Mathematical synthesis of the cortical circulation for the whole mouse brain —part II: Microcirculatory closure

AbstractRecent advancements in multiphoton imaging and vascular reconstruction algorithms have increased the amount of data on cerebrovascular circulation for statistical analysis and hemodynamic simulations. Experimental observations offer fundamental insights into capillary network topology but mainly within a narrow field of view typically spanning a small fraction of the cortical surface (less than 2%). In contrast, larger ‐resolution imaging modalities, such as computed tomography (CT) or magnetic resonance imaging (MRI), have whole‐brain coverage but capture only larger blood vessels, overlooking the microscopic capillary bed. To integrate data acquired at multiple length scales with different neuroimaging modal ities and to reconcile brain‐wide macroscale information with microscale multiphoton data, we developed a method for synthesizing hemodynamically equivalent vascular networks for the entire cerebral circulation. This computational approach is intended to aid in the quantification of patterns of ce rebral blood flow and metabolism for the entire brain. In part I, we described the mathematical framework for image‐guided generation of synthetic vascular networks covering the large cerebral arteries from the circle of Willis through the pial surface network leading back to the venous sinuses. H ere in part II, we introduce novel procedures for creatingmicrocirculatory closure that mimics a realistic capillary bed. We demonstrate our capability to synthesize ...
Source: Microcirculation - Category: Research Authors: Tags: ORIGINAL ARTICLE Source Type: research