Fecal Microbiota Transplantation Reduces Symptoms in Some Patients With Irritable Bowel Syndrome with Predominant Abdominal Bloating: Short- and Long-Term Results from a Placebo-Controlled Randomized Trial
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder associated with intestinal dysbiosis. Given reported promising results of open-label fecal microbiota transplantation (FMT) therapy in patients with predominant abdominal bloating, we studied efficacy of this treatment in a randomized, placebo-controlled trial. (Source: Gastroenterology)
Source: Gastroenterology - July 15, 2020 Category: Gastroenterology Authors: Tom Holvoet, Marie Joossens, Jorge F. V ázquez-Castellanos, Evelien Christiaens, Lander Heyerick, Jerina Boelens, Bruno Verhasselt, Hans van Vlierberghe, Martine De Vos, Jeroen Raes, Danny De Looze Source Type: research

The Influence of Gut and Tumor Microbiome on Pancreatic Cancer Outcomes
Pancreatic cancer is a highly fatal malignancy with overall 5-year survival of under 10%, within the context of increasing incidence rates worldwide (Clin Gastroenterol Hepatol 2020 Mar 5. pii: S1542-3565(20)30276-7 [Epub ahead of print]). Even among the minority of patients who are diagnosed with early stage disease and undergo resection, most survive less than 5 years (short-term survivors (STS), however a unique subset of patients survive>5 years post-surgery coined long-term survivors (LTS) (Clin Cancer Res 2015;21:1944 –1950). (Source: Gastroenterology)
Source: Gastroenterology - July 14, 2020 Category: Gastroenterology Authors: Natalia Khalaf, Hashem El-Serag, Fasiha Kanwal, Johanna Chan Source Type: research

Comparative Efficacy Trials in Inflammatory Bowel Disease
We may stumble and fall but shall rise again; it should be enough if we did not run away from the battle. (Source: Gastroenterology)
Source: Gastroenterology - July 14, 2020 Category: Gastroenterology Authors: Reena Khanna, G.Y. Zhou, Waqqas Afif Source Type: research

Assessment of evidence quality in IBD guidance: The use and misuse of GRADE
(Source: Gastroenterology)
Source: Gastroenterology - July 14, 2020 Category: Gastroenterology Authors: Morris Gordon, Gordon Guyatt Source Type: research

Insights from Pharmacovigilance: Gastrointestinal Related Immune Checkpoint Inhibitor Adverse Events
(Source: Gastroenterology)
Source: Gastroenterology - July 14, 2020 Category: Gastroenterology Authors: Stephen W. Reese, Maya Marchese, Julia McNabb-Baltar Source Type: research

Postprandial chylomicron output and transport through intestinal lymphatics are not impaired in active Crohn ’s disease
(Source: Gastroenterology)
Source: Gastroenterology - July 14, 2020 Category: Gastroenterology Authors: Li-Hao Huang, Parakkal Deepak, Matthew A. Ciorba, Bettina Mittendorfer, Bruce W. Patterson, Gwendalyn J. Randolph Source Type: research

Risk of Small Bowel Adenocarcinoma, Adenomas, and Carcinoids in a Nationwide Cohort of Individuals With Celiac Disease
The incidence of small bowel cancers is increasing. Associations have been made between celiac disease and small bowel cancers, but there have been no detailed studies of large cohorts. (Source: Gastroenterology)
Source: Gastroenterology - July 14, 2020 Category: Gastroenterology Authors: Louise Emilsson, Carol Semrad, Benjamin Lebwohl, Peter HR. Green, Jonas F. Ludvigsson Source Type: research

AGA Clinical Practice Update on Small Intestinal Bacterial Overgrowth: Expert Review
Thanks to ready access to hydrogen breath testing, small intestinal bacterial overgrowth is now commonly diagnosed among individuals presenting with a variety of gastrointestinal and even non-gastrointestinal complaints and is increasingly implicated, in lay press and media in the causation of a diverse array of disorders. Its definition, however, remains controversial and true prevalence, accordingly, undefined. The purpose of this review, therefore, was to provide a historical background to the concept of SIBO, critically review current concepts of SIBO (including symptomatology, pathophysiology, clinical consequences, d...
Source: Gastroenterology - July 14, 2020 Category: Gastroenterology Authors: Eamonn MM. Quigley, Joseph A. Murray, Mark Pimentel Source Type: research

Aga clinical practice update on reducing rates of post endoscopy esophageal adenocarcinoma: commentary
(Source: Gastroenterology)
Source: Gastroenterology - July 13, 2020 Category: Gastroenterology Authors: Sachin Wani, C. Prakash Gyawali, David A. Katzka Source Type: research

Clinical Challenges and Images in GI: An extraordinary cause of dyspnoea and weight loss.
(Source: Gastroenterology)
Source: Gastroenterology - July 13, 2020 Category: Gastroenterology Authors: Timothy P. Hanrahan, Mark Goodwin, Adam Testro Source Type: research

Activating Transcription Factor 6 Mediates Inflammatory Signals in Intestinal Epithelial Cells Upon Endoplasmic Reticulum Stress
Excess and unresolved endoplasmic reticulum (ER) stress in intestinal epithelial cells (IECs) promotes intestinal inflammation. Activating transcription factor 6 (ATF6) is one of the signaling mediators of ER stress. We studied the pathways that regulate ATF6 and its role for inflammation in IECs. (Source: Gastroenterology)
Source: Gastroenterology - July 12, 2020 Category: Gastroenterology Authors: Stephanie T. Stengel, Antonella Fazio, Simone Lipinski, Martin T. Jahn, Konrad Aden, Go Ito, Felix Wottawa, Jan W.P. Kuiper, Olivia I. Coleman, Florian Tran, Dora Bordoni, Joana P. Bernardes, Marlene Jentzsch, Anne Luzius, Sandra Bierwirth, Berith Messner Source Type: research

High-Throughput Screen Identifies Host and Microbiota Regulators of Intestinal Barrier Function
The intestinal barrier protects intestinal cells from microbes and antigens in the lumen —breaches can alter the composition of the intestinal microbiota, the enteric immune system, and metabolism. We performed a screen to identify molecules that disrupt and support the intestinal epithelial barrier and tested their effects in mice. (Source: Gastroenterology)
Source: Gastroenterology - July 8, 2020 Category: Gastroenterology Authors: Inna Grosheva, Danping Zheng, Maayan Levy, Omer Polansky, Alexandra Lichtenstein, Ofra Golani, Mally Dori-Bachash, Claudia Moresi, Hagit Shapiro, Sara Del Mare-Roumani, Rafael Valdes-Mas, Yiming He, Hodaya Karbi, Minhu Chen, Alon Harmelin, Ravid Straussma Source Type: research

PTPN2 Regulates Interactions Between Macrophages and Intestinal Epithelial Cells to Promote Intestinal Barrier Function.
The mechanisms by which macrophages regulate intestinal epithelial cell (IEC) barrier properties are poorly understood. Protein tyrosine phosphatase non-receptor type 2 (PTPN2) protects the IEC barrier from inflammation-induced disruption and regulates macrophage functions. We investigated whether PTPN2 controls interactions between IECs and macrophages to maintain intestinal barrier function. (Source: Gastroenterology)
Source: Gastroenterology - July 8, 2020 Category: Gastroenterology Authors: Marianne R. Spalinger, Anica Sayoc-Becerra, Alina N. Santos, Ali Shawki, Vinicius Canale, Moorthy Krishnan, Anna Niechcial, Nicole Obialo, Michael Scharl, Jiang Li, Meera G. Nair, Declan F. McCole Source Type: research

Intestinal Virome Signature Associated With Severity of Nonalcoholic Fatty Liver Disease
Alterations in the gut microbiome have been associated with the severity of nonalcoholic fatty liver disease (NAFLD). These studies focused exclusively on the bacteria in the microbiome; we investigated changes in the viral microbiome (virome) in patients with NAFLD. (Source: Gastroenterology)
Source: Gastroenterology - July 8, 2020 Category: Gastroenterology Authors: Sonja Lang, M ünevver Demir, Anna Martin, Lu Jiang, Xinlian Zhang, Yi Duan, Bei Gao, Hilmar Wisplinghoff, Philipp Kasper, Christoph Roderburg, Frank Tacke, Hans-Michael Steffen, Tobias Goeser, Juan G. Abraldes, Xin M. Tu, Rohit Loomba, Peter Stärkel, Da Source Type: research

Combined Fasting Serum C4 and Primary Bile Acids from a Single Stool Sample Diagnose Bile Acid Diarrhea
(Source: Gastroenterology)
Source: Gastroenterology - July 6, 2020 Category: Gastroenterology Authors: Priya Vijayvargiya, Michael Camilleri, Ann Taylor, Irene Busciglio, Edward V. Loftus, Leslie J. Donato Source Type: research

A meta-analysis confirms that antibiotic prophylaxis is not needed for endoscopic ultrasound-guided fine needle aspiration of pancreatic cysts
(Source: Gastroenterology)
Source: Gastroenterology - July 6, 2020 Category: Gastroenterology Authors: Antonio Facciorusso, Vincenzo Rosario Buccino, Rodolfo Sacco Source Type: research

Antibiotic propylaxis for eus-guided diagnostic interventions on pancreatic cysts: a never ending story
(Source: Gastroenterology)
Source: Gastroenterology - July 6, 2020 Category: Gastroenterology Authors: Edoardo Troncone, Francesca D ’Aversa, Alberto Larghi Source Type: research

The influence of different types of serum cholesterol on the prognosis of HBV related HCC patients needs more attention
(Source: Gastroenterology)
Source: Gastroenterology - July 6, 2020 Category: Gastroenterology Authors: Xiajie Wen, Shuang Liu, Fengmin Lu Source Type: research

The Nightmare Monitoring of JAKinhibs
(Source: Gastroenterology)
Source: Gastroenterology - July 6, 2020 Category: Gastroenterology Authors: Stephane Paul, X. Roblin. Source Type: research

A proof of concept study: Esophagogastroduodenoscopy is an aerosol-generating procedure and continuous oral suction during the procedure reduces the amount of aerosol generated
(Source: Gastroenterology)
Source: Gastroenterology - July 6, 2020 Category: Gastroenterology Authors: Shannon Melissa Chan, Tsz Wah Ma, Marc Ka-Chun Chong, Daniel Leonard Chan, Enders Kwok Wai Ng, Philip Wai Yan Chiu Source Type: research

The course of Covid 19 in Inflammatory Bowel Disease: protective role of TNF antagonists Response to: Corticosteroids, but not TNF Antagonists, are Associated with Adverse COVID-19 Outcomes in Patients With Inflammatory Bowel Diseases: Results from an International Registry
(Source: Gastroenterology)
Source: Gastroenterology - July 6, 2020 Category: Gastroenterology Authors: Maria Cappello, Anita Busacca, Laura Guida Source Type: research

Gastrointestinal involvements in children with COVID-related multisystem inflammatory syndrome
(Source: Gastroenterology)
Source: Gastroenterology - July 1, 2020 Category: Gastroenterology Authors: Tai-Heng Chen, Wei-Tsun Kao, Yung-Hao Tseng Source Type: research

STATE OF EVIDENCE IN MINIMALLY INVASIVE MANAGEMENT OF GASTROESOPHAGEAL REFLUX: Findings of a Scoping Review
s and Aims: Endoscopic management of gastroesophageal reflux disease (GERD) are increasingly employed. The aim of this scoping review was to assess the volume of available evidence on benefit of endoscopic and minimally surgical therapies for GERD. (Source: Gastroenterology)
Source: Gastroenterology - July 1, 2020 Category: Gastroenterology Authors: Michael F. Vaezi, Nicholas J. Shaheen, V. Raman Muthusamy Source Type: research

Pre-procedural COVID testing: The “New Normal.”
(Source: Gastroenterology)
Source: Gastroenterology - July 1, 2020 Category: Gastroenterology Authors: Trilokesh D. Kidambi, Gregory E. Idos, James L. Lin Source Type: research

The courage to return to everyday life at the time of covid-19: the point of view of inflammatory bowel disease patients needing endoscopy.
(Source: Gastroenterology)
Source: Gastroenterology - July 1, 2020 Category: Gastroenterology Authors: Filippo Mocciaro, Daniela Scimeca, Roberto Di Mitri Source Type: research

TP63, SOX2, and KLF5 Establish a Core Regulatory Circuitry That Controls Epigenetic and Transcription Patterns in Esophageal Squamous Cell Carcinoma Cell Lines
We investigated the transcriptome of esophageal squamous cell carcinoma (ESCC) cells, activity of gene regulatory (enhancer and promoter regions), and the effects of blocking epigenetic regulatory proteins. (Source: Gastroenterology)
Source: Gastroenterology - June 29, 2020 Category: Gastroenterology Authors: Yan-Yi Jiang, Yuan Jiang, Chun-Quan Li, Ying Zhang, Pushkar Dakle, Harvinder Kaur, Jian-Wen Deng, Ruby Yu-Tong Lin, Lin Han, Jian-Jun Xie, Yiwu Yan, Ngan Doan, Yueyuan Zheng, Anand Mayakonda, Masaharu Hazawa, Liang Xu, YanYu Li, Luay Aswad, Maya Jeitany, Source Type: research

Recurrent APC splice variant c.835-8A > G in patients with unexplained colorectal polyposis fulfilling the colibactin mutational signature
(Source: Gastroenterology)
Source: Gastroenterology - June 27, 2020 Category: Gastroenterology Authors: D. Terlouw, M. Suerink, A. Boot, T. van Wezel, M. Nielsen, H. Morreau Source Type: research

Dropping the Diagnosis
(Source: Gastroenterology)
Source: Gastroenterology - June 26, 2020 Category: Gastroenterology Authors: Saam Dilmaghani, Seth Sweetser Source Type: research

A Patient with Primary Sclerosing Cholangitis and Diffuse Biliary Dilation
(Source: Gastroenterology)
Source: Gastroenterology - June 26, 2020 Category: Gastroenterology Authors: M. Phillip Fejleh, Sung-Eun Yang, Stephen Kim Source Type: research

An Enlarging Hepatic Mass of Unknown Etiology
(Source: Gastroenterology)
Source: Gastroenterology - June 26, 2020 Category: Gastroenterology Authors: Michael M. Skaret, Diego A. Vicente, Adam C. Deising Source Type: research

Alterations in Fecal Fungal Microbiome of Patients With COVID-19 During Time of Hospitalization until Discharge
SARS-CoV-2 infects intestinal cells, and might affect the intestinal microbiota. We investigated changes in the fecal fungal microbiomes (mycobiome) of patients with SARS-CoV-2 infection during hospitalization and upon recovery. (Source: Gastroenterology)
Source: Gastroenterology - June 26, 2020 Category: Gastroenterology Authors: Tao Zuo, Hui Zhan, Fen Zhang, Qin Liu, Eugene Y.K. Tso, Grace C.Y. Lui, Nan Chen, Amy Li, Wenqi Lu, Francis K.L. Chan, Paul K.S. Chan, Siew C. Ng Source Type: research

Unusual colonic polyp in a young woman
(Source: Gastroenterology)
Source: Gastroenterology - June 26, 2020 Category: Gastroenterology Authors: Reto Bertolini, Peter K. Bode, Mikael Sawatzki Source Type: research

Probiotics Reduce Mortality and Morbidity in Preterm, Low Birth Weight Infants: a Systematic Review and Network Meta-analysis of Randomized Trials
We aimed to compare the effectiveness of single- vs multiple-strain probiotics in a network meta-analysis of randomized trials. (Source: Gastroenterology)
Source: Gastroenterology - June 24, 2020 Category: Gastroenterology Authors: Rebecca L. Morgan, Geoffrey A. Preidis, Purna C. Kashyap, Adam V. Weizman, Behnam Sadeghirad, McMaster Probiotic, Prebiotic, and Synbiotic Work Group (*Names and affiliations in appendix), Yaping Chang, Ivan D. Florez, Farid Foroutan, Shaneela Shahid, Den Source Type: research

Spotlight: COVID-19 PPE and Endoscopy
(Source: Gastroenterology)
Source: Gastroenterology - June 23, 2020 Category: Gastroenterology Authors: Shazia M. Siddique, Shahnaz Sultan, Joseph K. Lim, Osama Altayar, Perica Davitkov, Joseph D. Feuerstein, Yngve Falck-Ytter, Hashem B. El-Serag, AGA Source Type: research

Intestinal Epithelial Expression of MHCII Determines Severity of Chemical, T Cell-Induced, and Infectious Colitis in Mice
Intestinal epithelial cells (IECs) provide a barrier that separates the mucosal immune system from the luminal microbiota. IECs constitutively express low levels of major histocompatibility complex (MHC) class II proteins, which are upregulated upon exposure interferon gamma. We investigated the effects of deleting MHCII proteins specifically in mice with infectious, dextran sodium sulfate (DSS)-, and T cell-induced colitis. (Source: Gastroenterology)
Source: Gastroenterology - June 23, 2020 Category: Gastroenterology Authors: Deepa R. Jamwal, Daniel Laubitz, Christy A. Harrison, Vanessa Figliuolo da Paz, Christopher M. Cox, Rachel Wong, Monica Midura-Kiela, Michael A. Gurney, David G. Besselsen, Prashanth Setty, Lonnie Lybarger, Deepta Bhattacharya, Jean M. Wilson, Fayez K. Gh Source Type: research

Incremental Benefit of Achieving Endoscopic and Histologic Remission in Patients with Ulcerative Colitis: A Systematic Review and Meta-Analysis
Clinical remission, defined by a composite of patient reported outcomes and Mayo endoscopy subscore (MES) 0 or 1 is a recommended treatment target in patients with ulcerative colitis (UC). We estimated whether incorporating more rigorous remission definitions, of endoscopic remission (MES 0) and histologic remission, affects risk of relapse. (Source: Gastroenterology)
Source: Gastroenterology - June 22, 2020 Category: Gastroenterology Authors: Hyuk Yoon, Sushrut Jangi, Parambir S. Dulai, Brigid S. Boland, Larry J. Prokop, Vipul Jairath, Brian G. Feagan, William J. Sandborn, Siddharth Singh Source Type: research

Ongoing Trials Will Not Determine the Comparative Effectiveness of Colorectal Cancer Screening Tests
(Source: Gastroenterology)
Source: Gastroenterology - June 22, 2020 Category: Gastroenterology Authors: Ø. Holme, M. Kalager, M. Bretthauer, H.O. Adami, L. Helsingen, M. Løberg Source Type: research

IL22BP Mediates the Anti-Tumor Effects of Lymphotoxin Against Colorectal Tumors in Mice and Humans
Unregulated activity of interleukin 22 (IL22) promotes intestinal tumorigenesis in mice. IL22 binds the antagonist IL22 subunit alpha 2 (IL22RA2, also called IL22BP). We studied if alterations in IL22BP contribute to colorectal carcinogenesis in humans and mice. (Source: Gastroenterology)
Source: Gastroenterology - June 22, 2020 Category: Gastroenterology Authors: Jan Kempski, Anastasios D. Giannou, Kristoffer Riecken, Lilan Zhao, Babett Steglich, J öran Lücke, Laura Garcia-Perez, Karl-Frederick Karstens, Anna Wöstemeier, Mikolaj Nawrocki, Penelope Pelczar, Mario Witkowski, Sven Nilsson, Leonie Konczalla, Ahmad Source Type: research

The inhibitory PVRL1/PVR/TIGIT axis in immune therapy for HCC
(Source: Gastroenterology)
Source: Gastroenterology - June 20, 2020 Category: Gastroenterology Authors: Hua Peng, Yang-Xin Fu Source Type: research

IRE1A Stimulates Hepatocyte-derived Extracellular Vesicles That Promote Inflammation in Mice With Steatohepatitis
Endoplasmic reticulum to nucleus signaling 1 (ERN1, also called IRE1A) is a sensor of the unfolded protein response that is activated in livers of patients with nonalcoholic steatohepatitis (NASH). Hepatocytes release ceramide-enriched inflammatory extracellular vesicles (EVs) following activation of IRE1A. We studied the effects of inhibiting IRE1A on release of inflammatory EVs in mice with diet-induced steatohepatitis. (Source: Gastroenterology)
Source: Gastroenterology - June 20, 2020 Category: Gastroenterology Authors: Debanjali Dasgupta, Yasuhiko Nakao, Amy S. Mauer, Jill M. Thompson, Tejasav S. Sehrawat, Chieh-Yu Liao, Anuradha Krishnan, Fabrice Lucien, Qianqian Guo, Mengfei Liu, Fei Xue, Masanori Fukushima, Tomohiro Katsumi, Aditya Bansal, Mukesh K. Pandey, Jessica L Source Type: research

Human Plasminogen Exacerbates Clostridioides difficile Enteric Disease and Alters the Spore Surface
The protease plasmin is an important wound healing factor, but it is not clear how it affects gastrointestinal infection-mediated damage, such as that resulting from Clostridioides difficile. We investigated the role of plasmin in C difficile-associated disease. This bacterium produces a spore form that is required for infection, so we also investigated the effects of plasmin on spores. (Source: Gastroenterology)
Source: Gastroenterology - June 20, 2020 Category: Gastroenterology Authors: M.M. Awad, M.L. Hutton, A.J. Quek, W.P. Klare, S.J. Mileto, K. Mackin, D. Ly, V. Oorschot, M. Bosnjak, G. Jenkin, P.J. Conroy, N. West, A. Fulcher, A. Costin, C.J. Day, M.P. Jennings, R.L. Medcalf, M. Sanderson-Smith, S.J. Cordwell, R.H.P. Law, J.C. Whiss Source Type: research

Adherence of infusible biologics during the time of COVID-19 among patients with Inflammatory Bowel Disease: A nationwide VA cohort study
(Source: Gastroenterology)
Source: Gastroenterology - June 20, 2020 Category: Gastroenterology Authors: Nabeel Khan, Dhruvan Patel, Dawei Xie, Tyler Pernes, James Lewis, Yu-Xiao Yang Source Type: research

AGA Clinical Practice Update on Endoscopic Therapies for Non-Variceal Upper Gastrointestinal Bleeding: Expert Review
The purpose of this AGA Institute Clinical Practice Update is to review the available evidence and expert recommendations regarding the use of endoscopic therapies in treating patients with non-variceal upper GI bleeding. (Source: Gastroenterology)
Source: Gastroenterology - June 20, 2020 Category: Gastroenterology Authors: Daniel K. Mullady, Andrew Y. Wang, Kevin A. Waschke Source Type: research

Diffuse Pancreas Swelling in a Patient with Multiple Myeloma
(Source: Gastroenterology)
Source: Gastroenterology - June 19, 2020 Category: Gastroenterology Authors: Akane Hara, Kosuke Minaga, Tomohiro Watanabe Source Type: research

Pustular Skin Lesions
(Source: Gastroenterology)
Source: Gastroenterology - June 19, 2020 Category: Gastroenterology Authors: Mohammed T. Awad, Momen Banifadel Source Type: research

A life-threatening complication of upper endoscopy
(Source: Gastroenterology)
Source: Gastroenterology - June 19, 2020 Category: Gastroenterology Authors: Tobias Schlosser, Paula Piechotta, Thomas Karlas Source Type: research

Is heterozygosity for the alpha-1 antitrypsin risk allele Pi*MZ disease modifier or genetic risk factor?
(Source: Gastroenterology)
Source: Gastroenterology - June 19, 2020 Category: Gastroenterology Authors: Heinz Zoller, Sonja Wagner, Herbert Tilg Source Type: research

Utility of Surveillance and Screening Colonoscopy in Older Adults
(Source: Gastroenterology)
Source: Gastroenterology - June 19, 2020 Category: Gastroenterology Authors: Y. Claire Dorsey, Jatin Roper Source Type: research

Asbestos exposure and increased risk of intrahepatic cholangiocarcinoma: enough to infer causality?
Brandi G and Tavolari S. Asbestos and Intrahepatic Cholangiocarcinoma. Cells 2020, 9, 421 (Source: Gastroenterology)
Source: Gastroenterology - June 19, 2020 Category: Gastroenterology Authors: Carlo La Vecchia, Marcello Lotti, Massimo Colombo Source Type: research

IL1B Increases Intestinal Tight Junction Permeability by Upregulation of MIR200C-3p, Which Degrades Occludin mRNA
Defects in the epithelial tight junction (TJ) barrier contribute to development of intestinal inflammation associated with diseases. Interleukin 1 beta (IL1B) increases intestinal permeability in mice. We investigated microRNAs that are regulated by IL1B and their effects on expression of TJ proteins and intestinal permeability. (Source: Gastroenterology)
Source: Gastroenterology - June 19, 2020 Category: Gastroenterology Authors: Manmeet Rawat, Meghali Nighot, Rana Al-Sadi, Yash Gupta, Dharmaprakash Viszwapriya, Gregory Yochum, Walter Koltun, Thomas Y. Ma Source Type: research