Issue Information
(Source: Microcirculation)
Source: Microcirculation - November 18, 2021 Category: Research Tags: ISSUE INFORMATION Source Type: research
Cutaneous iontophoresis of vasoactive medications in patients with scleroderma ‐associated pulmonary arterial hypertension
ConclusionsPatients with SSc-PAH have a lower cutaneous microvascular response to a prostacyclin analog treprostinil and the sGC activator A-350619 when compared with patients with SSc and no evidence of PH on screening tests, presumably due to a peripheral reduction in prostacyclin receptor expression and nitric oxide bioavailability. (Source: Microcirculation)
Source: Microcirculation - November 17, 2021 Category: Research Authors: Sami Al Abdi,
Allaa Almoushref,
Tawfeq Naal,
Celia A. Melillo,
Kulwant S. Aulak,
Mostafa K. Ahmed,
Soumya Chatterjee,
Kristin B. Highland,
Raed A. Dweik,
Adriano R. Tonelli Tags: ORIGINAL ARTICLE Source Type: research
Modeling acute and chronic vascular responses to a major arterial occlusion
ConclusionsStructural adaptation of the vasculature allows for increased blood flow to the collateral-dependent region after occlusion. Although flow is still below pre-occlusion levels, model predictions indicate that interventions which enhance collateral arteriogenesis would have the greatest potential for restoring flow. (Source: Microcirculation)
Source: Microcirculation - November 15, 2021 Category: Research Authors: Erin Zhao,
Jared Barber,
Chandan K. Sen,
Julia Arciero Tags: ORIGINAL ARTICLE Source Type: research
Skin trauma rapidly induces thermoregulatory plexus hyperemia, while an increased nutritive papillary capillary function can be detected after 24 hours
Conclusion≈24h after skin trauma, increased function of the nutritive papillary capillaries can be detected by CAVM. (Source: Microcirculation)
Source: Microcirculation - November 12, 2021 Category: Research Authors: Liv Kristin Wikslund,
Vivian Shubira Amundsen,
Anne Kari Kvernebo, Øyvind Krøvel‐Velle Standal,
Knut Kvernebo Tags: ORIGINAL ARTICLE Source Type: research
Cutaneous Iontophoresis of Vasoactive Medications in Patients with Scleroderma ‐ Associated Pulmonary Arterial Hypertension
ConclusionsPatients with SSc-PAH have a lower cutaneous microvascular response to a prostacyclin analog treprostinil and the sGC activator A-350619 when compared with patients with SSc and no evidence of PH on screening tests, presumably due to a peripheral reduction in prostacyclin receptor expression and nitric oxide bioavailability. (Source: Microcirculation)
Source: Microcirculation - November 6, 2021 Category: Research Authors: Sami Al Abdi,
Allaa Almoushref,
Tawfeq Naal,
Celia Melillo,
Kulwant S. Aulak,
Mostafa K. Ahmed,
Soumya Chatterjee,
Kristin Highland,
Raed A. Dweik,
Adriano R. Tonelli Tags: ORIGINAL ARTICLE Source Type: research
Differential hyperpolarization to substance P and calcitonin gene ‐related peptide in smooth muscle versus endothelium of mouse mesenteric artery
ConclusionsCalcitonin gene-related peptide elicits greater hyperpolarization than substance P. Substance P hyperpolarizes both cell layers through KCa channels and involves endothelium-derived NO in smooth muscle. Endothelial hyperpolarization to CGRP requires KCa channels, while KATP channels mediate hyperpolarization in smooth muscle. Differential K+ channel activation in smooth muscle and endothelium through sensory neurotransmission may selectively tune mesenteric blood flow. (Source: Microcirculation)
Source: Microcirculation - October 23, 2021 Category: Research Authors: Charles E. Norton,
Erika M. Boerman,
Steven S. Segal Tags: ORIGINAL ARTICLE Source Type: research
Differential hyperpolarization to substance P and calcitonin gene related peptide in smooth muscle versus endothelium of mouse mesenteric artery
ConclusionsCGRP elicits greater hyperpolarization than substance P. Substance P hyperpolarizes both cell layers through KCa channels and involves endothelium-derived NO in smooth muscle. Endothelial hyperpolarization to CGRP requires KCa channels, while KATP channels mediate hyperpolarization in smooth muscle. Differential K+ channel activation in smooth muscle and endothelium through sensory neurotransmission may selectively tune mesenteric blood flow. (Source: Microcirculation)
Source: Microcirculation - October 11, 2021 Category: Research Authors: Charles E. Norton,
Erika M. Boerman,
Steven S. Segal Tags: ORIGINAL ARTICLE Source Type: research
Issue Information
(Source: Microcirculation)
Source: Microcirculation - October 6, 2021 Category: Research Tags: ISSUE INFORMATION Source Type: research
Quantitative Contrast ‐Enhanced Ultrasound for the Differentiation of Kidney Allografts with Significant Histopathological Injury
ConclusionsRI and NRI groups had shorter ΔTTPm-c compared to the MC group. AUROCs for both patient groups were good, making ΔTTPm-c a promising CEUS parameter for distinguishing patients with significant histopathological injury. (Source: Microcirculation)
Source: Microcirculation - September 27, 2021 Category: Research Authors: Eva Vi čič,
Nika Kojc,
Tomaž Hovelja,
Miha Arnol,
Damjana Ključevšek Tags: ORIGINAL ARTICLE Source Type: research
Subclinical Heart Remodeling and Dysfunction in Relation to Peripheral Endothelial Dysfunction: a general population study
ConclusionThe association between subclinical heart maladaptation and decreased microvascular reactivity supports the involvement of endothelial dysfunction in HFpEF pathogenesis. Time-integrated profiling of microvascular vasoreactivity may enable early detection of HFpEF in the community. (Source: Microcirculation)
Source: Microcirculation - September 27, 2021 Category: Research Authors: Nicholas Cauwenberghs,
Sarah Godderis,
Franti šek Sabovčik,
Véronique Cornelissen,
Tatiana Kuznetsova Tags: ORIGINAL ARTICLE Source Type: research
A bioengineered lymphatic vessel model for studying lymphatic endothelial cell ‐cell junction and barrier function
ConclusionsLV-on-chip reveals integrin α5 as a regulator of lymphatic barrier function and provides a platform for studying lymphatic barrier function in various conditions. (Source: Microcirculation)
Source: Microcirculation - September 27, 2021 Category: Research Authors: Aria R. Henderson,
Isabelle S. Ilan,
Esak Lee Tags: ORIGINAL ARTICLE Source Type: research
Sublingual Microcirculation predicts Survival after Out ‐of‐Hospital Cardiac Arrest
ConclusionEstimating short-term prognosis of OHCA patients with ROSC may be supported by measuring the PPVsmall at the sublingual microcirculation 6 hours after admission. (Source: Microcirculation)
Source: Microcirculation - September 26, 2021 Category: Research Authors: Fabian Vo ß,
Matthias Karbenn,
Till Hoffmann,
Julian Schweitzer,
Christian Jung,
Michael Bernhard,
Peter Kienbaum,
Malte Kelm,
Ralf Westenfeld Tags: ORIGINAL ARTICLE Source Type: research
Abstracts from the 46th Annual Meeting of Japanese Society for Microcirculation
AbstractLast year, in September 2020, due to the COVID-19 pandemic, the conference was a hybrid of venue type and WEB type, but the 45th annual meeting of the Japanese Society for Microcirculation was held very magnificently under the President of annual meeting, Dr. Yuji Naito (Kyoto Prefectural University of Medicine). At that time, I was elected as the President of the Japanese Society for Microcirculation as the second term from 2020, and for the first time, I had the opportunity to give a lecture of President of the society. (Source: Microcirculation)
Source: Microcirculation - September 26, 2021 Category: Research Authors: Masato Matsuo Tags: ORIGINAL ARTICLE Source Type: research
Prolonged mechanical ventilation increases diaphragm arteriole circumferential stretch without changes in stress/stretch: Implications for the pathogenesis of ventilator ‐induced diaphragm dysfunction
ConclusionDuring prolonged MV, medial costal diaphragm arteriolar shear stress is severely diminished. Despite no change in the material behavior (stress/stretch), prolonged MV resulted in altered structural and mechanical properties (i.e. elevated circumferential stretch) of medial costal diaphragm arterioles. This provides important novel mechanistic insights into the impaired diaphragm blood flow capacity and vascular dysfunction following prolonged MV. (Source: Microcirculation)
Source: Microcirculation - September 2, 2021 Category: Research Authors: Andrew G. Horn,
Olivia N. Kunkel,
Dryden R. Baumfalk,
Mikaela E. Simon,
Kiana M. Schulze,
Wei ‐Wen Hsu,
Judy Muller‐Delp,
David C. Poole,
Bradley J. Behnke Tags: ORIGINAL ARTICLE Source Type: research
Capturing Membrane Trafficking Events During 3D Angiogenic Development in Vitro
ConclusionsOur results establish that the fibrin-bead sprouting assay is well-suited for imaging of trafficking events during angiogenic growth. (Source: Microcirculation)
Source: Microcirculation - August 20, 2021 Category: Research Authors: Caitlin R. Francis,
Erich J. Kushner Tags: REVIEW ARTICLE Source Type: research
