Subgroup and per-protocol analyses from the Hypertension in the Very Elderly Trial

Background:The results of the Hypertension in the Very Elderly Trial showed positive benefits from blood pressure-lowering treatment in those aged 80 and over. Method:An analysis by the pre-specified subgroups [age, sex, history of cardiovascular disease (CVD) and initial SBP] was performed. The Hypertension in the Very Elderly Trial was a randomized, double-blind, placebo-controlled trial of 3845 participants aged 80 and over with SBPs of 160–199 mmHg and diastolic pressures below 110 mmHg recruited from Europe, China, Australasia and Tunisia. Active treatment was indapamide sustained-release 1.5 mg with the addition of perindopril 2–4 mg as required to reach a target blood pressure of less than 150/80 mmHg. Results:For total mortality, benefits were consistent: men [hazard ratio 0.82, 95% confidence interval (CI) 0.62–1.11], women (hazard ratio 0.77, 95% CI 0.66–0.99), those aged 80–84.9 (hazard ratio 0.76, 95% CI 0.60–0.96), those aged 85 and over (hazard ratio 0.87, 95% CI 0.64–1.20), those with a history of CVD (hazard ratio 0.76, 95% CI 0.48–1.20) and those without (hazard ratio 0.81, 95% CI 0.65–0.99), and similarly across a range of baseline SBPs. The point estimates for cardiovascular mortality, strokes, heart failure and cardiovascular events were all in favour of benefit. In the per-protocol analysis, strokes were reduced by 34% (P = 0.026), total mortality by 28% (P = 0.001), cardiovascular event by 37% (P 
Source: Journal of Hypertension - Category: Cardiology Tags: ORIGINAL PAPERS: Elderly Source Type: research