Assessment of Hormonal Contraceptive Utilization and Associated Odds of Hypercoagulopathy in Patients with Venous Malformations Using a National Claims Database
ConclusionsThese findings suggest that patients with VM may safely use HCs with careful consideration of other risk factors for thromboses. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - January 10, 2023 Category: Drugs & Pharmacology Source Type: research
Cost Effectiveness of Rituximab Therapy for Rheumatoid Arthritis: A Systematic Review and Meta-Analysis of Cost-Utility Studies
ConclusionRituximab is cost effective compared to other DMARDs but not if used as third-line therapy after failure of biologics. There is a need to generate context-specific evidence for the lower income settings. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - January 9, 2023 Category: Drugs & Pharmacology Source Type: research
Correction to: Cost ‑Utility Analysis of Pegaspargase for the Treatment of Acute Lymphoblastic Leukemia in Greece
(Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - December 29, 2022 Category: Drugs & Pharmacology Source Type: research
Use of Methotrexate in Girls and Women of Childbearing Age, Occurrence of Methotrexate-Exposed Pregnancies and Their Outcomes in Germany: A Claims Data Analysis
ConclusionsIn Germany, the use of methotrexate in women of childbearing age has substantially increased since 2004. Despite the known teratogenic effect, there was a considerable number of exposed pregnancies. Also, malformations likely associated with methotrexate and thus avoidable were observed. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - December 21, 2022 Category: Drugs & Pharmacology Source Type: research
CHAnges in Diuretic Medication Prescribing and Surrogate Laboratory Parameters After Initiating EmpagliflOziN in Veterans (CHAMPION Cohort Study)
ConclusionsThis hypothesis-generating study suggests that sodium-glucose cotransporter type 2 inhibitors may lower diuretic requirements, further supported by a reduction in weight in the intervention cohort.Graphical Abstract (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - December 14, 2022 Category: Drugs & Pharmacology Source Type: research
Long-Term Safety and Effectiveness of Erenumab in Patients with Migraine: A Systematic Review and Single-Arm Meta-analysis
ConclusionsErenumab has a favorable safety profile, with a low incidence of serious AEs, and sustained efficacy over ≥1 year of follow-up in the treatment of migraine. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - December 8, 2022 Category: Drugs & Pharmacology Source Type: research
Pharmacokinetics and Safety of Follitropin Delta in Gonadotropin Down-Regulated Healthy Chinese Women
ConclusionsThe administration of single doses of follitropin delta to healthy Chinese women demonstrated dose-proportional pharmacokinetics over the dose range of 12 –24 μg, and these doses were well tolerated.Clinical Trial RegistrationClinicaltrials.gov registration no. NCT04150861. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - December 7, 2022 Category: Drugs & Pharmacology Source Type: research
Therapeutic Polypeptides and Peptidomimetics: Powerful Tools for COVID-19 Treatment
AbstractThe coronavirus disease 2019 (COVID-19) pandemic has swept the whole world and brought about a public health crisis of unprecedented proportions. To combat the rapid transmission and possible deaths due to the disease, researchers and companies around the world are developing all possible strategies. Due to the advantages of safety, specificity, and fewer adverse effects, polypeptide and peptidomimetic drugs are considered promising strategies. This review comprehensively summarizes and discusses the progress in development of peptide drugs for use in the treatment of COVID-19. Based on the latest results in this f...
Source: Clinical Drug Investigation - December 3, 2022 Category: Drugs & Pharmacology Source Type: research
Safety and Efficacy of Edaravone in Patients with Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-analysis
ConclusionsCompared with placebo, edaravone may provide potential clinical benefits in the treatment of ALS and may not increase the number of AEs and deaths. However, due to the low-quality evidence of the included studies and the small sample size, more high-quality and high-standard research evidence is needed to confirm these results.Protocol RegistrationThis study was registered on PROSPERO (ID: CRD 42022319997). (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - December 3, 2022 Category: Drugs & Pharmacology Source Type: research
Correction to: Comment on “Efficacy and Safety of Subcutaneous Esketamine in the Treatment of Suicidality in Major Depressive Disorder and Bipolar Depression”
(Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - December 2, 2022 Category: Drugs & Pharmacology Source Type: research
Authors ’ Response to Comment on “Efficacy and Safety of Subcutaneous Esketamine in the Treatment of Suicidality in Major Depressive Disorder and Bipolar Depression”
(Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - November 25, 2022 Category: Drugs & Pharmacology Source Type: research
Correction to: Risk Factors for Nephrotoxicity in Methicillin-Resistant Staphylococcus aureus Bacteraemia: A Post Hoc Analysis of the CAMERA2 Trial
(Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - November 19, 2022 Category: Drugs & Pharmacology Source Type: research
Comment on “Efficacy and Safety of Subcutaneous Esketamine in the Treatment of Suicidality in Major Depressive Disorder and Bipolar Depression”
(Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - November 16, 2022 Category: Drugs & Pharmacology Source Type: research
Acknowledgement to Referees
(Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - November 14, 2022 Category: Drugs & Pharmacology Source Type: research
Gastric Glitch: A New Functional Disease Treated with Buspirone and Prucalopride in an N-of-1 Double-Blind Clinical Trial
(Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - November 12, 2022 Category: Drugs & Pharmacology Source Type: research
