Socio ‐economic inequalities, modifiable lifestyle risk factors and retinal vessel calibers: The African‐PREDICT Study
ConclusionAt young ages, retinal vessel calibers associated differently with modifiable lifestyle risk factors within each SES group. Our data highlights the importance of detecting adverse lifestyle risk factors among young adults from diverse socioeconomic settings to improve prevention of cardiovascular disease. (Source: Microcirculation)
Source: Microcirculation - May 19, 2021 Category: Research Authors: Vuledzani Felicia Maugana,
Ruan Kruger,
Aletta Elisabeth Schutte,
Wayne Smith Tags: ORIGINAL ARTICLE Source Type: research
The influence of hemorrhagic shock on ocular microcirculation by obtained by laser speckle flowgraphy in a white rabbit model
ConclusionThis rabbit hemorrhagic shock model confirmed that ocular microcirculation measurements by LSFG feasibly reflect variations of systemic hemodynamics during hemorrhagic shock and recovery. (Source: Microcirculation)
Source: Microcirculation - May 19, 2021 Category: Research Authors: Kento Watanabe,
Tomoaki Shiba,
Tetsuya Komatsu,
Kiyoshi Sakuma,
Megumi Aimoto,
Yoshinobu Nagasawa,
Akira Takahara,
Yuichi Hori Tags: ORIGINAL ARTICLE Source Type: research
Higher Cerebral Small Vessel Disease Burden is Associated with Smaller Hematoma Volume in Mixed ‐Location Intracerebral Hemorrhage
ConclusionsHigher CSVD burden is associated with smaller hematoma volume in mixed ‐location ICH, but not in non‐mixed ICH, which is novel and needs further studies with larger sample size to confirm our results and explore the underlying mechanisms. (Source: Microcirculation)
Source: Microcirculation - May 12, 2021 Category: Research Authors: Mangmang Xu,
Yajun Cheng,
Shihong Zhang,
Shuting Zhang,
Quhong Song,
Lukai Zheng,
Meng Liu,
Ming Liu Tags: ORIGINAL ARTICLE Source Type: research
Role of TRPV4 Channel in Vasodilation and Neovascularization
AbstractThe transient receptor potential vallinoid type 4 (TRPV4) channel, a Ca2+‐permeable nonselective cation channel, is widely distributed in the circulatory system, particularly in vascular endothelial cells (ECs) and smooth muscle cells (SMCs). The TRPV4 channel is activated by various endogenous and exogenous stimuli, including shear stress, low intravascular pressure, and arachidonic acid. TRPV4 has a role in mediating vascular tone and arterial blood pressure. The activation of the TRPV4 channel induces Ca2+ influx, thereby resulting in endothelium ‐dependent hyperpolarization and SMC relaxation through SKCa a...
Source: Microcirculation - May 10, 2021 Category: Research Authors: Miao Chen,
Xiucun Li Tags: REVIEW ARTICLE Source Type: research
The Relationship Between Retinal Microcirculation and Right Heart Catheterization and Echocardiography Findings in Patients with Idiopathic Pulmonary Arterial Hypertension
ConclusionsThe positive correlation of retinal perfusion at SCP and DCP with right ‐sided echocardiographic and hemodynamic measurements unveiled that retinal microcirculation is affected by the pressure alterations in the pulmonary circulation of IPAH patients. (Source: Microcirculation)
Source: Microcirculation - May 10, 2021 Category: Research Authors: Vedat Hekimsoy,
Hilal K ılınç Hekimsoy,
Mehmet Ali Şekeroğlu,
Ergün Barış Kaya,
Lale Tokgözoğlu Tags: ORIGINAL ARTICLE Source Type: research
Carotid stiffness is associated with retinal microvascular dysfunction —The Maastricht study
ConclusionIn this population ‐based study greater carotid, but not aortic, stiffness was associated with worse retinal flicker light‐induced dilation and this association was stronger in individuals with type 2 diabetes. Hence, carotid stiffness may be a determinant of retinal microvascular dysfunction. (Source: Microcirculation)
Source: Microcirculation - May 7, 2021 Category: Research Authors: Frank C. T. Heide,
Tan Lai Zhou,
Ronald M. A. Henry,
Alfons J. H. M. Houben,
Abraham A. Kroon,
Pieter C. Dagnelie,
Martien C. J. M. Dongen,
Simone J. P. M. Eussen,
Tos T. J. M. Berendschot,
Jan S. A. G. Schouten,
Carroll A. B. Webers,
Miranda T Tags: ORIGINAL ARTICLE Source Type: research
Cold ‐induced vasodilation in abstinent smokers with and without a 12‐hour nicotine patch
This study was designed to identify the effects of a 12 ‐h nicotine patch administration on cold induced vasodilation (CIVD) in healthy young chronic smokers following 16 h of abstinence from smoking. Two laser Doppler probes and temperature thermocouples were placed on the dorsal part of the distal phalanx of the middle and ring fingers of 7 smokers (>12 cigarettes/day). Following 16 h of abstinence from smoking, smokers were tested with and without administration of a 21 mg transdermal nicotine patch (NicoDerm®). Each participant's right hand was immersed in cold (~5 °C) water for 40 min. Cutaneous vascular cond...
Source: Microcirculation - May 4, 2021 Category: Research Authors: Kichang Lee,
Christopher C. Cheatham,
Gary W. Mack Tags: ORIGINAL ARTICLE Source Type: research
Carotid stiffness is associated with retinal microvascular dysfunction – The Maastricht Study
ConclusionIn this population ‐based study greater carotid, but not aortic, stiffness was associated with worse retinal flicker light‐induced dilation and this association was stronger in individuals with type 2 diabetes. Hence, carotid stiffness may be a determinant of retinal microvascular dysfunction. (Source: Microcirculation)
Source: Microcirculation - April 27, 2021 Category: Research Authors: Frank CT Van Der Heide,
Tan Lai Zhou,
Ronald MA Henry,
Alfons JHM Houben,
Abraham A Kroon,
Pieter C Dagnelie,
Martien CJM Van Dongen,
Simone JPM Eussen,
Tos TJM Berendschot,
Jan SAG Schouten,
Carroll AB Webers,
Miranda T Schram,
Marleen MJ van Tags: ORIGINAL ARTICLE Source Type: research
Issue Information
(Source: Microcirculation)
Source: Microcirculation - April 22, 2021 Category: Research Tags: ISSUE INFORMATION Source Type: research
Cold ‐induced vasodilation in abstinent smokers with and without a 12 hour nicotine patch
This study was designed to identify the effects of a 12 hr nicotine patch administration on cold induced vasodilation (CIVD) in healthy young chronic smokers following 16 hours of abstinence from smoking. Two laser Doppler probes and temperature thermocouples were placed on the dorsal part of the distal phalanx of the middle and ring fingers of 7 smokers (>12 cigarettes/day). Following 16 ‐hour of abstinence from smoking, smokers were tested with and without administration of a 21 mg transdermal nicotine patch (NicoDerm®). Each participant ’s right hand was immersed in cold (~5 °C) water for 40 minutes. Cutaneous ...
Source: Microcirculation - April 20, 2021 Category: Research Authors: Kichang Lee,
Christopher C. Cheatham,
Gary W. Mack Tags: ORIGINAL ARTICLE Source Type: research
Skin microvascular function and renal hemodynamics in overweight patients with type 2 diabetes: a cross ‐sectional study
ConclusionThese findings indicate that microvascular dysfunction in overweight adults with T2D is associated with lower mGFR and ERPF and higher ERVR. We hypothesize that increased renal vascular resistance may contribute to glomerular dysfunction due to impaired renal perfusion. (Source: Microcirculation)
Source: Microcirculation - April 17, 2021 Category: Research Authors: Emma J. Bouman,
Mark M. Smits,
Erik J. van Bommel,
Marcel H.A. Muskiet,
Anne C. Hesp,
Erik H. Sern é,
Jaap A. Joles,
Daniël H. van Raalte Tags: ORIGINAL ARTICLE Source Type: research
Evidence for Role of Capillaries in Regulation of Skeletal Muscle Oxygen Supply
ConclusionThese results support our hypothesis that individual capillary units play a role in regulating their erythrocyte supply in response to a changing O2 environment. (Source: Microcirculation)
Source: Microcirculation - April 15, 2021 Category: Research Authors: Nour W. Ghonaim,
Graham M. Fraser,
Daniel Goldman,
Stephanie Milkovich,
Jun Yang,
Christopher G. Ellis Tags: ORIGINAL ARTICLE Source Type: research
Mathematical synthesis of the cortical circulation for the whole mouse brain —part II: Microcirculatory closure
AbstractRecent advancements in multiphoton imaging and vascular reconstruction algorithms have increased the amount of data on cerebrovascular circulation for statistical analysis and hemodynamic simulations. Experimental observations offer fundamental insights into capillary network topology but mainly within a narrow field of view typically spanning a small fraction of the cortical surface (less than 2%). In contrast, larger ‐resolution imaging modalities, such as computed tomography (CT) or magnetic resonance imaging (MRI), have whole‐brain coverage but capture only larger blood vessels, overlooking the microscopic ...
Source: Microcirculation - April 9, 2021 Category: Research Authors: Grant Hartung,
Shoale Badr,
Samuel Mihelic,
Andrew Dunn,
Xiaojun Cheng,
Sreekanth Kura,
David A. Boas,
David Kleinfeld,
Ali Alaraj,
Andreas A. Linninger Tags: ORIGINAL ARTICLE Source Type: research
Development and validation of a novel microfluidic device for the manipulation of skeletal muscle microvascular blood flow in vivo.
ConclusionsThis novel microfluidic device allows for a controlled delivery of dissolved substances to constrained regions of microvasculature while simultaneously allowing for visualization and measurement of blood flow within discrete vessels and networks. (Source: Microcirculation)
Source: Microcirculation - April 6, 2021 Category: Research Authors: Gaylene M Russell McEvoy,
Hamza Shogan,
Richard J Sov é,
Graham M Fraser Tags: ORIGINAL ARTICLE Source Type: research
Three ‐dimensional microvascular network reconstruction from in vivo images with adaptation of the regional inhomogeneity in the signal‐to‐noise ratio
In conclusion, the present methods allow consistent segmentation of microvasculature by adapting the local inhomogeneity in the SNR, whi ch can be useful for quantitative comparison of the microvascular networks, such as under disease conditions where SNR in the 2PLSM images varies over space and time. (Source: Microcirculation)
Source: Microcirculation - March 31, 2021 Category: Research Authors: Takuma Sugashi,
Hiroya Yuki,
Tomoya Niizawa,
Hiroyuki Takuwa,
Iwao Kanno,
Kazuto Masamoto Tags: ORIGINAL ARTICLE Source Type: research
