Cover Image
The cover image is based on the Original ArticleStandardized microfl uidic assessment of red blood cell mediated microcapillary occlusion: association with clinical phenotype and hydroxyurea responsiveness in sickle cell disease by Umut Gurkan et al.,https://doi.org/10.1111/micc.12662. (Source: Microcirculation)
Source: Microcirculation - March 1, 2021 Category: Research Authors: Yuncheng Man,
Erdem Kucukal,
Ran An,
Allison Bode,
Jane A. Little,
Umut A. Gurkan Tags: COVER IMAGE Source Type: research
Issue Information
(Source: Microcirculation)
Source: Microcirculation - March 1, 2021 Category: Research Tags: ISSUE INFORMATION Source Type: research
The presence of diabetes mellitus further impairs structural and functional capillary density in patients with chronic kidney disease
ConclusionsCapillary density during postocclusive hyperemia and after venous congestion is lower in diabetic compared to non ‐diabetic CKD patients, a finding indicative that diabetes is an additional factor contributing to microcirculatory structural and functional impairment in CKD. These differences are more prominent in CKD stage 3b. (Source: Microcirculation)
Source: Microcirculation - March 1, 2021 Category: Research Authors: Maria Schoina,
Charalampos Loutradis,
Marieta Theodorakopoulou,
Theodoros Dimitroulas,
Eva Triantafillidou,
Michael Doumas,
Asterios Karagiannis,
Alexandros Garyfallos,
Aikaterini Papagianni,
Pantelis Sarafidis Tags: ORIGINAL RESEARCH Source Type: research
Systemic microvascular endothelial dysfunction is associated with left ventricular ejection fraction reduction in chronic Chagas disease patients
ConclusionsWe have shown for the first time that the reduction of MR is associated with a decrease of LVEF in a cohort of chronic CD patients. The results were not affected by comorbidities, such as hypertension or diabetes. The evaluation of systemic endothelial function may be useful to tailor therapeutic and preventive approaches, targeted at systolic left ventricular failure associated with chronic CD cardiomyopathy. (Source: Microcirculation)
Source: Microcirculation - March 1, 2021 Category: Research Authors: Daniel Arthur Barata Kasal,
Ademar Britto,
Val éria Verri,
Andrea De Lorenzo,
Eduardo Tibirica Tags: ORIGINAL RESEARCH Source Type: research
Standardized microfluidic assessment of red blood cell –mediated microcapillary occlusion: Association with clinical phenotype and hydroxyurea responsiveness in sickle cell disease
ConclusionsWe demonstrated that RBC ‐mediated microcapillary occlusion and OI associated with subject clinical phenotype and HU responsiveness in SCD. The presented standardized microfluidic assay may be useful for evaluating clinical phenotype and assessing therapeutic outcomes in SCD, including emerging targeted and curative treat ments that aim to improve RBC deformability and microcirculatory health. (Source: Microcirculation)
Source: Microcirculation - March 1, 2021 Category: Research Authors: Yuncheng Man,
Erdem Kucukal,
Ran An,
Allison Bode,
Jane A. Little,
Umut A. Gurkan Tags: ORIGINAL RESEARCH Source Type: research
Mild obesity does not affect the forearm muscle microvascular responses to hyperglycemia
ConclusionEven though obese individuals showed impaired postprandial brachial artery function, the current findings suggest that mild obesity does not affect the forearm skeletal muscle responses to glucose ingestion. (Source: Microcirculation)
Source: Microcirculation - March 1, 2021 Category: Research Authors: Rog ério Nogueira Soares,
Raylene A. Reimer,
Patricia K. Doyle‐Baker,
Juan M. Murias Tags: ORIGINAL ARTICLE Source Type: research
Effect of cytosol viscosity on the flow behavior of red blood cell suspensions in microvessels
ConclusionsThe weak effect on the flow resistance and RBC ‐FL explains why RBCs can contain a high concentration of hemoglobin for efficient oxygen delivery, without a pronounced increase in the flow resistance. Furthermore, our results suggest that significant alterations in microvascular flow in various pathologies are likely not due to mere changes in cytosolic viscosity. (Source: Microcirculation)
Source: Microcirculation - March 1, 2021 Category: Research Authors: Wei Chien,
Gerhard Gompper,
Dmitry A. Fedosov Tags: ORIGINAL ARTICLE Source Type: research
Effects of exenatide on microvascular reactivity in patients with type 2 diabetes and coronary artery disease: A randomized controlled study
ConclusionsThree months' daily treatment with the GLP ‐1RA exenatide in T2DM patients with CAD showed no significant effects on skin microvascular function or blood glucose control, while this study confirms a reduction in body weight and blood pressure by exenatide, as compared to conventional antidiabetic drug treatment. (Source: Microcirculation)
Source: Microcirculation - March 1, 2021 Category: Research Authors: Nikolaos Östlund Papadogeorgos,
Jeanette Kuhl,
Angela Shore,
Thomas Kahan,
Gun Jörneskog,
Majid Kalani Tags: ORIGINAL ARTICLE Source Type: research
Cover Image
The cover image is based on the Original ArticleStandardized microfl uidic assessment of red blood cell mediated microcapillary occlusion: association with clinical phenotype and hydroxyurea responsiveness in sickle cell disease by Umut Gurkan et al.,https://doi.org/10.1111/micc.12662. (Source: Microcirculation)
Source: Microcirculation - March 1, 2021 Category: Research Authors: Yuncheng Man,
Erdem Kucukal,
Ran An,
Allison Bode,
Jane A. Little,
Umut A. Gurkan Tags: COVER IMAGE Source Type: research
Issue Information
(Source: Microcirculation)
Source: Microcirculation - March 1, 2021 Category: Research Tags: ISSUE INFORMATION Source Type: research
The Impact of Thrombo ‐inflammation on the Cerebral Microcirculation
AbstractThe intertwined processes of thrombosis and inflammation (termed ‘thrombo‐inflammation’) are significant drivers of cerebrovascular diseases and as such they represent prime targets for drug discovery programs focusing on treatment and management of cerebrovascular diseases. Most cerebrovascular events result from chronic systemic microcirculatory dysfuncti on due to underlying conditions e.g. hypertension, diabetes mellitus, coronary artery disease, dyslipidemia and sickle cell disease. Immune cells especially neutrophils play a critical role in the onset as well as maintenance of neuroinflammatory responses...
Source: Microcirculation - February 27, 2021 Category: Research Authors: Junaid Ansari,
Felicity N.E. Gavins Tags: REVIEW Source Type: research
Calendar of Events
(Source: Microcirculation)
Source: Microcirculation - February 26, 2021 Category: Research Tags: ISSUE INFORMATION Source Type: research
Clinical Perspectives on the Microcirculation
AbstractAn opportunity exists to advance our understanding of the microcirculation and capabilities to therapeutically manipulate it by connecting clinicians with basic science researchers. This special topic issue emphasizes the impacts of the microcirculation on different aspects of clinical medicine and showcases how microvascular research might bridge knowledge gaps to improve patient outcomes. Co ‐authored by clinicians and basic science researchers, our collection of review articles focuses on the roles of microvascular function and dysfunction in the prognosis, diagnosis, and therapeutic management of various dise...
Source: Microcirculation - February 25, 2021 Category: Research Authors: Asher A. Mendelson,
Fong Lam,
Shayn M. Peirce,
Walter L. Murfee Tags: REVIEW Source Type: research