Advanced glycated end ‐products inhibit dilation through constitutive endothelial RAGE and Nox1/4 in rat isolated skeletal muscle arteries

ConclusionThese observations suggest RAGE are constitutively expressed in the endothelium of the rat CMA and may be activated by AGE to stimulate Nox1/4 and ROS formation with resulting inhibition of NO and BKCa-mediated endothelium-dependent dilation.

Source: Microcirculation - November 21, 2023 Category: Research Authors: Nadim Naser, Chenchel K. Lonj, Matthew Rikard ‐Bell, Shaun L. Sandow, Timothy V. Murphy Tags: ORIGINAL ARTICLE Source Type: research