PD-1 Signaling Promotes Tumor-Infiltrating Myeloid-Derived Suppressor Cells and Gastric Tumorigenesis in Mice
Immune checkpoint inhibitors have limited efficacy in many tumors. We investigated mechanisms of tumor resistance to inhibitors of programmed cell death 1 (PDCD1, also called PD1) in mice with gastric cancer, and the role of its ligand, PDL1. (Source: Gastroenterology)
Source: Gastroenterology - October 28, 2020 Category: Gastroenterology Authors: Woosook Kim, Timothy H. Chu, Henrik Nienh üser, Zhengyu Jiang, Armando Del Portillo, Helen E. Remotti, Ruth A. White, Yoku Hayakawa, Hiroyuki Tomita, James G. Fox, Charles G. Drake, Timothy C. Wang Source Type: research

Hyperlipasemia and potential pancreatic injury patterns in COVID-19: A marker of severity or innocent bystander?
(Source: Gastroenterology)
Source: Gastroenterology - October 28, 2020 Category: Gastroenterology Authors: Hemant Goyal, Sonali Sachdeva, Abhilash Perisetti, Rupinder Mann, Sumant Inamdar, Benjamin Tharian Source Type: research

Regeneration Defects in Yap and Taz Mutant Mouse Livers are Caused by Bile Duct Disruption and Cholestasis
The Hippo pathway and its downstream effectors YAP and TAZ (YAP/TAZ) are heralded as important regulators of organ growth and regeneration. However, different studies provided contradictory conclusions about their role during regeneration of different organs ranging from promoting proliferation to inhibiting it. Here, we resolve the function of YAP/TAZ during regeneration of the liver, where Hippo ’s role in growth control has been studied most intensely. (Source: Gastroenterology)
Source: Gastroenterology - October 27, 2020 Category: Gastroenterology Authors: Elisabeth Verboven, Iv án M. Moya, Leticia Sansores-Garcia, Jun Xie, Hanne Hillen, Weronika Kowalczyk, Gerlanda Vella, Stefaan Verhulst, Stéphanie A. Castaldo, Ana Algueró-Nadal, Lucia Romanelli, Cristina Mercader-Celma, Natália A. Souza, Soheil Sohei Source Type: research

Pancreatic beta cells communicate with vagal sensory neurons
Destroying visceral sensory nerves impacts pancreatic islet function, glucose metabolism and diabetes onset, but how islet endocrine cells interact with sensory neurons has not been studied. (Source: Gastroenterology)
Source: Gastroenterology - October 26, 2020 Category: Gastroenterology Authors: Madina Makhmutova, Jonathan Weitz, Alejandro Tamayo, Elizabeth Pereira, Maria Boulina, Joana Alma ça, Rayner Rodriguez-Diaz, Alejandro Caicedo Source Type: research

Epithelial TLR4 signaling activates DUOX2 to induce microbiota-driven tumorigenesis
Chronic colonic inflammation leads to dysplasia and cancer in patients with inflammatory bowel disease (IBD). We have described the critical role of innate immune signaling via toll-like receptor 4 (TLR4) in the pathogenesis of dysplasia and cancer. In the current study, we interrogate the intersection of TLR4 signaling, epithelial redox activity, and the microbiota in colitis-associated neoplasia. (Source: Gastroenterology)
Source: Gastroenterology - October 23, 2020 Category: Gastroenterology Authors: Juan F. Burgue ño, Julia Fritsch, Eddy E. Gonzalez, Kevin S. Landau, Ana M. Santander, Irina Fernández, Hajar Hazime, Julie M. Davies, Rebeca Santaolalla, Matthew C. Phillips, Sophia Diaz, Rishu Dheer, Nivis Brito, Judith Pignac-Kobinger, Ester Fernánd Source Type: research

Reduction of IBD healthcare during the COVID-19 pandemic: a nationwide retrospective cohort study
(Source: Gastroenterology)
Source: Gastroenterology - October 22, 2020 Category: Gastroenterology Authors: Maarten te Groen, Monica E.W. Derks, Chantal C.H.J. Kuijpers, Iris D. Nagtegaal, Frank Hoentjen Source Type: research

Prevalence and Effect of Genetic Risk of Thrombo-embolic Disease in Inflammatory Bowel Disease.
The largest cause of mortality in patients with inflammatory bowel disease (IBD) remains thrombo-embolic disease (TED). Recent reports have demonstrated that both monogenic and polygenic factors contribute to TED and 10% of ‘healthy’ subjects are genetically at high risk for TED. Our aim was to utilize whole exome sequencing (WES) and genome-wide genotyping to determine the proportion of IBD patients genetically at risk for TED and investigate the effect of genetic risk of TED in IBD. (Source: Gastroenterology)
Source: Gastroenterology - October 21, 2020 Category: Gastroenterology Authors: Takeo Naito, Gregory J. Botwin, Talin Haritunians, Dalin Li, Shaohong Yang, Michelle Khrom, Jonathan Braun, NIDDK IBD Genetics Consortium, Lisa Abbou, Emebet Mengesha, Christine Stevens, Atsushi Masamune, Mark Daly, Dermot P.B. McGovern Source Type: research

Central reading of ulcerative colitis clinical trial videos using neural networks
Machine reading of endoscopic videos in an ulcerative colitis clinical trial shows promise in replacing central readers with excellent machine-to-human interobserver agreement for UCEIS and endoscopic Mayo score (Source: Gastroenterology)
Source: Gastroenterology - October 21, 2020 Category: Gastroenterology Authors: Klaus Gottlieb, James Requa, William Karnes, Ranga Chandra Gudivada, Jie Shen, Efren Rael, Vipin Arora, Tyler Dao, Andrew Ninh, James McGill Source Type: research

Effects of Race and Ethnicity on Diagnosis and Management of Inflammatory Bowel Diseases
Although Crohn ’s disease (CD) and ulcerative colitis (UC) have been considered as disorders that affect individuals of European ancestry, the epidemiology of the inflammatory bowel diseases (IBDs) is changing. Coupled with the increasing incidence of IBD in previously low-incidence areas, the population demogra phics of IBD in the United States are also changing, with increases among non-white races and ethnicities. It is therefore important to fully understand the epidemiology and progression of IBD in different racial and ethnic groups, and the effects of race and ethnicity on access to care, utilization of resour...
Source: Gastroenterology - October 20, 2020 Category: Gastroenterology Authors: Edward L. Barnes, Edward V. Loftus, Michael D. Kappelman Source Type: research

An endoscopic surprise in a child with chronic diarrhea
(Source: Gastroenterology)
Source: Gastroenterology - October 20, 2020 Category: Gastroenterology Authors: Durga Prasad, Abhai Verma, Madhu Mati Goel Source Type: research

Cancer Screening during COVID-19: A Perspective from NCI ’s PROSPR consortium
(Source: Gastroenterology)
Source: Gastroenterology - October 20, 2020 Category: Gastroenterology Authors: Douglas A. Corley, Mai Sedki, Debra P. Ritzwoller, Robert T. Greenlee, Christine Neslund-Dudas, Katharine A. Rendle, Stacey A. Honda, Joanne E. Schottinger, Natalia Udaltsova, Anil Vachani, Sarah Kobrin, Christopher I. Li, Jennifer S. Haas Source Type: research

Pain and pigmentation: A puzzling presentation
(Source: Gastroenterology)
Source: Gastroenterology - October 20, 2020 Category: Gastroenterology Authors: Sunil Gupta, Michael J. Bourke, Nicholas G. Burgess Source Type: research

Efficacy and outcome of Tofacitinib in Immune checkpoint inhibitor colitis.
(Source: Gastroenterology)
Source: Gastroenterology - October 20, 2020 Category: Gastroenterology Authors: Shrinivas Bishu, Joanna Melia, William Sharfman, Christopher D. Lao, Leslie A. Fecher, Peter DR. Higgins Source Type: research

It's All The RAVE: Time to Give up on “Chronic Radiation Proctitis” Misnomer
(Source: Gastroenterology)
Source: Gastroenterology - October 20, 2020 Category: Gastroenterology Authors: Sultan Mahmood, Steven Bollipo, Scott Steele, Robert G. Bristow, Ananya Choudhury, Kathryn Oakland, Jarad Martin Source Type: research

Hematemesis, abnormal liver function and polymicrobial bacteremia: a rare complication of a common cancer
(Source: Gastroenterology)
Source: Gastroenterology - October 19, 2020 Category: Gastroenterology Authors: Matthew Smale, Julia Freckelton, Jacinta Holmes Source Type: research

The promise of maintaining diet induced weight loss by swallowing one ’s own feces: time to provide a do-it-yourself manual?
(Source: Gastroenterology)
Source: Gastroenterology - October 19, 2020 Category: Gastroenterology Authors: M. Nieuwdorp, K.L. Madsen Source Type: research

Behavioral and Diet Therapies in Integrated Care for Patients with Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is a common, symptom-based condition that has negative effects on quality of life and costs healthcare systems billions of dollars each year. Until recently, management of IBS has focused on over the counter and prescription medications that reduce symptoms in fewer than half of patients. Patients have increasingly sought natural solutions for their IBS symptoms. However, behavioral techniques and dietary modification can be effective in treatment of IBS. Behavioral interventions include gastrointestinal-focused cognitive behavioral therapy and gut-directed hypnotherapy, to modify interaction...
Source: Gastroenterology - October 19, 2020 Category: Gastroenterology Authors: W.D. Chey, L. Keefer, K. Whelan, P.R. Gibson Source Type: research

AGA Clinical Practice Update on Diagnosis and Management of Immune Checkpoint Inhibitor (ICI) Colitis and Hepatitis: Expert Review
Immune checkpoint inhibitors (ICIs) have transformed the treatment landscape for oncology, leading to durable remissions in a subset of patients but also a broad range of potentially life-threatening inflammatory toxicities, many of which involve the gastrointestinal (GI) tract and liver. The purpose of this expert review is to update gastroenterologists on the GI and hepatic toxicities of ICIs and provide practice advice on their diagnosis and management. (Source: Gastroenterology)
Source: Gastroenterology - October 17, 2020 Category: Gastroenterology Authors: Michael Dougan, Yinghong Wang, Alberto Rubio-Tapia, Joseph K. Lim Source Type: research

Covering the Cover
(Source: Gastroenterology)
Source: Gastroenterology - October 16, 2020 Category: Gastroenterology Authors: Andrew T. Chan Tags: Covering the Cover Source Type: research

The SARS-CoV-2 attachment receptor ACE2 is decreased in Crohn ’s disease and regulated by microbial and inflammatory signaling
(Source: Gastroenterology)
Source: Gastroenterology - October 16, 2020 Category: Gastroenterology Authors: Jay Vasant Patankar, Mircea Chiriac, Malte Lehmann, Anja A. K ühl, Raja Atreya, Christoph Becker Source Type: research

Association of HPV genotype 16 lineages with anal cancer histologies among African Americans
(Source: Gastroenterology)
Source: Gastroenterology - October 16, 2020 Category: Gastroenterology Authors: Hassan Brim, Lisa Mirabello, Sara Bass, Debra H. Ford, John M. Carethers, Hassan Ashktorab Source Type: research

Influence of Telemedicine-First Intervention on Patient Visit Choice, Post-Visit Care, and Patient Satisfaction in Gastroenterology
(Source: Gastroenterology)
Source: Gastroenterology - October 16, 2020 Category: Gastroenterology Authors: Craig A. Munroe, Teresa Y. Lin, Smita Rouillard, Jeffrey Fox, Jeffrey K. Lee, Douglas A. Corley Source Type: research

Transplanting microbes for irritable bowels or irritated microbes or both?
(Source: Gastroenterology)
Source: Gastroenterology - October 16, 2020 Category: Gastroenterology Authors: Paul W. O ’Toole, Fergus Shanahan Source Type: research

Reply to GASTRO-D-20-01179
(Source: Gastroenterology)
Source: Gastroenterology - October 14, 2020 Category: Gastroenterology Authors: Yael R. Nobel, Daniel E. Freedberg Source Type: research

Colonoscopist Performance and Colorectal Cancer Risk after Adenoma Removal to Stratify Surveillance: two nationwide observational studies
Colonoscopy surveillance after adenoma removal is an increasing burden in many countries. Surveillance recommendations consider characteristics of removed adenomas, but not colonoscopist performance. We investigated the impact of colonoscopist performance on colorectal cancer risk after adenoma removal. (Source: Gastroenterology)
Source: Gastroenterology - October 13, 2020 Category: Gastroenterology Authors: Paulina Wieszczy, Elisabeth Waldmann, Magnus L øberg, Jaroslaw Regula, Maciej Rupinski, Marek Bugajski, Kathryn Gray, Mette Kalager, Monika Ferlitsch, Michal F. Kaminski, Michael Bretthauer Source Type: research

Winter is coming! Clinical, immunological, and practical considerations for vaccinating patients with IBD during the COVID pandemic
(Source: Gastroenterology)
Source: Gastroenterology - October 13, 2020 Category: Gastroenterology Authors: Gil Y. Melmed, David T. Rubin, Dermot P.B. McGovern Source Type: research

Correction
Lee JK, Jensen CD, Levin TR, et  al. Long-term Risk of Colorectal Cancer and Related Death After Adenoma Removal in a Large, Community-based Population. Gastroenterology 2020;158:884-894. (Source: Gastroenterology)
Source: Gastroenterology - October 12, 2020 Category: Gastroenterology Tags: Correction Source Type: research

Worldwide Burden of, Risk Factors for, and Trends in Pancreatic Cancer
We evaluated global and regional burdens of, risk factors for, and epidemiologic trends in pancreatic cancer among groups of different sexes and ages. (Source: Gastroenterology)
Source: Gastroenterology - October 12, 2020 Category: Gastroenterology Authors: Junjie Huang, Veeleah Lok, Chun Ho Ngai, Lin Zhang, Jinqiu Yuan, Xiang Qian Lao, Kelvin Ng, Charing Chong, Zhi-Jie Zheng, Martin CS. Wong Source Type: research

Computer aided diagnosis with monochromatic light endoscopy for scoring histological remission in ulcerative colitis.
(Source: Gastroenterology)
Source: Gastroenterology - October 12, 2020 Category: Gastroenterology Authors: Peter Bossuyt, Gert De Hertogh, Tom Eelbode, S éverine Vermeire, Raf Bisschops Source Type: research

Race, Ethnicity, and Socioeconomic Status are Associated with Prolonged Time to Treatment After a Diagnosis of Colorectal Cancer: A Large Population-Based Study
(Source: Gastroenterology)
Source: Gastroenterology - October 12, 2020 Category: Gastroenterology Authors: Aileen Bui, Liu Yang, Anthony Myint, Folasade P. May Source Type: research

Identifying novel susceptibility genes for colorectal cancer risk from a transcriptome-wide association study of 125,478 subjects
Susceptibility genes and the underlying mechanisms for the majority of risk loci identified by genome-wide association studies (GWAS) for colorectal cancer (CRC) risk remain largely unknown. We conducted a transcriptome-wide association study (TWAS) to identify putative susceptibility genes. (Source: Gastroenterology)
Source: Gastroenterology - October 11, 2020 Category: Gastroenterology Authors: Xingyi Guo, Weiqiang Lin, Wanqing Wen, Jeroen Huyghe, Stephanie Bien, Qiuyin Cai, Tabitha Harrison, Zhishan Chen, Conghui Qu, Jiandong Bao, Jirong Long, Yuan Yuan, Fangqin Wang, Mengqiu Bai, Goncalo R. Abecasis, Demetrius Albanes, Sonja I. Berndt, St éph Source Type: research

Epigenomic Evaluation of Cholangiocyte TGF β Signaling Identifies a Selective Role for Histone 3 Lysine 9 Acetylation in Biliary Fibrosis
Transforming growth factor β (TGFβ) upregulates cholangiocyte-derived signals that activate myofibroblasts and promote fibrosis. Using epigenomic and transcriptomic approaches, we sought to distinguish the epigenetic activation mechanisms downstream of TGFβ that mediate transcription of fibrogenic signals. (Source: Gastroenterology)
Source: Gastroenterology - October 11, 2020 Category: Gastroenterology Authors: Sayed Obaidullah Aseem, Nidhi Jalan-Sakrikar, Cheng Chi, Amaia Navarro-Corcuera, Thiago M. De Assuncao, Feda H. Hamdan, Shiraj Chowdhury, Jesus M. Banales, Steven A. Johnsen, Vijay H. Shah, Robert C. Huebert Source Type: research

Famotidine Use Is Not Associated With 30-day Mortality: A Coarsened Exact Match Study in 7158 Hospitalized COVID-19 Patients from a Large Healthcare System
(Source: Gastroenterology)
Source: Gastroenterology - October 11, 2020 Category: Gastroenterology Authors: Samrat Yeramaneni, Pratik Doshi, Kenneth Sands, Mandelin Cooper, Dax Kurbegov, Gregg Fromell Source Type: research

Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer
Continuing recalcitrance to therapy cements pancreatic cancer (PC) as the most lethal malignancy, which is set to become the second leading cause of cancer death in our society. The study aim was to investigate the association between DNA damage response (DDR), replication stress and novel therapeutic response in PC to develop a biomarker driven therapeutic strategy targeting DDR and replication stress in PC. (Source: Gastroenterology)
Source: Gastroenterology - October 8, 2020 Category: Gastroenterology Authors: Stephan B. Dreyer, Rosie Upstill-Goddard, Viola Paulus-Hock, Clara Paris, Eirini-Maria Lampraki, Eloise Dray, Bryan Serrels, Giuseppina Caligiuri, Selma Rebus, Dennis Plenker, Zachary Galluzzo, Holly Brunton, Richard Cunningham, Mathias Tesson, Craig Nour Source Type: research

High-Fidelity Drug Induced Liver Injury Screen Using Human PSC-derived Organoids
Preclinical identification of compounds at risk of causing drug induced liver injury (DILI) remains a significant challenge in drug development, highlighting a need for a predictive human system to study complicated DILI mechanism and susceptibility to individual drug. Here, we established a human liver organoid (HLO) based screening model for analyzing DILI pathology at organoid resolution. (Source: Gastroenterology)
Source: Gastroenterology - October 8, 2020 Category: Gastroenterology Authors: Tadahiro Shinozawa, Masaki Kimura, Yuqi Cai, Norikazu Saiki, Yosuke Yoneyama, Rie Ouchi, Hiroyuki Koike, Mari Maezawa, Ran-Ran Zhang, Andrew Dunn, Autumn Ferguson, Shodai Togo, Kyle Lewis, Wendy Thompson, Akihiro Asai, Takanori Takebe Source Type: research

An Unusual Cause of Watery Diarrhea
(Source: Gastroenterology)
Source: Gastroenterology - October 8, 2020 Category: Gastroenterology Authors: Najib Nassani, Constantine Melitas, Edward Villa Source Type: research

An unusual case of small bowel obstruction
(Source: Gastroenterology)
Source: Gastroenterology - October 8, 2020 Category: Gastroenterology Authors: Thomas Worland, Ashley Bloom, Marcus Robertson Source Type: research

A Rare Skin Complication Associated with Crohn's disease
(Source: Gastroenterology)
Source: Gastroenterology - October 8, 2020 Category: Gastroenterology Authors: Rosaline Chung-Yee Hui, Kang- Ling Kuo, Tzu-Wei Yang Source Type: research

“Malignant” liver cysts cause liver failure and recurrence
(Source: Gastroenterology)
Source: Gastroenterology - October 8, 2020 Category: Gastroenterology Authors: Chuan Shen, Zhipeng Zong, Ning Xu Source Type: research

A baffling case of recurrent hematochezia
(Source: Gastroenterology)
Source: Gastroenterology - October 8, 2020 Category: Gastroenterology Authors: Trisha Pasricha, Fateh Bazerbachi, Braden Kuo Source Type: research

The Great Escape: The Surprising Finding in a Case of Acute Vomiting
(Source: Gastroenterology)
Source: Gastroenterology - October 8, 2020 Category: Gastroenterology Authors: Sujata Syamal, Amie Hinshaw, Tony Lulgjuraj Source Type: research

Uncommon Cause of Adult Appendix Cecal Intussusception Removed under Colonoscopy
(Source: Gastroenterology)
Source: Gastroenterology - October 8, 2020 Category: Gastroenterology Authors: Chunpeng Zhu, Xuyong Chen, Xinliang Lu Source Type: research

Clinical Challenges and Images in GI: Morphologic and Microscopic Characterization of an Usual Pancreatic Cystic Lesion
(Source: Gastroenterology)
Source: Gastroenterology - October 7, 2020 Category: Gastroenterology Authors: Stephen A. Firkins, Wei Chen, Somashekar G. Krishna Source Type: research

CLINICAL CHALLENGES AND IMAGES IN GI An Unusual Mechanical Cause of Upper Gastrointestinal Hemorrhage
(Source: Gastroenterology)
Source: Gastroenterology - October 7, 2020 Category: Gastroenterology Authors: Nghiem B. Ha, Connie W. Wang, Najwa El-Nachef Source Type: research

History!
(Source: Gastroenterology)
Source: Gastroenterology - October 7, 2020 Category: Gastroenterology Authors: Luke J. Nayak, Arjun R. Sondhi, Maria Westerhoff Source Type: research

A case of jejunal stricture and mesenteric lymphadenopathy in a young man
(Source: Gastroenterology)
Source: Gastroenterology - October 7, 2020 Category: Gastroenterology Authors: Stanislav Bushik, Naaz Nasar, Daniel J. Gross Source Type: research

A Rare Cause of a Liver Tumor Nodule
(Source: Gastroenterology)
Source: Gastroenterology - October 7, 2020 Category: Gastroenterology Authors: Ivy Yenwen Chau, Yen Ying Chen, Gar Yang Chau Source Type: research

COVID-19 and Jaundice
(Source: Gastroenterology)
Source: Gastroenterology - October 7, 2020 Category: Gastroenterology Authors: Michael Weaver, Scott McHenry, Koushik Das Source Type: research

Fibrates for itch (FITCH) in fibrosing cholangiopathies: a double blind, randomized, placebo-controlled trial
Pruritus may seriously impair quality of life in patients with cholestatic diseases such as primary or secondary sclerosing cholangitis (PSC, SSC) and primary biliary cholangitis (PBC). Pharmacological strategies show limited efficacy and can provoke serious side effects. We hypothesized that bezafibrate, a broad peroxisome proliferator-activated receptor (PPAR) agonist, relieves cholestasis-associated itch by alleviating hepatobiliary injury. The aim of this investigator-initiated FITCH trial ( “Fibrates for cholestatic ITCH”) was to assess effects of bezafibrate on pruritus in patients with PSC, PBC and SSC. ...
Source: Gastroenterology - October 4, 2020 Category: Gastroenterology Authors: Elsemieke de Vries, Ruth Bolier, Jorn Goet, Albert Par és, Jef Verbeek, Marleen de Vree, Joost Drenth, Karel van Erpecum, Karin van Nieuwkerk, Frans van der Heide, Nahid Mostafavi, Jeltje Helder, Cyriel Ponsioen, Ronald Oude Elferink, Henk van Buuren, Ul Source Type: research

Reply to Letter to the Editor: Presence of SARS-Coronavirus-2 in the ileal mucosa: another evidence for infection of GI tract by this virus (GASTRO-D-20-01382)
(Source: Gastroenterology)
Source: Gastroenterology - October 2, 2020 Category: Gastroenterology Authors: Fei Xiao, Meiwen Tang, Hong Shan Source Type: research