Covering the Cover
Targeted next-generation sequencing on clinical isolates and formalin-fixed, paraffin-embedded biopsies can be used to determine antimicrobial susceptibility for Helicobacter pylori infections. (Source: Gastroenterology)
Source: Gastroenterology - October 22, 2021 Category: Gastroenterology Tags: Covering the Cover Source Type: research

Cover 1
(Source: Gastroenterology)
Source: Gastroenterology - October 22, 2021 Category: Gastroenterology Source Type: research

Editorial Board
(Source: Gastroenterology)
Source: Gastroenterology - October 22, 2021 Category: Gastroenterology Source Type: research

Table of Contents
(Source: Gastroenterology)
Source: Gastroenterology - October 22, 2021 Category: Gastroenterology Source Type: research

Elsewhere in The AGA Journals
(Source: Gastroenterology)
Source: Gastroenterology - October 22, 2021 Category: Gastroenterology Source Type: research

Information for Authors and Readers
Gastroenterology is the premiere journal in the  field of gastrointestinal disease and is led by an internationally renowned board of editors. As the official journal of the AGA Institute, Gastroenterology delivers up-to-date and authoritative coverage of both basic and clinical gastroenterology and hepatology. Regular features include research and perspectives by leading authorities, reports on the latest technologies for diagnosing and treating digestive diseases, images illustrating important clinical findings, reviews of scholarly media, medical news, meeting summaries, video abstracts, and mon...
Source: Gastroenterology - October 22, 2021 Category: Gastroenterology Source Type: research

Clinical Decision Support Tool: Management of Coagulation Disorders in Patients With Cirrhosis
(Source: Gastroenterology)
Source: Gastroenterology - October 22, 2021 Category: Gastroenterology Tags: Clinical Practice Guideline Source Type: research

Spotlight: Management of Coagulation Disorders in Patients With Cirrhosis
(Source: Gastroenterology)
Source: Gastroenterology - October 22, 2021 Category: Gastroenterology Authors: Perica Davitkov, Cynthia W. Ko, Shahnaz Sultan Tags: Clinical Practice Guidelines Source Type: research

Single-cell transcriptomics reveals a conserved metaplasia program in pancreatic injury
Acinar to ductal metaplasia (ADM) occurs in the pancreas in response to tissue injury and is a potential precursor for adenocarcinoma. The goal of these studies was to define the populations arising from ADM, the associated transcriptional changes, and markers of disease progression. (Source: Gastroenterology)
Source: Gastroenterology - October 22, 2021 Category: Gastroenterology Authors: Zhibo Ma, Nikki K. Lytle, Bob Chen, Nidhi Jyotsana, Sammy Weiser Novak, Charles J. Cho, Leah Caplan, Olivia Ben-Levy, Abigail C. Neininger, Dylan T. Burnette, Vincent Q. Trinh, Marcus C.B. Tan, Emilee A. Patterson, Rafael Arrojo e Drigo, Rajshekhar R. Gir Source Type: research

AGA Clinical Practice Update on Surveillance After Pathologically Curative Endoscopic Submucosal Dissection of Early Gastrointestinal Neoplasia in the United States: Commentary
The purpose of this American Gastroenterological Association (AGA) Institute Clinical Practice Update was to review the available evidence and provide expert advice regarding surveillance using endoscopy and other relevant modalities after removal of dysplastic lesions and early gastrointestinal cancers with endoscopic submucosal dissection deemed to be pathologically curative. This Clinical Practice Update was commissioned and approved by the AGA Institute Clinical Practice Updates Committee and the AGA Governing Board to provide timely guidance on a topic of high clinical importance to the AGA membership, and underwent i...
Source: Gastroenterology - October 21, 2021 Category: Gastroenterology Authors: Andrew Y. Wang, Joo Ha Hwang, Amit Bhatt, Peter V. Draganov Tags: Clinical Practice Update-Commentary Source Type: research

A Rare Complication of Barium Swallow Test
(Source: Gastroenterology)
Source: Gastroenterology - October 21, 2021 Category: Gastroenterology Authors: Kosei Takagi, Noriyuki Kanehira, Kazuyuki Matsumoto Source Type: research

An uncommon cause of hematemesis in a patient with end-stage renal disease
(Source: Gastroenterology)
Source: Gastroenterology - October 21, 2021 Category: Gastroenterology Authors: Sean Kien-Fatt Lee, Julian Chi-Leung Wong, Jun Jie Ng Source Type: research

Dysphagia in MEN
(Source: Gastroenterology)
Source: Gastroenterology - October 21, 2021 Category: Gastroenterology Authors: Grace E. Kim, Lindsay Alpert, Uzma D. Siddiqui Source Type: research

Esophageal stricture: Not your usual culprit?
(Source: Gastroenterology)
Source: Gastroenterology - October 21, 2021 Category: Gastroenterology Authors: Zunirah Ahmed, Mary R. Schwartz, Eamonn MM. Quigley Source Type: research

Minority ibs patients receive more gi-related procedures than white counterparts: nuances in disparities research
(Source: Gastroenterology)
Source: Gastroenterology - October 21, 2021 Category: Gastroenterology Authors: Amisha Ahuja Source Type: research

Specialized mechanosensory epithelial cells in mouse gut intrinsic tactile sensitivity
The gastrointestinal (GI) tract extracts nutrients from ingested meals while protecting the organism from infectious agents frequently present in meals. Consequently, most animals conduct the entire digestive process within the GI tract while keeping the luminal contents entirely outside the body, separated by the tightly sealed GI epithelium. Therefore, like skin and oral cavity, the GI tract must sense luminal contents ’ chemical and physical properties to optimize digestion. Specialized sensory enteroendocrine cells (EECs) in GI epithelium intimately interact with luminal contents. (Source: Gastroenterology)
Source: Gastroenterology - October 21, 2021 Category: Gastroenterology Authors: Anthony J. Treichel, Isabelle Finholm, Kaitlyn R. Knutson, Constanza Alcaino, Sara T. Whiteman, Matthew R. Brown, Aleksey Matveyenko, Andrew Wegner, Halil Kacmaz, Arnaldo Mercado-Perez, Gabriella Bedekovicsne Gajdos, Tamas Ordog, Madhusudan Grover, Joseph Source Type: research

Mirror mirror on the wall, who is the fittest of them all: a novel prediction model for postoperative hepatic decompensation in patients with cirrhosis
Patients with cirrhosis carry an increased risk for mortality and morbidity after surgery (Ann Surg 2021;274:e345-54). Assessing the surgical risks for these patients has been a challenging issue for providers, given the complicated pathophysiology and lack of large prospective trials. Several models have been used to estimate post-surgical mortality for patients with cirrhosis, including the Model End-stage Liver Disease (MELD), Mayo Risk Score (MRS), and Child Turcotte Pugh (CTP) score. Recently, Mahmud et al. (Source: Gastroenterology)
Source: Gastroenterology - October 21, 2021 Category: Gastroenterology Authors: Tzu-Hao Lee, Jatin Roper, Lindsay King Source Type: research

Endoscopic surveillance in IBD: The VIRTUE is in high definition.
(Source: Gastroenterology)
Source: Gastroenterology - October 21, 2021 Category: Gastroenterology Authors: Tommaso Lorenzo Parigi, Laurent Peyrin-Biroulet, Silvio Danese Source Type: research

HLA Class I analysis provides insight into the genetic and epigenetic background of immune evasion in colorectal cancer with high microsatellite instability.
A detailed understanding of antitumor immunity is essential for optimal cancer immune therapy. Although defective mutations in the B2M and HLA-ABC genes, which encode molecules essential for antigen presentation, have been reported in several studies, the effects of these defects on tumor immunity have not been quantitatively evaluated. (Source: Gastroenterology)
Source: Gastroenterology - October 20, 2021 Category: Gastroenterology Authors: Masahito Kawazu, Toshihide Ueno, Koichi Saeki, Nicolas Sax, Yosuke Togashi, Takayuki Kaneseki, Keigo Chida, Fumishi Kishigami, Kazuhito Sato, Shinya Kojima, Masafumi Otsuka, Akihito Kawazoe, Hitomi Nishinakamura, Yuka Maeda, Yoko Yamamoto, Kazuo Yamashita Source Type: research

Comparing colorectal cancer screening outcomes in the International Cancer Screening Network (ICSN): A Consortium proposal
(Source: Gastroenterology)
Source: Gastroenterology - October 20, 2021 Category: Gastroenterology Authors: N. Segnan, E. Dekker, V.P. Doria-Rose, C. Senore, L. Rabeneck, I. Lansdorp-Vogelaar, ICSN Colorectal Cancer Screening Working Group, Additional corporate authors Source Type: research

Prolonged impairment of short-chain fatty acid and L-isoleucine biosynthesis in gut microbiome in patients with COVID-19
SARS-CoV-2 infection is associated with altered gut microbiota composition. Phylogenetic groups of gut bacteria involved in the metabolism of short chain fatty acids were depleted in SARS-CoV-2-infected patients. We aimed to characterize functional profile of gut microbiome in patients with COVID-19 before and after disease resolution. (Source: Gastroenterology)
Source: Gastroenterology - October 20, 2021 Category: Gastroenterology Authors: Fen Zhang, Yating Wan, Tao Zuo, Yun Kit Yeoh, Qin Liu, Lin Zhang, Hui Zhan, Wenqi Lu, Wenye Xu, Grace C.Y. Lui, Amy Y.L. Li, Chun Pan Cheung, Chun Kwok Wong, Paul K.S. Chan, Francis K.L. Chan, Siew C. Ng Source Type: research

Loss of Endothelial TSPAN12 Promotes Fibrostenotic Eosinophilic Esophagitis via Endothelial Cell –Fibroblast Crosstalk
Eosinophilic esophagitis (EoE) can progress to fibrostenosis by unclear mechanisms. Herein, we investigated gene dysregulation in fibrostenotic EoE, its association with clinical parameters and specific pathways, and the functional consequences. (Source: Gastroenterology)
Source: Gastroenterology - October 20, 2021 Category: Gastroenterology Authors: Tetsuo Shoda, Ting Wen, Julie M. Caldwell, Netali Ben-Baruch Morgenstern, Garrett A. Osswald, Mark Rochman, Lydia E. Mack, Jennifer M. Felton, J. Pablo Abonia, Nicoleta C. Arva, Dan Atkins, Peter A. Bonis, Kelley E. Capocelli, Margaret H. Collins, Evan S. Source Type: research

Connecting the dots: Dietary fat, microbiota dysbiosis, altered metabolome and colon cancer
(Source: Gastroenterology)
Source: Gastroenterology - October 20, 2021 Category: Gastroenterology Authors: Emilie Viennois, Andrew T. Gewirtz, Benoit Chassaing Source Type: research

Burden and Cost of Gastrointestinal, Liver, and Pancreatic Diseases in the United States: Update 2021
Gastrointestinal diseases account for considerable health care use and expenditures. We estimated the annual burden, costs, and research funding associated with gastrointestinal, liver, and pancreatic diseases in the United States. (Source: Gastroenterology)
Source: Gastroenterology - October 19, 2021 Category: Gastroenterology Authors: Anne F. Peery, Seth D. Crockett, Caitlin C. Murphy, Elizabeth T. Jensen, Hannah P. Kim, Matthew D. Egberg, Jennifer L. Lund, Andrew M. Moon, Virginia Pate, Edward L. Barnes, Courtney L. Schlusser, Todd H. Baron, Nicholas J. Shaheen, Robert S. Sandler Source Type: research

Clinical Management of Pancreatic Premalignant Lesions
(Source: Gastroenterology)
Source: Gastroenterology - October 18, 2021 Category: Gastroenterology Authors: Kjetil S øreide, Giovanni Marchegiani Source Type: research

Timeline of development of pancreatic cancer and implications for successful early detection in high-risk individuals
To successfully implement imaging-based pancreatic cancer (PC) surveillance, it is key to understand the timeline and morphological features of neoplastic progression. We aimed to investigate the progression to neoplasia from serial prediagnostic pancreatic imaging tests in high-risk individuals, and identify factors associated with successful early detection. (Source: Gastroenterology)
Source: Gastroenterology - October 18, 2021 Category: Gastroenterology Authors: Kasper A. Overbeek, Michael G. Goggins, Mohamad Dbouk, Iris J.M. Levink, Brechtje D.M. Koopmann, Miguel Chuidian, Ingrid C.A.W. Konings, Salvatore Paiella, Julie Earl, Paul Fockens, Thomas M. Gress, Margreet G.E.M. Ausems, Jan-Werner Poley, Nirav C. Thosa Source Type: research

MicroRNA-15a/16-1 Prevents Hepatocellular Carcinoma by Disrupting the Communication between Kupffer Cells and Tregs
This study was designed to investigate how microRNAs regulate immunosuppression in HCC. (Source: Gastroenterology)
Source: Gastroenterology - October 18, 2021 Category: Gastroenterology Authors: Ningning Liu, Ching Wen Chang, Clifford J. Steer, Xin Wei Wang, Guisheng Song Source Type: research

STRAP: a Bridge between Mutant APC and Wnt/ ß-Catenin Signaling in Intestinal Cancer
(Source: Gastroenterology)
Source: Gastroenterology - October 18, 2021 Category: Gastroenterology Authors: Lopa Mishra Source Type: research

New role for fatty acid receptor regulation of immune cells to control intestinal inflammation
(Source: Gastroenterology)
Source: Gastroenterology - October 18, 2021 Category: Gastroenterology Authors: Michael J. Rosen Source Type: research

AGA Institute and CAP Quality Measure Development for Detection of MMR Deficiency and Lynch Syndrome Management
(Source: Gastroenterology)
Source: Gastroenterology - October 15, 2021 Category: Gastroenterology Authors: David A. Leiman, Diana M. Cardona, Sonia S. Kupfer, Jonathan Rosenberg, Gregary T. Bocsi, Heather Hampel, American Gastroenterological Association Quality Committee and the College of American Pathologists Quality Payment Measure Committee Source Type: research

Acinar cell enriched –microRNA-802 connects the dots between Kras signaling, acinar ductal metaplasia and pancreatic cancer
(Source: Gastroenterology)
Source: Gastroenterology - October 15, 2021 Category: Gastroenterology Authors: Thomas D. Schmittgen, Lorenzo F. Sempere Source Type: research

Reply to Li J et al and Sun L et al.
(Source: Gastroenterology)
Source: Gastroenterology - October 14, 2021 Category: Gastroenterology Authors: Stefano Francesco Crin ò, Gianenrico Rizzatti, Alberto Larghi Source Type: research

Correction
Gebert J, Gelincik O, Oezcan-Wahlbrink M, et  al. Recurrent Frameshift Neoantigen Vaccine Elicits Protective Immunity With Reduced Tumor Burden and Improved Overall Survival in a Lynch Syndrome Mouse Model. Gastroenterology 2021;161:1288–1302. (Source: Gastroenterology)
Source: Gastroenterology - October 14, 2021 Category: Gastroenterology Tags: Correction Source Type: research

Post-endoscopy esophageal neoplasia in barrett ’s esophagus: consensus statements from an international expert panel
(Source: Gastroenterology)
Source: Gastroenterology - October 13, 2021 Category: Gastroenterology Authors: Sachin Wani, Rena Yadlapati, Siddharth Singh, Tarek Sawas, David A. Katzka, Post-Endoscopy Esophageal Neoplasia Expert Consensus Panel Source Type: research

Pathology Reporting of Esophagus Endoscopic Resections: Recommendations from the International Collaboration on Cancer Reporting
(Source: Gastroenterology)
Source: Gastroenterology - October 13, 2021 Category: Gastroenterology Authors: Alfred K. Lam, Iris D. Nagtegaal, Dataset Authoring Committee for the development of the ICCR Dataset for Endoscopic Resection of the Esophagus and Esophagogastric Junction Source Type: research

An antigenically diverse, representative panel of envelope glycoproteins for HCV vaccine development
Development of a prophylactic hepatitis C virus (HCV) vaccine will require accurate and reproducible measurement of neutralizing breadth of vaccine-induced antibodies. Currently available HCV panels may not adequately represent the genetic and antigenic diversity of circulating HCV strains, and the lack of standardization of these panels makes it difficult to compare neutralization results obtained in different studies. Here, we describe the selection and validation of a genetically and antigenically diverse reference panel of 15 HCV pseudoparticles (HCVpp) for neutralization assays. (Source: Gastroenterology)
Source: Gastroenterology - October 13, 2021 Category: Gastroenterology Authors: Jordan H. Salas, Richard A. Urbanowicz, Johnathan D. Guest, Nicole Frumento, Alexis Figueroa, Kaitlyn E. Clark, Zhenyong Keck, Vanessa M. Cowton, Sarah J. Cole, Arvind H. Patel, Thomas R. Fuerst, Heidi E. Drummer, Marian Major, Alexander W. Tarr, Jonathan Source Type: research

Changes in metabolic syndrome status are associated with altered risk of pancreatic cancer: A nationwide cohort study
Metabolic syndrome (MetS) is reversible; however, the effect of changes in MetS status on pancreatic cancer risk is unknown. We aimed to investigate the effects of changes and persistence in MetS status on pancreatic cancer risk. (Source: Gastroenterology)
Source: Gastroenterology - October 12, 2021 Category: Gastroenterology Authors: Joo-Hyun Park, Kyungdo Han, Jung Yong Hong, Young Suk Park, Kyu Yeon Hur, Gunseog Kang, Joon Oh Park Source Type: research

The Stanford Colonoscopy Quality Assurance Program: Lessons from the intersection of quality improvement and clinical research
(Source: Gastroenterology)
Source: Gastroenterology - October 12, 2021 Category: Gastroenterology Authors: Uri Ladabaum Source Type: research

A microsatellite in the coding sequence of HLA-A/B is a mutation hotspot in colon cancer with microsatellite instability.
(Source: Gastroenterology)
Source: Gastroenterology - October 12, 2021 Category: Gastroenterology Authors: William J. Raab, Arabella Mazzocchi, Paolo Radice, Debashis Sahoo, Chiara Castelli, Piero Dalerba, Collaborators from the Colon Cancer Immunology and Immunotherapy (CCII) study group, Mahdi Behroozikhah, Claudia Lombardo, Luisa Novellino, Ingrid Cifola, C Source Type: research

CME Exam 1: The Tight Junction Protein ZO-1 Is Dispensable for Barrier Function But Critical for Effective Mucosal Repair
(Source: Gastroenterology)
Source: Gastroenterology - October 7, 2021 Category: Gastroenterology Tags: Continuing Medical Education (CME)/MOC Activities Source Type: research

Host-microbiota interactions in the esophagus during homeostasis and allergic inflammation
Microbiota composition and mechanisms of host-microbiota interactions in the esophagus are unclear. Herein, we aimed to uncover fundamental information about the esophageal microbiome and its potential significance to eosinophilic esophagitis (EoE). (Source: Gastroenterology)
Source: Gastroenterology - October 7, 2021 Category: Gastroenterology Authors: Michael Brusilovsky, Riyue Bao, Mark Rochman, Andrea M. Kemter, Cathryn R. Nagler, Marc E. Rothenberg Source Type: research

Incidence and mortality in upper gastrointestinal cancer after negative endoscopy for gastroesophageal reflux disease
This study aimed to assess whether and to what extent a negative upper endoscopy in patients with GERD is associated with a decreased incidence and mortality in upper gastrointestinal cancer (esophageal, gastric, or duodenal cancer). (Source: Gastroenterology)
Source: Gastroenterology - October 7, 2021 Category: Gastroenterology Authors: Dag Holmberg, Giola Santoni, My Catarina von Euler-Chelpin, Martti F ärkkilä, Joonas H. Kauppila, John Maret-Ouda, Eivind Ness-Jensen, Jesper Lagergren Source Type: research

Activating Immune Recognition in Pancreatic Ductal Adenocarcinoma via Autophagy Inhibition, MEK blockade and CD40 Agonism
We examined the functional effects of combined MEK and autophagy inhibition on the PDA immune microenvironment and the efficacy of synergizing the combined inhibition of MEK and autophagy with CD40 agonism against PDA using immunocompetent model systems. (Source: Gastroenterology)
Source: Gastroenterology - October 7, 2021 Category: Gastroenterology Authors: Honglin Jiang, Tristan Courau, Joseph Borison, Alexa J. Ritchie, Aaron T. Mayer, Matthew F. Krummel, Eric A. Collisson Source Type: research

Uniting the Global Gastroenterology Community to Meet the Challenge of Climate Change and Non-Recyclable Waste
Climate change has been described as the biggest global health threat of the 21st century1 and has significant implications for gastrointestinal (GI) health and disease,2 which is the focus of this consensus commentary provided by the World Gastroenterology Organisation (WGO) Climate Change Working Group (CCWG). The CCWG has members from 18 countries representing high, medium, and low-income populations. The WGO includes gastroenterology societies from 108 countries, which represent more than 60,000 medical practitioner members. (Source: Gastroenterology)
Source: Gastroenterology - October 7, 2021 Category: Gastroenterology Authors: Desmond Leddin, M. Bishr Omary, Andrew Veitch, Geoffrey Metz, Naima Amrani, Lars Aabakken, Raja Affendi Raja Ali, Mario Reis Alvares-Da-Silva, David Armstrong, Sedat Boyacioglu, Ye Chen, Reda Elwakil, Kwong-Ming Fock, Saeed S. Hamid, Govind Makharia, Finl Tags: Commentary Source Type: research

“Going the extra mile”: A Sox10 target, Cdh19, is Required for Sacral NC Migration in ENS Development
(Source: Gastroenterology)
Source: Gastroenterology - October 6, 2021 Category: Gastroenterology Authors: Justin A. Avila, E Michelle Southard-Smith Source Type: research

COVID-19 mRNA Vaccine Short-Term Safety in Patients with Inflammatory Bowel Disease
(Source: Gastroenterology)
Source: Gastroenterology - October 6, 2021 Category: Gastroenterology Authors: Emily Spiera, Manasi Agrawal, Ryan Ungaro Source Type: research

Epidemiology, Etiology, and Treatment of Gastroparesis: Real-World Evidence From a Large US National Claims Database
In 100,000 US adults, 267.7 have gastroparesis (falling to 21.5 when using a strict disease definition). Causes of gastroparesis include diabetes (57.4%), surgery (15.0%), medication (11.8%), and unknown/uncertain reasons (11.3%). (Source: Gastroenterology)
Source: Gastroenterology - October 5, 2021 Category: Gastroenterology Authors: Yizhou Ye, Yu Yin, Susanna Y. Huh, Christina Almansa, Dimitri Bennett, Michael Camilleri Tags: Clinical —Alimentary Tract Source Type: research

Single-Cell DNA Sequencing Reveals Chromosomal Diversity in HCC and a Novel Model of HCC Evolution
Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related deaths in the world.1 Effective treatment is challenging, and the best therapies can extend a patient ’s life by only a matter of months.2,3 In recent years, single-cell characterization of a limited number of cells suggested that chromosome copy number alterations (CNAs) occur in HCC and are a source of intratumor heterogeneity (ITH).4,5 Unfortunately, our understanding of the scope and mechanism s of CNA-driven diversity in HCC is limited. (Source: Gastroenterology)
Source: Gastroenterology - October 5, 2021 Category: Gastroenterology Authors: Sierra R. Wilson, Andrew W. Duncan Tags: Editorial Source Type: research

Epidemiology, etiology and treatment of gastroparesis: real-world evidence from a large US national claims database
While gastroparesis carries a considerable healthcare and patient burden, associated epidemiological data are limited. To provide new real-world evidence for gastroparesis, we estimated disease prevalence, and investigated patient demographics and disease etiology in a large US claims database. (Source: Gastroenterology)
Source: Gastroenterology - October 5, 2021 Category: Gastroenterology Authors: Y. Ye, Y. Yin, S.Y. Huh, C. Almansa, D. Bennett, M. Camilleri Source Type: research

Single Cell DNA Sequencing Reveals Chromosomal Diversity in HCC and a Novel Model of HCC Evolution
(Source: Gastroenterology)
Source: Gastroenterology - October 5, 2021 Category: Gastroenterology Authors: Sierra R. Wilson, Andrew W. Duncan Source Type: research