In CRC Screening, Timing is Almost Everything
(Source: Gastroenterology)
Source: Gastroenterology - February 25, 2021 Category: Gastroenterology Authors: Anath A. Flugelman, Øyvind Holme Source Type: research

Circulating Tumor DNA Detection Using Digital Polymerase Chain Reaction —Promising But Needs Improvement
(Source: Gastroenterology)
Source: Gastroenterology - February 25, 2021 Category: Gastroenterology Authors: Junfeng Du, Wenxian Guan, Xiaofei Shen Source Type: research

Inclusion of carcinoids in early onset colorectal tumor incidence rates: Adenocarcinoma in young adults still the major problem
(Source: Gastroenterology)
Source: Gastroenterology - February 25, 2021 Category: Gastroenterology Authors: Peter M. Fields, Lynn F. Butterly, Joseph C. Anderson Source Type: research

iPSC-derived hepatocytes from patients with nonalcoholic fatty liver disease display a disease-specific gene expression profile
(Source: Gastroenterology)
Source: Gastroenterology - February 25, 2021 Category: Gastroenterology Authors: Caroline C. Duwaerts, Dounia Le Guillou, Chris L. Her, Nathaniel J. Phillips, Holger Willenbring, Aras N. Mattis, Jacquelyn J. Maher Source Type: research

Direct Measurement of ATP7B Peptides is Highly Effective in the Diagnosis of Wilson Disease
Both existing clinical criteria and genetic testing have significant limitations for the diagnosis of Wilson ’s Disease (WD) often creating ambiguities in patient identification leading to delayed diagnosis and ineffective management. ATP7B protein concentration, indicated by direct measurement of surrogate peptides from patient dried blood spot (DBS) samples, could provide primary evidence of WD. ATP7B concentrations were measured in patient samples from diverse backgrounds, diagnostic potential is determined, and results are compared to biochemical and genetic results from individual patients. (Source: Gastroenterology)
Source: Gastroenterology - February 25, 2021 Category: Gastroenterology Authors: Christopher J. Collins, Fan Yi, Remwilyn Dayuha, Phi Duong, Simon Horslen, Michelle Camarata, Ayse K. Coskun, Roderick H.J. Houwen, Tudor L. Pop, Heinz Zoller, Han-wook Yoo, Sung Won Jung, Karl H. Weiss, Michael L. Schilsky, Peter Ferenci, Sihoun Hahn Source Type: research

Response to: Olesen SW, “Fecal microbiota transplantation “donor effects” are not clinically relevant for Clostridioides difficile infection.”
(Source: Gastroenterology)
Source: Gastroenterology - February 24, 2021 Category: Gastroenterology Authors: Colleen R. Kelly, Gary D. Wu, Loren A. Laine Source Type: research

SoMe – The Next Glass Ceiling?,
(Source: Gastroenterology)
Source: Gastroenterology - February 23, 2021 Category: Gastroenterology Authors: Sophie Balzora, Anita Afzali, Meenakshi Bewtra Source Type: research

Reply to Letters to the Editor on Probiotic Guidelines
(Source: Gastroenterology)
Source: Gastroenterology - February 23, 2021 Category: Gastroenterology Authors: Geoffrey A. Preidis, Grace L. Su, Rebecca L. Morgan Source Type: research

Beneficial effect of tacrolimus … Cyclosporin A, still up for discussion!
(Source: Gastroenterology)
Source: Gastroenterology - February 22, 2021 Category: Gastroenterology Authors: Isaac Ruiz Source Type: research

The Colonic Mucosal MicroRNAs, MicroRNA-219a-5p and MicroRNA-338-3p, are Downregulated in Irritable Bowel Syndrome and are Associated with Barrier Function and MAPK signaling
Alterations in microRNA (miRNA) and in the intestinal barrier are putative risk factors for irritable bowel syndrome (IBS). We aimed to identify differentially expressed colonic mucosal miRNAs, their targets in IBS compared to healthy controls (HCs), and putative downstream pathways. (Source: Gastroenterology)
Source: Gastroenterology - February 19, 2021 Category: Gastroenterology Authors: Swapna Mahurkar-Joshi, Carl Robert Rankin, Elizabeth Jane Videlock, Artin Soroosh, Abhishek Verma, Ariela Khandadash, Dimitrios Iliopoulos, Charalabos Pothoulakis, Emeran A. Mayer, Lin Chang Source Type: research

IL-33 and eosinophils link inflammation and metaplasia in a mouse model of chronic gastritis with intestinalizing features
(Source: Gastroenterology)
Source: Gastroenterology - February 19, 2021 Category: Gastroenterology Authors: Carlo De Salvo, Theresa T. Pizarro Source Type: research

Gastroparesis: a dead-end street after all?
(Source: Gastroenterology)
Source: Gastroenterology - February 19, 2021 Category: Gastroenterology Authors: Jan Tack, Jolien Schol, Michael Horowitz Source Type: research

Canadian association of gastroenterology clinical practice guideline for immunizations in patients with inflammatory bowel disease (ibd). part 1: live vaccines
Patients with inflammatory bowel disease (IBD) may be at increased risk of some vaccine-preventable diseases (VPDs). The effectiveness and safety of vaccinations may be altered by immunosuppressive therapies or IBD itself. The aim of these guidelines was to develop recommendations for the immunization of adult and pediatric patients with IBD. This publication focuses on live vaccines.background (Source: Gastroenterology)
Source: Gastroenterology - February 19, 2021 Category: Gastroenterology Authors: Eric I. Benchimol, Frances Tse, Matthew W. Carroll, Jennifer C. deBruyn, Shelly A. McNeil, Anne Pham-Huy, Cynthia H. Seow, Lisa L. Barrett, Talat Bessissow, Nicholas Carman, Gil Y. Melmed, Otto G. Vanderkooi, John K. Marshall, Jennifer L. Jones Source Type: research

Multiple Hepatic and Pulmonary Tumours Combined with Bilateral Adrenal Masses in a Young Female with von Hippel-Lindau Disease
(Source: Gastroenterology)
Source: Gastroenterology - February 18, 2021 Category: Gastroenterology Authors: T. Kolokotronis, H. Reis Source Type: research

An international consensus to standardize integration of histopathology in ulcerative colitis clinical trials
Histopathology is an emerging treatment target in ulcerative colitis (UC) clinical trials. We aim to provide guidance on standardizing biopsy collection protocols, identifying optimal evaluative indices, and defining thresholds for histologic response and remission after treatment. (Source: Gastroenterology)
Source: Gastroenterology - February 18, 2021 Category: Gastroenterology Authors: Christopher Ma, Rocio Sedano, Ahmed Almradi, Niels Vande Casteele, Claire E. Parker, Leonardo Guizzetti, David F. Schaeffer, Robert H. Riddell, Reetesh K. Pai, Robert Battat, Bruce E. Sands, Christophe Rosty, Marla C. Dubinsky, Florian Rieder, Noam Harpaz Source Type: research

Endoscopic Submucosal Dissection (ESD) in North America: A Large Prospective Multicenter Study
Endoscopic submucosal dissection (ESD) in Asia has been shown to be superior to endoscopic mucosal resection (EMR) and surgery for the management of selected early gastrointestinal cancers. We aimed to evaluate technical outcomes of ESD in North America. (Source: Gastroenterology)
Source: Gastroenterology - February 18, 2021 Category: Gastroenterology Authors: Peter V. Draganov, Hiroyuki Aihara, Michael S. Karasik, Saowanee Ngamruengphong, Abdul Aziz Aadam, Mohamed O. Othman, Neil Sharma, Ian S. Grimm, Alaa Rostom, B. Joseph Elmunzer, Salmaan A. Jawaid, Donevan Westerveld, Yaseen B. Perbtani, Brenda J. Hoffman, Source Type: research

Clinical Implications of colorectal cancer stem cells in the age of single-cell OMICs and targeted therapies.
The cancer stem cell (CSC) concept emerged from the recognition of inherent tumor heterogeneity and suggests that within a given tumor, in analogy to normal tissues, there exists a cellular hierarchy composed of a minority of more primitive cells with enhanced longevity (i.e., CSCs) that give rise to shorter-lived, more differentiated cells (i.e., cancer bulk populations), which on their own are not capable of tumor perpetuation. CSCs can be responsible for cancer therapeutic resistance to conventional, targeted, and immunotherapeutic treatment modalities, and for cancer progression through CSC-intrinsic molecular mechanis...
Source: Gastroenterology - February 18, 2021 Category: Gastroenterology Authors: Markus H. Frank, Brian J. Wilson, Jason S. Gold, Natasha Y. Frank Source Type: research

Association Between Collagenous and Lymphocytic Colitis and Risk of Severe COVID-19
(Source: Gastroenterology)
Source: Gastroenterology - February 18, 2021 Category: Gastroenterology Authors: Hamed Khalili, Tenghao Zheng, Jonas S öderling, Emma Larsson, COVID-19 and microscopic colitis collaborators, Mauro D'Amato, Jonas F. Ludvigsson Source Type: research

Heavy on the stomach
(Source: Gastroenterology)
Source: Gastroenterology - February 17, 2021 Category: Gastroenterology Authors: Cedric Van De Bruaene, Anne Hoorens, Steven De Coninck Source Type: research

Clinical Challenges and Images in GI: An unusual cause of abdominal pain.
(Source: Gastroenterology)
Source: Gastroenterology - February 17, 2021 Category: Gastroenterology Authors: Jos é Paulo Couto, Ana Cristina Rodrigues Source Type: research

A unique case of esophagitis in an immunocompromised patient.
(Source: Gastroenterology)
Source: Gastroenterology - February 17, 2021 Category: Gastroenterology Authors: Olgun Akman, Rodica Gheorghe, Charles N. Bernstein Source Type: research

Gastrointestinal Manifestations of a Rare Lipid Storage Disorder
(Source: Gastroenterology)
Source: Gastroenterology - February 17, 2021 Category: Gastroenterology Authors: Mine Merve Yilmaz, Mercedes Martinez, Huaibin Mabel Ko Source Type: research

Colonic Bluish-black Patches in a 57-year-old woman with Crohn ’s Disease
(Source: Gastroenterology)
Source: Gastroenterology - February 17, 2021 Category: Gastroenterology Authors: Puo-Hsien Le, Chia-Jung Kuo, Ren-Chin Wu Source Type: research

Paraesophageal hiatal hernia
(Source: Gastroenterology)
Source: Gastroenterology - February 17, 2021 Category: Gastroenterology Authors: Hsueh-Chien Chiang, Jui-Wen Kang, Xi-Zhang Lin Source Type: research

Guidelines on Pancreatic Cystic Neoplasms: major inconsistencies with available evidence and clinical practice Results from an International survey
(Source: Gastroenterology)
Source: Gastroenterology - February 17, 2021 Category: Gastroenterology Authors: Giovanni Marchegiani, Roberto Salvia, “Verona EBM 2020 on IPMN” Source Type: research

Development and Validation of a Novel Computed-Tomography Enterography Radiomic Approach for Characterization of Intestinal Fibrosis in Crohn ’s Disease
No reliable method for evaluating intestinal fibrosis in Crohn ’s disease (CD) exists; therefore, we developed a computed-tomography enterography (CTE)–based radiomic model (RM) for characterising intestinal fibrosis in CD. (Source: Gastroenterology)
Source: Gastroenterology - February 17, 2021 Category: Gastroenterology Authors: Xuehua Li, Dong Liang, Jixin Meng, Jie Zhou, Zhao Chen, Siyun Huang, Baolan Lu, Yun Qiu, Mark E. Baker, Ziyin Ye, Qinghua Cao, Mingyu Wang, Chenglang Yuan, Zhihui Chen, Shengyu Feng, Yuxuan Zhang, Marietta Iacucci, Subrata Ghosh, Florian Rieder, Canhui Su Source Type: research

Lack of consistent associations between pharmacological gastric acid suppression and adverse outcomes in patients with COVID-19: meta-analysis of observational studies.
(Source: Gastroenterology)
Source: Gastroenterology - February 17, 2021 Category: Gastroenterology Authors: Faisal Kamal, Muhammad Ali Khan, Sachit Sharma, Zaid Imam, Colin W. Howden Source Type: research

Correction
Li D, Li N, Zhang Y-F, et  al. Persistent Polyfunctional Chimeric Antigen Receptor T Cells That Target Glypican 3 Eliminate Orthotopic Hepatocellular Carcinomas in Mice. Gastroenterology 2020;158:2250-2265. (Source: Gastroenterology)
Source: Gastroenterology - February 16, 2021 Category: Gastroenterology Tags: Correction Source Type: research

Correction
Kesong P, Lele K, Li Y, et  al. Histone demethylase JMJD2D interacts with β-catenin to induce transcription and activate colorectal cancer cell proliferation and tumor growth in mice. Gastroenterology 2019;156: 1112–1126. (Source: Gastroenterology)
Source: Gastroenterology - February 15, 2021 Category: Gastroenterology Tags: Correction Source Type: research

Mortality, reoperation and hospital stay within 90 days of primary and secondary antireflux surgery in a population-based multinational study
Absolute rates and risk factors of short-term outcomes after antireflux surgery remain largely unknown. We aimed to clarify absolute risks and risk factors for poor 90-day outcomes of primary laparoscopic and secondary antireflux surgery. (Source: Gastroenterology)
Source: Gastroenterology - February 12, 2021 Category: Gastroenterology Authors: Manar Yanes, Giola Santoni, John Maret-Ouda, Sheraz Markar, Eivind Ness-Jensen, Joonas Kauppila, Martti F ärkkilä, Elsebeth Lynge, Eero Pukkala, Laufey Tryggvadóttir, My von Euler-Chelpin, Jesper Lagergren Source Type: research

Identification of an Anti-Integrin αvβ6 Autoantibody in Patients with Ulcerative Colitis
Ulcerative colitis is the most frequent type of inflammatory bowel disease and is characterized by colonic epithelial cell damage. Although involvement of autoimmunity has been suggested in ulcerative colitis, specific autoantigens/antibodies are yet to be elucidated. (Source: Gastroenterology)
Source: Gastroenterology - February 11, 2021 Category: Gastroenterology Authors: Takeshi Kuwada, Masahiro Shiokawa, Yuzo Kodama, Sakiko Ota, Nobuyuki Kakiuchi, Yasuhito Nannya, Hajime Yamazaki, Hiroyuki Yoshida, Takeharu Nakamura, Shimpei Matsumoto, Yuya Muramoto, Shuji Yamamoto, Yusuke Honzawa, Katsutoshi Kuriyama, Kanako Okamoto, To Source Type: research

In Esophageal Squamous Cells from Eosinophilic Esophagitis Patients, Th2 Cytokines Increase Eotaxin-3 Secretion through Effects on Intracellular Calcium and a Non-Gastric Proton Pump
In upper airway cells, Th2 cytokines that signal through IL-4 receptor alpha (IL4R α) have been shown to stimulate eotaxin-3 secretion via a non-gastric proton pump (ngH+,K+ATPase). To seek novel targets for eosinophilic esophagitis (EoE) treatments, we evaluated ngH+,K+ATPase expression in EoE squamous cells, and explored molecular pathways involved in eotaxin-3 secretion by IL4 Rα signaling. (Source: Gastroenterology)
Source: Gastroenterology - February 10, 2021 Category: Gastroenterology Authors: Eunice Odiase, Xi Zhang, Yan Chang, Melissa Nelson, Uthra Balaji, Jinghua Gu, Qiuyang Zhang, Zui Pan, Stuart Jon Spechler, Rhonda F. Souza Source Type: research

Microbial community heterogeneity within colorectal neoplasia and its correlation with colorectal carcinogenesis
Gut microbial dysbiosis has pivotal involvement in colorectal cancer (CRC). However, the intratumoural microbiota and its association with CRC progression remains elusive. Hence, we aimed to determine the microbial community architecture within a neoplasia (CRC or adenoma) and its contribution to colorectal carcinogenesis. (Source: Gastroenterology)
Source: Gastroenterology - February 10, 2021 Category: Gastroenterology Authors: Weixin Liu, Xiang Zhang, Hongzhi Xu, Shengmian Li, Harry Cheuk-Hay Lau, Qiongyun Chen, Bin Zhang, Liuyang Zhao, Huarong Chen, Joseph Jao-Yiu Sung, Jun Yu Source Type: research

Dieting for Success: What Baseline Gut Microbiota Can Tell You About Your Chances of Losing Weight
(Source: Gastroenterology)
Source: Gastroenterology - February 10, 2021 Category: Gastroenterology Authors: Raylene A. Reimer, Nathalie M. Delzenne Source Type: research

The Celiac Disease Microbiome Depends on the PC ’s of the Puzzle.
(Source: Gastroenterology)
Source: Gastroenterology - February 10, 2021 Category: Gastroenterology Authors: Martin Tobi, Harvinder Talwar, Benita McVicker Source Type: research

Letter to the editor - Effects of Early Placement of Transjugular Portosystemic Shunts in Patients With High-Risk Acute Variceal Bleeding: a Meta-analysis of Individual Patient Data
(Source: Gastroenterology)
Source: Gastroenterology - February 9, 2021 Category: Gastroenterology Authors: Raoel Maan, Sarwa Darwish Murad, Adriaan J. van der Meer Source Type: research

Functional Restoration of Bacteriomes and Viromes by Fecal Microbiota Transplantation
Fecal microbiota transplantation (FMT) is an effective therapy for recurrent Clostridioides difficile infection (rCDI). However, the overall mechanisms underlying FMT success await comprehensive elucidation, and the safety of FMT has recently become a serious concern because of the occurrence of drug-resistant bacteremia transmitted by FMT. We investigated whether functional restoration of the bacteriomes and viromes by FMT could be an indicator of successful FMT. (Source: Gastroenterology)
Source: Gastroenterology - February 9, 2021 Category: Gastroenterology Authors: Kosuke Fujimoto, Yasumasa Kimura, Jessica R. Allegretti, Mako Yamamoto, Yao-zhong Zhang, Kotoe Katayama, Georg Tremmel, Yunosuke Kawaguchi, Masaki Shimohigoshi, Tetsuya Hayashi, Miho Uematsu, Kiyoshi Yamaguchi, Yoichi Furukawa, Yutaka Akiyama, Rui Yamaguc Source Type: research

Impact of antimicrobial resistance rates on eradication of Helicobacter pylori in a United States population
(Source: Gastroenterology)
Source: Gastroenterology - February 9, 2021 Category: Gastroenterology Authors: Erick A. Argueta, Mohd Amer Alsamman, Steven F. Moss, Erika M.C. D ’Agata Source Type: research

Colorectal Cancer Incidence after Colonoscopy at Ages 45-49 or 50-54 Years
Colorectal cancer (CRC) incidence at ages (Source: Gastroenterology)
Source: Gastroenterology - February 9, 2021 Category: Gastroenterology Authors: Maanek Sehgal, Uri Ladabaum, Alka Mithal, Harminder Singh, Manisha Desai, Gurkirpal Singh Source Type: research

Lack of high-quality studies in drug-induced acute pancreatitis A response to the letter of Teich et al.
(Source: Gastroenterology)
Source: Gastroenterology - February 9, 2021 Category: Gastroenterology Authors: B álint Erőss, Péter Hegyi Source Type: research

CME Exam 1: Successful Therapy of Esophageal Fistulas by Endoscopic Injection of Emulsified Adipose Tissue Stromal Vascular Fraction
(Source: Gastroenterology)
Source: Gastroenterology - February 6, 2021 Category: Gastroenterology Tags: Continuing Medical Education (CME)/MOC Activities Source Type: research

CME Exam 2: Diarrhea in a Retired Couple from Mexico
(Source: Gastroenterology)
Source: Gastroenterology - February 6, 2021 Category: Gastroenterology Tags: Continuing Medical Education (CME)/MOC Activities Source Type: research

CME Exam 3: Colonoscopist Performance and Colorectal Cancer Risk After Adenoma Removal to Stratify Surveillance: Two Nationwide Observational Studies
(Source: Gastroenterology)
Source: Gastroenterology - February 6, 2021 Category: Gastroenterology Tags: Continuing Medical Education (CME)/MOC Activities Source Type: research

REPLY to letters to the editor regarding manuscript Rubin DT, Feuerstein JD, Wang AY, Cohen RD, AGA Clinical Practice Update on Management of Inflammatory Bowel Disease During the COVID-19 Pandemic: Expert Commentary, Gastroenterology (2020)
(Source: Gastroenterology)
Source: Gastroenterology - February 6, 2021 Category: Gastroenterology Authors: Russell D. Cohen, Joseph D. Feuerstein, David T. Rubin Source Type: research

Healthy mind, healthy body: chronic depression may pre-date the development of IBD by up to 9 years.
(Source: Gastroenterology)
Source: Gastroenterology - February 4, 2021 Category: Gastroenterology Authors: Keeley M. Fairbrass, David J. Gracie, Alexander C. Ford Source Type: research

SARS-CoV-2 entry molecules ’ expression and COVID-19 in inflammatory bowel disease: is the gut critical?
(Source: Gastroenterology)
Source: Gastroenterology - February 3, 2021 Category: Gastroenterology Authors: Jan Krzysztof Nowak, Rahul Kalla, Jack Satsangi Source Type: research

Functional dyspepsia and gastroparesis in tertiary care are interchangeable syndromes with common clinical and pathological features
(Source: Gastroenterology)
Source: Gastroenterology - February 3, 2021 Category: Gastroenterology Authors: Pankaj J. Pasricha, Madhu Grover, Katherine P. Yates, Thomas L. Abell, Cheryl E. Bernard, Kenneth L. Koch, Richard W. McCallum, Irene Sarosiek, Braden Kuo, Robert Bulat, Jiande Chen, Robert Shulman, Linda Lee, James Tonascia, Laura A. Miriel, Frank Hamilt Source Type: research

Physician-patient communication is key to improve IBD management during COVID-19 pandemic
(Source: Gastroenterology)
Source: Gastroenterology - February 3, 2021 Category: Gastroenterology Authors: Ferdinando D ’Amico, Laurent Peyrin-Biroulet, Silvio Danese Source Type: research

Ustekinumab for Ulcerative colitis
(Source: Gastroenterology)
Source: Gastroenterology - February 3, 2021 Category: Gastroenterology Authors: Reena Khanna, Waqqas Afif Source Type: research

Reply to the editor's letter: PAF1 regulates the stemness of pancreatic cancer stem cells
(Source: Gastroenterology)
Source: Gastroenterology - February 3, 2021 Category: Gastroenterology Authors: Saswati Karmakar, Moorthy P. Ponnusamy, Surinder K. Batra Source Type: research