FLI1 and ERG protein degradation is regulated via Cathepsin B lysosomal pathway in Human Dermal Microvascular Endothelial Cells

ConclusionsInhibition of cathepsin B was effective in reversing the reduction of FLI1 and ERG protein levels after treatment with IFN α or SSc sera, suggesting that targeting cathepsin B may have a beneficial effect in SSc vascular disease.

Source: Microcirculation - September 25, 2020 Category: Research Authors: Celestina Mazzotta, Grace Marden, Alessandra Farina, Andreea Bujor, Marcin A. Trojanowski, Maria Trojanowska Tags: ORIGINAL RESEARCH Source Type: research