Histone ‐stimulated platelet adhesion to mouse cremaster venules in vivo is dependent on von Willebrand factor
ConclusionsHistone-induced platelet adhesion to microvessels in vivo is vWF-dependent and TLR4-independent. Platelet-derived vWF was not necessary for histone-induced platelet aggregation ex vivo. These data are consistent with the notion that endothelial vWF, rather than platelet vWF, mediates histone-induced platelet adhesion in vivo. (Source: Microcirculation)
Source: Microcirculation - September 3, 2022 Category: Research Authors: Justin A. Courson,
Fong W. Lam,
Kimberly W. Langlois,
Rolando E. Rumbaut Tags: ORIGINAL ARTICLE Source Type: research
Recent advancement of imaging strategies of the lymphatic system: Answer to the decades old questions
AbstractThe role of the lymphatic system in maintaining tissue homeostasis and a number of different pathophysiological conditions has been well established. The complex and delicate structure of the lymphatics along with the limitations of conventional imaging techniques makes lymphatic imaging particularly difficult. Thus in-depth high resolution imaging of lymphatic system is key to understanding the progression of lymphatic diseases and cancer metastases and would greatly benefit clinical decisions. In recent years, the advancement of imaging technologies and development of new tracers suitable for clinical application...
Source: Microcirculation - August 16, 2022 Category: Research Authors: Priyanka Banerjee,
Sukanya Roy,
Sanjukta Chakraborty Tags: REVIEW Source Type: research
Issue Information
(Source: Microcirculation)
Source: Microcirculation - July 27, 2022 Category: Research Tags: ISSUE INFORMATION Source Type: research
Isolation and Short ‐Term Culturing of Primary Lymphatic Endothelial Cells from Collecting Lymphatics: A Techniques Study
ConclusionsThis method provides an innovative tool for routine isolation and study of primary LECs from specific collecting lymphatic vessels from any mouse, and in fact, from other species. (Source: Microcirculation)
Source: Microcirculation - July 26, 2022 Category: Research Authors: Kelli L. Jablon,
Victoria L. Akerstrom,
Min Li,
Stephen E. Braun,
Charles E. Norton,
Jorge A. Castorena ‐Gonzalez Tags: ORIGINAL ARTICLE Source Type: research
Hydrodynamic Model for Renal Microvascular Filtration: Effects of Physiological and Hemodynamic Changes on Glomerular Size ‐selectivity
ConclusionOur results indicate that glomerular hypertension and the reduction in the oncotic pressure decreases glomerular macromolecule filtration. Reduction of RPF and changes in the glomerular barrier structure associated with DN, however, increase the solute sieving. Damage to GAGs caused by hyperglycemia is likely to be the most prominent factor affecting glomerular size-selectivity. (Source: Microcirculation)
Source: Microcirculation - July 26, 2022 Category: Research Authors: Numpong Punyaratabandhu,
Panadda Dechadilok,
Wannapong Triampo,
Pisut Katavetin Tags: ORIGINAL ARTICLE Source Type: research
Perioperative trajectory of plasma viscosity: a prospective, observational, exploratory study in cardiac surgery
ConclusionPlasma viscosity had a low coefficient of variation and low perioperative changes, suggesting tight regulation. Studies linking plasma viscosity with outcome would require large patient cohorts. (Source: Microcirculation)
Source: Microcirculation - July 16, 2022 Category: Research Authors: Liana Valeanu,
Stefan Andrei,
Carmen Ginghina,
Cornel Robu,
Adrian Ciurciun,
Cosmin Balan,
Mihai Stefan,
Anca Stoian,
Iulia Stanculea,
Andreea Cheta,
Laura Dima,
Ovidiu Stiru,
Daniela Filipescu,
Serban ‐Ion Bubenek‐Turconi,
Dan Longrois Tags: ORIGINAL ARTICLE Source Type: research
Photoacoustic Imaging for Microcirculation
AbstractMicrocirculation facilitates blood-tissue exchange of nutrients and regulates blood perfusion. It is, therefore, essential in maintaining tissue health. Aberrations in microcirculation are potentially indicative of underlying cardiovascular and metabolic pathologies. Thus, quantitative information about it is of great clinical relevance. Photoacoustic imaging (PAI) is a capable technique that relies on the generation of imaging contrast via the absorption of light and can image at micron-scale resolution. PAI is especially desirable to map microvasculature as hemoglobin strongly absorbs light and can generate a pho...
Source: Microcirculation - July 7, 2022 Category: Research Authors: Shubham Mirg,
Kevin L. Turner,
Haoyang Chen,
Patrick J. Drew,
Sri ‐Rajasekhar Kothapalli Tags: REVIEW Source Type: research
Nail fold microangiopathy in adolescents with type 1 diabetes: Relation to diabetic vascular complications
ConclusionAdolescents with T1D have significantly higher NVC changes than controls. These changes were more evident in those having vascular complications than those without. Thus, NVC can be a potential non-invasive tool for early assessment and follow-up of the microvasculature among adolescents with T1D. (Source: Microcirculation)
Source: Microcirculation - June 15, 2022 Category: Research Authors: Abeer Ahmed Abdelmaksoud,
Shaymaa Maher Daifallah,
Nouran Yousef Salah,
Ahmed Salah Saber Tags: ORIGINAL ARTICLE Source Type: research
Effect of the Snake Venom Component Crotamine on Lymphatic Endothelial Cell Responses and Lymph Transport
ConclusionThis evidence suggests that snake venom components may have an impact on the function of the lymphatic system. This needs to be studied in greater detail as there are numerous venom components that may have effects on aspects of the lymphatic system. This would not only provide basic information on the pathobiology of snakebite but also provide targets for improved therapeutics to treat snakebite. (Source: Microcirculation)
Source: Microcirculation - June 11, 2022 Category: Research Authors: Hongjiang Si,
Chunhiu Yin,
Wei Wang,
Peter Davies,
Elda Sanchez,
Montamas Suntravat,
David Zawieja,
Walter Cromer Tags: ORIGINAL ARTICLE Source Type: research
Endothelial Cell Membrane Cholesterol Content Regulates the Contribution of TRPV4 Channels in ACh ‐induced Vasodilation in Rat Gracilis Arteries
ConclusionEC membrane cholesterol impedes the contribution of TRPV4 channels in EDH-mediated dilation. These results provide additional evidence for the importance of plasma membrane cholesterol content in regulating intracellular signaling and vascular function. (Source: Microcirculation)
Source: Microcirculation - June 11, 2022 Category: Research Authors: Emily E. Morin,
Sophia Salbato,
Benjimen R. Walker,
Jay S. Naik Tags: ORIGINAL ARTICLE Source Type: research
Peripheral endothelial and microvascular damage in liver cirrhosis: a systematic review and meta ‐analysis
ConclusionsNo differences in peripheral endothelial function assessed with semi-invasive or non-invasive functional methods exist between cirrhotic and non-cirrhotic subjects. The increasing co-existence of cardiovascular risk factors leading to impaired vascular reactivity in cirrhotic patients may partly explain these findings. (Source: Microcirculation)
Source: Microcirculation - June 3, 2022 Category: Research Authors: Ioanna Papagiouvanni,
Marieta P. Theodorakopoulou,
Pantelis Sarafidis,
Emmanouil Sinakos,
Ioannis Goulis Tags: ORIGINAL ARTICLE Source Type: research
Retinal Vascular Profile in Predicting Incident Cardiometabolic Diseases among Individuals with Diabetes
ConclusionWe found that RVPs improved the prediction of HTN in individuals with diabetes, but add limited information for CVD, DKD and HLD predictions. (Source: Microcirculation)
Source: Microcirculation - June 2, 2022 Category: Research Authors: Bjorn Kaijun Betzler,
Charumathi Sabanayagam,
Yih ‐Chung Tham,
Carol Y. Cheung,
Ching‐Yu Cheng,
Tien‐Yin Wong,
Simon Nusinovici Tags: ORIGINAL ARTICLE Source Type: research
Ultrasound Monitoring of Microcirculation: An original study from the laboratory bench to the clinic
ConclusionsOur data demonstrated SMI and MFI used with vascular probes operating at higher frequencies provided resolutions acceptable for microvasculature visualization, paving the path for future development of ultrasound devices for microcirculation monitoring. (Source: Microcirculation)
Source: Microcirculation - May 25, 2022 Category: Research Authors: Fariba Aghabaglou,
Ana Ainechi,
Haley Abramson,
Eli Curry,
Tarana Parvez Kaovasia,
Serene Kamal,
Molly Acord,
Smruti Mahapatra,
Aliaksei Pustavoitau,
Beth Smith,
Javad Azadi,
Jennifer K. Son,
Ian Suk,
Nicholas Theodore,
Betty M. Tyler,
Amir Tags: ORIGINAL ARTICLE Source Type: research
Engineering approaches to investigate the roles of lymphatics vessels in rheumatoid arthritis
AbstractRheumatoid arthritis (RA) is one of the most common chronic inflammatory joint disorders. While our understanding of the autoimmune processes that lead to synovial degradation has improved, a majority of patients are still resistant to current treatments and require new therapeutics. An understudied and promising area for therapy involves the roles of lymphatic vessels (LVs) in RA progression, which has been observed to have a significant effect on mediating chronic inflammation. RA disease progression has been shown to correlate with dramatic changes in LV structure and interstitial fluid drainage, manifesting in ...
Source: Microcirculation - May 25, 2022 Category: Research Authors: Samantha E. Kraus,
Esak Lee Tags: REVIEW Source Type: research
Nail fold microangiopathy in adolescents with type 1 diabetes; relation to diabetic vascular complications
ConclusionAdolescents with T1D have significantly higher NVC changes than controls. These changes were more evident in those having vascular complications than those without. Thus, NVC can be a potential noninvasive tool for early assessment and follow-up of the microvasculature among adolescents with T1D. (Source: Microcirculation)
Source: Microcirculation - May 25, 2022 Category: Research Authors: Abeer Ahmed Abd El Maksood,
Shaymaa Maher Daifallah,
Ahmed Salah Saber,
Nouran Yousef Salah Tags: ORIGINAL ARTICLE Source Type: research
