Altered red blood cell deformability —A novel hypothesis for retinal microangiopathy in diabetic retinopathy
ConclusionImpaired RBC deformability measured by a microfluidic cross ‐slot channel in DM patients with different grades of DR underscores the contribution of RBC rheological properties to the pathogenesis and progression of DM related microangiopathy. (Source: Microcirculation)
Source: Microcirculation - August 10, 2020 Category: Research Authors: Justin Kok Soon Tan,
Xin Wei,
Peter Agustinus Wong,
Jie Fang,
Sangho Kim,
Rupesh Agrawal Tags: ORIGINAL ARTICLE Source Type: research
Implication of nuclear factor ‐erythroid 2‐like 2/heme oxygenase 1 pathway in the protective effects of coenzyme Q10 against preeclampsia‐like in a rat model
ConclusionCoenzyme Q10 attenuated placental inflammatory and oxidative stress, thereby protecting the rats against preeclampsia by activating the Nrf2/HO ‐1 pathway. (Source: Microcirculation)
Source: Microcirculation - August 9, 2020 Category: Research Authors: Lei Li,
Hongyan Li,
Qian Zhou,
Yuan Lu,
Pengzheng Chen,
Xietong Wang,
Heyong Zhao Tags: ORIGINAL ARTICLE Source Type: research
Soluble Epoxide Hydrolase Inhibition Improves Cognitive Function and Parenchymal Artery Dilation in a Hypertensive Model of Chronic Cerebral Hypoperfusion
ConclusionsThese data suggest that sEH inhibitors may be viable treatments for cognitive impairments associated with hypertension and CCH. (Source: Microcirculation)
Source: Microcirculation - August 6, 2020 Category: Research Authors: Nusrat Matin,
Courtney Fisher,
Teresa A Lansdell,
Bruce D Hammock,
Jun Yang,
William F. Jackson,
Anne M Dorrance Tags: ORIGINAL RESEARCH Source Type: research
Issue Information
Microcirculation, Volume 27, Issue 5, July 2020. (Source: Microcirculation)
Source: Microcirculation - August 2, 2020 Category: Research Tags: ISSUE INFORMATION Source Type: research
Sublethal mechanical shear stress increases the elastic shear modulus of red blood cells but does not change capillary transit velocity
AbstractBlood exposure to supraphysiological shear stress within mechanical circulatory support is suspected of reducing red blood cell (RBC) deformability and being primal in the pathogenesis of several secondary complications. No prior works have explored RBC dynamics with the resolution required to determine shear elastic modulus, and/or cell capillary velocity, following exposure to mechanical stresses.Healthy RBCs were exposed to 0,5,50, and 100Pa in a Couette shearing system. For comparison, blood was also exposed to heat treatment – a method that predictably increases RBC rigidity. Shear modulus assessment require...
Source: Microcirculation - July 31, 2020 Category: Research Authors: Antony P. McNamee,
Geoff D. Tansley,
Michael J. Simmonds Tags: ORIGINAL RESEARCH Source Type: research
The need to freeze —Dehydration during specimen preparation for electron microscopy collapses the endothelial glycocalyx regardless of fixation method
ConclusionsBoth chemical and cryogenic fixation followed by dehydration lead to substantial collapse of the glycocalyx. Cryogenic fixation without freeze substitution could be a way forward although transmission soft x ‐ray tomography based solely on amplitude contrast seems unsuitable. (Source: Microcirculation)
Source: Microcirculation - July 25, 2020 Category: Research Authors: Casper Hempel,
Sergey Kapishnikov,
Ana Joaquina Perez ‐Berna,
Stephan Werner,
Peter Guttmann,
Eva Pereiro,
Klaus Qvortrup,
Thomas Lars Andresen Tags: ORIGINAL ARTICLE Source Type: research
Implication of Nrf2/HO ‐1 pathway in the protective effects of coenzyme Q10 against preeclampsia‐like in a rat model
ConclusionCoenzyme Q10 attenuated placental inflammatory and oxidative stress, thereby protecting the rats against preeclampsia by activating the Nrf2/HO ‐1 pathway. (Source: Microcirculation)
Source: Microcirculation - July 21, 2020 Category: Research Authors: Lei Li,
Hongyan Li,
Qian Zhou,
Yuan Lu,
Pengzheng Chen,
Xietong Wang,
Heyong Zhao Tags: ORIGINAL RESEARCH Source Type: research
Therapeutic interventions to restore microcirculatory perfusion following experimental hemorrhagic shock and fluid resuscitation: a systematic review
ConclusionImproving mitochondrial function, inhibition of complement inhibition and reducing microvascular leakage via restoration of endothelial barrier function seems beneficial to restore microcirculatory perfusion following hemorrhagic shock and fluid resuscitation. (Source: Microcirculation)
Source: Microcirculation - July 19, 2020 Category: Research Authors: Anoek L.I. van Leeuwen,
Nicole A.M. Dekker,
Elise P. Jansma,
Christa Boer,
Charissa E. van den Brom Tags: REVIEWS Source Type: research
Altered Red blood cell deformability – A novel hypothesis for retinal microangiopathy in diabetic retinopathy
ConclusionImpaired RBC deformability measured by a microfluidic cross slot channel in DM patients with different grades of DR underscores the contribution of RBC rheological properties to the pathogenesis and progression of DM related microangiopathy. (Source: Microcirculation)
Source: Microcirculation - July 13, 2020 Category: Research Authors: Justin Kok Soon Tan,
Xin Wei,
Peter Agustinus Wong,
Jie Fang,
Sangho Kim,
Rupesh Agrawal Tags: ORIGINAL RESEARCH Source Type: research
Pathophysiology, Classification, and MRI Parallels in Microvascular Disease of the Heart and Brain
AbstractDiagnostic imaging technology in vascular disease has long focused on large vessels and the pathologic processes that impact them. With improved diagnostic techniques, investigators are now able to uncover many underlying mechanisms and prognostic factors for microvascular disease. In the heart and brain, these pathologic entities include coronary microvascular disease and cerebral small vessel disease, both of which have significant impact on patients, causing angina, myocardial infarction, heart failure, stroke and dementia. In the current paper we will discuss parallels in pathophysiology, classification, and di...
Source: Microcirculation - July 7, 2020 Category: Research Authors: Michael A. Thomas,
Saman Hazany,
Benjamin M. Ellingson,
Peng Hu,
Kim ‐Lien Nguyen Tags: REVIEWS Source Type: research
Compromised regulation of the rat brain parenchymal arterioles in vasopressin ‐associated acute hyponatremia
ConclusionsAVP ‐associated hyponatremia leads to constriction and dysregulation of parenchymal arterioles which may impair neurovascular coupling. (Source: Microcirculation)
Source: Microcirculation - June 29, 2020 Category: Research Authors: Marta Aleksandrowicz,
Ewa Kozniewska Tags: ORIGINAL RESEARCH Source Type: research
An evaluation of dermal microcirculatory occlusion under repeated mechanical loads: implication of lymphatic impairment in pressure ulcers
AbstractPressure ulcers are caused by prolonged mechanical loads deforming the underlying soft tissues. However, the mechanical loads for microcirculatory occlusion are unknown. The present study was designed to characterise the simultaneous response of microvascular and lymphatic structures under repeated mechanical loading.The effects of two distinct loading/unloading cycles involving i) incremental pressures 30, 60 and 90mmHg and ii) three repeated cycles of 30mmHg, were evaluated on a cohort of able ‐bodied volunteers. Microvascular response involved the monitoring of transcutaneous gas tensions, while dermal lymphat...
Source: Microcirculation - June 29, 2020 Category: Research Authors: P.R. Worsley,
H. Crielaard,
C.W.J. Oomens,
D.L Bader Tags: ORIGINAL RESEARCH Source Type: research
Monitoring the microcirculation in the diagnosis and follow ‐up of systemic sclerosis patients: focus on pulmonary and peripheral vascular manifestations
AbstractSystemic sclerosis (SSc) is a connective tissue disease, characterized by vascular damage and progressive fibrosis, affecting the skin and internal organs. The vascular changes include functional and structural abnormalities in the microcirculation, which play a central role not only in diagnosis, but also in the prognosis and follow ‐up of systemic sclerosis patients. Nailfold videocapillaroscopy (NVC) is a safe, validated, non‐invasive, inexpensive, reliable and reproducible method that allows for the evaluation of structural changes in scleroderma microangiopathy. However, capillary blood flow/perfusion cann...
Source: Microcirculation - June 29, 2020 Category: Research Authors: B. Ruaro,
MG. Nallino,
A. Casabella,
F. Salton,
P. Confalonieri,
A. De Tanti,
C. Bruni Tags: REVIEWS Source Type: research
Pericytes improve locomotor recovery after spinal cord injury in male and female neonatal rats
ConclusionsHIF ‐activated pericytes promote vascular density in males post‐SCI. Acute delivery of non‐HIF‐activated pericytes at the site of injury can improve motor recovery post‐SCI. (Source: Microcirculation)
Source: Microcirculation - June 29, 2020 Category: Research Authors: Jamie N. Mayo,
Sierra D. Kauer,
Michele R. Brumley,
Shawn E. Bearden Tags: ORIGINAL RESEARCH Source Type: research
The need to freeze ‐ dehydration during specimen preparation for electron microscopy collapses the endothelial glycocalyx regardless of fixation method
ConclusionsBoth chemical and cryogenic fixation followed by dehydration lead to substantial collapse of the glycocalyx. Cryogenic fixation without freeze substitution could be a way forward although transmission soft x ‐ray tomography based solely on amplitude contrast seems unsuitable. (Source: Microcirculation)
Source: Microcirculation - June 15, 2020 Category: Research Authors: Casper Hempel,
Sergey Kapishnikov,
Ana Joaquina Perez ‐Berna,
Stephan Werner,
Peter Guttmann,
Eva Pereiro,
Klaus Qvortrup,
Thomas Lars Andresen Tags: ORIGINAL RESEARCH Source Type: research
