Fecal microbiota transplantation for recurrent C. difficile infection can be the best therapeutic option in severely immunocompromised patients depending on a case-by-case assessment of the benefit/risk ratio
(Source: Gastroenterology)
Source: Gastroenterology - April 26, 2024 Category: Gastroenterology Authors: Nicolas BENECH, Nadim CASSIR, Tatiana GALPERINE, Laurent ALRIC, Julien SCANZI, Harry SOKOL, French Fecal Transplant Group (GFTF) Tags: Correspondence Source Type: research

“The OCEAN Study: Has Octreotide Quenched the Thirst for Angiodysplasia-Related Bleed?”
(Source: Gastroenterology)
Source: Gastroenterology - April 26, 2024 Category: Gastroenterology Authors: Avinash Tiwari Tags: Correspondence Source Type: research

Basket, Umbrella, and Platform Trials: The Potential for Master Protocol -Based Trials in Inflammatory Bowel Disease
(Source: Gastroenterology)
Source: Gastroenterology - April 25, 2024 Category: Gastroenterology Authors: Sailish Honap, Bruce E. Sands, Vipul Jairath, Silvio Danese, Eric Vicaut, Laurent Peyrin-Biroulet Tags: Commentary Source Type: research

A Curious Case of Colitis
(Source: Gastroenterology)
Source: Gastroenterology - April 25, 2024 Category: Gastroenterology Authors: Elida Voth, Amanda Johnson Tags: Electronic Gastro Curbside Consult Source Type: research

Measuring post-colonoscopy colorectal cancers: Variations in methodology to address indicator timeliness and use in high-risk populations
(Source: Gastroenterology)
Source: Gastroenterology - April 24, 2024 Category: Gastroenterology Authors: Jill Tinmouth, Branson Chen, Yue Niu, Kyle Silveira, Linda Rabeneck, Catherine Dub é, Cancer Control and Evidence Integration PCCRC Method Working Group, Ontario Health, Cancer Control Tags: Research Letter Source Type: research

Real-world Stool-based mSDC2 Test Improved Detection of Advanced Colorectal Neoplasia for Colorectal Cancer Screening: A Prospective, Multicenter, Community-based Study.
(Source: Gastroenterology)
Source: Gastroenterology - April 24, 2024 Category: Gastroenterology Authors: Shengbing Zhao, Zixuan He, Xiangyu Sui, Song Zhang, Zhaoshen Li, Yu Bai, Community-based CRC Screening Study Group Tags: Research Letter Source Type: research

New insights on genes, gluten and immunopathogenesis of celiac disease
Celiac disease (CeD) is a gluten-induced enteropathy that develops in genetically susceptible individuals on consumption of cereal gluten proteins. It is a unique complex immune disorder to study as the driving antigen is known and the tissue targeted by the immune reaction can be interrogated. This review integrates findings gained from genetic, biochemical and immunological studies, which together have revealed mechanisms of gluten peptide modification and HLA binding thereby enabling a maladapted anti-gluten immune response. (Source: Gastroenterology)
Source: Gastroenterology - April 24, 2024 Category: Gastroenterology Authors: Val érie Abadie, Arnold Han, Bana Jabri, Ludvig M. Sollid Tags: Invited 2024 13th Issue: Celiac Disease Source Type: research

Past, present and future of non-invasive tests to assess gluten exposure, celiac disease activity, and end-organ damage
Although many biomarkers have been proposed and several are in widespread clinical use, there is no single readout or combination of readouts that correlates tightly with gluten exposure, disease activity or end-organ damage in treated celiac disease patients. Challenges to developing and evaluating better biomarkers include significant interindividual variability related to immune amplification of gluten exposure and how effects of immune activation are manifest. Furthermore, the current “gold standard” for assessment of end-organ damage, small intestinal biopsy, is itself highly imperfect, such that a marker that is ...
Source: Gastroenterology - April 24, 2024 Category: Gastroenterology Authors: Jocelyn A. Silvester, Luca Elli, Chaitan Khosla, Jason Tye-Din Tags: Invited 2024 13th Issue: Celiac Disease Source Type: research

The Economic Iceberg of Celiac Disease: More than the Cost of Gluten-Free Food
Celiac disease (CeD) is a chronic autoimmune disorder of global relevance, with the potential for acute and long-term complications. However, the economic burden of CeD is rarely considered and largely thought of as limited to the cost of gluten-free food. Fortunately, recent research has shed light on the various societal costs of CeD across the healthcare continuum.In this article, we summarize the current evidence on the economic impacts of CeD which suggest that the societal economic burden of CeD stretches beyond the cost of gluten-free food. (Source: Gastroenterology)
Source: Gastroenterology - April 24, 2024 Category: Gastroenterology Authors: Soran R. Bozorg, Anne Lee, Karl M årild, Joseph Murray Tags: Invited 2024 13th Issue: Celiac Disease Source Type: research

Gastro Digest: Co-occurring MASLD and diabetes is associated with increased incidence of cardiovascular events and mortality
(Source: Gastroenterology)
Source: Gastroenterology - April 24, 2024 Category: Gastroenterology Authors: Catherine Mezzacappa Tags: Gastro Digest Source Type: research

Reply to Benech et al.
(Source: Gastroenterology)
Source: Gastroenterology - April 24, 2024 Category: Gastroenterology Authors: Byron P. Vaughn, Dina Kao, Colleen R. Kelly Tags: Correspondence Source Type: research

Comments on "Thoracoabdominal Wall Motion –Guided Biofeedback Treatment of Abdominal Distension: A Randomized Placebo-Controlled Trial"
(Source: Gastroenterology)
Source: Gastroenterology - April 24, 2024 Category: Gastroenterology Authors: Paola Iovino, Maria Cristina Neri, Lucia D'Alba, Antonella Santonicola, Stefan Lucian Popa, Giuseppe Chiarioni Tags: Correspondence Source Type: research

A Rare Case Mimicking Congenital Hepatic Fibrosis
(Source: Gastroenterology)
Source: Gastroenterology - April 23, 2024 Category: Gastroenterology Authors: Chenyi Jiang, Min Lian, Xiong Ma Tags: Electronic Gastro Curbside Consult Source Type: research

Changing fate: how EGFRs "pit" cell vs cell in the stomach
(Source: Gastroenterology)
Source: Gastroenterology - April 22, 2024 Category: Gastroenterology Authors: Sumimasa Arimura, Sarah To, Jason C. Mills Tags: Editorials Source Type: research

Severe Acute Hepatitis of Unknown Etiology in Children: New Virus or Immune Dysregulation
(Source: Gastroenterology)
Source: Gastroenterology - April 22, 2024 Category: Gastroenterology Authors: Luz Helena Gutierrez Sanchez, Samar H. Ibrahim Tags: Commentary Source Type: research