Abstracts from the 47th Annual Meeting of Japanese Society for Microcirculation
(Source: Microcirculation)
Source: Microcirculation - November 20, 2022 Category: Research Tags: ABSTRACT Source Type: research
Issue Information
(Source: Microcirculation)
Source: Microcirculation - November 19, 2022 Category: Research Tags: ISSUE INFORMATION Source Type: research
Lentiviral overexpression of VEGFC in transplanted MSCs leads to resolution of swelling in a mouse tail lymphedema model
AbstractDysfunction of the lymphatic system following injury, disease, or cancer treatment can lead to lymphedema, a debilitating condition with no cure. Despite the various physical therapy and surgical options available, most treatments are palliative and fail to address the underlying lymphatic vascular insufficiency driving lymphedema progression. Stem cell therapy provides a promising alternative in the treatment of various chronic diseases with a wide range of therapeutic effects that reduce inflammation, fibrosis, and oxidative stress, while promoting lymphatic vessel (LV) regeneration. Specifically, stem cell trans...
Source: Microcirculation - November 13, 2022 Category: Research Authors: Eleftheria Michalaki,
Josephine M. Rudd,
Lauren Liebman,
Rahul Wadhwani,
Levi B. Wood,
Nick J. Willett,
J. Brandon Dixon Tags: ORIGINAL ARTICLE Source Type: research
Back Cover
The cover image is based on the Original ArticleLymphatic microcirculation profile in the progression of hypertension in spontaneously hypertensive rats by Bing Wang et al.,https://doi.org/10.1111/micc.12724. (Source: Microcirculation)
Source: Microcirculation - October 31, 2022 Category: Research Tags: BACK COVER Source Type: research
Front Cover
The cover image is based on the Special Issue:Visualizing the Microcirculation. Image Credit: All the contributing authors of the Special Issue. (Source: Microcirculation)
Source: Microcirculation - October 31, 2022 Category: Research Tags: FRONT COVER Source Type: research
Issue Information
(Source: Microcirculation)
Source: Microcirculation - October 31, 2022 Category: Research Tags: ISSUE INFORMATION Source Type: research
Visualizing the Microcirculation
(Source: Microcirculation)
Source: Microcirculation - October 31, 2022 Category: Research Authors: Janaka Senarathna,
Arvind P. Pathak Tags: EDITORIAL Source Type: research
RNA ‐seq profiling reveals different pathways between remodeled vessels and myocardium in hypertrophic cardiomyopathy
ConclusionsWe demonstrate the existence of distinctive pathways between remodeled arterioles and cardiomyocytes in HCM patients and controls at the transcriptome level. (Source: Microcirculation)
Source: Microcirculation - October 15, 2022 Category: Research Authors: Annalinda Pisano,
Loredana Le Pera,
Raffaella Carletti,
Bruna Cerbelli,
Maria G. Pignataro,
Angelina Pernazza,
Fabrizio Ferre,
Maria Lombardi,
Davide Lazzeroni,
Iacopo Olivotto,
Ornella E. Rimoldi,
Chiara Foglieni,
Paolo G. Camici,
Giulia d'A Tags: ORIGINAL ARTICLE Source Type: research
Impact of Goreisan components on rat mesenteric collecting lymphatic vessel pumping
ConclusionsCollectively, the results suggest that some components of Goreisan have a direct, rapid impact on lymphatic pumping. These findings provide new insights but also raise new questions about the therapeutic potential of Goreisan in patients with secondary lymphedema. (Source: Microcirculation)
Source: Microcirculation - October 8, 2022 Category: Research Authors: Michiko Jo,
Andrea N. Trujillo,
Naotoshi Shibahara,
Jerome W. Breslin Tags: ORIGINAL ARTICLE Source Type: research
RNA ‐seq profiling reveals different pathways between remodelled vessels and myocardium in Hypertrophic Cardiomyopathy
ConclusionsWe demonstrate the existence of distinctive pathways between remodelled arterioles and cardiomyocytes in HCM patients and controls at the transcriptome level. (Source: Microcirculation)
Source: Microcirculation - October 5, 2022 Category: Research Authors: Annalinda Pisano,
Loredana Le Pera,
Raffaella Carletti,
Bruna Cerbelli,
Maria Gemma Pignataro,
Angelina Pernazza,
Fabrizio Ferre,
Maria Lombardi,
Davide Lazzeroni,
Iacopo Olivotto,
Ornella E. Rimoldi,
Chiara Foglieni,
Paolo G. Camici,
Giulia Tags: ORIGINAL ARTICLE Source Type: research
GATA2 regulates blood/lymph separation in a platelet ‐dependent and lymphovenous valve‐independent manner
AbstractLymphatic vessels collect interstitial fluid, immune cells and digested lipids and return these bodily fluids to blood through two pairs of lymphovenous valves (LVVs). Like other cardiovascular valves LVVs prevent the backflow of blood into the lymphatic vessels. In addition to LVVs platelets are necessary to prevent the entry of blood into the lymphatic vessels. Platelet thrombi are observed at LVVs suggesting that LVVs and platelets function in synergy to regulate blood/lymphatic separation. However, whether platelets can regulate blood/lymph separation independently of LVVs is not known. We have determined that ...
Source: Microcirculation - October 5, 2022 Category: Research Authors: Md. Riaj Mahamud,
Xin Geng,
Lijuan Chen,
Zoheb Ahmed,
Yenchun Ho,
R. Sathish Srinivasan Tags: ORIGINAL ARTICLE Source Type: research
The Impact of Goreisan Components on Rat Mesenteric Collecting Lymphatic Vessel Pumping
AbstractGoreisan is a traditional herbal formulation with diuretic properties tested as a clinical therapeutic to alleviate lymphedema in Japan. The present study aimed to determine how Goreisan and its five different components affect lymphatic pump function. Mesenteric collecting lymphatics were isolated from anesthetized Sprague Dawley rats and mounted on resistance-matched glass micropipettes in a 37 °C physiological salt solution bath for studies. Diameter was continuously measured to obtain the following lymphatic pump parameters: contraction frequency (CF), end diastolic diameter (EDD), and end systolic diameter (E...
Source: Microcirculation - September 29, 2022 Category: Research Authors: Michiko Jo,
Andrea N. Trujillo,
Naotoshi Shibahara,
Jerome W. Breslin Tags: ORIGINAL ARTICLE Source Type: research
Irisin inhibits NLRP3 inflammasome activation in HG/HF incubated cardiac microvascular endothelial cells with H/R injury
ConclusionThe current study demonstrated for the first time that irisin inhibits NLRP3 inflammasome activation in CMECs as a novel mechanism in myocardial ischemia/reperfusion injury in diabetes. (Source: Microcirculation)
Source: Microcirculation - September 24, 2022 Category: Research Authors: Chao Xin,
Jinglong Zhang,
Ningbo Hao,
Jianan Wang,
Hui Liu,
Hanwen Wei,
Yong Wang,
Chengzhu Wang,
Shuo Wang,
Chengrong Zheng,
Zheng Zhang,
Zhitao Jin Tags: ORIGINAL ARTICLE Source Type: research
EDITORIAL Visualizing the Microcirculation
AbstractOver the last century, scientific discoveries have revealed the critical role of the microcirculation in maintaining homeostasis and the etiology of diseases ranging from cancer to COVID-19. These advances have coincided with and even been made possible by the exponential progress in imaging and visualization techniques capable of characterizing the structural and functional diversity of the microcirculation. Consequently, this special issue (SI) showcases a broad selection of tools and methods for elucidating the role of the microcirculation in health and disease. In this exciting compendium of globally contribute...
Source: Microcirculation - September 20, 2022 Category: Research Authors: Janaka Senarathna,
Arvind P. Pathak Tags: EDITORIAL Source Type: research
Analysis and Visualization Methods for Detecting Functional Activation Using Laser Speckle Contrast Imaging
AbstractPrevious studies have used regional cerebral blood flow (CBF) hemodynamic response to measure brain activities. In this work, we used a laser speckle contrast imaging (LSCI) apparatus to sample the CBF activation in somatosensory cortex (S1BF) with a repetitive whisker stimulation. Traditionally, the CBF activations were processed by depicting the change percentage above baseline. Thus, there is a limitation on the influence of different methods to detect activations in LSCI. First, principal component analysis (PCA) was performed to denoise the CBF signal. As the signal of the first principal component (PC1) showe...
Source: Microcirculation - September 8, 2022 Category: Research Authors: Peng Hu,
Bochao Niu,
Hang Yang,
Yang Xia,
Donna Chen,
Chun Meng,
Ke Chen,
Bharat Biswal Tags: ORIGINAL ARTICLE Source Type: research
