Polyuria, Polydipsia and Possible Diabetes Insipidus?
Discussion The body is smart. It has mechanisms for maintaining balances within the body in a closely controlled manner but allows for a variety of states. This is very true for fluid balance in the body which is highly controlled between almost all of the major body organ systems. When fluid is low, the sensor sends signals for us to drink, and conserves fluid until we can. When the fluid is high, the kidneys excrete the excess and sends signals not to drink. Usually it works very well. While there are many pathological states that can cause polyuria and/or polydipsia, the most common reason is excessive fluid intake beca...
Source: PediatricEducation.org - March 7, 2022 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Rectal Diclofenac Likely Comparable to Rectal Indomethacin for Post-ERCP Pancreatitis Rectal Diclofenac Likely Comparable to Rectal Indomethacin for Post-ERCP Pancreatitis
An exploratory network analysis of post-retrograde cholangiopancreatography (ERCP) prophylaxis suggests that rectal diclofenac can be used interchangeably with rectal indomethacin to reduce costs, researchers say.Reuters Health Information (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - July 19, 2021 Category: Gastroenterology Tags: Gastroenterology News Source Type: news

Indomethacin-responsive Headaches--A Narrative Review Indomethacin-responsive Headaches--A Narrative Review
The NSAID indomethacin is effective for a very specific subset of headache disorders. This review explores its pharmacokinetics, pharmacodynamics, and proposed mechanisms of action in these disorders.Headache (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - June 28, 2021 Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news

indomethacin, Indocin, Indocin-SR (Discontinued Brand in U.S.)
Title: indomethacin, Indocin, Indocin-SR (Discontinued Brand in U.S.)Category: MedicationsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 6/26/2019 12:00:00 AM (Source: MedicineNet Migraine General)
Source: MedicineNet Migraine General - June 26, 2019 Category: Neurology Source Type: news

Over-the-counter painkillers like aspirin and ibuprofen may make C.difficile more aggressive  
A study by Vanderbilt University found just 20 per cent of mice treated with the non-steroidal anti-inflammatory drug indomethacin before being exposed to C.difficile survived the infection. (Source: the Mail online | Health)
Source: the Mail online | Health - January 8, 2019 Category: Consumer Health News Source Type: news

Indomethacin Capsules (New - Discontinuation)
Drug Shortage (Source: FDA Drug Shortages)
Source: FDA Drug Shortages - May 8, 2018 Category: Drugs & Pharmacology Source Type: news

Glenmark recalls over 1 lakh bottles of anti-inflammatory drug in US
Glenmark Pharmaceuticals Inc USA is recalling 109,080 bottles of Indomethacin capsules USP, 50 mg, 100-count bottle, manufactured by Glenmark Pharmaceuticals at its Goa plant, USFDA said. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - April 5, 2018 Category: Pharmaceuticals Source Type: news

Hope for Kevin ’s heart: Five-year-old shines after novel treatment for Ebstein’s anomaly
As the lights dimmed and Pharrell Williams’ “Happy” blasted from loudspeakers, Kevin Nolan III took to the stage for his very first dance recital. Sporting striped pants, a turquoise bow tie and a black top hat, Kevin joined his class in performing two hip-hop jazz routines to a packed house. Kevin’s mood was perfectly in step with the song’s lyrics. “He had so much fun,” says Kevin’s mom, Laura. “He said he can’t wait to get on stage again.” While a first dance recital is a big deal for any 5-year-old, it’s especially poignant for Kevin, who was diagnosed prenatally with Ebstein’s anomaly, a rare...
Source: Thrive, Children's Hospital Boston - September 6, 2017 Category: Pediatrics Authors: Ellen Greenlaw Tags: Diseases & Conditions Our Patients’ Stories Dr. Pedro del Nido Dr. Wayne Tworetsky Ebstein's anomaly Fetal Cardiology Program Source Type: news

A cluster of immunoresolvents links coagulation to innate host defense in human blood
Blood coagulation is a protective response that prevents excessive bleeding upon blood vessel injury. We investigated the relationship between coagulation and the resolution of inflammation and infection by lipid mediators (LMs) through metabololipidomics-based profiling of human whole blood (WB) during coagulation. We identified temporal clusters of endogenously produced prothrombotic and proinflammatory LMs (eicosanoids), as well as specialized proresolving mediators (SPMs). In addition to eicosanoids, a specific SPM cluster was identified that consisted of resolvin E1 (RvE1), RvD1, RvD5, lipoxin B4, and maresin 1, each ...
Source: Signal Transduction Knowledge Environment - August 1, 2017 Category: Science Authors: Norris, P. C., Libreros, S., Chiang, N., Serhan, C. N. Tags: STKE Research Resources Source Type: news

Glenmark gets USFDA nod for generic anti-inflammatory drug
The approval granted to Glenmark Pharmaceuticals Inc by the USFDA is for Indomethacin extended-release capsules of 75 mg strength, the company said in a statement. (Source: The Economic Times Healthcare and Biotech News)
Source: The Economic Times Healthcare and Biotech News - June 27, 2017 Category: Pharmaceuticals Source Type: news

Less Post-ERCP Pancreatitis With Lactated Ringer's Plus Rectal Indomethacin Less Post-ERCP Pancreatitis With Lactated Ringer's Plus Rectal Indomethacin
Infusion of lactated Ringer ' s solution along with rectal administration of indomethacin was associated with lower rates of post-ERCP pancreatitis (PEP) in a randomized, placebo-controlled trial.Reuters Health Information (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - December 1, 2016 Category: Surgery Tags: Gastroenterology News Source Type: news

I get by with help from my friends: Maintaining immune cells in head and neck cancer
(Medical University of South Carolina) In an article published Sept. 22, 2016 in Frontiers in Immunology, researchers at the Medical University of South Carolina and the Ralph H. Johnson VA Medical Center report that inhibiting prostaglandin production slows the progression of premalignant lesions to head and neck squamous cell carcinoma. Preclinical studies showed that treatment of premalignant lesions with indomethacin, a nonsteroidal anti-inflammatory drug similar to aspirin, increased the presence of immune cells and lessened tumor burden. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 30, 2016 Category: Global & Universal Source Type: news

Indocin IV (Indomethacin Inj) - updated on RxList
(Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - November 28, 2016 Category: Drugs & Pharmacology Source Type: news

Certain painkillers 'could increase risk of heart failure'
Arthritis patients who take common painkillers such as ibuprofen could be at a greater risk of heart failure, according to a new large-scale study.The research, led by the University of Milano-Bicocca in Italy and utilising data from more than eight million patients, has offered evidence that non-steroidal anti-inflammatory drugs (NSAIDs) may lead to an elevated risk of a person being hospitalised with heart problems, meaning caution may need to be employed when using them.The heart health risks of NSAIDsPublished in the British Medical Journal, the study aimed to investigate the cardiovascular safety of NSAIDs and to...
Source: Arthritis Research UK - September 29, 2016 Category: Rheumatology Source Type: news

Ibuprofen-like painkillers linked to an increased risk of heart failure
Conclusion This useful and well-conducted study isn't the first to say NSAIDs may raise the risk of heart failure. We've known for some time that NSAIDs can have side effects, especially when used at high doses and for long periods. What this study does help show is the different levels of risk between different NSAIDs, and confirms that the risk depends partly on the dose. It's important to remember that the study only included people who were prescribed NSAIDs and not people who'd bought them over the counter. The information is most useful to older people taking prescribed NSAIDs long-term for conditions such as go...
Source: NHS News Feed - September 29, 2016 Category: Consumer Health News Tags: Medication Heart/lungs Source Type: news