Redefining diuretics use in hypertension: why select a thiazide-like diuretic?

Diuretics are listed in hypertension guidelines as one of three equally weighted first-line treatment options. In order to differentiate between antihypertensives, a lot of discussion has been directed at side effect profiles and as a result, has created a perhaps disproportionate fear of the metabolic effects that can be associated with diuretics. Data, however, show that the risk of a clinically meaningful change in laboratory parameters is very low, whereas the benefits of volume control and natriuresis are high and the reductions in morbidity and mortality are clinically significant. Moreover, as clinically significant differences in safety and efficacy profiles exist among diuretics, several international guidelines have started making a distinction between thiazides (hydrochlorothiazide) and thiazide-like (chlorthalidone, indapamide) diuretics; and some of them now recommend longer acting thiazide-like diuretics. In time, pending more data, chlorthalidone and indapamide may need to be subdivided further into separate classifications.
Source: Journal of Hypertension - Category: Cardiology Tags: REVIEWS AND META-ANALYSES Source Type: research

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Publication date: Available online 4 June 2020Source: Pharmacological ResearchAuthor(s): Ying Huang, Changming Xie, Xiaoke Chen, Qianhui Hong, Hui Huang
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
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Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Tags: J Obstet Gynaecol Source Type: research
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Source: bizjournals.com Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
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Source: European Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Source Type: research
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Source: Revista Brasileira de Epidemiologia - Category: Epidemiology Source Type: research
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Source: Revista Brasileira de Epidemiologia - Category: Epidemiology Source Type: research
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Source: Revista Brasileira de Epidemiologia - Category: Epidemiology Source Type: research
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Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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