Cost-Effectiveness Analysis of Camrelizumab Plus Rivoceranib Versus Sorafenib as a First-Line Therapy for Unresectable Hepatocellular Carcinoma in the Chinese Health Care System
ConclusionsCamrelizumab plus rivoceranib was more cost effective than sorafenib as first-line therapy for unresectable HCC in the Chinese setting. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - February 1, 2024 Category: Drugs & Pharmacology Source Type: research
Forty-Eight-Month Monitoring of Disease Activity in Patients with Long-Standing Rheumatoid Arthritis Treated with TNF- α Inhibitors: Time for Clinical Outcome Prediction and Biosimilar vs Biologic Originator Performance
ConclusionsWe conclude that biosimilars of adalimumab and etanercept have equivalent effectiveness over a long period of time compared to their originator drugs, and also that the levels of disease activity after 6 months of tumor necrosis factor- α inhibitors (originator drugs and biosimilars) might predict the response to therapy at 4 years in patients with long-standing rheumatoid arthritis. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - January 31, 2024 Category: Drugs & Pharmacology Source Type: research
Demystifying Dry Powder Inhaler Resistance with Relevance to Optimal Patient Care
AbstractThe selection of an inhaler device is a key component of respiratory disease management. However, there is a lack of clarity surrounding inhaler resistance and how it impacts inhaler selection. The most common inhaler types are dry powder inhalers (DPIs) that have internal resistance and pressurised metered dose inhalers (pMDIs) that use propellants to deliver the drug dose to the airways. Inhaler resistance varies across the DPIs available on the market, depending largely on the design geometry of the device but also partially on formulation parameters. Factors influencing inhaler choice include measures such as f...
Source: Clinical Drug Investigation - January 10, 2024 Category: Drugs & Pharmacology Source Type: research
Correction to: Association Between Antidiabetic Drugs and Delirium: A Study Based on the Adverse Drug Event Reporting Database in Japan
(Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - January 10, 2024 Category: Drugs & Pharmacology Source Type: research
A Real-World Observational Study to Evaluate the Safety and Effectiveness of Fluticasone Furoate –Oxymetazoline Fixed Dose Combination Nasal Spray in Patients with Allergic Rhinitis
ConclusionThe fixed-dose combination of once-daily fluticasone furoate and oxymetazoline hydrochloride nasal spray 27.5/50 mcg was effective in relieving the nasal congestion and reduction of TNSS, TOSS and TSS in patients suffering from AR. The combination was safe and well tolerated with no rebound congestion throughout the treatment period. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - January 9, 2024 Category: Drugs & Pharmacology Source Type: research
Maximizing the Value of Chronic Myeloid Leukemia Management Using Tyrosine Kinase Inhibitors in the USA: Potential Determinants and Consequences of Healthcare Resource Utilization and Costs, with Proposed Optimization Approaches
ConclusionsHealthcare resource utilization and costs of chronic myeloid leukemia care may be considered barometers of ineffective management, including mutation-driven tyrosine kinase inhibitor resistance and switching as well as non-adherence and intolerance. Future prospective research is warranted to help determine whether costs can be reduced and other treatment outcomes optimized via more proactive and effective diagnostic interventions (i.e., regular molecular monitoring and proactive mutational testing) and treatment approaches. The strengths and limitations of this review include its emphasis on observational resea...
Source: Clinical Drug Investigation - January 5, 2024 Category: Drugs & Pharmacology Source Type: research
Antibiotic-Associated Acute Kidney Injury Among Older Adults: A Case-Crossover Study
ConclusionThe potential of sulfamethoxazole/trimethoprim and fluoroquinolones to be associated with AKI raises the significant need for vigilant prescribing of these antibiotics in older adults. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - January 3, 2024 Category: Drugs & Pharmacology Source Type: research
Association Between Antidiabetic Drugs and Delirium: A Study Based on the Adverse Drug Event Reporting Database in Japan
ConclusionsOur results suggest no association between diabetes and delirium; however, using sulfonylurea and insulin may be associated with delirium development. Nonetheless, these findings should be validated in future studies. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - December 23, 2023 Category: Drugs & Pharmacology Source Type: research
Real-World Effectiveness and Safety of Baricitinib in Patients with Atopic Dermatitis
(Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - December 19, 2023 Category: Drugs & Pharmacology Source Type: research
Food Effect on the Pharmacokinetics of VC004, a Tropomyosin Receptor Kinase Inhibitor: A Randomized Crossover Trial in Healthy Chinese Subjects
ConclusionsThe intake of high calorie food decreased the absorption rate and increased the Tmax of VC004, while the AUC values were similar in both groups. No serious adverse event was reported. In conclusion, food does not alter the pharmacokinetics and safety profile of VC004 in a clinically meaningful manner.Trial RegistrationClinicalTrials.gov ID: NCT055528120. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - December 19, 2023 Category: Drugs & Pharmacology Source Type: research
Comparison of Long-Term Effectiveness and Safety of Upadacitinib for Atopic Dermatitis Between Dupilumab-Exposed and Dupilumab-Naïve Patients
ConclusionsThis study confirmed the clinical effectiveness of upadacitinib treatment in adult patients in a real-world setting with moderate-to-severe AD who had discontinued dupilumab due to poor effectiveness or adverse events and who were biologic na ïve; therefore, previous treatments do not seem to affect the response to upadacitinib treatment. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - December 17, 2023 Category: Drugs & Pharmacology Source Type: research
Cost Effectiveness of Tofacitinib for the Treatment of Active Ankylosing Spondylitis in Greece
ConclusionsTofacitinib was estimated to be a cost-effective option for the treatment of active ankylosing spondylitis in Greece for both biologic-naive and biologic-experienced patients. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - December 16, 2023 Category: Drugs & Pharmacology Source Type: research
Lecanemab: More Questions Than Answers!
AbstractThe approval of lecanemab by the US Food and Drug Administration has been touted as a defining moment in the treatment of Alzheimer ’s disease. Lecanemab, an anti-amyloid beta monoclonal antibody, is the first Alzheimer’s disease drug targeting amyloid beta that has shown statistically significant cognitive benefits in phase III trials. However, there have been many questions raised over the clinical relevance of the otherwi se minimal cognitive improvements. Furthermore, its rapid approval has been mired in controversy, in addition to the reports of adverse events such as amyloid-related imaging abnormalities ...
Source: Clinical Drug Investigation - December 14, 2023 Category: Drugs & Pharmacology Source Type: research
Needle-Free Jet Injector-Assisted Triamcinolone Treatment of Keloids and Hypertrophic Scars is Effective and Well Tolerated in Children
ConclusionsElectronic pneumatic jet injector-assisted intralesional triamcinolone acetonide is an effective and well-tolerated treatment for keloids and hypertrophic scars in children. It should be considered as an alternative non-traumatic delivery method, especially in children with needle phobia or severe pain during previous needle injections. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - December 13, 2023 Category: Drugs & Pharmacology Source Type: research
Comparison of the Incidence of Adverse Events Between Japanese and Non-Japanese Healthy Subjects in Phase I Studies: A Systematic Review and Meta-Analysis
ConclusionsOur research suggested that racial factors such as race-dependent nature influence a drug safety assessment. With knowledge of these differences, it is expected that Japan will actively conduct multi-regional clinical trials, in which more diverse populations are included. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - December 2, 2023 Category: Drugs & Pharmacology Source Type: research
