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Regulation of voltage ‐gated potassium channels in vascular smooth muscle during hypertension and metabolic disorders
This article is protected by copyright. All rights reserved. (Source: Microcirculation)
Source: Microcirculation - October 16, 2017 Category: Research Authors: Madeline Nieves ‐Cintrón, Arsalan U. Syed, Matthew A. Nystoriak, Manuel F. Navedo Tags: Invited Reviews Source Type: research

The British Microcirculation Society
(Source: Microcirculation)
Source: Microcirculation - October 7, 2017 Category: Research Tags: ABSTRACTS Source Type: research

Effects of different ‐intensity laser acupuncture at two adjacent same‐meridian acupoints on nitric oxide and soluble guanylate cyclase releases in human
ConclusionsThis is the first evidence reporting that LA induced significant elevations of NO‐sGC releases over acupoints, and the enhanced signal molecules contribute to local circulation, which improves the beneficial effects of the therapy. (Source: Microcirculation)
Source: Microcirculation - October 7, 2017 Category: Research Authors: Wan ‐Ling Jiang, Hua‐Jiang Wei, Zhou‐Yi Guo, Yi‐Rong Ni, Hong‐Qin Yang, Shu‐Sen Xie Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
(Source: Microcirculation)
Source: Microcirculation - October 7, 2017 Category: Research Tags: ISSUE INFORMATION Source Type: research

Kv7 potassium channels as signal transduction intermediates in the control of microvascular tone
This article is protected by copyright. All rights reserved. (Source: Microcirculation)
Source: Microcirculation - October 4, 2017 Category: Research Authors: Kenneth L. Byron, Lyubov I. Brueggemann Tags: Reviews Source Type: research

Hepatic Transudation Barrier Properties
ConclusionsTaken together, these findings suggest that the hepatic transudation barrier is highly permeable at elevated sinusoidal pressures. These fundamental studies provide a better understanding of the hepatic transudation barrier properties and transudation under conditions that are physiologically and clinically relevant to ascites formation.This article is protected by copyright. All rights reserved. (Source: Microcirculation)
Source: Microcirculation - October 1, 2017 Category: Research Authors: R M Dongaonkar, R H Stewart, C M Quick, K L Uray, C S Cox, G A Laine Tags: Original Research Source Type: research

The relationship between forearm skin speed resolved perfusion and oxygen saturation, and finger arterial pulsation amplitudes, as indirect measures of endothelial function
ConclusionWe have demonstrated for the first time, a relationship between forearm skin microcirculatory perfusion and oxygen saturation and finger peripheral arterial tonometry. Both local heating and reactive hyperemia are useful skin provocations. Further studies are needed to understand the precise regulation mechanisms of blood flow and oxygenation during these tests.This article is protected by copyright. All rights reserved. (Source: Microcirculation)
Source: Microcirculation - October 1, 2017 Category: Research Authors: Sara Bergstrand, Maria ‐Aurora Morales, Giuseppe Coppini, Marcus Larsson, Tomas Strömberg Tags: Original Research Source Type: research

Increased myoendothelial feedback is associated with increased connexin37 and IK1 channel expression in mesenteric arteries of diet ‐induced hyperhomocysteinemic mice
Abstract ObjectivePreviously, we found that diet‐induced HHcy in mice caused decreased eNOS expression and signaling in mesenteric arteries, but greatly enhanced non‐NOS, non‐prostacyclin‐dependent vasodilation, which involves myoendothelial gap junction (MEJ) communication. To further assess whether HHcy enhances MEJ communication, this study examined endothelium‐dependent attenuation of phenylephrine‐induced vasoconstriction (myoendothelial feedback) and key molecules involved. MethodsMyoendothelial feedback was examined in isolated mouse mesenteric arteries, after 6‐wk diet‐induced HHcy, using pressure m...
Source: Microcirculation - August 31, 2017 Category: Research Authors: Robin C. Looft ‐Wilson, Cara R. Goodell, Christina A. Mutch, Stephanie M. Mutchler, Kayla L. Miller, Monique Guraya Tags: Original Research Source Type: research

Influence of feeding hematocrit and perfusion pressure on hematocrit reduction (F åhræus effect) in an artificial microvascular network
ConclusionsThe magnitude of the network Fåhræus effect in an AMVN is inversely related to feeding hematocrit and perfusion pressure.This article is protected by copyright. All rights reserved. (Source: Microcirculation)
Source: Microcirculation - August 12, 2017 Category: Research Authors: Walter H. Reinhart, Nathaniel Z. Piety, Sergey S. Shevkoplyas Tags: Original Research Source Type: research

Dosing of indocyanine ‐green for intraoperative laser fluorescence angiography in kidney transplantation
ConclusionsFluorescence angiography with ICG is an emerging tool for the intraoperative quality control and evaluation of microperfusion in kidney transplantation. A dose of 0.02 mg ICG per kg body weight is recommended in order to ensure the quantitative assessment with SPY‐Q.This article is protected by copyright. All rights reserved. (Source: Microcirculation)
Source: Microcirculation - August 8, 2017 Category: Research Authors: Ulrich Rother, Andreas L.H. Gerken, Ioannis Karampinis, Madeline Klumpp, Susanne Regus, Alexander Meyer, Hendrik Apel, Bernhard K. Kr ämer, Karl Hilgers, Werner Lang, Kai Nowak Tags: Original Research Source Type: research

Agent ‐based Computational Model of Retinal Angiogenesis Simulates Microvascular Network Morphology as a Function of Pericyte Coverage
ConclusionThis study supports a role for pericytes as a physical buffer to signal propagation during vascular network formation – a barrier that may be important for generating healthy microvascular network patterns.This article is protected by copyright. All rights reserved. (Source: Microcirculation)
Source: Microcirculation - August 8, 2017 Category: Research Authors: Joseph Walpole, Feilim Mac Gabhann, Shayn M Peirce, John C Chappell Tags: Original Research Source Type: research

Short ‐term (48 hours) intravenous serelaxin infusion has no effect on myogenic tone or vascular remodeling in rat mesenteric arteries
Abstract BackgroundShort‐term IV sRLX (recombinant human relaxin‐2) infusion enhances endothelium‐dependent relaxation in mesenteric arteries. This is initially underpinned by increased NO followed by a transition to prostacyclin. The effects of short‐term IV sRLX treatment on pressure‐induced myogenic tone and vascular remodeling in these arteries are unknown. Therefore, we investigated the effects of sRLX infusion on pressure‐induced myogenic tone and passive mechanical wall properties in mesenteric arteries. MethodsMesenteric artery myogenic tone and passive mechanics were examined after 48‐hours and 10‐...
Source: Microcirculation - August 3, 2017 Category: Research Authors: Maria Jelinic, Chen Huei Leo, Sarah A. Marshall, Sevvandi N. Senadheera, Laura J. Parry, Marianne Tare Tags: ORIGINAL ARTICLE Source Type: research

Astrocyte activation and capillary remodeling in modified bilateral common carotid artery occlusion mice
Abstract ObjectiveThe cerebral ischemia leads to brain dysfunction with neuron degeneration and responses from astrocytes and vessels. The aim of this study was to study the changes of astrocyte and microvessel in modified BCCAO mice. MethodsAdult transgenic Tie2‐GFP mice were subjected to modified BCCAO operation and cranial window implantation. CBF and neurological injury were examined after ischemia. Astrocytes and vessels were investigated by two‐photon laser‐scanning microscope and confocal laser‐scanning microscope in vivo. ResultsThe CBF decreased to approximately 40% of the baseline in the ischemic mice (P
Source: Microcirculation - August 3, 2017 Category: Research Authors: Jiangman Song, Di Nan, Qihua He, Lu Yang, Huailian Guo Tags: ORIGINAL ARTICLE Source Type: research

Pericyte modulation by a functional antibody obtained by a novel single ‐cell selection strategy
ConclusionsThe selection method provides an efficient platform for the selection of functional antibodies which target pericytes. We obtain an antibody that interacts with a fibronectin epitope important for pericyte mobility and functionality. Targeting of this epitope in pathologies where pericytes are implicated could potentially be of therapeutic benefit. (Source: Microcirculation)
Source: Microcirculation - August 3, 2017 Category: Research Authors: Jesper Just, Simon Lykkemark, Charlotte H. Nielsen, Ali R. Roshenas, Kim R. Drasbek, Steen V. Petersen, Toke Bek, Peter Kristensen Tags: ORIGINAL ARTICLE Source Type: research

Increased survivability of ischemic skin flap tissue in Flk ‐1+/− mice by Pellino‐1 intervention
ConclusionOur findings reveal that Peli1 is a proangiogenic molecule that acts downstream of VEGF‐Flk‐1 and restores angiogenesis and enhances skin flap survivability. (Source: Microcirculation)
Source: Microcirculation - August 3, 2017 Category: Research Authors: Chandra K. Rednam, Rickesha L. Wilson, Vaithinathan Selvaraju, Muhammad T. Rishi, Mahesh Thirunavukkarasu, Vladimir Coca ‐Soliz, Rajesh Lakshmanan, John A. Palesty, David W. McFadden, Nilanjana Maulik Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
(Source: Microcirculation)
Source: Microcirculation - August 3, 2017 Category: Research Tags: ISSUE INFORMATION Source Type: research

KV channels and the regulation of vascular smooth muscle tone
This article is protected by copyright. All rights reserved. (Source: Microcirculation)
Source: Microcirculation - August 1, 2017 Category: Research Authors: William F. Jackson Tags: Reviews Source Type: research

Assessment of the test ‐retest reliability of human gingival blood flow measurements by Laser Speckle Contrast Imaging in a healthy cohort
ConclusionsLaser Speckle Contrast Imaging has good short and long‐term reliability regardless of lip retraction or an indirect view. This technique seems to be appropriate for the long‐term clinical follow‐up of gingival microcirculation.This article is protected by copyright. All rights reserved. (Source: Microcirculation)
Source: Microcirculation - August 1, 2017 Category: Research Authors: Eszter Moln ár, Réka Fazekas, Zsolt Lohinai, Zsuzsanna Tóth, János Vág Tags: Original Research Source Type: research

KV channel trafficking and control of vascular tone
This article is protected by copyright. All rights reserved. (Source: Microcirculation)
Source: Microcirculation - August 1, 2017 Category: Research Authors: Raquibul Hasan, Jonathan H. Jaggar Tags: Invited Reviews Source Type: research

Retinal vessel morphology in rheumatoid arthritis: association with systemic inflammation, subclinical atherosclerosis and cardiovascular risk
We examined retinal microvascular diameters in RA, particularly in regard with systemic inflammation, subclinical atherosclerosis and cardiovascular risk. MethodsRetinal images from RA patients and controls were processed using computerized software, to obtain central retinal arteriolar (CRAE) and venular (CRVE) equivalent and arteriovenous ratio (AVR). Subclinical atherosclerosis was assessed with carotid intima‐media thickness (cIMT), and 10‐year risk of general cardiovascular disease was calculated. ResultsBoth CRAE (78.8±8.9 vs 90.2±9.9 μm, p
Source: Microcirculation - August 1, 2017 Category: Research Authors: Panagiota Anyfanti, Areti Triantafyllou, Eugenia Gkaliagkousi, Nikolaos Koletsos, Georgios Athanasopoulos, Xenophon Zabulis, Vasiliki Galanopoulou, Spyros Aslanidis, Stella Douma Tags: Original Research Source Type: research

Acute simvastatin treatment restores cerebral functional capillary density and attenuates angiotensin II ‐induced microcirculatory changes in a model of primary hypertension
Abstract ObjectiveWe investigated the acute effects of simvastatin on cerebral microvascular rarefaction and dysfunction in spontaneously hypertensive rats (SHRs). MethodsMale Wistar Kyoto rats (WKY) and SHRs were divided into 4 groups of 8 animals each: WKY‐CTL and SHR‐CTL, treated with 0.9% saline; and WKY+SIM and SHR+SIM, treated with simvastatin (30 mg/kg/day) for 3 days by gavage. Cerebral functional capillary density (FCD) was assessed by intravital fluorescence videomicroscopy. Microvascular cerebral blood flow (mCBF) before and after administration within the cranial window of angiotensin II (1 μM) was inves...
Source: Microcirculation - August 1, 2017 Category: Research Authors: Felipe Freitas, Vanessa Estato, Patricia Reis, Hugo C. Castro ‐Faria‐Neto, Vinícius Carvalho, Rafael Torres, Marcos A. Lessa, Eduardo Tibiriçá Tags: Original Research Source Type: research

Effect of direct cold atmospheric plasma (diCAP) on microcirculation of intact skin in a controlled mechanical environment
ConclusiondiCAP‐treatment of intact skin notably enhances microcirculation for a therapeutically relevant period. This effect is specific to the plasma treatment and not an effect of the applied pressure. Prolonged treatment durations lead to more pronounced effects.This article is protected by copyright. All rights reserved. (Source: Microcirculation)
Source: Microcirculation - August 1, 2017 Category: Research Authors: Thomas Borchardt, Jennifer Ernst, Andreas Helmke, Murat Tanyeli, Arndt F. Schilling, Gunther Felmerer, Wolfgang Vi öl Tags: Original Research Source Type: research

Between ‐day reliability of local thermal hyperaemia in the forearm and index finger using single point laser‐Doppler flowmetry
ConclusionFor all sites, LTH reliability was acceptable for the timing, and for the initial peak and plateau using CVC or %CVC44°C.This article is protected by copyright. All rights reserved. (Source: Microcirculation)
Source: Microcirculation - August 1, 2017 Category: Research Authors: Gregory W. McGarr, Gary J. Hodges, Stephen S. Cheung Tags: Original Research Source Type: research

Endothelial precursor cells stimulate pericyte ‐like coverage of bone marrow derived mesenchymal stem cells through PDGF‐BB induction, which is enhanced by substance‐P
ConclusionsBM‐EPCs along with SP promote the pericyte‐like coverage of BM‐MSCs on endothelial tubules possibly through the induction of PDGF‐BB.This article is protected by copyright. All rights reserved. (Source: Microcirculation)
Source: Microcirculation - August 1, 2017 Category: Research Authors: Mingzi Zhang, Woosung Ahn, Sumin Kim, Hyun Sook Hong, Chengshi Quan, Youngsook Son Tags: Original Research Source Type: research

Hypoxia ‐enhanced adhesion of red blood cells in microscale flow
ConclusionsThe approach presented here enabled the control of oxygen tension in blood during microscale flow and the quantification of RBC adhesion in a cost‐efficient and patient‐specific manner. We identified a unique patient population in which RBCs showed enhanced adhesion in hypoxia in vitro. Clinical correlates suggest a more severe clinical phenotype in this subgroup. (Source: Microcirculation)
Source: Microcirculation - July 10, 2017 Category: Research Authors: Myeongseop Kim, Yunus Alapan, Anima Adhikari, Jane A. Little, Umut A. Gurkan Tags: ORIGINAL ARTICLE Source Type: research

Microfluidics Technologies and Approaches for Studying the Microcirculation
Abstract A challenge for basic and applied microvascular research is the lack of ex vivo experimental platforms that mimic the structural and functional complexity that is inherent to the microcirculation in living organisms. This Special Topic Issue highlights the emergence of microfluidic‐based approaches as tools for recapitulating physiologically relevant network architectures and hemodynamics to study biochemical and biomechanical mechanisms of microvascular function and adaptation. This collection of review and original research articles showcases the value of microfluidics in bridging the gap between in vivo and i...
Source: Microcirculation - July 10, 2017 Category: Research Authors: Walter L. Murfee, Shayn M. Peirce Tags: EDITORIAL Source Type: research

Issue Information
(Source: Microcirculation)
Source: Microcirculation - July 10, 2017 Category: Research Tags: ISSUE INFORMATION Source Type: research

The hypertension of hemophilia is associated with vascular remodeling in the joint
ConclusionsVascular remodeling in hemophilic joints is associated with hypertension and elevated blood pressures. Since hypertension is a grave risk factor for intracranial hemorrhage, a prominent cause of mortality in hemophilia patients, future studies are needed to address the causal pathways between vascular joint remodeling and blood pressure.This article is protected by copyright. All rights reserved. (Source: Microcirculation)
Source: Microcirculation - June 19, 2017 Category: Research Authors: Richard FW Barnes, Thomas J Cramer, Tudor H Hughes, Annette von Drygalski Tags: Original Research Source Type: research

Lymph node effective vascular permeability and chemotherapy uptake
ConclusionsLymph node effective vascular permeability can be increased (~4‐fold) by VEGF‐A. However, no significant increase in chemotherapy uptake was measured by pre‐treatment with VEGF‐A.This article is protected by copyright. All rights reserved. (Source: Microcirculation)
Source: Microcirculation - May 16, 2017 Category: Research Authors: Eelco FJ Meijer, Cedric Blatter, Ivy X Chen, Echoe Bouta, Dennis Jones, Ethel R Pereira, Keehoon Jung, Benjamin J. Vakoc, James W Baish, Timothy P Padera Tags: Original Research Source Type: research

Model ‐based inference from microvascular measurements: Combining experimental measurements and model predictions using a Bayesian probabilistic approach
ConclusionOur Bayesian probabilistic approach may be suitable for optimizing data acquisition and for analyzing and reporting large data sets acquired as part of microvascular imaging studies. (Source: Microcirculation)
Source: Microcirculation - May 15, 2017 Category: Research Authors: Peter M. Rasmussen, Amy F. Smith, Sava Sakad žić, David A. Boas, Axel R. Pries, Timothy W. Secomb, Leif Østergaard Tags: ORIGINAL ARTICLE Source Type: research

Issue Information
(Source: Microcirculation)
Source: Microcirculation - May 15, 2017 Category: Research Tags: ISSUE INFORMATION Source Type: research

Estimating Blood Flow in Skeletal Muscle Arteriolar Trees Reconstructed from In Vivo Data Using the Fry Approach
ConclusionsWe have developed and validated a computational method that can accurately estimate RBC flow distribution in skeletal muscle arteriolar trees in the absence of complete boundary data.This article is protected by copyright. All rights reserved. (Source: Microcirculation)
Source: Microcirculation - May 4, 2017 Category: Research Authors: Zahra Farid, Amani H. Saleem, Baraa K. Al ‐Khazraji, Dwayne N. Jackson, Daniel Goldman Tags: Original Research Source Type: research

Effects of Different Intensity Laser Acupuncture at Two Adjacent Same ‐meridian Acupoints on Nitric Oxide and Soluble Guanylate Cyclase Releases in Human
ConclusionsThis is the first evidence reporting that LA induced significant elevations of NO‐sGC releases over acupoints, the enhanced signal molecules contribute to local circulation, which improves the beneficial effects of the therapy.This article is protected by copyright. All rights reserved. (Source: Microcirculation)
Source: Microcirculation - May 1, 2017 Category: Research Authors: Wan ‐Ling Jiang, Hua‐Jiang Wei, Zhou‐Yi Guo, Yi‐Rong Ni, Hong‐Qin Yang, Shu‐Sen Xie Tags: Original Article Source Type: research

Acute skin trauma induces hyperemia, but superficial papillary nutritive perfusion remains unchanged
ConclusionThe results indicate that skin nutritive papillary capillary function can be assessed by CAVM and DRS, but not with LDPM because of its dependence of the deep plexus perfusion.This article is protected by copyright. All rights reserved. (Source: Microcirculation)
Source: Microcirculation - May 1, 2017 Category: Research Authors: Liv Kristin Sundheim, Ane Halse Sporast øyl, Torjus Wester, Göran Salerud, Knut Kvernebo Tags: Original Research Source Type: research

Effect of sympathetic nerve blockade on low ‐frequency oscillations of forearm and leg skin blood flow in healthy humans
Abstract ObjectiveExamine the effect of inhibiting sympathetic function on cutaneous vasomotion in the forearm and leg MethodsIntradermal microdialysis fibres were placed in the forearm and leg, one as an untreated control (lactated Ringer's) the other perfused with bretylium tosylate to block sympathetic nerves. Skin blood flow was monitored using laser‐Doppler flowmetry. Baseline was collected for 10 min before local skin temperature was increased to 42°C. Spectral analysis was performed using a Morlet wavelet ResultsBretylium tosylate increased skin blood flow during baseline in the forearm (d=1.6, p
Source: Microcirculation - May 1, 2017 Category: Research Authors: Gary J. Hodges, Matthew M. Mallette, Zachary T. Martin, Andrew T. Del Pozzi Tags: Original Research Source Type: research

Differences in optic nerve head microcirculation between evening and morning in patients with coronary artery disease
ConclusionOcular microcirculation obtained from LSFG may provide a window for detecting changes in microvasculature related to CAD.This article is protected by copyright. All rights reserved. (Source: Microcirculation)
Source: Microcirculation - May 1, 2017 Category: Research Authors: Tomoaki Shiba, Mao Takahashi, Tadashi Matsumoto, Yuichi Hori Tags: Original Research Source Type: research

Rosa Rugosa Flavonoids Alleviate Myocardial Ischemia Reperfusion Injury in Mice by Suppressing JNK and p38 MAPK
ConclusionRRF significantly inhibited MIRI through anti‐oxidative, anti‐inflammatory and anti‐apoptosis effects, and mechanisms were associated with its inhibition on phosphorylation of JNK and p38 MAPK.This article is protected by copyright. All rights reserved. (Source: Microcirculation)
Source: Microcirculation - May 1, 2017 Category: Research Authors: Xuehui Zhang, Yuhui Wang, Wanli Shen, Shangzhi Ma, Wen Chen, Rong Qi Tags: Original Research Source Type: research

Muscle microcirculation alterations and relation to dipping status in newly diagnosed untreated patients with arterial hypertension ‐ A pilot study
Abstract ObjectiveThe importance of abnormalities observed in the microcirculation of patients with arterial hypertension (AH) is being increasingly recognized. The authors aimed to evaluate skeletal muscle microcirculation in untreated, newly diagnosed hypertensive patients with Near Infrared Spectroscopy (NIRS), a non‐invasive method that evaluates microcirculation. MethodsWe evaluated 34 subjects, 17 patients with AH (13 males, 49±13y, BMI: 26±2 kg/m2) and 17 healthy controls (12 males, 49±15y, BMI: 25±3 kg/m2). The thenar muscle tissue oxygen saturation (StO2, %) was measured by NIRS befor...
Source: Microcirculation - May 1, 2017 Category: Research Authors: Georgios Tzanis, Stavros Dimopoulos, Chris Manetos, Eleni Koroboki, Efstathios Manios, Ioannis Vasileiadis, Nikolaos Zakopoulos, Serafim Nanas Tags: Original Research Source Type: research

Impaired neurovascular reactivity in the microvasculature of pregnant women with preeclampsia
Abstract Preeclampsia (PE) is associated with maternal vascular dysfunction, leading to serious cardiovascular risk both during and following pregnancy. ObjectiveTo assess microvascular reactivity in pregnant women with PE. MethodsA cross‐sectional study was performed in 36 pregnant women with PE and 36 normotensive pregnant women (C) in the third trimester. Skin microvascular blood flow was measured using laser Doppler flowmetry at rest (RF), during the maximum hyperaemic response to brief arterial occlusion (MF) and during the sympathetically‐mediated constrictor response to deep inspiratory breath hold (IBH). Result...
Source: Microcirculation - May 1, 2017 Category: Research Authors: Karine Ferreira Agra, Isabelle Eunice Albuquerque Pontes, Jos é Roberto da Silva, José Natal Figueiroa, Geraldine F Clough, João Guilherme Bezerra Alves Tags: Original Research Source Type: research

Blood pressure normalization via pharmacotherapy improves cutaneous microvascular function through NO ‐dependent and –independent mechanisms
Abstract Hypertension is associated with endothelial dysfunction and vascular remodeling. ObjectiveTo assess effects of antihypertensive pharmacotherapy on eNOS and iNOS‐dependent mechanisms and maximal vasodilator capacity in the cutaneous microvasculature MethodsIntradermal microdialysis fibers were placed in 15 normotensive (SBP 111±2 mmHg), 12 unmedicated hypertensive (SBP 142±2 mmHg), and 12 medicated hypertensive (SBP 120±2 mmHg) subjects. Treatments were control, iNOS‐inhibited (1400w), and NOS‐inhibited (L‐NAME). Red cell flux, measured during local heating (42⁰C) and acetylcholine (A...
Source: Microcirculation - May 1, 2017 Category: Research Authors: Daniel H. Craighead, Caroline J. Smith, Lacy M. Alexander Tags: Original Research Source Type: research

Nonenzymatic glycation interferes with fibronectin ‐integrin interactions in vascular smooth muscle cells
ConclusionsGlycation of FN shifts the nature of cellular adhesion from integrin‐ to RAGE‐dependent mechanisms. (Source: Microcirculation)
Source: Microcirculation - April 25, 2017 Category: Research Authors: Srijita Dhar, Zhe Sun, Gerald A. Meininger, Michael A. Hill Tags: ORIGINAL ARTICLE Source Type: research

The pro ‐inflammatory cytokine TNF‐α inhibits lymphatic pumping via activation of the NF‐κB‐iNOS signaling pathway
ConclusionsThese findings suggest that TNF‐α decreases mesenteric lymphatic contractility by activating the NF‐κB‐iNOS signaling pathway. This mechanism could contribute to the alteration of lymphatic pumping reported in intestinal inflammation. (Source: Microcirculation)
Source: Microcirculation - April 25, 2017 Category: Research Authors: Yingxuan Chen, Sonia Rehal, Simon Roizes, Hai ‐Lei Zhu, William C. Cole, Pierre‐Yves von der Weid Tags: ORIGINAL ARTICLE Source Type: research

Role of moesin, Src, and ROS in advanced glycation end product ‐induced vascular endothelial dysfunction
Abstract The disruption of endothelial integrity and the occurrence of angiogenesis in response to AGEs contribute greatly to micro‐ and macrovascular complications associated with DM. Among human dermal, brain, and retinal vascular ECs, activation of ERM, moesin, by phosphorylation of Thr‐558 is involved in AGE‐induced hyperpermeability and angiogenesis via the Rho and ROCK (Rho/ROCK) and p38 pathways. Src also plays an important role in AGE‐induced endothelial barrier dysfunction by phosphorylating moesin, VE‐cadherin, and FAK. Furthermore, recent studies have demonstrated that ROS serve as a key mediator of th...
Source: Microcirculation - April 25, 2017 Category: Research Authors: Wei ‐jin Zhang, Pei‐xin Li, Xiao‐hua Guo, Qiao‐bing Huang Tags: INVITED REVIEW Source Type: research

Cellular cross talk, inflammatory signals, and enhanced microvascular permeability
Abstract Microvascular leakage remains a significant clinical problem for which there is no specific therapeutic available. This Special Topics issue of the journal Microcirculation features reviews pertaining to the cellular and molecular mechanisms that control the integrity of the microvascular barrier. (Meegan et al., Microcirculation, 2017) summarize recent research findings about how neutrophil extracellular traps and how these can cause injury to the microvascular barrier.( Zhang et al. Microcirculation, 2017) highlight the microvascular response to advanced glycation end‐products that are formed as part...
Source: Microcirculation - April 25, 2017 Category: Research Authors: Jerome W. Breslin Tags: EDITORIAL Source Type: research

Capillary endothelial cells as coordinators of skeletal muscle blood flow during active hyperemia
Abstract In this invited review, we explore the burgeoning possibility of capillary endothelial cells as coordinators of skeletal muscle blood flow in response to muscle contraction. The idea that the capillary is an active vascular unit in skeletal muscle microcirculation starkly diverges from the traditional dogma that seats arterioles as the central controllers of blood flow during exercise. This review aims to incite discussion as we revisit and rethink the role of capillary endothelial cells in skeletal muscle. We discuss the potential for a mismatch in the architectural relationships between the arteriolar microvascu...
Source: Microcirculation - April 25, 2017 Category: Research Authors: Coral L. Murrant, Iain R. Lamb, Nicole M. Novielli Tags: INVITED REVIEW Source Type: research

Issue Information
(Source: Microcirculation)
Source: Microcirculation - April 25, 2017 Category: Research Tags: ISSUE INFORMATION Source Type: research

Quantitative depth resolved microcirculation imaging with optical coherence tomography angiography (Part ΙΙ): Microvascular network imaging
This article is protected by copyright. All rights reserved. (Source: Microcirculation)
Source: Microcirculation - April 17, 2017 Category: Research Authors: Wanrong Gao Tags: Reviews Source Type: research

Cdc42 regulates branching in angiogenic sprouting in vitro
ConclusionsOur findings suggest that Cdc42 can affect multiple morphogenetic processes during angiogenic sprouting and ultimately impact the architecture of the vasculature.This article is protected by copyright. All rights reserved. (Source: Microcirculation)
Source: Microcirculation - April 4, 2017 Category: Research Authors: Duc ‐Huy T Nguyen, Lin Gao, Alec Wong, Christopher S. Chen Tags: Original Research Source Type: research

Roles of NADPH oxidase and mitochondria in flow ‐induced vasodilation of human adipose arterioles: ROS induced ROS release in coronary artery disease
ConclusionsThese findings indicate that ROS produced by NADPH oxidase are an upstream component of the mitochondria‐dependent pathway contributing to flow‐dependent H2O2 generation and dilation in peripheral microvessels from patients with CAD. We conclude that in CAD, both mitochondria and NADPH oxidase contribute to FID through a redox mechanism in visceral arterioles.This article is protected by copyright. All rights reserved. (Source: Microcirculation)
Source: Microcirculation - April 1, 2017 Category: Research Authors: Natalya S. Zinkevich, Ibra S. Fancher, David D. Gutterman, Shane A. Phillips Tags: Original Research Source Type: research

The impact of endotoxin on jejunal tissue oxygenation
We examined the effects of systemic endotoxin on jejunal mucoal microcirculatory parameters in anesthetized pigs. Materials and methodsJejunal mucosal tissue PO2 was measured employing Clark‐type surface oxygen electrodes. Oxygen saturation of jejunal microvascular hemoglobin was determined by tissue reflectance spectrophotometry. Jejunal microcirculatory blood flow was assessed by laser Doppler flowmetry. Microvascular conductance and rhythmical oscillation of the tissue PO2 were calculated. Systemic hemodynamic variables, mesenteric‐venous and systemic acid base and blood gas variables, and lactate measurements were ...
Source: Microcirculation - April 1, 2017 Category: Research Authors: Werner Pajk, Karl ‐Heinz Stadlbauer, Axel Kleinsasser, Oskar Kotzinger, Hanno Ulmer, Walter Hasibeder, Hans Knotzer Tags: Original Research Source Type: research