Factor Xa Inhibitor, Rivaroxaban, Regulates the Burden of Atrial Fibrillation and Ventricular Premature Captures
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2020 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research

Agomelatine Use in Child and Adolescent Psychiatry
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2020 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research

Risperidone-Associated Acute Eosinophilic Pneumonia
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2020 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research

Report of Clinic Unresponsive Chemotherapy-Associated Hepatitis B Reactivation and Hepatitis in Lung Cancer
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2020 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research

Chemotherapy-associated Hepatitis B Reactivation in Patients with Lung Cancer
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2020 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research

Fluoxetine and Paroxetine: Repositioning as a Therapeutic Alternative in the Treatment of Various Diseases
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2020 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research

Blinatumomab-Associated Neurological Adverse Events
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2020 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research

Comparative Effectiveness of All Available Treatments for Metastatic Hormone-Sensitive Prostate Cancer: A Network Meta-analysis
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2020 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research

Spontaneous Compartment Syndrome of the Lower Extremity in a Patient on Warfarin
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2020 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research

Topiramate-Associated Acute Angle Closure Glaucoma With Myopic Shift
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2020 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research

Afatinib Achieved Remarkable Disease Control in a Chinese Patient With Lung Adenocarcinoma Harboring Rare EGFR Exon 18–25 Kinase Domain Duplication
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2020 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research

Quetiapine-Associated Pseudotumor Cerebri
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2020 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research

Repositioning or Redirection of Antidepressant Drugs in the Treatment of Bacterial and Fungal Infections
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2020 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research

Methylphenidate-Induced Yawning: A Thermoregulatory Connection
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2020 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research

Acyclovir Neurotoxicity in an Elderly Patient With End-Stage Renal Failure
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2020 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research

Oxcarbazepine for Gambling Disorder
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2020 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research

Effects of Creatine in Trained Athletes: A Meta-analysis of 21 Randomized Placebo-Controlled Trials
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2020 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research

Lipid Emulsion Therapy for Quetiapine Overdose
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2020 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research

Bivalirudin Use During Pulmonary Vein Isolation in a Patient With Heparin-Induced Thrombocytopenia
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2020 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research

Pulmonary Capillary Hemangioma-like Pulmonary Artery Hypertension Associated With Interferon-Alpha Therapy
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2020 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research

Fentanyl-Induced Thrombocytopenia
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2020 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research

Anti-Xa Activity in Elderly Xabans-Treated Patients With Atrial Fibrillation
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2020 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research

Clinical Factors Affecting Bevacizumab Efficacy With and Without Conventional Chemotherapy in Metastatic Colon Cancer
Conclusions: Better OS among mCRC patients with resectable primary and metastatic tumors was seen. This is the first study to demonstrate slightly better outcome in males and negative influence of diabetes on outcome in mCRC treated with BZ. (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2020 Category: Drugs & Pharmacology Tags: Therapeutic Opinion Source Type: research

Melatonin Use in Psychiatry—Quo Vadis?
Melatonin use in clinical psychiatry is currently rife, and the trend of utilization is on the rise. Efficacy coupled with safety and lack of abuse potential render melatonin an attractive therapeutic option. Data from neuroscience accrue speaking to the idea of a pluripotent molecule beyond a mere sleeping aid. Here, authors would shed some light on melatonin use in psychiatry while examining the extant evidence. (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2020 Category: Drugs & Pharmacology Tags: Therapeutic Opinion Source Type: research

Precision Surgery for Obesity
Precision medicine is targeted towards improving the effectiveness of treatment, reducing the side effects of drugs and reducing medical costs. The application of precision surgery for obesity is a new concept that involves 2 stages: the first stage is to attain a precise obesity surgery, and the second stage is to achieve individualized obese gene therapy. In this article, we discuss the value of precision surgery for obesity, its stages and its future application to improve obesity surgery. Due to recent advancements in medical technologies, genetics, surgical and clinical research; precision surgery for obesity will lea...
Source: American Journal of Therapeutics - September 1, 2020 Category: Drugs & Pharmacology Tags: Therapeutic Opinion Source Type: research

Vitamin D Supplementation in COVID-19 Patients: A Clinical Case Series
Conclusions: Vitamin D supplementation may serve as a viable alternative for curtailing acute respiratory distress syndrome in patients in underserved communities where resources to expensive and sought-after medications may be scarce. Randomized clinical trials will serve as an appropriate vessel to validate the efficacy of the therapeutic regimen and dissection of the pathway. (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2020 Category: Drugs & Pharmacology Tags: Therapeutic Innovation Source Type: research

Advances in the Pharmacogenomics of Antiplatelet Therapy
Conclusions: Genotype-guided selection of antiplatelet therapy is expected to be useful in patients undergoing percutaneous coronary intervention (PCI) with a high risk of adverse outcomes. The patient–physician discussion should be an essential part of this decision-making process. Large-scale multicenter randomized controlled trials using the point-of-care genotype assay are needed to investigate this approach further before its use can be recommended in all comers. (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2020 Category: Drugs & Pharmacology Tags: Therapeutic Advance Source Type: research

Common Pathways for Pain and Depression-Implications for Practice
Conclusions: Pharmacological and nonpharmacological interventions targeting cortical changes in pain and depression are promising, but more clinical studies are needed to validate their usefulness. (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2020 Category: Drugs & Pharmacology Tags: Therapeutic Advance Source Type: research

Efficacy and Safety of Omalizumab for Chronic Spontaneous Urticaria: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Conclusion: Omalizumab caused a significantly greater reduction in weekly itch score, weekly hive score, DLQI, and UAS7 in CSU patients than the placebo. However, high-quality, multicenter RCTs with a larger sample size are needed to confirm the safety of omalizumab, and whether AEs are caused by omalizumab or other factors. (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2020 Category: Drugs & Pharmacology Tags: Meta-analysis Source Type: research

Mannitol Role in the Management of Intradialytic Hypotension
Conclusions: Mannitol may be considered for the management of IDH; however, additional studies are required to evaluate the long-term risk and benefits associated with mannitol, as it carries a risk of accumulation in the body. (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2020 Category: Drugs & Pharmacology Tags: Systematic Review and Clinical Guidelines Source Type: research

Effect of a 30-Month Health-Promoting Program on the Prevalence of Cardiovascular Risk Factors in Patients With First Episode Schizophrenia
Conclusions: Patients with FES show increases in cardiovascular risk factors at index. Short observation periods and the presumption of linear trajectories may indicate that the effect of health-promoting programs is ineffective, as the effects are curvilinear and improvements appear only after 1 year. The implication clinically is the importance of a long intervention period regarding lifestyle modifications to ascertain improvement among patients with FES. (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2020 Category: Drugs & Pharmacology Tags: Original Investigation Source Type: research

A Glutathione Precursor Reduces Oxidative Injury to Cultured Embryonic Cardiomyocytes
Conclusions: It is concluded that the glutathione precursor γGlu-Cys protects cultured embryonic cardiomyocytes from apoptosis-associated oxidative injury. (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2020 Category: Drugs & Pharmacology Tags: Original Investigation Source Type: research

Metabolic Monitoring of Child and Adolescent Patients on Atypical Antipsychotics by Psychiatrists and Primary Care Providers
Conclusions: Metabolic monitoring rate of child and adolescent patients on SGAs was low overall. No statistically significant differences were seen between psychiatry and PCP except a significantly higher rate of fasting plasma glucose level monitoring at baseline among PCP. Limitations to the study include the small sample size obtained for the period investigated and insufficient documentation in some electronic charts. Extending the period studied may increase the statistical significance of the data. (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - September 1, 2020 Category: Drugs & Pharmacology Tags: Original Investigation Source Type: research

Opioid Crises—the Perspective From a Developing Country
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - July 1, 2020 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research

Elevated Liver Enzymes Unmask Severe Statin-Induced Muscle Injury
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - July 1, 2020 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research

Olanzapine-Associated Portal and Superior Mesenteric Vein Thrombosis
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - July 1, 2020 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research

A Case of Lenalidomide-Associated Papulopustular Rash: Beyond the Epidermal Growth Factor Receptor Inhibitor Spectrum
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - July 1, 2020 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research

Immune-Mediated Colitis due to Concurrent Ipilimumab and Nivolumab Therapy Treated With Infliximab
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - July 1, 2020 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research

Diltiazem and Hiatal Hernia: An Unknown Association
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - July 1, 2020 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research

Electroconvulsive Therapy for Anticholinergic and Benzodiazepine Nonresponsive Tardive Oculogyric Crisis: A Case Report
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - July 1, 2020 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research

Omeprazole-Associated Necrotizing Pancreatitis
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - July 1, 2020 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research

Sideroblastic Anemia Associated With Isoniazid Prophylaxis in a Person Living With HIV
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - July 1, 2020 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research

Imatinib-Associated Pneumocystis jirovecii Pneumonia in a Patient With Chronic Myeloid Leukemia
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - July 1, 2020 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research

Valproic Acid in the Treatment of Secondary Mania Caused by Metastatic Brain Tumors
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - July 1, 2020 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research

Acute Kidney Injury in Patients Using Amikacin in Intensive Care Unit—A Paired Case–Control Study With Meropenem
No abstract available (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - July 1, 2020 Category: Drugs & Pharmacology Tags: Letters to the Editor Source Type: research

COVID-19 and Avoiding Ibuprofen. How Good Is the Evidence?
Ibuprofen is an over-the-counter medication that is used widely for the treatment of pain and fever during COVID-19 pandemic. A concern was raised regarding the safety of ibuprofen use because of its role in increasing ACE2 levels within the Renin–Angiotensin–Aldosterone system. ACE2 is the coreceptor for the entry of SARS-CoV-2 into cells, and so, a potential increased risk of contracting COVID-19 disease and/or worsening of COVID-19 infection was feared with ibuprofen use. However, available data from limited studies show administration of recombinant ACE2 improves lung damage caused by respiratory viruses, s...
Source: American Journal of Therapeutics - July 1, 2020 Category: Drugs & Pharmacology Tags: Therapeutic Opinion Source Type: research

Implementation of a Weight-Based Protocol for the Management of Steroid-Induced Hyperglycemia
Background: Hyperglycemia is a recognized complication of supraphysiological steroid dosing. There are no consensus guidelines on optimal treatment of steroid-induced hyperglycemia. We assessed the safety of a weight-based insulin protocol for persons treated with supraphysiological doses of steroids to examine the efficacy of using this protocol in patients with diabetes treated with prednisone or methylprednisolone. Areas of Uncertainty: There is uncertainty about the optimal dosing of insulin to manage steroid-induced hyperglycemia; thus, a weight-based protocol was created with the goal of reaching euglycemia fast...
Source: American Journal of Therapeutics - July 1, 2020 Category: Drugs & Pharmacology Tags: Therapeutic Innovation Source Type: research

Self-Medicating for Pain: A Public Health Perspective
Conclusions: Pain and self-medication must be addressed, including in medical practice, starting from their multidimensionality from the following perspectives: medicobiological, sociocultural, instructive-educational, legal-political, and especially ethical. They are not only individual health problems but also become, when connected with a stigma, a public health problem. (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - July 1, 2020 Category: Drugs & Pharmacology Tags: Systematic Review and Clinical Guidelines Source Type: research

Therapeutic Interventions for Adjustment Disorder: A Systematic Review
Conclusions: Psychotherapy seems indicated for mildly symptomatic adjustment disorder. Given the fact that adjustment disorder with severe symptoms is associated with a high risk of suicidal ideation and suicide attempts, clinicians must consider the potential benefit of using psychotropic agents such as benzodiazepines, antidepressants, or etifoxine. (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - July 1, 2020 Category: Drugs & Pharmacology Tags: Systematic Review and Clinical Guidelines Source Type: research

Propofol Infusion and Acute Pancreatitis: A Review
Conclusions: Although, the mechanism of propofol-induced pancreatitis is not fully understood, and the causal relationship of propofol-induced hypertriglyceridemia or idiosyncratic drug reaction has remained unproven. Clinicians should be aware of the association between propofol and pancreatitis, and any patient presenting with abdominal pain after propofol infusion should be evaluated for AP and treated promptly to avoid complications. (Source: American Journal of Therapeutics)
Source: American Journal of Therapeutics - July 1, 2020 Category: Drugs & Pharmacology Tags: Systematic Review and Clinical Guidelines Source Type: research