Issue Information
Microcirculation, Volume 27, Issue 2, February 2020. (Source: Microcirculation)
Source: Microcirculation - March 21, 2020 Category: Research Tags: ISSUE INFORMATION Source Type: research

The British Microcirculation Society
Microcirculation, Volume 27, Issue 2, February 2020. (Source: Microcirculation)
Source: Microcirculation - March 21, 2020 Category: Research Tags: ABSTRACTS Source Type: research

Cover Image
Cover Caption: The cover image is based on the Original Article Lymphatic ‐to‐Blood Vessel Transition in Adult Microvascular Networks: A Discovery Made Possible by a Top‐Down Approach to Biomimetic Model Development by Walter Murfee et al.,https://doi.org/10.1111/micc.12595. (Source: Microcirculation)
Source: Microcirculation - March 21, 2020 Category: Research Authors: Mohammad S. Azimi, Jessica M. Motherwell, Nicholas A. Hodges, Garret R. Rittenhouse, Dima Majbour, Stacey L. Porvasnik, Christine E. Schmidt, Walter L. Murfee Tags: COVER IMAGE Source Type: research

The influence of hyperglycemia on neutrophil extracellular trap formation and endothelial glycocalyx damage in a mouse model of type 2 diabetes
ConclusionNeutrophil activation and cell death induce endothelial glycocalyx damage, and NETs formation also participates in the mechanisms of vascular injury in type 2 diabetes. (Source: Microcirculation)
Source: Microcirculation - March 21, 2020 Category: Research Authors: Tatsuhiko Hirota, Jerrold H. Levy, Toshiaki Iba Tags: ORIGINAL RESEARCH Source Type: research

Sublingual microcirculation in prehospital critical care medicine: A proof ‐of‐concept study
ConclusionThe prehospital sublingual measurement is safe and valid. Despite normal macrocirculation, microcirculation was impaired and correlated with National Advisory Committee on Aeronautics. (Source: Microcirculation)
Source: Microcirculation - March 21, 2020 Category: Research Authors: Raphael Romano Bruno, Markus Reed, Nana ‐Yaw Bimpong‐Buta, Johanna M. Muessig, Maryna Masyuk, Stephan Binneboessel, Marcus Franz, Malte Kelm, Christian Jung Tags: ORIGINAL ARTICLE Source Type: research

The systemic microcirculation in dialysis populations
AbstractIn a rapidly expanding population of patients with chronic kidney disease, including 2  million people requiring renal replacement therapy, cardiovascular mortality is 15 times greater than the general population. In addition to traditional cardiovascular risk factors, more poorly defined risks related to uremia and its treatments appear to contribute to this exaggerated risk. In thi s context, the microcirculation may play an important early role in cardiovascular disease associated with chronic kidney disease. Experimentally, the uremic environment and dialysis have been linked to multiple pathways causing m...
Source: Microcirculation - March 21, 2020 Category: Research Authors: Jennifer Williams, Mark Gilchrist, David Strain, Donald Fraser, Angela Shore Tags: REVIEW Source Type: research

REAVER: A Program for Improved Analysis of High ‐resolution Vascular Network Images
We present REAVER (Rapid Editable Analysis of Vessel Elements Routine), an open‐source tool that researchers can use to analyze high‐resolution 2D fluorescent images of blood vessel networks, and assess its performance compared to alternative image analysis pr ograms. Using a dataset of manually analyzed images from a variety of murine tissues as a ground‐truth, REAVER exhibited the highest accuracy and precision for all vessel architecture metrics quantified, including vessel length density, vessel area fraction, mean vessel diameter, and branchpoint c ount, along with the highest pixel‐by‐pixel accuracy for the...
Source: Microcirculation - March 21, 2020 Category: Research Authors: Bruce A. Corliss, Richard W. Doty, Corbin Mathews, Paul A. Yates, Tingting Zhang, Shayn M. Peirce Tags: ORIGINAL RESEARCH Source Type: research

Capillary microscopy in Europeans with idiopathic Moyamoya angiopathy
ConclusionsMMD is not associated with microvascular changes of the nailfold capillaries. In this respect, it is clearly distinct from SLE. (Source: Microcirculation)
Source: Microcirculation - March 21, 2020 Category: Research Authors: Oliver Sander, Jan Claudius Schwitalla, Marius Ringelstein, Orhan Aktas, Matthias Schneider, Peter Berlit, Hans ‐Peter Hartung, Philipp Albrecht, Markus Kraemer Tags: ORIGINAL ARTICLE Source Type: research

REAVER: A Program for Improved Analysis of High ‐resolution Vascular Network Images
We present REAVER (Rapid Editable Analysis of Vessel Elements Routine), an open‐source tool that researchers can use to analyze high‐resolution 2D fluorescent images of blood vessel networks, and assess its performance compared to alternative image analysis pr ograms. Using a dataset of manually analyzed images from a variety of murine tissues as a ground‐truth, REAVER exhibited the highest accuracy and precision for all vessel architecture metrics quantified, including vessel length density, vessel area fraction, mean vessel diameter, and branchpoint c ount, along with the highest pixel‐by‐pixel accuracy for the...
Source: Microcirculation - March 18, 2020 Category: Research Authors: Bruce A. Corliss, Richard W. Doty, Corbin Mathews, Paul A. Yates, Tingting Zhang, Shayn M. Peirce Tags: ORIGINAL RESEARCH Source Type: research

Sublingual microcirculation in prehospital critical care medicine: A proof ‐of‐concept study
ConclusionThe prehospital sublingual measurement is safe and valid. Despite normal macrocirculation, microcirculation was impaired and correlated with National Advisory Committee on Aeronautics. (Source: Microcirculation)
Source: Microcirculation - March 5, 2020 Category: Research Authors: Raphael Romano Bruno, Markus Reed, Nana ‐Yaw Bimpong‐Buta, Johanna M. Muessig, Maryna Masyuk, Stephan Binneboessel, Marcus Franz, Malte Kelm, Christian Jung Tags: ORIGINAL ARTICLE Source Type: research

The influence of hyperglycemia on neutrophil extracellular trap formation and endothelial glycocalyx damage in a mouse model of type 2 diabetes
ConclusionNeutrophil activation and cell death induce endothelial glycocalyx damage, and NETs formation also participates in the mechanisms of vascular injury in type 2 diabetes. (Source: Microcirculation)
Source: Microcirculation - March 4, 2020 Category: Research Authors: Tatsuhiko Hirota, Jerrold H. Levy, Toshiaki Iba Tags: ORIGINAL RESEARCH Source Type: research

Capillary Microscopy in Europeans with Idiopathic Moyamoya Angiopathy
ConclusionsMMD is not associated with microvascular changes of the nailfold capillaries. In this respect, it is clearly distinct from SLE. (Source: Microcirculation)
Source: Microcirculation - March 1, 2020 Category: Research Authors: Oliver Sander, Jan Claudius Schwitalla, Marius Ringelstein, Orhan Aktas, Matthias Schneider, Peter Berlit, Hans ‐Peter Hartung, Philipp Albrecht, Markus Kraemer Tags: ORIGINAL RESEARCH Source Type: research

Cover Image
Cover Caption: The cover image is based on the Original Article Lymphatic ‐to‐Blood Vessel Transition in Adult Microvascular Networks: A Discovery Made Possible by a Top‐Down Approach to Biomimetic Model Development by Walter Murfee et al.,https://doi.org/10.1111/micc.12595. (Source: Microcirculation)
Source: Microcirculation - February 21, 2020 Category: Research Authors: Mohammad S. Azimi, Jessica M. Motherwell, Nicholas A. Hodges, Garret R. Rittenhouse, Dima Majbour, Stacey L. Porvasnik, Christine E. Schmidt, Walter L. Murfee Tags: COVER IMAGE Source Type: research

Issue Information
Microcirculation, Volume 27, Issue 2, February 2020. (Source: Microcirculation)
Source: Microcirculation - February 20, 2020 Category: Research Tags: ISSUE INFORMATION Source Type: research

The British Microcirculation Society
Microcirculation, Volume 27, Issue 2, February 2020. (Source: Microcirculation)
Source: Microcirculation - February 20, 2020 Category: Research Tags: ABSTRACTS Source Type: research

The Systemic Microcirculation In Dialysis Populations
AbstractIn a rapidly expanding population of patients with chronic kidney disease, including 2 million people requiring renal replacement therapy, cardiovascular mortality is 15 times greater than the general population. In addition to traditional cardiovascular risk factors, more poorly defined risks related to uraemia and it ’s treatments appear to contribute to this exaggerated risk. In this context, the microcirculation may play an important early role in cardiovascular disease associated with chronic kidney disease. Experimentally the uraemic environment and dialysis have been linked to multiple pathways causing...
Source: Microcirculation - February 17, 2020 Category: Research Authors: Jennifer Williams, Mark Gilchrist, David Strain, Donald Fraser, Angela Shore Tags: REVIEW Source Type: research

Sublingual microcirculation in Prehospital Critical Care Medicine – a Proof of Concept Study
ConclusionThe prehospital sublingual measurement is safe and valid. Despite normal macrocirculation, microcirculation was impaired and correlated with NACA. (Source: Microcirculation)
Source: Microcirculation - February 17, 2020 Category: Research Authors: Raphael Romano Bruno, Markus Reed, Nana ‐Yaw Bimpong‐Buta, Johanna M. Muessig, Maryna Masyuk, Stephan Binneboessel, Marcus Franz, Malte Kelm, Christian Jung Tags: ORIGINAL RESEARCH Source Type: research

High ‐dose Nitroglycerin Administered during Rewarming Preserves Erythrocyte Deformability in Cardiac Surgery with Cardiopulmonary Bypass
ConclusionsHigh ‐dose nitroglycerin administered during cardiopulmonary bypass improves erythrocyte deformability through activating phosphorylation of aquaporin 1, vasodilator‐stimulated phosphoprotein and focal adhesion kinase in erythrocytes. (Source: Microcirculation)
Source: Microcirculation - February 10, 2020 Category: Research Authors: Ying ‐Hsuan Tai, You‐Hsiang Chu, Hsiang‐Ling Wu, Su‐Man Lin, Mei‐Yung Tsou, Cheng‐Hsiung Huang, Hsiao‐Huang Chang, Chih‐Cherng Lu Tags: ORIGINAL RESEARCH Source Type: research

Aging alters spontaneous and neurotransmitter ‐mediated Ca2+ signaling in smooth muscle cells of mouse mesenteric arteries
ConclusionWith aging, we suggest that altered RyR expression in SMCs contributes to impaired ability of sensory neurotransmission to restore Ca2+ signaling underlying vasomotor control during sympathetic activation. (Source: Microcirculation)
Source: Microcirculation - February 10, 2020 Category: Research Authors: Erika M. Boerman, Steven S. Segal Tags: ORIGINAL RESEARCH Source Type: research

Higher levels of daily physical activity are associated with better skin microvascular function in type 2 diabetes – The Maastricht Study
ConclusionHigher levels of total and higher ‐intensity physical activity were associated with greater skin microvascular vasodilation in individuals with, but not in those without T2D. (Source: Microcirculation)
Source: Microcirculation - February 10, 2020 Category: Research Authors: Ben M. S örensen, Frank C.T. van der Heide, Alfons J.H.M. Houben, Annemarie Koster, Tos T.J.M. Berendschot, Jan S.A.G. Schouten, Abraham A. Kroon, Carla J.H. van der Kallen, Ronald M.A. Henry, Martien C.J.M van Dongen, Simone J.P.M. Eussen, Ha Tags: ORIGINAL RESEARCH Source Type: research

Modeling acute blood flow responses to a major arterial occlusion
ConclusionsAlthough unable to compensate fully for an occlusion, the model demonstrates the importance of the shear response in collateral arteries and the metabolic response in the distal microcirculation in acute adaptations to a major arterial occlusion. (Source: Microcirculation)
Source: Microcirculation - February 10, 2020 Category: Research Authors: Erin Zhao, Jared Barber, Myson Burch, Joseph Unthank, Julia Arciero Tags: ORIGINAL RESEARCH Source Type: research

Role of endothelium ‐independent vasodilation in the relationship between visceral adiposity and reduced cognitive performance in older adults with type 2 diabetes
AbstractObjectiveIn this cross ‐sectional analysis, we sought to assess the relationship of adiposity and forearm microvascular reactivity with cognitive dysfunction among older Asians with type 2 diabetes (T2D).MethodsSubjects with T2D aged ≥55 years were analysed (N=907). Cognitive performance was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and Mini‐Mental State Exam (MMSE). Visceral fat area (VFA) was estimated by tetrapolar multi‐frequency bioimpedance. Forearm microvascular en dothelium‐dependent vasodilation (EDV) and endothelium‐independent vasodilation ...
Source: Microcirculation - February 10, 2020 Category: Research Authors: Mei Chung Moh, Serena Low, Tze Pin Ng, Keven Ang, Tavintharan Subramaniam, Chee Fang Sum, Pek Yee Kwan, Simon Biing Ming Lee, Wern Ee Tang, Lim Su Chi Tags: ORIGINAL RESEARCH Source Type: research

The effect of sphingosine ‐1‐phosphate on the endothelial glycocalyx during ischemia‐reperfusion injury in the isolated rat heart
ConclusionThese results suggest that S1P ‐induced cardioprotection against I/R injury is not mediated by the maintenance of syndecan‐1 in the endothelial glycocalyx. (Source: Microcirculation)
Source: Microcirculation - February 10, 2020 Category: Research Authors: Hala Araibi, Elizabeth van der Merwe, Asfree Gwanyanya, Roisin Kelly ‐Laubscher Tags: ORIGINAL RESEARCH Source Type: research

Modeling acute blood flow responses to a major arterial occlusion
ConclusionsAlthough unable to compensate fully for an occlusion, the model demonstrates the importance of the shear response in collateral arteries and the metabolic response in the distal microcirculation in acute adaptations to a major arterial occlusion. (Source: Microcirculation)
Source: Microcirculation - January 30, 2020 Category: Research Authors: Erin Zhao, Jared Barber, Myson Burch, Joseph Unthank, Julia Arciero Tags: ORIGINAL RESEARCH Source Type: research

Role of endothelium ‐independent vasodilation in the relationship between visceral adiposity and reduced cognitive performance in older adults with type 2 diabetes
AbstractObjectiveIn this cross ‐sectional analysis, we sought to assess the relationship of adiposity and forearm microvascular reactivity with cognitive dysfunction among older Asians with type 2 diabetes (T2D).MethodsSubjects with T2D aged ≥55 years were analysed (N=907). Cognitive performance was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and Mini‐Mental State Exam (MMSE). Visceral fat area (VFA) was estimated by tetrapolar multi‐frequency bioimpedance. Forearm microvascular en dothelium‐dependent vasodilation (EDV) and endothelium‐independent vasodilation ...
Source: Microcirculation - January 30, 2020 Category: Research Authors: Mei Chung Moh, Serena Low, Tze Pin Ng, Keven Ang, Tavintharan Subramaniam, Chee Fang Sum, Pek Yee Kwan, Simon Biing Ming Lee, Wern Ee Tang, Lim Su Chi Tags: ORIGINAL RESEARCH Source Type: research

Higher levels of daily physical activity are associated with better skin microvascular function in type 2 diabetes – The Maastricht Study
ConclusionHigher levels of total and higher ‐intensity physical activity were associated with greater skin microvascular vasodilation in individuals with, but not in those without T2D. (Source: Microcirculation)
Source: Microcirculation - January 29, 2020 Category: Research Authors: Ben M. S örensen, Frank C.T. van der Heide, Alfons J.H.M. Houben, Annemarie Koster, Tos T.J.M. Berendschot, Jan S.A.G. Schouten, Abraham A. Kroon, Carla J.H. van der Kallen, Ronald M.A. Henry, Martien C.J.M van Dongen, Simone J.P.M. Eussen, Ha Tags: ORIGINAL RESEARCH Source Type: research

Aging alters spontaneous and neurotransmitter ‐mediated Ca2+ signaling in smooth muscle cells of mouse mesenteric arteries
ConclusionWith aging, we suggest that altered RyR expression in SMCs contributes to impaired ability of sensory neurotransmission to restore Ca2+ signaling underlying vasomotor control during sympathetic activation. (Source: Microcirculation)
Source: Microcirculation - January 28, 2020 Category: Research Authors: Erika M. Boerman, Steven S. Segal Tags: ORIGINAL RESEARCH Source Type: research

High ‐dose Nitroglycerin Administered during Rewarming Preserves Erythrocyte Deformability in Cardiac Surgery with Cardiopulmonary Bypass
ConclusionsHigh ‐dose nitroglycerin administered during cardiopulmonary bypass improves erythrocyte deformability through activating phosphorylation of aquaporin 1, vasodilator‐stimulated phosphoprotein and focal adhesion kinase in erythrocytes. (Source: Microcirculation)
Source: Microcirculation - January 28, 2020 Category: Research Authors: Ying ‐Hsuan Tai, You‐Hsiang Chu, Hsiang‐Ling Wu, Su‐Man Lin, Mei‐Yung Tsou, Cheng‐Hsiung Huang, Hsiao‐Huang Chang, Chih‐Cherng Lu Tags: ORIGINAL RESEARCH Source Type: research

Issue Information
Microcirculation, Volume 27, Issue 1, January 2020. (Source: Microcirculation)
Source: Microcirculation - January 14, 2020 Category: Research Tags: ISSUE INFORMATION Source Type: research

Correlation between longitudinal strain analysis and coronary microvascular dysfunction in patients with heart failure with preserved ejection fraction
ConclusionOur results show that cardiac contractile mechanics are altered in patients with heart failure with preserved ejection fraction at a subclinical level hard to identifiable with conventional echocardiography. The dysfunction of the microcirculation and the consequent alteration of the TIMI frame count probably results in a reduction of myocardial performance. (Source: Microcirculation)
Source: Microcirculation - January 14, 2020 Category: Research Authors: Vincenzo Sucato, Alfredo Ruggero Galassi, Salvatore Novo, Antonino Saladino, Salvatore Evola, Giuseppina Novo Tags: ORIGINAL ARTICLE Source Type: research

Pyridoxamine improves metabolic and microcirculatory complications associated with nonalcoholic fatty liver disease
ConclusionPyridoxamine modulates oxidative stress, advanced glycation end products, TNF ‐α transcripts levels, and metabolic disturbances, being a potential treatment for nonalcoholic fatty liver disease‐associated microcirculatory and metabolic complications. (Source: Microcirculation)
Source: Microcirculation - January 14, 2020 Category: Research Authors: Evelyn Nunes Goulart da Silva Pereira, Raquel Rangel Silvares, Edgar Eduardo Ilaquita Flores, Karine Lino Rodrigues, Anissa Daliry Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
Microcirculation, Volume 27, Issue 1, January 2020. (Source: Microcirculation)
Source: Microcirculation - January 14, 2020 Category: Research Tags: ISSUE INFORMATION Source Type: research

Pyridoxamine improves metabolic and microcirculatory complications associated with nonalcoholic fatty liver disease
ConclusionPyridoxamine modulates oxidative stress, advanced glycation end products, TNF ‐α transcripts levels, and metabolic disturbances, being a potential treatment for nonalcoholic fatty liver disease‐associated microcirculatory and metabolic complications. (Source: Microcirculation)
Source: Microcirculation - January 14, 2020 Category: Research Authors: Evelyn Nunes Goulart da Silva Pereira, Raquel Rangel Silvares, Edgar Eduardo Ilaquita Flores, Karine Lino Rodrigues, Anissa Daliry Tags: ORIGINAL ARTICLE Source Type: research

Relationship between shape of peripheral initial lymphatics and efficiency of mechanical stimulation –induced lymph formation
ConclusionsWe conclude that irregularly shaped initial lymphatics may lead to efficient lymph formation induced by mechanical stimulation of the tissue. (Source: Microcirculation)
Source: Microcirculation - January 13, 2020 Category: Research Authors: Fumitaka Ikomi, Sumiyo Hiruma Tags: ORIGINAL RESEARCH Source Type: research

Post ‐occlusive reactive hyperemic response of skin microcirculation among extremely obese patients in the short and long term after bariatric surgery
AbstractObjectiveTo assess changes of post ‐occlusive reactive hyperemic response in skin microcirculation among extremely obese patients 10 days and 6 months after bariatric surgery for patients with and without hypertension.MethodsSkin blood flow was measured using PeriFlux laser Doppler fluxmetry. Data were analyzed in the entire group and two subgroups: with and without hypertension.ResultsData from 88 patients (mean age 42.1  ± 11.2 years, 40.5% men) were analyzed. Six months after bariatric surgery, the time to reach peak flows had been shortened (2.4 ± 1.7 vs 2.1&nb...
Source: Microcirculation - January 2, 2020 Category: Research Authors: Barbara Gryglewska, Anna G łuszewska, Bartosz Zarzycki, Anna Dzieża‐ Grudnik, Małgorzata Fedyk‐Łukasik, Piotr Major, Andrzej Budzyński, Jerzy Gąsowski, Tomasz Grodzicki Tags: ORIGINAL ARTICLE Source Type: research

Correlation between longitudinal strain analysis and coronary microvascular dysfunction in patients with heart failure with preserved ejection fraction
AbstractHeart failure with preserved ejection fraction (HFpEF) has overtaken heart failure in the setting of reduced ejection fraction as the most common form of heart failure and now comprises more than 50% of all patients with heart failure [1]. In a recently published work, Paulus et al. hypothesizes that endothelial dysfunction of the coronary microcirculation may alter the paracrine cross ‐talk signaling pathway between the coronary microcirculation and cardiomyocyte, through a reduction in the NO and downstream bioavailability of both cyclic guanosine monophosphate (cGMP) and protein kinase G (PKG) activity. (Source: Microcirculation)
Source: Microcirculation - December 31, 2019 Category: Research Authors: Vincenzo Sucato, Alfredo Ruggero Galassi, Salvatore Novo, Antonino Saladino, Salvatore Evola, Giuseppina Novo Tags: ORIGINAL RESEARCH Source Type: research

Pyridoxamine improves metabolic and microcirculatory complications associated with non ‐alcoholic fatty liver disease
ConclusionPM modulates oxidative stress, AGEs, TNF ‐α transcripts levels and metabolic disturbances, being a potential treatment for NAFLD‐associated microcirculatory and metabolic complications. (Source: Microcirculation)
Source: Microcirculation - December 25, 2019 Category: Research Authors: Evelyn Nunes Goulart da Silva Pereira, Raquel Rangel Silvares, Edgar Eduardo Ilaquita Flores, Karine Lino Rodrigues, Anissa Daliry Tags: ORIGINAL RESEARCH Source Type: research

Conjunctival Microcirculation Is Associated with Cerebral Cortex Microcirculation in Post ‐Resuscitation Mild Hypothermia: A Rat Model
This study aimed to compare the changes in sublingual and conjunctival microcirculation occurring with cerebral cortex microcirculation changes during mild hypothermia in a rat model of cardiac arrest. Twenty ‐four rats were randomized into mild hypothermia (M) or normothermia (C) groups. Ventricular fibrillation was electrically induced and left untreated for 8 min, followed by 8 min of cardiopulmonary resuscitation. The core temperature in group M reduced to 33±0.5°C at 13 min after restoration of spontaneous circulation (ROSC) and was maintained for 8 h. In group C, the core temperature was maintained at 37...
Source: Microcirculation - December 25, 2019 Category: Research Authors: Shen Zhao, Zhengfei Yang, Peng Sun, Xiaobo Wu, Wanchun Tang, Fei Shao, Ziren Tang Tags: ORIGINAL RESEARCH Source Type: research

Pyridoxamine improves metabolic and microcirculatory complications associated with non ‐alcoholic fatty liver disease
ConclusionPM modulates oxidative stress, AGEs, TNF ‐α transcripts levels and metabolic disturbances, being a potential treatment for NAFLD‐associated microcirculatory and metabolic complications. (Source: Microcirculation)
Source: Microcirculation - December 25, 2019 Category: Research Authors: Evelyn Nunes Goulart da Silva Pereira, Raquel Rangel Silvares, Edgar Eduardo Ilaquita Flores, Karine Lino Rodrigues, Anissa Daliry Tags: ORIGINAL RESEARCH Source Type: research

Epigenetic control of tumor angiogenesis
AbstractThe term “epigenetic” is used to refer to heritable alterations in chromatin that are not due to changes in DNA sequence. Different growth factors and vascular genes mediate the angiogenic process, which is regulated by epigenetic states of genes. The aim of this article is to analyze the role epigenetic mechanisms in the control and regulation of tumor angiogenetic processes. The reversibility of epigenetic events in contrast to genetic aberrations, makes them potentially suitable for therapeutic intervention. In this context, DNA methyltransferase (DNMT) and HDAC inhibitors indirectly – via the ...
Source: Microcirculation - December 21, 2019 Category: Research Authors: Domenico Ribatti, Roberto Tamma Tags: REVIEW ARTICLE Source Type: research

Issue Information
Microcirculation, Volume 26, Issue 8, November 2019. (Source: Microcirculation)
Source: Microcirculation - December 6, 2019 Category: Research Tags: ISSUE INFORMATION Source Type: research

Acute application of a transdermal nitroglycerin patch protects against prolonged forearm ischemia ‐induced microvascular dysfunction
We examined the ability of a local nitric oxide donor (transdermal nitroglycerin, GTN) administered during prolonged cuff forearm occlusion to protect against microvascular dysfunction and to alter brachial artery dilation.MethodsTen healthy men (28 ±8 y) participated in the study. During the control visit they completed three vascular occlusion tests (VOT) in the right arm termed, PRE (5‐min occlusion), POSTimmediate (20 ‐min occlusion) and POST30min (5 ‐min occlusion). During the GTN visit, subjects completed the same VOT tests, but with a GTN patch placed over the contralateral forearm during the 20 min occ...
Source: Microcirculation - November 29, 2019 Category: Research Authors: Rogerio N. Soares, David N. Proctor, Gustavo V. de Oliveira, Thiago Silveira Alvares, Juan M. Murias Tags: ORIGINAL RESEARCH Source Type: research

Long noncoding RNA XIST participates hypoxia ‐induced angiogenesis in human brain microvascular endothelial cells through regulating miR‑485/SOX7 axis
ConclusionAltogether, the present study suggested that XIST is required to maintain VEGF signaling expression in HBMEC under hypoxia condition and plays a vital role in hypoxia ‐induced angiogenesis via miR‐485‐3p/SOX7 axis. (Source: Microcirculation)
Source: Microcirculation - November 29, 2019 Category: Research Authors: Chenggong Hu, Xue Bai, Chang Liu, Zhi Hu Tags: ORIGINAL RESEARCH Source Type: research

Acute application of a transdermal nitroglycerin patch protects against prolonged forearm ischemia ‐induced microvascular dysfunction
We examined the ability of a local nitric oxide donor (transdermal nitroglycerin, GTN) administered during prolonged cuff forearm occlusion to protect against microvascular dysfunction and to alter brachial artery dilation.MethodsTen healthy men (28 ±8 y) participated in the study. During the control visit they completed three vascular occlusion tests (VOT) in the right arm termed, PRE (5‐min occlusion), POSTimmediate (20 ‐min occlusion) and POST30min (5 ‐min occlusion). During the GTN visit, subjects completed the same VOT tests, but with a GTN patch placed over the contralateral forearm during the 20 min occ...
Source: Microcirculation - November 29, 2019 Category: Research Authors: Rogerio N. Soares, David N. Proctor, Gustavo V. de Oliveira, Thiago Silveira Alvares, Juan M. Murias Tags: ORIGINAL RESEARCH Source Type: research