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A cluster of immunoresolvents links coagulation to innate host defense in human blood
Blood coagulation is a protective response that prevents excessive bleeding upon blood vessel injury. We investigated the relationship between coagulation and the resolution of inflammation and infection by lipid mediators (LMs) through metabololipidomics-based profiling of human whole blood (WB) during coagulation. We identified temporal clusters of endogenously produced prothrombotic and proinflammatory LMs (eicosanoids), as well as specialized proresolving mediators (SPMs). In addition to eicosanoids, a specific SPM cluster was identified that consisted of resolvin E1 (RvE1), RvD1, RvD5, lipoxin B4, and maresin 1, each ...
Source: Signal Transduction Knowledge Environment - August 1, 2017 Category: Science Authors: Norris, P. C., Libreros, S., Chiang, N., Serhan, C. N. Tags: STKE Research Resources Source Type: news

Glenmark gets USFDA nod for generic anti-inflammatory drug
The approval granted to Glenmark Pharmaceuticals Inc by the USFDA is for Indomethacin extended-release capsules of 75 mg strength, the company said in a statement. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - June 27, 2017 Category: Pharmaceuticals Source Type: news

Less Post-ERCP Pancreatitis With Lactated Ringer's Plus Rectal Indomethacin Less Post-ERCP Pancreatitis With Lactated Ringer's Plus Rectal Indomethacin
Infusion of lactated Ringer's solution along with rectal administration of indomethacin was associated with lower rates of post-ERCP pancreatitis (PEP) in a randomized, placebo-controlled trial.Reuters Health Information (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - December 1, 2016 Category: Surgery Tags: Gastroenterology News Source Type: news

I get by with help from my friends: Maintaining immune cells in head and neck cancer
(Medical University of South Carolina) In an article published Sept. 22, 2016 in Frontiers in Immunology, researchers at the Medical University of South Carolina and the Ralph H. Johnson VA Medical Center report that inhibiting prostaglandin production slows the progression of premalignant lesions to head and neck squamous cell carcinoma. Preclinical studies showed that treatment of premalignant lesions with indomethacin, a nonsteroidal anti-inflammatory drug similar to aspirin, increased the presence of immune cells and lessened tumor burden. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 30, 2016 Category: Global & Universal Source Type: news

Indocin IV (Indomethacin Inj) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - November 28, 2016 Category: Drugs & Pharmacology Source Type: news

Certain painkillers 'could increase risk of heart failure'
Arthritis patients who take common painkillers such as ibuprofen could be at a greater risk of heart failure, according to a new large-scale study.The research, led by the University of Milano-Bicocca in Italy and utilising data from more than eight million patients, has offered evidence that non-steroidal anti-inflammatory drugs (NSAIDs) may lead to an elevated risk of a person being hospitalised with heart problems, meaning caution may need to be employed when using them.The heart health risks of NSAIDsPublished in the British Medical Journal, the study aimed to investigate the cardiovascular safety of NSAIDs and to...
Source: Arthritis Research UK - September 29, 2016 Category: Rheumatology Source Type: news

Ibuprofen-like painkillers linked to an increased risk of heart failure
Conclusion This useful and well-conducted study isn't the first to say NSAIDs may raise the risk of heart failure. We've known for some time that NSAIDs can have side effects, especially when used at high doses and for long periods. What this study does help show is the different levels of risk between different NSAIDs, and confirms that the risk depends partly on the dose. It's important to remember that the study only included people who were prescribed NSAIDs and not people who'd bought them over the counter. The information is most useful to older people taking prescribed NSAIDs long-term for conditions&...
Source: NHS News Feed - September 29, 2016 Category: Consumer Health News Tags: Medication Heart/lungs Source Type: news

Rectal Indomethacin Does Not Prevent Post-ERCP Pancreatitis Rectal Indomethacin Does Not Prevent Post-ERCP Pancreatitis
New research finds that prophylactic rectal indomethacin does not reduce incidence of post-ERCP pancreatitis. Should published guidelines be reconsidered? Gastroenterology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 27, 2016 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Indocin Oral Suspension (Indomethacin Oral Suspension) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - July 13, 2016 Category: Drugs & Pharmacology Source Type: news

Indocin (Indomethacin) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - July 11, 2016 Category: Drugs & Pharmacology Source Type: news

Indocin SR (Indomethacin Extended Release Capsules) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - June 24, 2016 Category: Drugs & Pharmacology Source Type: news

Indomethacin May Curb Pancreatitis After ERCPIndomethacin May Curb Pancreatitis After ERCP
Rectal indomethacin may cut the risk of pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP) in a wide range of patients, suggests a new study. Reuters Health Information (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - June 7, 2016 Category: Surgery Tags: Gastroenterology News Source Type: news

Tivorbex (Indomethacin Capsules) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - May 23, 2016 Category: Drugs & Pharmacology Source Type: news

Rectal indomethacin does not prevent pancreatitis post ERCP
Patients who receive rectal indomethacin after undergoing endoscopic retrograde cholangiopancreatography (ERCP) are not any less likely to develop pancreatitis than individuals who don’t, according... (Source: Family Practice News)
Source: Family Practice News - April 1, 2016 Category: Primary Care Source Type: news

Prednisolone, Indomethacin Similarly Effective for Acute Gout
Oral prednisolone is as effective as indomethacin for relieving pain in acute gout and should be considered a first-line treatment option, according to a report published online in Annals of Internal Medicine. (Source: Caring for the Ages)
Source: Caring for the Ages - March 30, 2016 Category: Health Management Authors: Mary Ann Moon Source Type: news

Oral Steroids, NSAIDs Equally Safe, Effective for Acute GoutOral Steroids, NSAIDs Equally Safe, Effective for Acute Gout
A large, multicenter randomized trial found that oral prednisolone and oral indomethacin were equally effective at reducing acute gout pain in patients presenting to emergency departments. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 23, 2016 Category: Consumer Health News Tags: Rheumatology News Source Type: news

Steroid May Be Safe, Effective Gout Treatment, Study Finds
MONDAY, Feb. 22, 2016 -- A steroid pill may be as good as a nonsteroidal anti-inflammatory drug (NSAID) for treating painful gout, new research suggests. Researchers who compared the steroid prednisolone with the arthritis medication indomethacin... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - February 23, 2016 Category: Journals (General) Source Type: news

Gout: Sleep apnea may raise your risk
Gout is the most common type of inflammatory arthritis and affects more than 8 million adults. Men are at a higher risk than women. And according to a new study, your risk for gout also climbs if you suffer from sleep apnea, a condition where your breathing repeatedly pauses while you sleep. What exactly is gout? Gout is triggered by the crystallization of uric acid within the joints. It happens like this: Your body produces uric acid from breaking down purines, a natural waste product of living cells. Normally, uric acid is dissolved in your blood and passes through your kidneys into your urine. However, sometimes your bo...
Source: New Harvard Health Information - November 17, 2015 Category: Consumer Health News Authors: Matthew Solan Tags: Arthritis Health Sleep gout sleep apnea Source Type: news

Jubilant Life gets USFDA nod for Indomethacin capsules
Drug firm Jubilant Life Sciences has received approval from the US health regulator to market Indomethacin capsule used for treating pains. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - October 7, 2015 Category: Pharmaceuticals Source Type: news

Teva Pharmaceutical recalls 38,858 bottles of drugs made by Emcure Pharmaceuticals in US market
The company is also recalling 7,694 bottles of anti- inflammatory drug indomethacin 25 mg, produced by Emcure Pharma, for non-adherence to CGMP. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - May 22, 2014 Category: Pharmaceuticals Source Type: news

Tivorbex (indomethacin) for the Treatment of Acute Pain
Tivorbex (indomethacin) is a nonsteroidal anti-inflammatory drug (NSAID) indicated for the treatment of mild to moderate acute pain in adults. (Source: Drug Development Technology)
Source: Drug Development Technology - March 28, 2014 Category: Pharmaceuticals Source Type: news

CNS effects of indomethacin: should patients be cautioned about decreased mental alertness and motor coordination? - Hegeman J, van den Bemt B, Weerdesteyn V, Nienhuis B, van Limbeek J, Duysens J.
AIMS: In many European countries as well as in the USA, the leaflet, or even the packaging of indomethacin, contains a specific warning to refrain from activities requiring mental alertness and motor coordination, such as driving a car. In this placebo-con... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - March 5, 2014 Category: Global & Universal Tags: Alcohol and Other Drugs Source Type: news

Tivorbex (Indomethacin Capsules) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - March 5, 2014 Category: Drugs & Pharmacology Source Type: news

Iroko's lower dose pain drug Tivorbex obtains FDA approval
US-based Iroko Pharmaceuticals has received approval from the US Food and Drug Administration (FDA) to use Tivorbex (indomethacin) capsules, a nonsteroidal anti-inflammatory drug (NSAID), at 20mg and 40mg doses to treat mild to moderate acute pain in… (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - February 26, 2014 Category: Pharmaceuticals Source Type: news

FDA Approves Another Lower-Dose NSAIDFDA Approves Another Lower-Dose NSAID
The new product, indomethacin 20 mg and 40 mg, is the company's second lower-dose NSAID to get FDA approval in about 4 months FDA Approvals (Source: Medscape Neurology and Neurosurgery Headlines)
Source: Medscape Neurology and Neurosurgery Headlines - February 25, 2014 Category: Neurology Tags: Neurology & Neurosurgery News Alert Source Type: news

Pro ArthMax by Human Science Foundation: Recall - Undeclared Drug Ingredients
Undeclared Chlorzoxazone, Nefopam, Diclofenac, Ibuprofen, Naproxen, and Indomethacin. Pro ArthMax has a reasonable probability of resulting in fatal adverse events. (Source: FDA MedWatch)
Source: FDA MedWatch - January 14, 2014 Category: American Health Source Type: news

indomethacin, Indocin, Indocin-SR (Discontinued Brand in U.S.)
Title: indomethacin, Indocin, Indocin-SR (Discontinued Brand in U.S.)Category: MedicationsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 12/5/2013 12:00:00 AM (Source: MedicineNet Medications General)
Source: MedicineNet Medications General - December 5, 2013 Category: Drugs & Pharmacology Source Type: news

indomethacin, Indocin, Indocin-SR (Discontinued Brand in U.S.)
Title: indomethacin, Indocin, Indocin-SR (Discontinued Brand in U.S.)Category: MedicationsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 12/5/2013 12:00:00 AM (Source: MedicineNet Migraine General)
Source: MedicineNet Migraine General - December 5, 2013 Category: Neurology Source Type: news

Rectal Indomethacin and Pancreatic Stents in High-Risk ERCPRectal Indomethacin and Pancreatic Stents in High-Risk ERCP
Do patients undergoing high-risk ERCP benefit from rectal indomethacin, or are prophylactic pancreatic stents still considered necessary? The American Journal of Gastroenterology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 23, 2013 Category: Consumer Health News Tags: Gastroenterology Journal Article Source Type: news

Submicron NSAIDs Demonstrate Efficacy At Lower Doses In Studies In Patients With Acute And Chronic Pain
Iroko Pharmaceuticals, LLC, a Philadelphia-based pharmaceutical company focused on the development and commercialization of innovative therapeutic products, is presenting positive Phase 3 data from its investigational submicron non-steroidal anti-inflammatory drug (NSAID) pipeline at two medical meetings. These presentations summarize the results of studies of lower dose submicron indomethacin in patients with post surgical pain, and lower dose submicron diclofenac in patients with osteoarthritis pain... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - April 15, 2013 Category: Consumer Health News Tags: Pain / Anesthetics Source Type: news

Iroko reports positive results from Phase III submicron indomethacin and diclofenac studies
Iroko Pharmaceuticals has reported positive results from its Phase III studies of lower dose submicron indomethacin in patients with post-surgical pain, and lower dose submicron diclofenac in patients with osteoarthritis pain. (Source: Drug Development Technology)
Source: Drug Development Technology - April 11, 2013 Category: Pharmaceuticals Source Type: news