Cover Image
Cover Caption: The cover image © Inga Saknite, Vanderbilt Dermatology Translational Research Clinic is based on the Original ArticleINDIVIDUAL CELL MOTION IN HEALTHY HUMAN SKIN MICROVASCULATURE BY REFLECTANCE CONFOCAL VIDEO MICROSCOPY by Inga Saknite et al.,https://doi.org/10.1111/micc.12621. (Source: Microcirculation)
Source: Microcirculation - October 11, 2020 Category: Research Authors: Inga Saknite,
Zijun Zhao,
J. Randall Patrinely,
Michael Byrne,
Madan Jagasia,
Eric R. Tkaczyk Tags: COVER IMAGE Source Type: research
Issue Information
Microcirculation, Volume 27, Issue 6, August 2020. (Source: Microcirculation)
Source: Microcirculation - October 11, 2020 Category: Research Tags: ISSUE INFORMATION Source Type: research
Standardized microfluidic assessment of red blood cell mediated microcapillary occlusion: association with clinical phenotype and hydroxyurea responsiveness in sickle cell disease
ConclusionsWe demonstrated that RBC mediated microcapillary occlusion and OI associated with subject clinical phenotype and IPS in SCD. The presented standardized microfluidic assay may be useful for evaluating clinical phenotype and assessing therapeutic outcomes in SCD, including emerging targeted and curative treatments that aim to improve RBC deformability and microcirculatory health. (Source: Microcirculation)
Source: Microcirculation - October 5, 2020 Category: Research Authors: Yuncheng Man,
Erdem Kucukal,
Ran An,
Allison Bode,
Jane A. Little,
Umut A. Gurkan Tags: ORIGINAL RESEARCH Source Type: research
Microvascular Dysfunction and Kidney Disease: Challenges and Opportunities?
The objective of this rev iew is to highlight the role of renal microvasculature in kidney disease. The overview will outline the impetus to study renal microvasculature, the bidirectional relationship between kidney disease and microvascular dysfunction, the key pathways driving microvascular disease such as vasoreactivity, the cell dynamics coordinating fibrosis and vessel rarefaction. Finally, we will also briefly highlight new therapies targeting the renal microvasculature to improve renal function. (Source: Microcirculation)
Source: Microcirculation - October 5, 2020 Category: Research Authors: Suraj Krishnan,
Ariana D. Suarez ‐Martinez,
Pooneh Bagher,
Anjelica Gonzalez,
Ruisheng Liu,
Walter L. Murfee,
Rajesh Mohandas Tags: INVITED REVIEWS Source Type: research
Sweat the small stuff: The human microvasculature and heart disease
AbstractTraditionally thought of primarily as the predominant regulator of myocardial perfusion, it is becoming more accepted that the human coronary microvasculature also exerts a more direct influence on the surrounding myocardium. Coronary microvascular dysfunction (CMD) not only precedes large artery atherosclerosis, but is associated with other cardiovascular diseases such as heart failure with preserved ejection fraction and hypertrophic cardiomyopathy. It is also highly predictive of cardiovascular events in patients with or without atherosclerotic cardiovascular disease. This review focuses on this recent paradigm ...
Source: Microcirculation - September 30, 2020 Category: Research Authors: Boran Katunaric,
Katie E. Cohen,
Andreas M. Beyer,
David D. Gutterman,
Julie K. Freed Tags: INVITED REVIEW Source Type: research
Cardiac and lung endothelial cells in response to fluid shear stress on physiological matrix stiffness and composition
ConclusionSubstrate stiffness plays an important role in regulating tissue ‐specific endothelial response to shear stress, which may be due to differences in their native microenvironments. Furthermore, cardiac and lung endothelial cell response to shear stress was significantly regulated by the type of coating used. (Source: Microcirculation)
Source: Microcirculation - September 28, 2020 Category: Research Authors: Cydnee Bacci,
Vanessa Wong,
Victor Barahona,
Nick Merna Tags: ORIGINAL RESEARCH Source Type: research
FLI1 and ERG protein degradation is regulated via Cathepsin B lysosomal pathway in Human Dermal Microvascular Endothelial Cells
ConclusionsInhibition of cathepsin B was effective in reversing the reduction of FLI1 and ERG protein levels after treatment with IFN α or SSc sera, suggesting that targeting cathepsin B may have a beneficial effect in SSc vascular disease. (Source: Microcirculation)
Source: Microcirculation - September 25, 2020 Category: Research Authors: Celestina Mazzotta,
Grace Marden,
Alessandra Farina,
Andreea Bujor,
Marcin A. Trojanowski,
Maria Trojanowska Tags: ORIGINAL RESEARCH Source Type: research
Coronary microvascular dysfunction in hypertrophic cardiomyopathy: Pathophysiology, assessment, and clinical impact
AbstractMyocardial ischemia constitutes one of the most important pathophysiological features in hypertrophic cardiomyopathy. Chronic and recurrent myocardial ischemia leads to fibrosis, which may culminate in myocardial dysfunction. Since the direct visualization of coronary microcirculation in vivo is not possible, its function must be studied indirectly. Invasive and noninvasive techniques allow microcirculatory dysfunction to be evaluated, including echocardiography, magnetic resonance, positron emission tomography, and cardiac catheterization. Blunted myocardial blood flow and coronary flow reserve have been suggested...
Source: Microcirculation - September 21, 2020 Category: Research Authors: S ílvia Aguiar Rosa,
Luís Rocha Lopes,
António Fiarresga,
Rui Cruz Ferreira,
Miguel Mota Carmo Tags: REVIEW ARTICLE Source Type: research
conditioning of endothelial cells from different
ConclusionSubstrate stiffness plays an important role in regulating tissue ‐specific endothelial response to shear stress, which may be due to differences in their native microenvironments. Furthermore, cardiac and lung endothelial cell response to shear stress was significantly regulated by the type of coating used. (Source: Microcirculation)
Source: Microcirculation - September 17, 2020 Category: Research Authors: Sathish Kumar Tags: ORIGINAL RESEARCH Source Type: research
Sweat the Small Stuff: The Human Microvasculature and Heart Disease
AbstractTraditionally thought of primarily as the predominant regulator of myocardial perfusion, it is becoming more accepted that the human coronary microvasculature also exerts a more direct influence on the surrounding myocardium. Coronary microvascular dysfunction (CMD), not only precedes large artery atherosclerosis, but is associated with other cardiovascular diseases such as heart failure with preserved ejection fraction (HFpEF) and hypertrophic cardiomyopathy (HCM). It is also highly predictive of cardiovascular events in patients with or without atherosclerotic cardiovascular disease. This review focuses on this r...
Source: Microcirculation - September 15, 2020 Category: Research Authors: Boran Katunaric,
Katie E. Cohen,
Andreas M. Beyer,
David D. Gutterman,
Julie K. Freed Tags: INVITED REVIEWS Source Type: research
Coronary Microvascular Dysfunction in Hypertrophic Cardiomyopathy. Pathophysiology, assessment and clinical impact
AbstractMyocardial ischemia constitutes one of the most important pathophysiological features in hypertrophic cardiomyopathy. Chronic and recurrent myocardial ischemia leads to fibrosis, which may culminate in myocardial dysfunction. Since the direct visualization of coronary microcirculationin vivo is not possible, its function must be studied indirectly. Invasive and non ‐invasive techniques allow microcirculatory dysfunction to be evaluated, including echocardiography, magnetic resonance, positron emission tomography and cardiac catheterization. Blunted myocardial blood flow and coronary flow reserve have been suggest...
Source: Microcirculation - September 7, 2020 Category: Research Authors: S ílvia Aguiar Rosa,
Luís Rocha Lopes,
António Fiarresga,
Rui Cruz Ferreira,
Miguel Mota Carmo Tags: REVIEW Source Type: research
MiR ‐98‐5p promotes ischemia/reperfusion‐induced microvascular dysfunction by targeting NGF and is a potential biomarker for microvascular reperfusion
ConclusionsMiR ‐98‐5p promotes microvascular dysfunction by targeting the NGF‐ TRPV1 axis. Serum miR‐98‐5p serve as a potential biomarker for microvascular reperfusion. (Source: Microcirculation)
Source: Microcirculation - September 5, 2020 Category: Research Authors: Yisen Hu,
Jingjie Xiong,
Hong Wen,
Heng Wei,
Xiaocong Zeng Tags: ORIGINAL RESEARCH Source Type: research
Vascular endothelial injury exacerbates coronavirus disease 2019: The role of endothelial glycocalyx protection
AbstractThe potential for a rapid increase in severity is among the most frightening aspects of severe acute respiratory syndrome coronavirus 2 infection. Evidence increasingly suggests that the symptoms of coronavirus disease ‐2019 (COVID‐19)‐related acute respiratory distress syndrome (ARDS) differ from those of classic ARDS. Recently, the severity of COVID‐19 has been attributed to a systemic, thrombotic, and inflammatory disease that damages not only the lungs but also multiple organs, including the heart, bra in, toes, and liver. This systemic form of COVID‐19 may be due to inflammation and vascular endothel...
Source: Microcirculation - August 30, 2020 Category: Research Authors: Hideshi Okada,
Shozo Yoshida,
Akira Hara,
Shinji Ogura,
Hiroyuki Tomita Tags: Review Source Type: research
Effect of orthostasis on the regulation of skin blood flow in upper and lower extremities in human
ConclusionsThe contribution of central mechanisms associated with respiration to blood flow regulation increased in lower extremities during orthostasis. (Source: Microcirculation)
Source: Microcirculation - August 28, 2020 Category: Research Authors: Irina V. Tikhonova,
Andrey A. Grinevich,
Irina E. Guseva,
Arina V. Tankanag Tags: ORIGINAL RESEARCH Source Type: research
Vascular endothelial injury exacerbates coronavirus disease 2019: The role of endothelial glycocalyx protection
AbstractThe potential for a rapid increase in severity is among the most frightening aspects of severe acute respiratory syndrome coronavirus 2 infection. Evidence increasingly suggests that the symptoms of coronavirus disease ‐2019 (COVID‐19)‐related acute respiratory distress syndrome (ARDS) differ from those of classic ARDS. Recently, the severity of COVID‐19 has been attributed to a systemic, thrombotic, and inflammatory disease that damages not only the lungs but multiple organs, including the heart, brain, t oes, and liver. This systemic form of COVID‐19 may be due to inflammation and vascular endothelial c...
Source: Microcirculation - August 12, 2020 Category: Research Authors: Hideshi Okada,
Shozo Yoshida,
Akira Hara,
Shinji Ogura,
Hiroyuki Tomita Tags: REVIEW Source Type: research
