Distinct structural and functional angiogenic responses are induced by different mechanical stimuli
ConclusionTargeted capillary growth in response to abluminal stretch is a potent driver of improved muscle fatigue resistance, while shear stress ‐driven angiogenesis has no beneficial effect on muscle function. In terms of capillarity, more is not necessarily better. (Source: Microcirculation)
Source: Microcirculation - January 23, 2021 Category: Research Authors: Roger W. P. Kissane,
Peter G. Tickle,
Natalie E. Doody,
Abdullah A. Al ‐Shammari,
Stuart Egginton Tags: ORIGINAL ARTICLE Source Type: research
Post ‐treatment with Yiqifumai injection and its main ingredients attenuates lipopolysaccharide‐induced microvascular disturbance in mesentery and ileum
ConclusionThese results demonstrated the beneficial effect of post ‐treatment, which is attributable to its main ingredient Rb1 and Sch, and likely mediated by targeting TLR‐4/Src/NF‐κB signaling pathway. (Source: Microcirculation)
Source: Microcirculation - January 23, 2021 Category: Research Authors: Ayididaer Ayan,
Kai Sun,
Chun ‐Shui Pan,
Li Yan,
Yu‐Ying Liu,
Dan‐Tong Li,
Jing‐Yu Fan,
Jing‐Yan Han Tags: ORIGINAL ARTICLE Source Type: research
Cerebral microcirculation in glioblastoma: a major determinant of diagnosis, resection and drug delivery
AbstractGlioblastoma (GBM) is the most common primary brain tumor with a dismal prognosis. Current standard of treatment is maximal, safe tumor resection followed by chemotherapy and radiation. Altered cerebral microcirculation and elevated blood ‐tumor barrier (BTB) permeability in tumor periphery due to glioma‐induced vascular dysregulation allow T1 contrast‐enhanced visualization of resectable tumor boundaries. Newer tracers that label the tumor and its vasculature are being increasingly used for intra‐operative delineation of gli oma boundaries for even more precise resection. Fluorescent 5‐aminolevulinic aci...
Source: Microcirculation - January 21, 2021 Category: Research Authors: Tavarekere N. Nagaraja,
Ian Y. Lee Tags: REVIEW Source Type: research
Young healthy adults with a family history of hypertension have increased microvascular reactivity but decreased macrovascular function
ConclusionsYoung +FHH adults have altered microvascular and macrovascular reactivity compared with young −FHH adults. (Source: Microcirculation)
Source: Microcirculation - January 20, 2021 Category: Research Authors: Evan L. Matthews,
John J. Guers,
Peter A. Hosick Tags: ORIGINAL ARTICLE Source Type: research
Visualization of brain microvasculature and blood flow in vivo: feasibility study using confocal laser endomicroscopy
ConclusionsCLEimagingallows assessmentof cerebral and tumor microvasculature and blood flow alterations with subcellular resolutionintraoperative imaging demonstratingprecise details of real ‐time cell movements.Research and clinical scenarios may benefit from this novel intraoperative in vivo microscopic fluorescence imaging modality. (Source: Microcirculation)
Source: Microcirculation - January 11, 2021 Category: Research Authors: Evgenii Belykh,
Xiaochun Zhao,
Brandon Ngo,
Dara S. Farhadi,
Adam Kindelin,
Saif Ahmad,
Nikolay L. Martirosyan,
Michael T. Lawton,
Mark C. Preul Tags: ORIGINAL ARTICLE Source Type: research
Standardized microfluidic assessment of red blood cell –mediated microcapillary occlusion: Association with clinical phenotype and hydroxyurea responsiveness in sickle cell disease
ConclusionsWe demonstrated that RBC ‐mediated microcapillary occlusion and OI associated with subject clinical phenotype and HU responsiveness in SCD. The presented standardized microfluidic assay may be useful for evaluating clinical phenotype and assessing therapeutic outcomes in SCD, including emerging targeted and curative treat ments that aim to improve RBC deformability and microcirculatory health. (Source: Microcirculation)
Source: Microcirculation - January 9, 2021 Category: Research Authors: Yuncheng Man,
Erdem Kucukal,
Ran An,
Allison Bode,
Jane A. Little,
Umut A. Gurkan Tags: ORIGINAL RESEARCH Source Type: research
Distinct structural and functional angiogenic responses are induced by different mechanical stimuli
ConclusionTargetted capillary growth in response to abluminal stretch is a potent driver of improved muscle fatigue resistance, while shear stress ‐driven angiogenesis has no beneficial effect on muscle function. In terms of capillarity, more is not necessarily better. (Source: Microcirculation)
Source: Microcirculation - January 8, 2021 Category: Research Authors: Roger W.P. Kissane,
Peter G. Tickle,
Natalie E. Doody,
Abdullah A. Al ‐Shammari,
Stuart Egginton Tags: ORIGINAL ARTICLE Source Type: research
Young Healthy Adults with a Family History of Hypertension Have Increased Microvascular Reactivity but Decreased Macrovascular Function
ConclusionsYoung +FHH adults have altered microvascular and macrovascular reactivity compared to young ‐FHH adults. (Source: Microcirculation)
Source: Microcirculation - January 8, 2021 Category: Research Authors: Evan L. Matthews,
John J. Guers,
Peter A. Hosick Tags: ORIGINAL ARTICLE Source Type: research
Thioredoxin deficiency exacerbates vascular dysfunction during diet ‐induced obesity in small mesenteric artery in mice
ConclusionsOur results indicate that deficiency of active Trx exacerbates MA contractile and relaxing properties during diet ‐induced obesity demonstrating that loss of redox balance in obesity is a key mechanism of vascular endothelial dysfunction. (Source: Microcirculation)
Source: Microcirculation - December 30, 2020 Category: Research Authors: Shannon Dunn,
Robert H. Hilgers,
Kumuda C. Das Tags: ORIGINAL ARTICLE Source Type: research
Dexmedetomidine protects cardiac microvascular endothelial cells from the damage of OGD/R through regulation of the PPAR δ‐mediated autophagy
This study explored the cardioprotective effects of Dex in cardiac microvascular endothelial cells (CMECs) in response to oxygen ‐glucose deprivation and re‐oxygenation (OGD/R) injury and its potential mechanism. CMECs was exposed to OGD/R with the pretreatment of different concentration of Dex, then. The results found that OGD/R significantly decreased cell viability, increased reactive oxygen species, caused disorder of autophagy and increased apoptotic rates in CMECs. However, Dex pretreatment enhanced the viability of the OGD/R‐treated CMECs, and effectively decreased reactive oxygen species production. Autophagy...
Source: Microcirculation - December 30, 2020 Category: Research Authors: Qingbo Shao,
Jing Xia,
Pinwen Wu,
Jiazhou Ying Tags: ORIGINAL ARTICLE Source Type: research
Effects of impaired microvascular flow regulation on metabolism ‐perfusion matching and organ function
AbstractImpaired tissue oxygen delivery is a major cause of organ damage and failure in critically ill patients, which can occur even when systemic parameters, including cardiac output and arterial hemoglobin saturation, are close to normal. This review addresses oxygen transport mechanisms at the microcirculatory scale, and how hypoxia may occur in spite of adequate convective oxygen supply. The structure of the microcirculation is intrinsically heterogeneous, with wide variations in vessel diameters and flow pathway lengths, and consequently also in blood flow rates and oxygen levels. The dynamic processes of structural ...
Source: Microcirculation - December 21, 2020 Category: Research Authors: Tuhin K. Roy,
Timothy W. Secomb Tags: REVIEW ARTICLE Source Type: research
Thioredoxin deficiency exacerbates vascular dysfunction during diet ‐induced obesity in small mesenteric artery in mice
ConclusionsOur results indicate that deficiency of active Trx exacerbates MA contractile and relaxing properties during diet ‐induced obesity demonstrating that loss of redox balance in obesity is a key mechanism of vascular endothelial dysfunction. (Source: Microcirculation)
Source: Microcirculation - December 14, 2020 Category: Research Authors: Shannon Dunn,
Robert H. Hilgers,
Kumuda C. Das Tags: ORIGINAL ARTICLE Source Type: research
A clinical perspective on adipose ‐derived cell therapy for enhancing microvascular health and function: Implications and applications for reconstructive surgery
The objective of this article is to share the clinical perspectives of reconstructive plastic surgeons regarding the use of ADC‐b ased therapies to help with flap tissue integration, revascularization, and wound healing. Specifically, the focus will be on considering the potential for ADC as therapeutic agents and how their clinical application motivates basic science opportunities. (Source: Microcirculation)
Source: Microcirculation - November 29, 2020 Category: Research Authors: V. Morgan Jones,
Ariana D. Suarez ‐Martinez,
Nicholas A. Hodges,
Walter L. Murfee,
Ramon Llull,
Adam J. Katz Tags: INVITED REVIEW Source Type: research
Effects of impaired microvascular flow regulation on metabolism ‐perfusion matching and organ function
AbstractImpaired tissue oxygen delivery is a major cause of organ damage and failure in critically ill patients, which can occur even when systemic parameters, including cardiac output and arterial hemoglobin saturation, are close to normal. This review addresses oxygen transport mechanisms at the microcirculatory scale, and how hypoxia may occur in spite of adequate convective oxygen supply. The structure of the microcirculation is intrinsically heterogeneous, with wide variations in vessel diameters and flow pathway lengths, and consequently also in blood flow rates and oxygen levels. The dynamic processes of structural ...
Source: Microcirculation - November 24, 2020 Category: Research Authors: Tuhin K. Roy,
Timothy W. Secomb Tags: REVIEW Source Type: research
The cerebral microvasculature: Basic and clinical perspectives on stroke and glioma
AbstractMicrovascular networks are vital components of the cardiovascular system, performing many key roles in maintaining the health and homeostasis of the tissues and organs in which they develop. As discussed in this review, the molecular and cellular components within the microcirculation orchestrate critical processes to establish functional capillary beds, including organization of endothelial cell (EC) polarity, guiding investment of vascular pericytes (PCs), and building the specialized extracellular matrix (ECM) that comprises the vascular basement membrane (vBM). Herein, we further discuss the unique features of ...
Source: Microcirculation - November 23, 2020 Category: Research Authors: Maruf M. Hoque,
Hanaa Abdelazim,
Clifton Jenkins ‐Houk,
Dawn Wright,
Biraj M. Patel,
John C. Chappell Tags: INVITED REVIEWS Source Type: research
