Flow ‐dependent regulation of rat mesenteric lymphatic vessel contractile response requires activation of endothelial TRPV4 channels

ConclusionsOur findings demonstrate a critical role for TRPV4 in the decrease in contraction frequency induced in lymphatic vessels by increases in flow rate via the production and action of nitric oxide and dilatory prostanoids.

Source: Microcirculation - December 4, 2023 Category: Research Authors: Jacques DuToit, Peter Brothers, Matthew Stephens, Keith Keane, Flavia Neto de  Jesus, Simon Roizes, Pierre‐Yves von der Weid Tags: ORIGINAL ARTICLE Source Type: research