Enlargement of opisthenar microcirculatory area predicts impaired heart function in severe acute coronary syndrome patients
AbstractImpaired microcirculation in acute coronary syndrome (ACS) patients manifests inadequate recovery and adverse clinical outcome. Here, we analyzed correlations between peripheral microcirculation and heart function in ACS patients. Opisthenar microvessel area (OMA) were measured with optical coherence tomography angiography (OCTA), cardiac functional indexes (echocardiograph) were assessed 48-72 hours after therapeutic interventions. Results showed that OMA normalized with heart rate (OMA-HR) were significantly greater in ACS patients with percutaneous intervention (ACS-PCI, n=25, stenosis> 80%) compared to th...
Source: Microcirculation - March 14, 2023 Category: Research Authors: Chen Chen,
Bai Lin Zhu,
Wei Da Zheng,
Zhen Yi Guo,
Xin Jin,
Zai Hao Zhao,
Mei Hua Lin,
Lan Cui,
Yin Hua Zhang Tags: ORIGINAL ARTICLE Source Type: research
Association between mean arterial pressure and sublingual microcirculation during major non ‐cardiac surgery: post‐hoc analysis of a prospective cohort
ConclusionsIn patients having elective major non-cardiac surgery with general anesthesia, sublingual microcirculation is well maintained when MAP ranges between 65 and 120 mmHg. It remains possible that sublingual perfusion will be a useful marker of tissue perfusion when MAP is lower than 65 mmHg. (Source: Microcirculation)
Source: Microcirculation - March 12, 2023 Category: Research Authors: Eleni Laou,
Nikolaos Papagiannakis,
Anastasia Michou,
Nicoletta Ntalarizou,
Dimitrios Ragias,
Zacharoula Angelopoulou,
Daniel I. Sessler,
Athanasios Chalkias Tags: ORIGINAL ARTICLE Source Type: research
Modeling Lymphangiogenesis: Pairing in vitro and in vivo metrics
AbstractLymphangiogenesis is the mechanism by which the lymphatic system develops and expands new vessels facilitating fluid drainage and immune cell trafficking. Models to study lymphangiogenesis are necessary for a better understanding of the underlying mechanisms and to identify or test new therapeutic agents that target lymphangiogenesis. Across the lymphatic literature, multiple models have been developed to study lymphangiogenesis in vitro and in vivo. In vitro, lymphangiogenesis can be modeled with varying complexity, from monolayers to hydrogels to explants, with common metrics for characterizing proliferation, mig...
Source: Microcirculation - February 10, 2023 Category: Research Authors: Aileen C. Suarez,
Jennifer H. Hammel,
Jennifer M. Munson Tags: REVIEW Source Type: research
Sublingual microcirculation and internal environment changes as early indications of sepsis: a prospective observational study
ConclusionChanges in microcirculation disturbance and the internal environment occurred before sepsis. The MFI and PLT are independent risk factors for sepsis. Sublingual microcirculation and PLT deterioration can be used as early warning indicators before sepsis. (Source: Microcirculation)
Source: Microcirculation - January 31, 2023 Category: Research Authors: Yi Lu,
Jun Yang,
Peng Li,
Fei Teng,
Shubin Guo Tags: ORIGINAL ARTICLE Source Type: research
Isolation of lymph shows dysregulation of STAT3 and CREB pathways in the spleen and liver during leukemia development in a rat model
AbstractAcute myeloid leukemia (AML) is a heterogeneous malignant condition characterized by massive infiltration of poorly differentiated white blood cells in the blood stream, bone marrow and extramedullary sites. During leukemic development, hepatosplenomegaly is expected to occur because large blood volumes are continuously filtered through these organs. We asked whether infiltration of leukemic blasts initiated a response that could be detected in the interstitial fluid phase of the spleen and liver in a rat model known to mimic human AML in growth characteristics and behavior. By cannulating efferent lymphatic vessel...
Source: Microcirculation - January 27, 2023 Category: Research Authors: Eli Sihn Samdal Steinskog,
Kenneth Finne,
Marianne Enger,
Lars Helgeland,
Per Ole Iversen,
Emmet McCormack,
Helge Wiig,
Olav Tenstad Tags: ORIGINAL ARTICLE Source Type: research
Issue Information
(Source: Microcirculation)
Source: Microcirculation - January 24, 2023 Category: Research Tags: ISSUE INFORMATION Source Type: research
Statistical and Topological Summaries Aid Disease Detection for Segmented Retinal Vascular Images
AbstractDisease complications can alter vascular network morphology and disrupt tissue functioning. Diabetic retinopathy, for example, is a complication of types 1 and 2 diabetes mellitus that can cause blindness. Microvascular diseases are assessed by visual inspection of retinal images, but this can be challenging when diseases exhibit silent symptoms or patients cannot attend in-person meetings. We examine the performance of machine learning algorithms in detecting microvascular disease when trained on statistical and topological summaries of segmented retinal vascular images. We apply our methods to four datasets that ...
Source: Microcirculation - January 13, 2023 Category: Research Authors: John T. Nardini,
Charles W. J. Pugh,
Helen M. Byrne Tags: ORIGINAL ARTICLE Source Type: research
Anxiety is associated with coronary microvascular dysfunction: results from the CAMADA study
ConclusionAnxiety patients had lower coronary flow reserve, anxiety was independently associated with coronary flow reserve. Psychological disorders may play an important role on coronary microvascular dysfunction. (Source: Microcirculation)
Source: Microcirculation - January 12, 2023 Category: Research Authors: Ying Li,
Weixian Xu,
Lijun Guo Tags: ORIGINAL ARTICLE Source Type: research
Serine proteases mediate leukocyte recruitment and hepatic microvascular injury in the acute phase following extended hepatectomy
ConclusionsEndothelial activation and leukocyte recruitment in the liver in response to the increment of sinusoidal shear rate were hallmarks in the acute phase after liver resection. SPs mediated leukocyte recruitment and contributed to the impairment of sinusoidal perfusion in an ICAM-1-dependent manner in the acute phase after liver resection. (Source: Microcirculation)
Source: Microcirculation - December 29, 2022 Category: Research Authors: Yunjie Zhang,
Patrick Huber,
Marc Praetner,
Alice Z öllner,
Lesca Holdt,
Andrej Khandoga,
Maximilian Lerchenberger Tags: ORIGINAL ARTICLE Source Type: research
KIR channel regulation of electrical conduction along cerebrovascular endothelium: Enhanced modulation during Alzheimer's disease
ConclusionsBrain endothelial KIR channel activity modulates bidirectional spread of vasoreactive signals with enhanced regulation of EC coupling during AD pathology. (Source: Microcirculation)
Source: Microcirculation - December 29, 2022 Category: Research Authors: Md A. Hakim,
Erik J. Behringer Tags: ORIGINAL ARTICLE Source Type: research
Comparison of laser speckle contrast imaging with laser Doppler perfusion imaging for tissue perfusion measurement
This study aimed to model the relationship between laser speckle contrast imaging (LSCI) and laser Doppler perfusion imaging (LDPI), for measuring tissue perfusion over a wide range of blood flux values.MethodsFifteen healthy volunteers (53% female, median age 29 (IQR 22-40) years) were enrolled in this study. We performed iontophoresis with sodium nitroprusside on the forearm to induce regional vasodilation to increase skin blood flux. Besides, a stepwise vascular occlusion was applied on the contralateral upper arm to reduce blood flux. Both techniques were compared using a linear mixed model analysis.ResultsBaseline blo...
Source: Microcirculation - December 16, 2022 Category: Research Authors: Goksel Guven,
Annemieke Dijkstra,
T. Martijn Kuijper,
Nicole Trommel,
Margriet E. van Baar,
Arzu Topeli,
Can Ince,
Cornelis H. van der Vlies Tags: ORIGINAL ARTICLE Source Type: research
Impairment of endothelial progenitor cells in women after kidney transplantation
ConclusionsAlterations of EPC populations may contribute to the higher cardiovascular risks after organ transplantation and should be considered in therapeutic strategies. (Source: Microcirculation)
Source: Microcirculation - December 10, 2022 Category: Research Authors: Nadia Meyer,
Katja Richter,
Lars Brodowski,
Constantin von Kaisenberg,
Anette Melk,
Bernhard Schmidt,
Florian P. Limbourg,
Bianca Schr öder‐Heurich,
Frauke von Versen‐Höynck Tags: ORIGINAL ARTICLE Source Type: research
Engineered models of the lymphatic vascular system: Past, Present, and Future
AbstractThe lymphatic vascular system is crucial for optimizing body fluid level, regulating immune function, and transporting lipid. Relative to the experimental models to investigate blood vasculature, there are significantly fewer tools to explore lymphatics. Althoughin vivo studies have contributed to major discoveries in the field, finding and characterizing lymphatic specific markers has opened the door to isolating lymphatic vessels and cells for buildingex vivo andin vitro platforms. These preparations have enabled the study and analysis of lymphatic vasculature in various physiological and pathophysiological condi...
Source: Microcirculation - November 23, 2022 Category: Research Authors: Amirali Selahi,
Abhishek Jain Tags: REVIEW Source Type: research
Abstracts from the 47th Annual Meeting of Japanese Society for Microcirculation
(Source: Microcirculation)
Source: Microcirculation - November 20, 2022 Category: Research Tags: ABSTRACT Source Type: research
Issue Information
(Source: Microcirculation)
Source: Microcirculation - November 19, 2022 Category: Research Tags: ISSUE INFORMATION Source Type: research
