Guideline for In Vivo Assessment of Adherent and Rolling Leukocytes in Human Skin Microvasculature via Reflectance Confocal Videomicroscopy
ConclusionThe guideline aids in the manual identification of adherent and rolling leukocytes viain vivo reflectance confocal videomicroscopy. (Source: Microcirculation)
Source: Microcirculation - August 19, 2021 Category: Research Authors: Zijun Zhao,
James Randall Patrinely,
Inga Saknite,
Michael Byrne,
Eric R. Tkaczyk Tags: ORIGINAL ARTICLE Source Type: research
Issue Information
(Source: Microcirculation)
Source: Microcirculation - August 17, 2021 Category: Research Tags: ISSUE INFORMATION Source Type: research
Lymphatic microcirculation profile in the progression of hypertension in spontaneously hypertensive rats
ConclusionsWe used an intravital lymphatic imaging system to observe that SHRs exhibit an impaired collecting lymphatic vasomotion profile and deteriorated contractility and reflux. (Source: Microcirculation)
Source: Microcirculation - August 6, 2021 Category: Research Authors: Bing Wang,
Youming Sheng,
Yuan Li,
Bingwei Li,
Jian Zhang,
Ailing Li,
Mingming Liu,
Honggang Zhang,
Ruijuan Xiu Tags: ORIGINAL ARTICLE Source Type: research
Cover Image
The cover image is based on the Original ArticleIntegrated Pancreatic Microcirculation Profiles of Streptozotocin-Induced and Insulin-Administrated Type 1 Diabetes Mellitus by Mingming Liu et al.,https://doi.org/10.1111/micc.12691. (Source: Microcirculation)
Source: Microcirculation - July 15, 2021 Category: Research Authors: Yuan Li,
Bingwei Li,
Bing Wang,
Mingming Liu,
Xiaoyan Zhang,
Ailing Li,
Jian Zhang,
Honggang Zhang,
Ruijuan Xiu Tags: COVER IMAGE Source Type: research
Issue Information
(Source: Microcirculation)
Source: Microcirculation - July 15, 2021 Category: Research Tags: ISSUE INFORMATION Source Type: research
Pulsatility Protects the Endothelial Glycocalyx during Extracorporeal Membrane Oxygenation
ConclusionThe maintenance of the PWSS by pulsatility during ECMO possesses beneficial effects on glycocalyx integrity. Moreover, pulsatility prevents EndMT in endothelial cells, and low pulsatility exhibits the best protective effects. The augmentation of pulsatility may be a plausible future direction to improve the clinical outcome in ECMO. (Source: Microcirculation)
Source: Microcirculation - July 10, 2021 Category: Research Authors: Yu Zhang,
Jianfeng Zeng,
Xiaoqian He,
Weidong Cao,
Xiaopeng Peng,
Guanhua Li Tags: ORIGINAL ARTICLE Source Type: research
Simulations of Increased Glomerular Capillary Wall Strain in the 5/6 ‐Nephrectomized Rat
ConclusionsOur findings indicate that glomerular capillary wall strain may deleteriously affect podocytes directly, as well as act in concert with other mechanical changes and environmental factors inherent to thein vivo setting to potentiate glomerular injury in severe renoprival conditions. (Source: Microcirculation)
Source: Microcirculation - July 1, 2021 Category: Research Authors: Owen Richfield,
Ricardo Cortez,
L. Gabriel Navar Tags: ORIGINAL ARTICLE Source Type: research
Myogenic Autoregulation in Bone Marrow Arterioles and In Vivo Intramedullary Pressure in Femora of Conscious, Female Long Evans Rats
ConclusionBone marrow arterioles have myogenic responsiveness and the autoregulatory zone corresponded with the range of IMP (15 mmHg – 51 mmHg) within the femoral diaphysis of conscious animals. (Source: Microcirculation)
Source: Microcirculation - June 22, 2021 Category: Research Authors: S. Noh,
S. Lee,
S. Green,
R. Prisby Tags: ORIGINAL ARTICLE Source Type: research
Spatial Distribution of Diabetic Capillary Non ‐Perfusion
ConclusionIn DR, SCP is more ischemic than DCP. This is in contrast to the previously described oxygenation dependent ischemic cascade following acute retinal vascular occlusions. This study provides further insight into the retinal ischemia in DR. (Source: Microcirculation)
Source: Microcirculation - June 10, 2021 Category: Research Authors: Khalil Ghasemi Falavarjani,
Reza Mirshahi,
Hamid Riazi ‐Esfahani,
Pasha Anvari,
Abbas Habibi,
Maryam Ashraf Khorasani,
Esrafil Shad Tags: ORIGINAL ARTICLE Source Type: research
Socioeconomic inequalities, modifiable lifestyle risk factors, and retinal vessel calibers: The African ‐PREDICT Study
ConclusionAt young ages, retinal vessel calibers associated differently with modifiable lifestyle risk factors within each SES group. Our data highlight the importance of detecting adverse lifestyle risk factors among young adults from diverse socioeconomic settings to improve prevention of cardiovascular disease. (Source: Microcirculation)
Source: Microcirculation - June 9, 2021 Category: Research Authors: Vuledzani Felicia Maugana,
Ruan Kruger,
Aletta Elisabeth Schutte,
Wayne Smith Tags: ORIGINAL ARTICLE Source Type: research
The role of tumor necrosis factor ‐α and interferon‐γ in the hyperglycemia‐induced ubiquitination and loss of platelet endothelial cell adhesion molecule‐1 in rat retinal endothelial cells
ConclusionTumor necrosis factor- α and IFN-γ may contribute to the hyperglycemia-induced loss of PECAM-1 in retinal endothelial cells, possibly by upregulating PECAM-1 ubiquitination. (Source: Microcirculation)
Source: Microcirculation - May 30, 2021 Category: Research Authors: Randa S. Eshaq,
Norman R. Harris Tags: ORIGINAL ARTICLE Source Type: research
Coronary microvascular dysfunction pathophysiology in COVID ‐19
AbstractRecently, accumulating evidence has highlighted the role of endothelial dysfunction in COVID-19 progression. Coronary microvascular dysfunction (CMD) plays a pivotal role in cardiovascular disease (CVD) and CVD-related risk factors (e.g., age, gender, hypertension, diabetes mellitus, obesity, etc.). Equally, these are also risk factors for COVID-19. The purpose of this review was to explore CMD pathophysiology in COVID-19, based on recent evidence. COVID-19 mechanisms were reviewed in terms of imbalanced renin-angiotensin-aldosterone-systems (RAAS), systemic inflammation and immune responses, endothelial dysfunctio...
Source: Microcirculation - May 20, 2021 Category: Research Authors: Jie Yin,
Shaoshen Wang,
Yang Liu,
Junhong Chen,
Dongye Li,
Tongda Xu Tags: REVIEW Source Type: research
Issue Information
(Source: Microcirculation)
Source: Microcirculation - May 19, 2021 Category: Research Tags: ISSUE INFORMATION Source Type: research
The role of TNF ‐α and IFN‐γ in the hyperglycemia‐induced ubiquitination and loss of PECAM‐1 in rat retinal endothelial cells
ConclusionTNF- α and IFN-γ may contribute to the hyperglycemia-induced loss of PECAM-1 in retinal endothelial cells, possibly by upregulating PECAM-1 ubiquitination. (Source: Microcirculation)
Source: Microcirculation - May 19, 2021 Category: Research Authors: Randa S. Eshaq,
Norman R. Harris Tags: ORIGINAL ARTICLE Source Type: research
Chronic Hypoxia Promoted Pulmonary Arterial Smooth Muscle Cells Proliferation through Upregulated CaSR ‐TRPC1/6 Pathway
AbstractAlthough both calcium sensing receptor (CaSR) and canonical transient receptor potential (TRPC) proteins contribute to chronic hypoxia (CH)-induced pulmonary arterial smooth muscle cells (PASMCs) proliferation, the relationship between CaSR and TRPC in hypoxic PASMCs proliferation remains poorly understood. We hypothesized that CH promotes PASMCs proliferation through CaSR-TRPC pathway. Rat PASMCs were isolated and treated with CH. Cell proliferation was assessed by cell counting, CCK-8 assay, and EdU incorporation. CaSR and TRPC expressions were determined by qPCR and Western blotting. Store-operated Ca2+ entry (S...
Source: Microcirculation - May 19, 2021 Category: Research Authors: Juan Xu,
Xing Wen,
Zhenli Fu,
Yongliang Jiang,
Wei Hong,
Rongmin Liu,
Shaoxing Li,
Weitao Cao,
Jinding Pu,
Lingmei Huang,
Bing Li,
Pixin Ran,
Gongyong Peng Tags: ORIGINAL ARTICLE Source Type: research
