tags: Meeting Report Source Type: research

Paradoxical psoriasiform reactions to antitumour necrosis factor ‐α drugs in hidradenitis suppurativa
(Source: British Journal of Dermatology)
Source: British Journal of Dermatology - November 10, 2017 Category: Dermatology Authors: L. Dequidt, O. Cogrel, S. Guillet, B. Milpied, A.S. Darrigade, M. Beylot ‐Barry, A. Pham‐Ledard Tags: Research Letter Source Type: research

Response to “Providing dermatological care in resource‐limited settings: barriers and potential solutions”
This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - November 9, 2017 Category: Dermatology Authors: A. Mah é, O. Faye Tags: Letter to the Editor Source Type: research

Psychological stress and psoriasis. A systematic review and meta ‐analysis
Abstract BackgroundPsychological stress has long been linked with psoriasis exacerbation/onset. However, it is unclear if they are associated. ObjectiveTo determine if antecedent psychological stress and psoriasis exacerbation/onset are associated. MethodsA comprehensive search of Pubmed, PsycINFO, Cochrane library, and clinicaltrials. gov databases was performed. Studies investigating the association between preceding psychological stress and psoriasis exacerbation/onset were classified as cross‐sectional, case‐control or cohort. Surveys evaluating beliefs regarding stress‐reactivity were analysed separately. Suitab...
Source: British Journal of Dermatology - November 9, 2017 Category: Dermatology Authors: I. Snast, O. Reiter, L. Atzmony, Y.A. Leshem, E. Hodak, D. Mimouni, L. Pavlovsky Tags: Systematic Review Source Type: research

Patients with atopic dermatitis with filaggrin loss ‐of‐function mutations show good but lower responses to immunosuppressive treatment
(Source: British Journal of Dermatology)
Source: British Journal of Dermatology - November 6, 2017 Category: Dermatology Authors: E. Roekevisch, M.M.G. Leeflang, M.E. Schram, L.E. Campbell, W.H. Irwin McLean, S. Kezic, J.D. Bos, P.I. Spuls, M.A. Middelkamp ‐Hup Tags: Research Letter Source Type: research

A systematic review of diagnostic criteria for psoriasis in adults and children: Evidence from studies with a primary aim to develop or validate diagnostic criteria
ConclusionClinical examination‐based diagnostic criteria are currently lacking for psoriasis. Future research could follow an international collaborative approach and employ high quality diagnostic accuracy study design. Existing and newly developed criteria require validation.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - November 6, 2017 Category: Dermatology Authors: E. Burden ‐Teh, R.C. Phillips, K.S. Thomas, S. Ratib, D. Grindlay, R. Murphy Tags: Review Article Source Type: research

Prevalence and incidence of chronic spontaneous urticaria in the entire Korean adult population
This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - November 6, 2017 Category: Dermatology Authors: Y. S Kim, S. H Park, K Han, C. H Bang, J. H Lee, Y. M Park Tags: Research Letter Source Type: research

The EVerT2 (Effective Verruca Treatments 2) trial: a randomized controlled trial of needling vs. nonsurgical debridement for the treatment of plantar verrucae
ConclusionsThere is no evidence that the needling technique is more clinically or cost‐effective than callus debridement. The results show a significant improvement in pain outcomes after needling compared with the debridement treatment alone. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - November 1, 2017 Category: Dermatology Authors: F. Hashmi, C. Fairhurst, S. Cockayne, M. Cullen, K. Bell, E. Coleman, M. Harrison ‐Blount, D. Torgerson Tags: Clinical Trial Source Type: research

Age ‐related reduction of dermal fibroblast size upregulates multiple matrix metalloproteinases as observed in aged human skin in vivo
ConclusionsCombined actions of the wide variety of MMPs that are constitutively elevated in aged dermis may be involved in the progressive degradation of dermal collagen fibrils. Age‐related elevations of multiple MMPs are likely to be a result of the reduction of fibroblast size via activation of AP‐1. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - November 1, 2017 Category: Dermatology Authors: Z. Qin, R.M. Balimunkwe, T. Quan Tags: Translational Research Source Type: research

Population ‐based Clinical Practice Research Datalink study using algorithm modelling to identify the true burden of hidradenitis suppurativa
ConclusionsContrary to results of previous population‐based studies, HS is relatively common, with a UK prevalence of 0.77%, one‐third being unrecognised, criteria‐diagnosed cases using the most stringent disease definition. If probable cases are included, HS prevalence rises to 1.19%.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - November 1, 2017 Category: Dermatology Authors: J.R. Ingram, S. Jenkins ‐Jones, D.W. Knipe, C.L.I. Morgan, R. Cannings‐John, V. Piguet Tags: Original Article Source Type: research

A randomized controlled trial to evaluate the effect of a new skincare regimen on skin barrier function in those with podoconiosis in Ethiopia
Summary BackgroundPodoconiosis affects an estimated 3 million people in Ethiopia with a further 19 million at risk. Volcanic soil and pathogens enter skin breaches in the feet causing inflammation, lymphoedema and hyperkeratosis. There is no robust evidence on optimal podoconiosis skincare regimens to improve skin barrier function (SBF). ObjectivesTo evaluate the effectiveness of a new, low‐cost, evidence‐based intervention to improve SBF in the lower limbs of those with podoconiosis. MethodsA randomized controlled trial (NCT02839772) was conducted over 3 months in two podoconiosis clinics (n = 193). The intervention c...
Source: British Journal of Dermatology - November 1, 2017 Category: Dermatology Authors: J. Brooks, S.J. Ersser, F. Cowdell, E. Gardiner, A. Mengistu, P.J. Matts Tags: General Dermatology Source Type: research

Development and validation of the International Hidradenitis Suppurativa Severity Score System (IHS4), a novel dynamic scoring system to assess HS severity
ConclusionsThe novel IHS4 is a validated tool to dynamically assess HS severity and can be used both in real‐life and the clinical trials setting. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - October 30, 2017 Category: Dermatology Authors: C.C. Zouboulis, T. Tzellos, A. Kyrgidis, G.B.E. Jemec, F.G. Bechara, E.J. Giamarellos ‐Bourboulis, J.R. Ingram, T. Kanni, I. Karagiannidis, A. Martorell, Ł. Matusiak, A. Pinter, E.P. Prens, D. Presser, S. Schneider‐Burrus, E. von Stebut, J.C. Szepiet Tags: Medical Dermatology Source Type: research

Research gaps in the management and prevention of cutaneous squamous cell carcinoma in organ transplant recipients
Summary Although tremendous progress has been made in recent years in skin cancer care for organ transplant recipients, significant gaps remain in data‐driven clinical guidelines, particularly for the treatment and prevention of cutaneous squamous cell carcinoma (cSCC), the most common malignancy among this population. In this review, we aim to summarize current knowledge around the management of cSCC and highlight the most significant gaps in knowledge that continue to pose challenges in the delivery of skin cancer care for organ transplant recipients. We suggest future directions for research that will bridge existing ...
Source: British Journal of Dermatology - October 30, 2017 Category: Dermatology Authors: M. Blomberg, S.Y. He, C. Harwood, S.T. Arron, S. Demehri, A. Green, M.M. Asgari, Tags: Scholarly Review Source Type: research

The pathogenesis of cutaneous squamous cell carcinoma in organ transplant recipients
We present an overview of those factors for which there is currently the most convincing evidence and highlight important gaps in our knowledge. In particular, a clear understanding of the interdependence and relative contributions of these co‐factors is currently lacking, yet has important implications for rational development of clinically relevant biomarkers and targeted strategies for treatment and prevention of post‐transplant keratinocyte cancers. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - October 30, 2017 Category: Dermatology Authors: C.A. Harwood, A.E. Toland, C.M. Proby, S. Euvrard, G.F.L. Hofbauer, M. Tommasino, J.N. Bouwes Bavinck, Tags: Scholarly Review Source Type: research

An open, multicentre, randomized clinical study in patients with bullous pemphigoid comparing methylprednisolone and azathioprine with methylprednisolone and dapsone
ConclusionsDue to the lower than intended number of patients, the results of the primary and secondary end points were not or only barely significant. Dapsone appeared to have a moderately higher corticosteroid‐sparing potential than azathioprine. The combination regimen of either drug with oral methylprednisolone is associated with a relatively low 1‐year mortality in this vulnerable patient population. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - October 29, 2017 Category: Dermatology Authors: M. Sticherling, A. Franke, E. Aberer, R. Gl äser, M. Hertl, C. Pfeiffer, B. Rzany, S. Schneider, I. Shimanovich, T. Werfel, A. Wilczek, D. Zillikens, E. Schmidt Tags: Clinical Trials Source Type: research

Supervised exercise training as an adjunct therapy for venous leg ulcers: a randomised controlled feasibility trial
ConclusionsOur findings support the feasibility and acceptability of both the supervised exercise programme in conjunction with compression therapy and the study procedures. The next step will be the design and implementation of an appropriately‐powered, multi‐centre trial.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - October 27, 2017 Category: Dermatology Authors: M. Klonizakis, G. A. Tew, A. Gumber, H. Crank, B. King, G. Middleton, J. A. Michaels Tags: Original Article Source Type: research

Natural history and clinical outcome of junctional epidermolysis bullosa generalized intermediate due to a LAMA3 mutation
This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - October 27, 2017 Category: Dermatology Authors: A. Reimer, A. Schwieger ‐Briel, Y. He, J. Leppert, F. Schauer, D. Kiritsi, H. Schneider, H. Ott, L. Bruckner‐Tuderman, C. Has Tags: Research Letter Source Type: research

Postzygotic mosa ïcism and incontinentia pigmenti in male patients:molecular diagnosis yield
This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - October 27, 2017 Category: Dermatology Authors: Z. Alabdullatif, J. Coulombe, J. Steffann, C. Bodemer, S. Hadj ‐Rabia Tags: Research Letter Source Type: research

Laser treatment of congenital melanocytic nevi: a systematic review
This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - October 27, 2017 Category: Dermatology Authors: C. A. M. Eggen, J. E. Lommerts, E. J. van Zuuren, J. Limpens, S. G. M. A Pasmans, A. Wolkerstorfer Tags: Systematic Review Source Type: research

In vivo Zika virus detection in human skin
This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - October 27, 2017 Category: Dermatology Authors: N. Cordel, V. H ébert, A. Vega Rua, C. Herrmann‐Storck Tags: Research Letter Source Type: research

Job change facilitates healing in a cohort of patients with occupational hand eczema
ConclusionChange of profession has a beneficial effect on eczema parameters, but a negative effect on HR‐QoL, indicated by increased DLQI. Change of work procedures while staying in the same profession positively influenced improvement, with no marked influence on HR‐QoL, and should be considered as an alternative to job change.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - October 27, 2017 Category: Dermatology Authors: T. K. Car øe, N. E. Ebbehøj, J. P. E. Bonde, S. G. Vejlstrup, T. Agner Tags: Original Article Source Type: research

Epidemiology of Staphylococcal Scalded Skin Syndrome in United States Children
Abstract BackgroundStaphylococcal scalded skin syndrome (SSSS) is a blistering dermatosis caused by exfoliative toxins released from Staphylococcus aureus. We sought to describe the incidence, costs, length of stay (LOS), comorbidities, and mortality of SSSS in US children. MethodsThe Nationwide Inpatient Sample 2008‐2012 was analyzed, including a 20% sample of US hospitalizations and 589 cases of SSSS. ResultsThe annual incidence of SSSS was 7.67 (range: 1.83–11.88) per‐million US children, with 45.1 cases per‐million US infants age
Source: British Journal of Dermatology - October 27, 2017 Category: Dermatology Authors: A. Staiman, D. Y Hsu, J. I Silverberg Tags: Original Article Source Type: research

Fluorescence ‐advanced videodermatoscopy: a new method for in vivo skin evaluation
(Source: British Journal of Dermatology)
Source: British Journal of Dermatology - October 27, 2017 Category: Dermatology Authors: M. Sanlorenzo, I. Vujic, V. De Giorgi, C. Tomasini, T. Deboli, P. Quaglino, M.T. Fierro, P. Broganelli Tags: Research Letter Source Type: research

Dermoscopy use by Canadian dermatologists and dermatology residents: a cross ‐sectional nationwide study
(Source: British Journal of Dermatology)
Source: British Journal of Dermatology - October 26, 2017 Category: Dermatology Authors: T. Burbidge, W. Davidson, L. Robertson Tags: Research Letter Source Type: research

The role of the microbiome in psoriasis: moving from disease description to treatment prediction?
This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - October 26, 2017 Category: Dermatology Authors: E.A. Langan, C.E.M. Griffiths, W. Solbach, J.K. Knobloch, D. Zillikens, D Tha çi Tags: Review Article Source Type: research

Letter to the Editor re: ‘Long‐term complications of Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN): the spectrum of chronic problems in patients who survive an episode of SJS/TEN necessitates multidisciplinary follow‐up’
(Source: British Journal of Dermatology)
Source: British Journal of Dermatology - October 25, 2017 Category: Dermatology Authors: C. Olteanu, N. Shear, R. Hashimoto, R. P. Dodiuk ‐Gad Tags: Letter to the Editor Source Type: research

Heat shock protein 70 potentiates interferon alpha production by plasmacytoid dendritic cells: relevance for cutaneous lupus and vitiligo pathogenesis
ConclusionsThese data demonstrate that interaction between HSP70 and pDCs in CLE and vitiligo is a prerequisite for the enhancement of IFN‐α production, and could be an interesting target. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - October 25, 2017 Category: Dermatology Authors: C. Jacquemin, J. Rambert, S. Guillet, D. Thiolat, N. Boukhedouni, M. ‐S. Doutre, A.‐S. Darrigade, K. Ezzedine, P. Blanco, A. Taieb, K. Boniface, J. Seneschal Tags: Translational Research Source Type: research

From basal cell carcinoma morphogenesis to the alopecia induced by hedgehog inhibitors: connecting the dots
Summary The deciphering of the hedgehog (Hh) signalling pathway implicated in the tumorigenesis of basal cell carcinoma (BCC) led to the development of targeted drug therapies, the Hh pathway inhibitors (HPIs) vismodegib and sonidegib. In the skin, physiological Hh signalling is activated in growing hair follicles (HFs), where it is required for proliferation of the epithelium of HFs during morphogenesis and for their postnatal growth. The effects of HPI treatment leading to the regression of BCC and the development of alopecia underpin the central role of the Hh pathway in BCC formation, as well as hair cycling. Given the...
Source: British Journal of Dermatology - October 25, 2017 Category: Dermatology Authors: C. Dessinioti, C. Antoniou, A.J. Stratigos Tags: Review Article Source Type: research

Clinical bandings of Patient ‐Oriented Eczema Measure scores among Japanese patients with atopic eczema
(Source: British Journal of Dermatology)
Source: British Journal of Dermatology - October 25, 2017 Category: Dermatology Authors: Y. Yasukochi, M. Kido ‐Nakahara, T. Nakahara, R. Kuroki, T. Koga, T. Mashino, Y. Kurihara, M. Furue Tags: Research Letter Source Type: research