Patient characteristics, ICU-specific supports, complications, and outcomes of persistent critical illness
ConclusionsMechanical ventilation beyond day 10 affected only two thirds of PerCI patients. However, VAP was a key complication in such patients. Discharge to chronic care facilities and hospital mortality were more common in PerCI patients. (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 21, 2019 Category: Gastroenterology Source Type: research

Actigraphic measures of sleep on the wards after ICU discharge
Publication date: Available online 16 August 2019Source: Journal of Critical CareAuthor(s): M. Elizabeth Wilcox, Gordon D. Rubenfeld, Karolina D. Walczak, Sandra E. Black, Mary Pat McAndrews, Andrew S. LimAbstractBackgroundThe purpose of this study was to use an objective measure to evaluate sleep quality on the ward after ICU discharge in survivors of critical illness.Materials and methodsThis was a prospective cohort study of 94 patients admitted to a multidisciplinary intensive care unit (ICU) between December 2013 and June 2017. Adult patients received ≥3 days of mechanical ventilation. Sleep quality was measured ...
Source: Journal of Critical Care - August 17, 2019 Category: Gastroenterology Source Type: research

Non-opioid analgesics as adjuvants to opioid for pain management in adult patients in the ICU: A systematic review and meta-analysis
Publication date: Available online 13 August 2019Source: Journal of Critical CareAuthor(s): Huiying Zhao, Shuguang Yang, Huixia Wang, Hua Zhang, Youzhong AnAbstractPurposeTo identify the impact of non-opioid analgesics as adjuvants to opioid on opioid consumption and its side effects, as well as the analgesic effectiveness in adult patients in the ICU.MethodsOnly randomized clinical trials using non-opioid analgesics for analgesia in the ICU were included. Pooled analyses with 95% CI were determined.ResultsTwelve studies (mainly surgical and Guillain-Barre syndrome patients) were included. Non-opioid analgesics as adjuvant...
Source: Journal of Critical Care - August 14, 2019 Category: Gastroenterology Source Type: research

Comparison of the sepsis-2 and sepsis-3 definitions in severely injured trauma patients
ConclusionsThe sepsis-3 definition identifies much fewer patients and is more strongly associated with adverse outcomes than the sepsis-2 definition. The sepsis-3 definition seems to be useful in the post trauma setting. (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 10, 2019 Category: Gastroenterology Source Type: research

Prospective validation and refinement of the APPROACH cardiovascular surgical intensive care unit readmission score
Publication date: Available online 9 August 2019Source: Journal of Critical CareAuthor(s): Sanam Verma, Danielle A. Southern, Ismail R. Raslan, Colleen M. Norris, Michelle M. Graham, Sean M. Bagshaw, Jayan Nagendran, Todd Maclure, Louise Y. Sun, Wu Dat Chin, Sean van DiepenAbstractPurposeThe APPROACH cardiovascular surgical intensive care unit (CVICU) readmission score has excellent discrimination and calibration for CVICU readmission after discharge to a surgical ward; however, it has not been prospectively validated.Material and methodsIn a prospective consecutive cohort of 805 patients ≥18 years admitted to the CVI...
Source: Journal of Critical Care - August 10, 2019 Category: Gastroenterology Source Type: research

Venous blood lactate concentrations in patients with shock: Interesting but not really helpful
Publication date: Available online 10 August 2019Source: Journal of Critical CareAuthor(s): Bernhard Wernly, Jan Bakker, Christian Jung (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 10, 2019 Category: Gastroenterology Source Type: research

P-values and significance: The null hypothesis that they are not related is correct
Publication date: Available online 10 August 2019Source: Journal of Critical CareAuthor(s): Sharon Einav, Michael O'Connor (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 10, 2019 Category: Gastroenterology Source Type: research

Combining biomarkers for acute kidney injury, moving forward with integration
Publication date: Available online 2 August 2019Source: Journal of Critical CareAuthor(s): Rajit K. Basu (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 9, 2019 Category: Gastroenterology Source Type: research

Structural features shared by ICUs belonging to research networks an international survey. “Critical care research network survey”
ConclusionsDespite different organizations, CCRN share similar ventures including the value of improving quality of critical care delivery. Participating ICUs share several structural and managerial patterns. These observations enlighten the importance of CCRN to enhance quality of critical care delivery. (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 9, 2019 Category: Gastroenterology Source Type: research

The impact of real-time chest compression feedback increases with application of the 2015 guidelines
Publication date: Available online 7 August 2019Source: Journal of Critical CareAuthor(s): Daniel Davis, Tifany Hoyne, Sara Wattenbarger, Kenan Kuntsal, Annemarie SilverAbstractBackgroundCardiac arrest survival depends upon chest compression quality. Real-time audiovisual feedback may improve compression guideline adherence, particularly with the more specific 2015 guidelines.MethodsSubjects included healthcare providers from multiple U.S. hospitals. Compression rate and depth were recorded using standard manikins and real-time audiovisual feedback defibrillators (ZOLL R Series). Subjects were enrolled before (n = 756)...
Source: Journal of Critical Care - August 8, 2019 Category: Gastroenterology Source Type: research

A pilot study evaluating a simple cardiac dysfunction score to predict complications and survival among critically-ill patients with traumatic brain injury
ConclusionCardiac dysfunction was common in patients with msTBI and independently associated with more severe brain injury and a reduction in hospital survival in this population. Further research is needed to validate the CDI and create more precise scoring tools. (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 8, 2019 Category: Gastroenterology Source Type: research

Nutritional status of patients hospitalized in the intensive care unit: A comprehensive report from Iranian hospitals, 2018
ConclusionNutritional status of patients hospitalized in ICU wards in Iran wassomewhat better than other countries that this could be due to the highly observed guidelines of patient's care in Iran. Anyway,it is suggested that a more precise tool of nutritional scoresto be validated for patients hospitalized in ICU·In addition, better medical care needs a well evaluation of nutritional insufficiencies and what is necessary for compensation using complementary regimens. (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 7, 2019 Category: Gastroenterology Source Type: research

Sepsis quality in safety-net hospitals: An analysis of Medicare's SEP-1 performance measure
ConclusionsExisting sepsis policies may harm safety-net hospitals and widen health disparities. Our findings suggest that strategies to promote collaboration among hospitals may be an avenue for sepsis performance improvement in safety-net hospitals. (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 7, 2019 Category: Gastroenterology Source Type: research

The perils of the best interests standard in end-of-life decision-making
Publication date: Available online 5 August 2019Source: Journal of Critical CareAuthor(s): Greg Yanke, Mohamed Rady, Joseph Verheijde (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 7, 2019 Category: Gastroenterology Source Type: research

Comparison between logistic regression and machine learning algorithms on survival prediction of traumatic brain injuries
ConclusionsThe twenty-two ML models selected have capabilities comparable to classical LR model for outcome prediction in STBI patients. Of these, Cubic SVM, Quadratic SVM, Linear SVM performed significantly better than LR. (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 7, 2019 Category: Gastroenterology Source Type: research

Association between DNA and RNA oxidative damage and mortality in septic patients
Publication date: Available online 5 August 2019Source: Journal of Critical CareAuthor(s): Leonardo Lorente, María M. Martín, Agustín F. González-Rivero, Antonia Pérez-Cejas, Pedro Abreu-González, Raquel Ortiz-López, José Ferreres, Jordi Solé-Violán, Lorenzo Labarta, César Díaz, Salomé Palmero, Alejandro JiménezAbstractPurposeDNA and RNA oxidative damage occurs during sepsis. Higher urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) levels (from oxidation of guanosine from DNA) have been found in non-surviving patients than in...
Source: Journal of Critical Care - August 7, 2019 Category: Gastroenterology Source Type: research

Legal adjudications at the end of life: The lack of difference between best interest and substantial harm standards in conflict resolution
Publication date: Available online 2 August 2019Source: Journal of Critical CareAuthor(s): Laura Hawryluck, James Downar, Joe Colangelo (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 4, 2019 Category: Gastroenterology Source Type: research

Combining biomarkers for acute kidney injury move forward with integration
Publication date: Available online 2 August 2019Source: Journal of Critical CareAuthor(s): Rajit K. Basu (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 4, 2019 Category: Gastroenterology Source Type: research

A combined biomarker of urinary neutrophil gelatinase-associated lipocalin and serum creatinine for the prediction of acute kidney injury: What else can we know?
Publication date: Available online 2 August 2019Source: Journal of Critical CareAuthor(s): Yuliang Zhao, Letian Yang, Ling Zhang, Ping Fu (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 4, 2019 Category: Gastroenterology Source Type: research

Editorial Board
Publication date: October 2019Source: Journal of Critical Care, Volume 53Author(s): (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 4, 2019 Category: Gastroenterology Source Type: research

Severe community acquired pneumonia: Prediction of outcome
Publication date: Available online 31 July 2019Source: Journal of Critical CareAuthor(s): Vijay Hadda (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 1, 2019 Category: Gastroenterology Source Type: research

Factors associated with mortality in severe community-acquired pneumonia: A multicenter cohort study - Response to letter
Publication date: Available online 31 July 2019Source: Journal of Critical CareAuthor(s): Rodolfo Espinoza (Source: Journal of Critical Care)
Source: Journal of Critical Care - August 1, 2019 Category: Gastroenterology Source Type: research

A pilot study of a novel molecular host response assay to diagnose infection in patients after high-risk gastro-intestinal surgery
ConclusionsSequential measurement of SeptiCyte LAB may have diagnostic value in the monitoring of surgical patients at high risk of postoperative infection, but its clinical performance in this setting needs to be validated. (Source: Journal of Critical Care)
Source: Journal of Critical Care - July 31, 2019 Category: Gastroenterology Source Type: research

In veno-venous ECMO oxygen delivery should be the focus
Publication date: Available online 27 July 2019Source: Journal of Critical CareAuthor(s): Joep M. Droogh, Annemieke Oude Lansink, Maurits H. Renes, Ethel Metz, Maarten W. Nijsten (Source: Journal of Critical Care)
Source: Journal of Critical Care - July 29, 2019 Category: Gastroenterology Source Type: research

Hemodynamic decompensation in normotensive patients admitted to the ICU with pulmonary embolism
ConclusionsAmong patients admitted to the ICU with acute normotensive PE, early hemodynamic decompensation was rare. In patients who experienced decompensation, major bleeding and thrombotic complications were equally likely to have been the precipitant— highlighting the risks of diagnostic anchoring in this population. As our results suggest that ICU-level care may not be necessary for many of these patients, additional tools are needed to assist in the triage of normotensive patients with PE. (Source: Journal of Critical Care)
Source: Journal of Critical Care - July 29, 2019 Category: Gastroenterology Source Type: research

Caring for critically ill patients with opioid use disorder: Phone a friend?
Publication date: Available online 25 July 2019Source: Journal of Critical CareAuthor(s): Kunal Karamchandani, Ashish K. Khanna (Source: Journal of Critical Care)
Source: Journal of Critical Care - July 26, 2019 Category: Gastroenterology Source Type: research

Corrigendum to ‘Decision-making in ICU – A systematic review of factors considered important by ICU clinician decision makers with regard to ICU triage decisions’. Journal of Critical Care 50(2019) pp99–110
Publication date: Available online 17 July 2019Source: Journal of Critical CareAuthor(s): Pragasan Dean Gopalan, Santosh Pershad (Source: Journal of Critical Care)
Source: Journal of Critical Care - July 19, 2019 Category: Gastroenterology Source Type: research

Cardiac output during targeted temperature management and renal function after out-of-hospital cardiac arrest
Publication date: Available online 15 July 2019Source: Journal of Critical CareAuthor(s): Johannes Grand, John Bro-Jeppesen, Christian Hassager, Malin Rundgren, Matilde Winther-Jensen, Jakob Hartvig Thomsen, Niklas Nielsen, Michael Wanscher, Jesper KjærgaardAbstractPurposeAfter resuscitation from out-of-hospital cardiac arrest (OHCA), renal injury and hemodynamic instability are common. We aimed to assess the association between low cardiac output during targeted temperature management (TTM) and acute kidney injury (AKI) after OHCA.Materials and methodsSingle-center substudy of 171 patients included in the prospectiv...
Source: Journal of Critical Care - July 16, 2019 Category: Gastroenterology Source Type: research

Right ventricular dysfunction in neurologically deceased organ donors: An observational study in a tertiary-care organ donor referral centre
ConclusionWe observed a high frequency of RV dysfunction in a sample of potential heart donors. However, the temporal evolution of RV dysfunction, the hemodynamic predictors of RV dysfunction, as well the link between donor RV dysfunction and recipient outcomes need to be assessed with further prospective studies. (Source: Journal of Critical Care)
Source: Journal of Critical Care - July 16, 2019 Category: Gastroenterology Source Type: research

Letter to the Editor: Can we just use E/e'ratio to estimate the diastolic function?
Publication date: Available online 13 July 2019Source: Journal of Critical CareAuthor(s): Pan Lingai, Yang Fuxun, Luo Xiaoxiu, Huang Xiaobo (Source: Journal of Critical Care)
Source: Journal of Critical Care - July 13, 2019 Category: Gastroenterology Source Type: research

Optimal vancomycin dosing regimens for critically ill patients with acute kidney injury during continuous renal replacement therapy: A Monte Carlo simulation study
Publication date: Available online 10 July 2019Source: Journal of Critical CareAuthor(s): Taniya Charoensareerat, Weerachai Chaijamorn, Apinya Boonpeng, Nattachai Srisawat, Chalermsri Pummangura, Sutthiporn Pattharachayakul (Source: Journal of Critical Care)
Source: Journal of Critical Care - July 11, 2019 Category: Gastroenterology Source Type: research

Challenges in the assessment of diastolic function after cardiac arrest
Publication date: Available online 10 July 2019Source: Journal of Critical CareAuthor(s): Jacob C. Jentzer, Nandan S. Anavekar, Sunil V. Mankad, Majd Khasawneh, Roger D. White, Gregory W. Barsness, Alejandro A. Rabinstein, Kianoush B. Kashani, Sorin V. Pislaru (Source: Journal of Critical Care)
Source: Journal of Critical Care - July 11, 2019 Category: Gastroenterology Source Type: research

Psychometric validation of the Chinese patient- and family satisfaction in the intensive care unit questionnaires
ConclusionsBoth Chinese PS-ICU-23 and FS-ICU-24 questionnaires have sound psychometric properties but family satisfaction may not be a good proxy for patient satisfaction in ICU. (Source: Journal of Critical Care)
Source: Journal of Critical Care - July 11, 2019 Category: Gastroenterology Source Type: research

A new era of critical care research in China
Publication date: Available online 9 July 2019Source: Journal of Critical CareAuthor(s): Jingtao Liu, Linlin Zhang, Penglin Ma (Source: Journal of Critical Care)
Source: Journal of Critical Care - July 10, 2019 Category: Gastroenterology Source Type: research

Subtherapeutic piperacillin concentrations in neurocritical patients
ConclusionSubtherapeutic piperacillin concentrations are common in neurocritical patients yet having a neurocritical admission diagnosis was not identified as an independent risk factor. (Source: Journal of Critical Care)
Source: Journal of Critical Care - July 10, 2019 Category: Gastroenterology Source Type: research

Hypotension within one-hour from starting CRRT is associated with in-hospital mortality
ConclusionHypotension occurs frequently in patients receiving CRRT despite having a reputation as the dialysis modality with better hemodynamic tolerance. It is an independent predictor for worse outcomes. Further studies are required to understand this phenomenon. (Source: Journal of Critical Care)
Source: Journal of Critical Care - July 10, 2019 Category: Gastroenterology Source Type: research

Quality of care and safety measures of acute renal replacement therapy: Workgroup statements from the 22nd acute disease quality initiative (ADQI) consensus conference
ConclusionCurrently, there remains few validated QIs for acute RRT. These need further evaluation, need benchmarks established, and ultimately require implementation into clinical practice. (Source: Journal of Critical Care)
Source: Journal of Critical Care - July 7, 2019 Category: Gastroenterology Source Type: research

Activation of pituitary axis according to underlying critical illness and its effect on outcome
ConclusionsPituitary axis function is frequently altered early after ICU admission, the magnitude of hormonal response being different according to the underlying critical illness. The activation of the hypothalamic pituitary adrenal axis was a strong predictor of ICU mortality. (Source: Journal of Critical Care)
Source: Journal of Critical Care - July 7, 2019 Category: Gastroenterology Source Type: research

Performance of plasma measurement of neutrophil gelatinase-associated lipocalin as a biomarker of bacterial infections in the intensive care unit
ConclusionsIn our cohort of ICU patients, plasma dNGAL was associated with presence of bacterial infections independent of AKI but it performed poor as a predictor of infections. Following antibiotic therapy, dNGAL markedly decreased–supporting further exploration of dNGAL-guided antibiotic de-escalation. (Source: Journal of Critical Care)
Source: Journal of Critical Care - July 4, 2019 Category: Gastroenterology Source Type: research

Rescue stem cell allograft in intensive care unit patients during septic shock with multi-organ failure
ConclusionAllograft should be considered as a rescue therapy in ICU for patients with aplasia, during septic shock with multi-organ failure, however close multidisciplinary discussion is required between intensivists and onco-hematologists. (Source: Journal of Critical Care)
Source: Journal of Critical Care - July 4, 2019 Category: Gastroenterology Source Type: research

Moral distress in intensive care unit personnel is not consistently associated with adverse medication events and other adverse events
ConclusionMoral distress in ICU personnel is generally not associated with medication errors or adverse events, or other adverse events, but it may be associated with both hyper-vigilance and distraction. (Source: Journal of Critical Care)
Source: Journal of Critical Care - July 4, 2019 Category: Gastroenterology Source Type: research

Time of admission to intensive care unit, strained capacity, and mortality: A retrospective cohort study
Publication date: Available online 29 June 2019Source: Journal of Critical CareAuthor(s): Filipe S. Cardoso, Nuno Germano, Luís Bento, Philip FortunaAbstractPurposeWe sought to study the association between afterhours ICU admission and ICU mortality considering measures of strained ICU capacity.Materials and methodsRetrospective analysis of 4141 admissions to 2 ICUs in Lisbon, Portugal (06/2016–06/2018). Primary exposure was ICU admission on 20:00 h–07:59 h. Primary outcome was ICU mortality. Measures of strained ICU capacity were: bed occupancy rate ≥ 90% and cluster of ICU admissions 2 h b...
Source: Journal of Critical Care - July 1, 2019 Category: Gastroenterology Source Type: research

Relationship between body weight and fluid balance in critically ill patients – A prospective observational study
Publication date: Available online 29 June 2019Source: Journal of Critical CareAuthor(s): Vishal Gupta, Kush Deshpande (Source: Journal of Critical Care)
Source: Journal of Critical Care - July 1, 2019 Category: Gastroenterology Source Type: research

Feasibility of a protocol to wean patients from continuous renal replacement therapy: A retrospective pilot observation
ConclusionOur data show the feasibility of a structured approach to wean AKI patients from RRT that bundles established interventions and brings the weaning into the physician's focus. (Source: Journal of Critical Care)
Source: Journal of Critical Care - July 1, 2019 Category: Gastroenterology Source Type: research

What to exclude when brain death is suspected
ConclusionsBrain death confounders are infrequently reported and formal studies are lacking. Mainly younger patients with polyneuritis and intoxications are described. As outcome, especially in the latter, is often favourable, high awareness and strict adherence to guidelines is crucial. The importance of identifying pathologies compatible with extensive and irreversible brain damage before proceeding to diagnostic tests should be emphasized. (Source: Journal of Critical Care)
Source: Journal of Critical Care - July 1, 2019 Category: Gastroenterology Source Type: research

A national survey of approaches to manage the ICU patient with opioid use disorder
ConclusionsFew institutional guidelines exist to provide clinicians with the tools necessary to prevent harm and promote recovery for this growing and vulnerable ICU population. (Source: Journal of Critical Care)
Source: Journal of Critical Care - July 1, 2019 Category: Gastroenterology Source Type: research

Outcomes following nighttime extubation in a high-intensity medical intensive care unit
Publication date: Available online 28 June 2019Source: Journal of Critical CareAuthor(s): Samir R. Patel, David A. Barounis, Anamaria Milas, Arya J. Nikamal, Ethan Estoos, Neesha Anand, Kara Nitti, Kenneth W. Dodd (Source: Journal of Critical Care)
Source: Journal of Critical Care - June 29, 2019 Category: Gastroenterology Source Type: research

Safety and efficacy of beta-blockers to improve oxygenation in patients on veno-venous ECMO
ConclusionsIn this study, use of BB in hypoxemic patients on V-V ECMO was safe and associated with a moderate increase in SaO2. (Source: Journal of Critical Care)
Source: Journal of Critical Care - June 28, 2019 Category: Gastroenterology Source Type: research

Quality of life assessment following amputation for septic shock: a long-term descriptive survey after symmetric peripheral gangrene
ConclusionICU survivors referred to rehabilitation centers after SPG-related amputations had impaired HRQOL. At the time of HRQOL assessment, they considered themselves in good health and preferred to be treated again despite disability. Appraisal of long-term functional outcome should not be used to guide end-of-life decision-making in this situation. (Source: Journal of Critical Care)
Source: Journal of Critical Care - June 28, 2019 Category: Gastroenterology Source Type: research

Safety of antimicrobial de-escalation for culture-negative severe pneumonia
ConclusionsWe observed similar ICU mortality and MDR pathogen occurrence in patients with culture-negative pneumonia presenting with sepsis/shock regardless of whether they received ADE. Additionally, ADE lowered the antimicrobial burden. (Source: Journal of Critical Care)
Source: Journal of Critical Care - June 28, 2019 Category: Gastroenterology Source Type: research