Evaluation of the Pharmacokinetics of Abiraterone Acetate and Abiraterone Following Single-Dose Administration of Abiraterone Acetate to Healthy Subjects
ConclusionThe ability to detect the low plasma abiraterone acetate concentrations, in addition to abiraterone, resulted in a complete characterization of the pharmacokinetics of abiraterone acetate that was not possible with other analytical methods that only measured the metabolite. The development of new bioanalytical methods such as these will allow for a more thorough understanding of the pharmacokinetics of abiraterone acetate, and this, in turn, can have an impact on both future examinations into abiraterone acetate pharmacokinetic behaviour and the evaluation of its generic formulations. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - January 22, 2019 Category: Drugs & Pharmacology Source Type: research

Correction to: Real-World Safety of Intravitreal Bevacizumab and Ranibizumab Treatments for Retinal Diseases in Thailand: A Prospective Observational Study
The Open Access license, which previously read. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - January 19, 2019 Category: Drugs & Pharmacology Source Type: research

Efficacy of Off-Label Topical Treatments for the Management of Androgenetic Alopecia: A Review
AbstractAndrogenetic alopecia (AGA) is characterized by non-scarring follicle miniaturization. Despite the success of approved therapies, commonly reported side effects and the need for continual use has led to the investigation of alternative therapies. The aim of this paper is to critically review the success of off-label, topical monotherapies for treatment of AGA in men. A literature search was conducted to obtain randomized, controlled and blinded studies that investigated off-label, topical, monotherapies in male patients. Hair density, hair diameter and hair growth were used to evaluate treatment success. Fourteen o...
Source: Clinical Drug Investigation - January 17, 2019 Category: Drugs & Pharmacology Source Type: research

Correction to: Unexpected Benefit from Alpelisib and Fulvestrant in a Woman with Highly Pre-treated ER-Positive, HER2-Negative PIK3CA Mutant Metastatic Breast Cancer
Dr. Arteaga serves on an Advisory Board for Novartis and was a consultant for AstraZeneca from 2015 to 2016. All other authors declare that they have no competing interests. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - January 12, 2019 Category: Drugs & Pharmacology Source Type: research

Opioid Use and Pain Control in the Elderly After Elective or Urgent Orthopaedic Surgery: A Retrospective Cohort Study
This study was conducted to evaluate whether older patients require lower opioid doses than their younger counterparts after undergoing an elective or urgent orthopaedic procedure, and to assess the cumulative incidence of adverse events and length of stay for each age group.MethodsA retrospective cohort study was performed to compare the mean opioid use and pain control between two groups of elderly patients (65 –79 years and ≥ 80 years of age). The study included 250 patients who underwent either an elective arthroplasty or urgent orthopaedic surgery following a fracture. Data were collected dur...
Source: Clinical Drug Investigation - January 10, 2019 Category: Drugs & Pharmacology Source Type: research

Clinical Characteristics of Japanese Patients with Palmoplantar Pustulosis
AbstractPalmoplantar pustulosis (PPP) is a chronic inflammatory disorder characterized by sterile pustules predominantly involving the palms and soles. The purpose of this review was to describe the characteristics of Japanese PPP patients as PPP is frequently observed within the Japanese population. Most Japanese dermatologists consider PPP a distinct entity, and co-existence of PPP and psoriasis is rare; however, outside Japan, PPP is often considered to be palmoplantar psoriasis, and an extra-palmoplantar lesion associated with PPP is considered to be psoriasis. PPP frequently develops or exacerbates following focal inf...
Source: Clinical Drug Investigation - January 10, 2019 Category: Drugs & Pharmacology Source Type: research

Response to Comments on “Pharmacokinetics, Pharmacodynamics, and Safety of the Novel Calcimimetic Agent Evocalcet in Healthy Japanese Subjects: First-in-Human Phase I Study”
(Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - January 10, 2019 Category: Drugs & Pharmacology Source Type: research

Comment on: Pharmacokinetics, Pharmacodynamics, and Safety of the Novel Calcimimetic Agent Evocalcet in Healthy Japanese Subjects: First-in-Human Phase I Study
(Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - January 10, 2019 Category: Drugs & Pharmacology Source Type: research

HIV Integrase Inhibitor Pharmacogenetics: An Exploratory Study
AbstractBackground and ObjectivesIntegrase strand transfer inhibitors (INSTIs), dolutegravir, elvitegravir, and raltegravir, have become integral in the treatment of HIV, with close monitoring of continued efficacy and tolerability. As side effect occurrence varies among subjects receiving these drugs, we sought to perform an exploratory analysis examining the role of several single-nucleotide polymorphisms (SNPs) on drug concentration changes, selected clinical outcomes, and the occurrence of subject-reported adverse events.MethodsAdults (aged  ≥ 18 years) receiving INSTI-based regimens for treatment...
Source: Clinical Drug Investigation - January 8, 2019 Category: Drugs & Pharmacology Source Type: research

Switching of Oral P2Y 12 Inhibitor Treatment in Patients with Acute Coronary Syndrome: Prevalence, Predictors, and Prognosis
ConclusionsIn a contemporary registry with ACS, in-hospital switching of antiplatelet drugs was frequent. Those switched to newer antiplatelets were younger and admitted more frequently for ST-elevation myocardial infarction. Post-discharge switching was infrequent. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - January 8, 2019 Category: Drugs & Pharmacology Source Type: research

Neratinib in Early-Stage Breast Cancer: A Profile of Its Use in the EU
AbstractNeratinib (Nerlynx®) is an oral, irreversible pan-human epidermal growth factor receptor (HER) tyrosine kinase inhibitor of HER1, HER2 and HER4. Neratinib therapy for 12  months significantly reduced the risk of invasive disease recurrence or death relative to placebo at both 2 and 5 years post-randomization in the pivotal ExteNET trial in women with early-stage HER2-positive breast cancer who had completed adjuvant trastuzumab. Subgroup analyses showed that patie nts with hormone receptor (HRc)-positive disease derived greater benefit with neratinib than patients with HRc-negative disease, and patien...
Source: Clinical Drug Investigation - January 3, 2019 Category: Drugs & Pharmacology Source Type: research

A Literature Review of Psychotropic Medications and Alcohol as Risk Factors for Falls in Community Dwelling Older Adults
AbstractPsychotropic medications and alcohol are potential risk factors for falls in older adults. However, there has been no appraisal of the literature on whether these medications, both singly and in combination with alcohol, are associated with falls in community dwelling older adults (those aged 60  years and older living independently without care). Four databases (PubMed, EMBASE, CINAHL and SCOPUS) and the grey literature (i.e. WHO, Public Health Agency of Canada) were searched using the following terms: benzodiazepine, anti-psychotics, anti-depressants, anti-epileptic, lithium, memantine, anti-hypertensives: d...
Source: Clinical Drug Investigation - December 17, 2018 Category: Drugs & Pharmacology Source Type: research

Effect of Levothyroxine Treatment on Incident Dementia in Adults with Atrial Fibrillation and Hypothyroidism
ConclusionsWe found that women with atrial fibrillation with levothyroxine treatment and hypothyroidism have a lower risk of incident dementia than women with atrial fibrillation without levothyroxine treatment and no hypothyroidism. The results should be confirmed in larger studies. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - December 14, 2018 Category: Drugs & Pharmacology Source Type: research

Effects on Satisfaction and Service Engagement of Paliperidone Palmitate Compared with Oral Paliperidone in Patients with Schizophrenia: An Open Label Randomized Controlled Trial
ConclusionsSignificant differences between the two formulations were found. PP1M was superior to paliperidone ER on global treatment satisfaction and convenience, on service engagement, and in reducing negative symptoms.The trial was registered in the Australian New Zealand Clinical Trials Registry (ANZCTR) with the code: ACTRN12618001113246. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - December 6, 2018 Category: Drugs & Pharmacology Source Type: research

Effects of Sodium-glucose Cotransporter 2 Inhibitors on Amputation, Bone Fracture, and Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus Using an Alternative Measure to the Hazard Ratio
ConclusionsCanagliflozin was shown to increase the risks of amputation and bone fracture compared with placebo when using the difference in RMST. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - November 30, 2018 Category: Drugs & Pharmacology Source Type: research

Correction to: Neuropsychological Assessment in Elderly Men with Benign Prostatic Hyperplasia Treated with Dutasteride
Catalano Antonino, Martino Gabriella, Bellone Federica, Papalia Maria, Lasco Carmen, Basile Giorgio, Sardella Alberto, Nicocia Giacomo, Morabito Nunziata, Lasco Antonino. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - November 26, 2018 Category: Drugs & Pharmacology Source Type: research

Comparison of Skin Cancer Incidence in Caucasian and Non-Caucasian Liver Vs. Lung Transplant Recipients: A Tale of Two Regimens
The objective of this study was to compare skin cancer development between Caucasian and non-Caucasian transplant recipients at the University of Southern California.MethodsWe performed a retrospective chart review of lung and liver transplantations to determine the incidence of post-transplant skin cancer. Participants included patients who underwent lung or liver transplantation between 2005 and 2013 at our institution. Patients included in the study were limited to those who survived through the study observation period.ResultsWe analyzed 475 patients who underwent transplantation, including 370 liver transplant recipie...
Source: Clinical Drug Investigation - November 23, 2018 Category: Drugs & Pharmacology Source Type: research

Relative and Absolute Risk of Tendon Rupture with Fluoroquinolone and Concomitant Fluoroquinolone/Corticosteroid Therapy: Population-Based Nested Case –Control Study
ConclusionsRisk of tendon rupture with fluoroquinolones depends on timing, cumulative dose and concomitant exposure to oral corticosteroids. Absolute risk significantly varied by age and concomitant corticosteroid exposure, affecting elderly patients the greatest. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - November 21, 2018 Category: Drugs & Pharmacology Source Type: research

A Systematic Review on the Extent and Quality of Pharmacoeconomic Publications in Egypt
ConclusionPharmacoeconomic evaluations in Egypt are still in their infancy. The Egyptian guidelines for economic evaluation should be adopted and the EQ-5D-5L value sets should be developed to increase the quality of economic research. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - November 20, 2018 Category: Drugs & Pharmacology Source Type: research

Drugs that Can Kill a Toddler with One Tablet or Teaspoonful: A 2018 Updated List
ConclusionWith the development of potent new medications, an increasing number of drugs are dangerous upon accidental exposure to toddlers and young children. The present 2018 list of documented fatal drugs has doubled compared with 2004, and special labeling of these medications is urgently needed to avoid such calamities. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - November 15, 2018 Category: Drugs & Pharmacology Source Type: research

Acknowledgement to Referees
(Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - November 12, 2018 Category: Drugs & Pharmacology Source Type: research

Efficacy and Safety of Eltrombopag for Aplastic Anemia: A Systematic Review and Meta-analysis
ConclusionsWith different treatments and in different conditions eltrombopag showed a distinctive effect for aplastic anemia. However, clone evolution and adverse events were associated with treatment. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - November 8, 2018 Category: Drugs & Pharmacology Source Type: research

Comment on: Botulinum Toxin Type A Overdoses: Analysis of the FDA Adverse Event Reporting System Database
(Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - November 3, 2018 Category: Drugs & Pharmacology Source Type: research

Response to “Comment on: Botulinum Toxin Type A Overdoses: Analysis of the FDA Adverse Event Reporting System Database”
(Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - November 3, 2018 Category: Drugs & Pharmacology Source Type: research

Safety and Efficacy Profile of Neratinib: A Systematic Review and Meta-Analysis of 23 Prospective Clinical Trials
ConclusionsNeratinib-based therapies led to a higher frequency of some AEs, although these were mostly tolerable. Most studies demonstrated that neratinib provides a benefit in survival outcome. When combined with other anticancer agents, neratinib may hold promise for treating breast cancer with central nervous system metastases. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - October 28, 2018 Category: Drugs & Pharmacology Source Type: research

Pharmacokinetics, Safety and Tolerability of Tylerdipine Hydrochloride, a Novel Dihydropyridine Dual L/T-type Calcium Channel Blocker, after Single and Multiple Oral Doses in Healthy Chinese Subjects
ConclusionTylerdipine hydrochloride was safe and well tolerated. The exposure (AUC) of tylerdipine over the dose range of 5 –30 mg increased in a greater than dose-proportional manner, whileCmax exhibited a rough but non-typical dose proportionality increase. A slight accumulation of tylerdipine was observed following multiple dosing.Study registrationsCTR20140862 and CTR20150660. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - October 27, 2018 Category: Drugs & Pharmacology Source Type: research

Neuropsychological Assessment in Elderly Men with Benign Prostatic Hyperplasia Treated with Dutasteride
AbstractBackground and ObjectiveBenign prostatic hyperplasia (BPH) is a common disease found in elderly men and 5 α-reductase (5α-R) inhibitors are a commonly used treatment option. 5α-reduced steroids are compounds that play a role in several functions across different organs and systems. In the adult brain, 5α-R accounts for neuroactive steroid production. Whether neuropsychological impairment could be du e to dutasteride treatment, a 5α-R inhibitor affecting the production of dihydrotestosterone (DHT), is still unknown. The aim of our study was to investigate neuropsychological features in ...
Source: Clinical Drug Investigation - October 26, 2018 Category: Drugs & Pharmacology Source Type: research

Is It Necessary to Perform the Pharmacological Interventions for Intrahepatic Cholestasis of Pregnancy? A Bayesian Network Meta-Analysis
ConclusionThis NMA of the RCTs clarified that the current intervention has no favorable effect on pruritus and other symptoms in ICP patients. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - October 24, 2018 Category: Drugs & Pharmacology Source Type: research

Cardiovascular Toxicities with Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors in Cancer Patients: A Meta-Analysis of 77 Randomized Controlled Trials
ConclusionsThe available data suggest that the use of VEGFR-TKIs is associated with a significantly increased risk of cardiovascular toxicities in cancer patients. Clinicians should be aware of this risk and perform regular cardiovascular monitoring. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - October 16, 2018 Category: Drugs & Pharmacology Source Type: research

Physicians ’ and Pharmacists’ Clinical Considerations for Elderly Patients with Type 2 Diabetes Mellitus: The IMPLICA2 Study
AbstractBackgroundManagement of elderly patients with type 2 diabetes mellitus (T2DM) is complex due to their age-related conditions. Several clinical guidelines provide specific recommendations for management of these patients  but little is known about their implementation in clinical practice.ObjectiveTo describe physician and community pharmacist perceptions and routine clinical practice in the management of elderly T2DM patients.MethodsCross-sectional study.ResultsA total of 993 physicians and 999 community pharmacists completed the questionnaire. More physicians than pharmacists agreed on the need to establish m...
Source: Clinical Drug Investigation - October 12, 2018 Category: Drugs & Pharmacology Source Type: research

The Association between Polypharmacy and Hip Fracture in Osteoporotic Women: A Nested Case –Control Study in South Korea
AbstractBackground and ObjectivePolypharmacy, regarded as an indicator of potentially inappropriate medications (PIMs), may lead to a higher risk of serious health consequences in elderly patients with osteoporosis. Thus, this study aimed to analyze the association between polypharmacy and hip fracture in patients with osteoporosis because only a limited number of studies have reported on this association, with inconsistent results to date.MethodsIn this nested case –control study using a population-based sample cohort, the target cases were female patients with hip fracture diagnosed with osteoporosis and aged&thins...
Source: Clinical Drug Investigation - October 10, 2018 Category: Drugs & Pharmacology Source Type: research

Impaired Renal Function May Not Negate the Efficacy of Tolvaptan in the Treatment of Cirrhotic Patients with Refractory Ascites
The objective of this study was to investigate the efficacy and safety of tolvaptan in patients with decompensated cirrhosis and severe chronic kidney disease (s-CKD).MethodsWe studied 43 patients with liver cirrhosis who received tolvaptan (7.5  mg/day) for refractory ascites. s-CKD was defined as an estimated glomerular filtration rate (eGFR) 
Source: Clinical Drug Investigation - October 4, 2018 Category: Drugs & Pharmacology Source Type: research

Safety, Tolerability, and Pharmacokinetics of the Novel Anti-influenza Agent Baloxavir Marboxil in Healthy Adults: Phase I Study Findings
ConclusionSingle-dose oral baloxavir marboxil was well tolerated, had a favorable safety profile, and had favorable pharmacokinetic characteristics, including a long half-life, supporting single oral dosing. The baloxavir acid area under the plasma concentration-time curve decreased with food intake by approximately 40%. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - October 4, 2018 Category: Drugs & Pharmacology Source Type: research

Safety and Plasma Concentrations of a Cyclin-dependent Kinase 9 (CDK9) Inhibitor, FIT039, Administered by a Single Adhesive Skin Patch Applied on Normal Skin and Cutaneous Warts
ConclusionThe FIT039 patch showed no topical or systemic adverse reactions when applied on normal skin or cutaneous warts. The safety and good adherence of the FIT039 patch are encouraging and support further studies to evaluate the efficacy of FIT039 in patients with cutaneous warts. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - October 4, 2018 Category: Drugs & Pharmacology Source Type: research

Impaired Renal Function May Not Negate the Efficacy of Tolvaptan in the Treatment of Cirrhotic Patients with Refractory Ascites
The objective of this study was to investigate the efficacy and safety of tolvaptan in patients with decompensated cirrhosis and severe chronic kidney disease (s-CKD).MethodsWe studied 43 patients with liver cirrhosis who received tolvaptan (7.5  mg/day) for refractory ascites. s-CKD was defined as an estimated glomerular filtration rate (eGFR) 
Source: Clinical Drug Investigation - October 4, 2018 Category: Drugs & Pharmacology Source Type: research

Safety, Tolerability, and Pharmacokinetics of the Novel Anti-influenza Agent Baloxavir Marboxil in Healthy Adults: Phase I Study Findings
ConclusionSingle-dose oral baloxavir marboxil was well tolerated, had a favorable safety profile, and had favorable pharmacokinetic characteristics, including a long half-life, supporting single oral dosing. The baloxavir acid area under the plasma concentration-time curve decreased with food intake by approximately 40%. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - October 4, 2018 Category: Drugs & Pharmacology Source Type: research

Safety and Plasma Concentrations of a Cyclin-dependent Kinase 9 (CDK9) Inhibitor, FIT039, Administered by a Single Adhesive Skin Patch Applied on Normal Skin and Cutaneous Warts
ConclusionThe FIT039 patch showed no topical or systemic adverse reactions when applied on normal skin or cutaneous warts. The safety and good adherence of the FIT039 patch are encouraging and support further studies to evaluate the efficacy of FIT039 in patients with cutaneous warts. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - October 4, 2018 Category: Drugs & Pharmacology Source Type: research

Signal Detection Between Fluoroquinolone Use and the Risk of Rhegmatogenous Retinal Detachment: Sequence Symmetry Analysis Using Nationwide South Korean Healthcare Database Between 2004 and 2015
ConclusionsOur detection suggests a possible association between fluoroquinolone use and RRD. However, possible overestimation and reverse causality bias may have influenced our findings due to the limitation of an SSA design. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - October 1, 2018 Category: Drugs & Pharmacology Source Type: research

A Review on Imiquimod Therapy and Discussion on Optimal Management of Basal Cell Carcinomas
AbstractBasal cell carcinoma (BCC) is the most common type of skin cancer with an increasing incidence. However, it is still poorly researched compared to many other human diseases. Today, cutaneous neoplasms are a frequent, major problem faced by medical professionals. BCC tumors can cause extensive cosmetic distress as well as disfigurement to patients especially when on the face. Treatment options include surgery, systemic agents, and topical agents. Over the past few decades more studies have been performed to evaluate the utility of topical imiquimod therapy for treatment of BCC. Imiquimod is a toll-like receptor that...
Source: Clinical Drug Investigation - October 1, 2018 Category: Drugs & Pharmacology Source Type: research

Pharmacokinetics, Pharmacodynamics, and Safety of the Novel Calcimimetic Agent Evocalcet in Healthy Japanese Subjects: First-in-Human Phase I Study
ConclusionsThese results suggest that evocalcet may have a comparable efficacy and better safety profile than that of cinacalcet, one of the current treatments for secondary hyperparathyroidism in patients with chronic kidney disease. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - October 1, 2018 Category: Drugs & Pharmacology Source Type: research

A Network Pharmacology-Based Analysis of Multi-Target, Multi-Pathway, Multi-Compound Treatment for Ovarian Serous Cystadenocarcinoma
ConclusionIn summary, latent drugs against ovarian serous cystadenocarcinoma were acquired and their target actions and pathways were determined by the network pharmacology strategy, which provides a new prospect for medicamentous therapy for ovarian serous cystadenocarcinoma. However, further in-depth studies are indispensable to increase the validity of this study. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - October 1, 2018 Category: Drugs & Pharmacology Source Type: research

Direct and Indirect Costs of Immunoglobulin Replacement Therapy in Patients with Common Variable Immunodeficiency (CVID) and X-Linked Agammaglobulinemia (XLA) in Italy
ConclusionsThis information provides a comprehensive perspective of the economic issues, and facilitates better-informed public health decision making, in the management of CVID and XLA in Italy. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - October 1, 2018 Category: Drugs & Pharmacology Source Type: research

Non-Compartmental Pharmacokinetics and Safety of Single-Dose Eldecalcitol (ED-71) in Healthy Chinese Adult Males
ConclusionPharmacokinetic exposure (Cmax and partial AUCs) was dose-proportional over the tested dose range of 0.5 –0.75 µg in healthy Chinese adult males. The pharmacokinetic character of eldecalcitol in Chinese subjects was similar to historical data from Japanese subjects. Eldecalcitol was well tolerated at doses ranging from 0.5 to 0.75 µg, with no new safety signals identified.Clinical Trial RegistrationThis study was registered at the China Food and Drug Administration (Registration number: 2014L02212 and 2014L02213), and also registered athttp://www.chinadrugtrials.org.cn (No. CTR20160430...
Source: Clinical Drug Investigation - October 1, 2018 Category: Drugs & Pharmacology Source Type: research

Successful Response to Osimertinib Rechallenge after Intervening Chemotherapy in an EGFR T790M-Positive Lung Cancer Patient
AbstractOsimertinib is the best treatment choice for patients with epidermal growth factor receptor (EGFR)-mutated advanced non-small-cell lung cancer (NSCLC) whose disease progresses on a first- or second-generation EGFR-tyrosine kinase inhibitor due to acquired T790M mutation. On the other hand, there is a lack of therapeutic strategies with proven efficacy at the time of progression on osimertinib. If not administered previously, platinum-based chemotherapy can provide some clinical benefit, while immunotherapy does not seem to work in this setting. Here, we report on a unique case of response to osimertinib rechallenge...
Source: Clinical Drug Investigation - October 1, 2018 Category: Drugs & Pharmacology Source Type: research

Indications for Systemic Fluoroquinolone Therapy in Europe and Prevalence of Primary-Care Prescribing in France, Germany and the UK: Descriptive Population-Based Study
ConclusionLarge numbers of fluoroquinolone products in Europe are listed for the treatment of milder infections such as acute bronchitis, acute sinusitis and uUTIs. Among the countries assessed, fluoroquinolones were commonly prescribed for these conditions and potentially should lead to a review of therapeutic guidelines. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - October 1, 2018 Category: Drugs & Pharmacology Source Type: research

Potential for Cost Saving with Iclaprim Owing to Avoidance of Vancomycin-Associated Acute Kidney Injury in Hospitalized Patients with Acute Bacterial Skin and Skin Structure Infections
ConclusionsIclaprim has the potential to reduce the economic burden of acute bacterial skin and skin structure infections in hospitalized patients at risk for vancomycin-associated acute kidney injury when iclaprim acquisition is US$300/day or less. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - October 1, 2018 Category: Drugs & Pharmacology Source Type: research

Cost Estimate of Immune-Related Adverse Reactions Associated with Innovative Treatments of Metastatic Melanoma
ConclusionThis study may represent a useful tool to understand the economic burden associated with the management of irAEs associated with patients affected by metastatic melanoma. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - October 1, 2018 Category: Drugs & Pharmacology Source Type: research

Identification of Somatic Disorders Related to Psychoactive Drug Use from an Inpatient Database in a French University Hospital
ConclusionsCombining extraction of ICD-10 codes and a focused review of a preselection of relevant hospitalisations appears to be efficient and time-saving. This method should be applied in other hospital settings before considering the exploration of inpatient data on a wider scale. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - October 1, 2018 Category: Drugs & Pharmacology Source Type: research

Signal Detection Between Fluoroquinolone Use and the Risk of Rhegmatogenous Retinal Detachment: Sequence Symmetry Analysis Using Nationwide South Korean Healthcare Database Between 2004 and 2015
ConclusionsOur detection suggests a possible association between fluoroquinolone use and RRD. However, possible overestimation and reverse causality bias may have influenced our findings due to the limitation of an SSA design. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - October 1, 2018 Category: Drugs & Pharmacology Source Type: research

Correction to: Gadobutrol: A Review in Contrast-Enhanced MRI and MRA
The article Gadobutrol: A Review in Contrast-Enhanced MRI and M (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - October 1, 2018 Category: Drugs & Pharmacology Source Type: research