The systemic microcirculation in dialysis populations
AbstractIn a rapidly expanding population of patients with chronic kidney disease, including 2 million people requiring renal replacement therapy, cardiovascular mortality is 15 times greater than the general population. In addition to traditional cardiovascular risk factors, more poorly defined risks related to uremia and its treatments appear to contribute to this exaggerated risk. In thi s context, the microcirculation may play an important early role in cardiovascular disease associated with chronic kidney disease. Experimentally, the uremic environment and dialysis have been linked to multiple pathways causing micro...
Source: Microcirculation - March 21, 2020 Category: Research Authors: Jennifer Williams,
Mark Gilchrist,
David Strain,
Donald Fraser,
Angela Shore Tags: REVIEW Source Type: research
REAVER: A Program for Improved Analysis of High ‐resolution Vascular Network Images
We present REAVER (Rapid Editable Analysis of Vessel Elements Routine), an open‐source tool that researchers can use to analyze high‐resolution 2D fluorescent images of blood vessel networks, and assess its performance compared to alternative image analysis pr ograms. Using a dataset of manually analyzed images from a variety of murine tissues as a ground‐truth, REAVER exhibited the highest accuracy and precision for all vessel architecture metrics quantified, including vessel length density, vessel area fraction, mean vessel diameter, and branchpoint c ount, along with the highest pixel‐by‐pixel accuracy for the...
Source: Microcirculation - March 21, 2020 Category: Research Authors: Bruce A. Corliss,
Richard W. Doty,
Corbin Mathews,
Paul A. Yates,
Tingting Zhang,
Shayn M. Peirce Tags: ORIGINAL RESEARCH Source Type: research
Capillary microscopy in Europeans with idiopathic Moyamoya angiopathy
ConclusionsMMD is not associated with microvascular changes of the nailfold capillaries. In this respect, it is clearly distinct from SLE. (Source: Microcirculation)
Source: Microcirculation - March 21, 2020 Category: Research Authors: Oliver Sander,
Jan Claudius Schwitalla,
Marius Ringelstein,
Orhan Aktas,
Matthias Schneider,
Peter Berlit,
Hans ‐Peter Hartung,
Philipp Albrecht,
Markus Kraemer Tags: ORIGINAL ARTICLE Source Type: research
REAVER: A Program for Improved Analysis of High ‐resolution Vascular Network Images
We present REAVER (Rapid Editable Analysis of Vessel Elements Routine), an open‐source tool that researchers can use to analyze high‐resolution 2D fluorescent images of blood vessel networks, and assess its performance compared to alternative image analysis pr ograms. Using a dataset of manually analyzed images from a variety of murine tissues as a ground‐truth, REAVER exhibited the highest accuracy and precision for all vessel architecture metrics quantified, including vessel length density, vessel area fraction, mean vessel diameter, and branchpoint c ount, along with the highest pixel‐by‐pixel accuracy for the...
Source: Microcirculation - March 18, 2020 Category: Research Authors: Bruce A. Corliss,
Richard W. Doty,
Corbin Mathews,
Paul A. Yates,
Tingting Zhang,
Shayn M. Peirce Tags: ORIGINAL RESEARCH Source Type: research
Sublingual microcirculation in prehospital critical care medicine: A proof ‐of‐concept study
ConclusionThe prehospital sublingual measurement is safe and valid. Despite normal macrocirculation, microcirculation was impaired and correlated with National Advisory Committee on Aeronautics. (Source: Microcirculation)
Source: Microcirculation - March 5, 2020 Category: Research Authors: Raphael Romano Bruno,
Markus Reed,
Nana ‐Yaw Bimpong‐Buta,
Johanna M. Muessig,
Maryna Masyuk,
Stephan Binneboessel,
Marcus Franz,
Malte Kelm,
Christian Jung Tags: ORIGINAL ARTICLE Source Type: research
