Endothelial deficiency of insulin ‐like growth factor‐1 receptor leads to blood–brain barrier disruption and accelerated endothelial senescence in mice, mimicking aspects of the brain aging phenotype
ConclusionsThese findings support the notion that IGF-1 signaling plays a crucial role in preserving a youthful cerebromicrovascular endothelial phenotype and maintaining the integrity of the BBB. (Source: Microcirculation)
Source: Microcirculation - December 12, 2023 Category: Research Authors: Rafal Gulej,
Boglarka Csik,
Janet Faakye,
Stefano Tarantini,
Santny Shanmugarama,
Siva Sai Chandragiri,
Peter Mukli,
Shannon Conley,
Anna Csiszar,
Zoltan Ungvari,
Andriy Yabluchanskiy, Ádám Nyúl‐Tóth Tags: ORIGINAL ARTICLE Source Type: research
Abstracts from the 48th Annual Meeting of Japanese Society for Microcirculation
(Source: Microcirculation)
Source: Microcirculation - December 9, 2023 Category: Research Tags: ABSTRACT Source Type: research
Flow ‐dependent regulation of rat mesenteric lymphatic vessel contractile response requires activation of endothelial TRPV4 channels
ConclusionsOur findings demonstrate a critical role for TRPV4 in the decrease in contraction frequency induced in lymphatic vessels by increases in flow rate via the production and action of nitric oxide and dilatory prostanoids. (Source: Microcirculation)
Source: Microcirculation - December 4, 2023 Category: Research Authors: Jacques DuToit,
Peter Brothers,
Matthew Stephens,
Keith Keane,
Flavia Neto de Jesus,
Simon Roizes,
Pierre‐Yves von der Weid Tags: ORIGINAL ARTICLE Source Type: research
Emerging role of YAP/TAZ in vascular mechanotransduction and disease
AbstractCells have an incredible ability to physically interact with neighboring cells and their environment. They can detect and respond to mechanical forces by converting mechanical stimuli into biochemical signals in a process known as mechanotransduction. This is a key process for the adaption of vascular smooth muscle and endothelial cells to altered flow and pressure conditions. Mechanical stimuli, referring to a physical force exerted on cells, are primarily sensed by transmembrane proteins and the actin cytoskeleton, which initiate a cascade of intracellular events, including the activation of signaling pathways, i...
Source: Microcirculation - November 28, 2023 Category: Research Authors: Olivia Ritsvall,
Sebastian Albinsson Tags: REVIEW Source Type: research
Advanced glycated end ‐products inhibit dilation through constitutive endothelial RAGE and Nox1/4 in rat isolated skeletal muscle arteries
ConclusionThese observations suggest RAGE are constitutively expressed in the endothelium of the rat CMA and may be activated by AGE to stimulate Nox1/4 and ROS formation with resulting inhibition of NO and BKCa-mediated endothelium-dependent dilation. (Source: Microcirculation)
Source: Microcirculation - November 21, 2023 Category: Research Authors: Nadim Naser,
Chenchel K. Lonj,
Matthew Rikard ‐Bell,
Shaun L. Sandow,
Timothy V. Murphy Tags: ORIGINAL ARTICLE Source Type: research
Vascular persistence following precision micropuncture
ConclusionsThis study further highlights that the intrinsic MP-induced vasculature continues to persist long-term. Its combination of rapid and stable angiogenesis represents a novel surgical platform for engineered scaffold and graft perfusion. (Source: Microcirculation)
Source: Microcirculation - November 11, 2023 Category: Research Authors: Summer N. Horchler,
Patrick C. Hancock,
Mingjie Sun,
Alexander T. Liu,
Sameer Massand,
Jessica C. El ‐Mallah,
Dana Goldenberg,
Olivia Waldron,
Mary E. Landmesser,
Shailaja Agrawal,
Srinivas V. Koduru,
Dino J. Ravnic Tags: ORIGINAL ARTICLE Source Type: research
Issue Information
(Source: Microcirculation)
Source: Microcirculation - November 8, 2023 Category: Research Tags: ISSUE INFORMATION Source Type: research
Vascular polycystin proteins in health and disease
AbstractPKD1 (polycystin 1) and PKD2 (polycystin 2) are expressed in a variety of different cell types, including arterial smooth muscle and endothelial cells. PKD1 is a transmembrane domain protein with a large extracellular N-terminus that is proposed to act as a mechanosensor and receptor. PKD2 is a member of the transient receptor potential (TRP) channel superfamily which is also termed TRPP1. Mutations in the genes which encode PKD1 and PKD2 lead to autosomal polycystic kidney disease (ADPKD). ADPKD is one of the most prevalent monogenic disorders in humans and is associated with extrarenal and vascular complications,...
Source: Microcirculation - October 13, 2023 Category: Research Authors: Ulrich C. Mbiakop,
Jonathan H. Jaggar Tags: REVIEW Source Type: research
Issue Information
(Source: Microcirculation)
Source: Microcirculation - October 10, 2023 Category: Research Tags: ISSUE INFORMATION Source Type: research
The effect of sepsis and reactive oxygen species on skeletal muscle interstitial oxygen pressure during contractions
ConclusionsOur results suggest that CLP-induced sepsis accelerated the decay ofPO2is at the onset of muscle contractions and maintained a low level ofPO2is during muscle contractions. (Source: Microcirculation)
Source: Microcirculation - October 7, 2023 Category: Research Authors: Naoki Hitosugi,
Kazuki Hotta,
Yoshikazu Taketa,
Ren Takamizawa,
Yutaka Fujii,
Ryo Ikegami,
Hajime Tamiya,
Tatsuro Inoue,
Atsuhiro Tsubaki Tags: ORIGINAL ARTICLE Source Type: research
The role of glycosaminoglycans in blood pressure regulation
AbstractEssential hypertension (HT) is the global health problem and is a major risk factor for the development of cardiovascular and kidney disease. High salt intake has been associated with HT and impaired kidney sodium excretion is considered to be a major mechanism for the development of HT. Although kidney has a very important role in regulation of BP, this traditional view of BP regulation was challenged by recent findings suggesting that nonosmotic tissue sodium deposition is very important for BP regulation. This new paradigm indicates that sodium can be stored and deposited nonosmotically in the interstitium witho...
Source: Microcirculation - October 5, 2023 Category: Research Authors: Baris Afsar,
Rengin Elsurer Afsar Tags: REVIEW Source Type: research
Arf6 is required for endocytosis and filamentous actin assembly during angiogenesis in vitro
ConclusionsOur findings highlight that endothelial Arf6 is a potent mediator of both actin regulation and endocytosis and is required for proper sprout formation. (Source: Microcirculation)
Source: Microcirculation - September 27, 2023 Category: Research Authors: Caitlin R. Francis,
Makenzie L. Bell,
Marina M. Skripnichuk,
Erich J. Kushner Tags: ORIGINAL ARTICLE Source Type: research
Estimation of shear stress heterogeneity along capillary segments in angiogenic rat mesenteric microvascular networks
ConclusionsThe results highlight the variability of shear stresses along angiogenic capillaries and motivate new discussions on how endothelial cells may respond in vivo to segment-specific microenvironment during angiogenesis. (Source: Microcirculation)
Source: Microcirculation - September 10, 2023 Category: Research Authors: Nien ‐Wen Hu,
Banks M. Lomel,
Elijah W. Rice,
Mir Md Nasim Hossain,
Malisa Sarntinoranont,
Timothy W. Secomb,
Walter L. Murfee,
Peter Balogh Tags: ORIGINAL ARTICLE Source Type: research
The association between hypoalbuminemia and microcirculation, endothelium, and glycocalyx disorders in children with sepsis
ConclusionsIn children with sepsis, an association was found between hypoalbuminemia and microcirculation changes, vascular permeability, and greater endothelial glycocalyx degradation. (Source: Microcirculation)
Source: Microcirculation - August 29, 2023 Category: Research Authors: Jaime Fern ández‐Sarmiento,
Ricardo Hernández‐Sarmiento,
María Paula Salazar,
Sofia Barrera,
Valeria Castilla,
Catalina Duque Tags: ORIGINAL ARTICLE Source Type: research
Progress in molecular mechanisms of coronary microvascular dysfunction
AbstractCoronary microvascular dysfunction is a high-risk factor for many cardiovascular events. However, because of multiple risk factors and limited understanding about its underlying pathophysiological mechanisms, it was easily misdiagnosed. Therefore, its clinical diagnosis and treatment were greatly restricted. Coronary microcirculation refers to microvessels that play an important role in the physiological regulation of myocardial perfusion and regulating blood flow distribution, fulfilling myocardial metabolic needs and moderating peripheral vascular resistance. In coronary microvascular dysfunction, vascular endoth...
Source: Microcirculation - August 23, 2023 Category: Research Authors: Hao Li,
Yuping Gao,
Yuanyuan Lin Tags: REVIEW Source Type: research
